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Article ; Online: Chronic Jetlag Alters the Landscape of the Pancreatic Lipidome.

Schwartz, Patrick B / Barrett-Wilt, Gregory A / Ronnekleiv-Kelly, Sean M

2022 Volume 51, Issue 1, Page(s) 80–89

Abstract: Objectives: The innate biologic clock plays a significant role in lipid metabolism, including the peripheral clock in the pancreas. However, an evaluation of the downstream lipids in the pancreatic lipidome is lacking. We sought to understand the ... ...

Abstract	Objectives: The innate biologic clock plays a significant role in lipid metabolism, including the peripheral clock in the pancreas. However, an evaluation of the downstream lipids in the pancreatic lipidome is lacking. We sought to understand the diurnal variations of lipids within the pancreatic lipidome. Methods: At 4 weeks of age, C57Bl/6J mice were subjected to either normal lighting conditions or a chronic jetlag (CJ) condition known to mimic chronic shiftwork in humans. At 9 months, mice were serially killed at 4-hour intervals for 24 hours. The pancreas was removed and subjected to untargeted liquid chromatography-mass spectrometry to examine the pancreatic lipidome. Results: A total of 4.7% of the pancreatic lipidome was rhythmically expressed, which increased to 12.9% after CJ. After CJ, there was a 4.58-hour shift in the timing of peak 24-hour lipid expression. Chronic jetlag also led to the enrichment of diacylglycerols and triglycerides, while promoting a decrease in lysophosphatidylcholines and 44-carbon acyl chain lipids. Conclusions: The pancreatic lipidome exhibits diurnal rhythmicity across a broad number of lipid classes. Chronic jetlag led to alterations in lipid composition that mirrored other metabolically active organs. Several of the reported changes may link altered sleep-wake cycles with known circadian disruption-induced pancreatic diseases.
MeSH term(s)	Animals ; Circadian Rhythm ; Humans ; Lipidomics ; Mice, Inbred C57BL ; Pancreatic Hormones/metabolism ; Sleep Deprivation/metabolism ; Mice
Chemical Substances	Pancreatic Hormones
Language	English
Publishing date	2022-02-23
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	632831-3
ISSN	1536-4828 ; 0885-3177
ISSN (online)	1536-4828
ISSN	0885-3177
DOI	10.1097/MPA.0000000000001962
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Article ; Online: Effect of twice-daily oral administration of a chondroitin sulfate-containing supplement on urine chondroitin sulfate concentrations in dogs.

Wood, Michael W / Barrett-Wilt, Gregory A

American journal of veterinary research

2020 Volume 80, Issue 8, Page(s) 799–805

Abstract: Objective: To quantify the magnitude and duration of changes in urine chondroitin sulfate concentration (uCS) as a result of oral administration of a chondroitin sulfate-containing supplement in dogs.: Animals: 8 healthy privately owned dogs.: ... ...

Abstract	Objective: To quantify the magnitude and duration of changes in urine chondroitin sulfate concentration (uCS) as a result of oral administration of a chondroitin sulfate-containing supplement in dogs. Animals: 8 healthy privately owned dogs. Procedures: A urine sample was collected from each dog via cystocentesis on day 1; free-catch midstream urine samples were collected once daily on days 2 through 5. Pretreatment uCS was established from those samples. Each dog then received a chondroitin sulfate-containing supplement (20 to 30 mg/kg, PO, q 12 h) for 8 days (on days 7 through 14). Urine samples were collected on days 8 through 12 and day 15. For each sample, uCS was quantified by liquid chromatography-tandem mass spectrometry. Variable urine concentration was accounted for by dividing the uCS by urine creatinine concentration (uCrea) to determine the uCS:uCrea ratio. Pretreatment uCS:uCrea ratios were compared with treatment uCS:uCrea ratios to calculate the fold change in uCS after supplement administration. Results: Among the study dogs, oral administration of the chondroitin sulfate-containing supplement resulted in a 1.9-fold increase in the median uCS:uCrea ratio. Data obtained on days 8 through 12 and day 15 indicated that the daily increase in uCS remained consistent and was not additive. Conclusions and clinical relevance: Results indicated that oral administration of supplemental chondroitin sulfate to dogs modestly increased uCS within 24 hours; however, subsequent supplement administration did not have an additive effect. A potential therapeutic benefit of persistently increased uCS in preventing recurrent urinary tract infections in dogs warrants investigation.
MeSH term(s)	Administration, Oral ; Animals ; Chondroitin Sulfates/administration & dosage ; Chondroitin Sulfates/urine ; Chromatography, Liquid/veterinary ; Dietary Supplements ; Dogs/urine ; Drug Administration Schedule ; Female ; Male ; Prospective Studies ; Tandem Mass Spectrometry/veterinary ; Urinalysis/veterinary
Chemical Substances	Chondroitin Sulfates (9007-28-7)
Language	English
Publishing date	2020-02-05
Publishing country	United States
Document type	Clinical Trial, Veterinary ; Journal Article
ZDB-ID	390796-x
ISSN	1943-5681 ; 0002-9645
ISSN (online)	1943-5681
ISSN	0002-9645
DOI	10.2460/ajvr.80.8.799
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Article: Effect of twice-daily oral administration of a chondroitin sulfate–containing supplement on urine chondroitin sulfate concentrations in dogs

Wood, Michael W / Barrett-Wilt, Gregory A

American journal of veterinary research. 2019 Aug., v. 80, no. 8

2019

Abstract: OBJECTIVE To quantify the magnitude and duration of changes in urine chondroitin sulfate concentration (uCS) as a result of oral administration of a chondroitin sulfate–containing supplement in dogs. ANIMALS 8 healthy privately owned dogs. PROCEDURES A ... ...

Abstract	OBJECTIVE To quantify the magnitude and duration of changes in urine chondroitin sulfate concentration (uCS) as a result of oral administration of a chondroitin sulfate–containing supplement in dogs. ANIMALS 8 healthy privately owned dogs. PROCEDURES A urine sample was collected from each dog via cystocentesis on day 1; free-catch midstream urine samples were collected once daily on days 2 through 5. Pretreatment uCS was established from those samples. Each dog then received a chondroitin sulfate–containing supplement (20 to 30 mg/kg, PO, q 12 h) for 8 days (on days 7 through 14). Urine samples were collected on days 8 through 12 and day 15. For each sample, uCS was quantified by liquid chromatography–tandem mass spectrometry. Variable urine concentration was accounted for by dividing the uCS by urine creatinine concentration (uCrea) to determine the uCS:uCrea ratio. Pretreatment uCS:uCrea ratios were compared with treatment uCS:uCrea ratios to calculate the fold change in uCS after supplement administration. RESULTS Among the study dogs, oral administration of the chondroitin sulfate–containing supplement resulted in a 1.9-fold increase in the median uCS:uCrea ratio. Data obtained on days 8 through 12 and day 15 indicated that the daily increase in uCS remained consistent and was not additive. CONCLUSIONS AND CLINICAL RELEVANCE Results indicated that oral administration of supplemental chondroitin sulfate to dogs modestly increased uCS within 24 hours; however, subsequent supplement administration did not have an additive effect. A potential therapeutic benefit of persistently increased uCS in preventing recurrent urinary tract infections in dogs warrants investigation.
Keywords	additive effect ; chondroitin sulfate ; creatinine ; dog diseases ; dogs ; liquid chromatography ; oral administration ; tandem mass spectrometry ; urinary tract diseases ; urine ; veterinary medicine
Language	English
Dates of publication	2019-08
Size	p. 799-805.
Publishing place	American Veterinary Medical Association
Document type	Article
ZDB-ID	390796-x
ISSN	1943-5681 ; 0002-9645
ISSN (online)	1943-5681
ISSN	0002-9645
DOI	10.2460/ajvr.80.8.799
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Article ; Online: Assessment of Truck-Mounted Area-Wide S-methoprene Applications to Manage West Nile Virus Vector Species in the Suburbs of Chicago, IL, USA.

Johnson, Haley E / Clifton, Mark / Harbison, Justin E / Erkapic, Anastazia / Barrett-Wilt, Gregory A / Paskewitz, Susan / Bartholomay, Lyric

Journal of medical entomology

2022 Volume 60, Issue 2, Page(s) 384–391

Abstract: West Nile virus remains the leading cause of arboviral neuroinvasive disease in the United States, despite extensive efforts to control the mosquito vectors involved in transmission. In this study, we evaluated the effectiveness of Altosid SR-20 (active ... ...

Abstract	West Nile virus remains the leading cause of arboviral neuroinvasive disease in the United States, despite extensive efforts to control the mosquito vectors involved in transmission. In this study, we evaluated the effectiveness of Altosid SR-20 (active ingredient, S-methoprene 20%) larvicide applications using truck-mounted ultra-low volume (ULV) dispersal equipment to target Culex pipiens Linnaeus (Diptera: Culicidae) and Cx. restuans (Theobald)larvae. A combination of emergence bioassays, open-field measurements of deposited S-methoprene and spray distribution using gas chromatography-mass spectrometry, and assessments of adult Culex spp. populations in response to applications were conducted over the summer of 2020 within the North Shore Mosquito Abatement District (IL, USA). Open-field applications revealed that dispersed Altosid SR-20 using ULV equipment was effective (75% emergence inhibition in susceptible lab strain Cx. pipiens larvae) up to 53 m. In suburban neighborhood applications, we found that S-methoprene deposition and larval emergence inhibition (EI) in front yards did not differ significantly from backyards. An overall EI of 46% and 28% were observed for laboratory strain Cx. pipiens and wild Cx. restuans larvae respectively, and both had an EI significantly higher than the untreated control group. The EI of exposed wild Cx. pipiens larvae did not differ from the untreated controls, suggesting an increased tolerance to S-methoprene. No difference in abundance of gravid or host-seeking adult Culex spp. post-application was detected between treated and untreated sites. These results document the ability of area-wide application to distribute S-methoprene, but this strategy will need further modifications and evaluation for Culex spp. management.
MeSH term(s)	Animals ; West Nile virus ; Methoprene ; Chicago ; Mosquito Vectors ; Seasons ; Culex/physiology ; Larva ; West Nile Fever/prevention & control
Chemical Substances	Methoprene (8B830OJ2UX)
Language	English
Publishing date	2022-11-05
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	410635-0
ISSN	1938-2928 ; 0022-2585
ISSN (online)	1938-2928
ISSN	0022-2585
DOI	10.1093/jme/tjac170
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Article ; Online: Bacteria: A novel source for potent mosquito feeding-deterrents.

Kajla, Mayur K / Barrett-Wilt, Gregory A / Paskewitz, Susan M

Science advances

2019 Volume 5, Issue 1, Page(s) eaau6141

Abstract: Antibiotic and insecticidal bioactivities of the extracellular secondary metabolites produced by entomopathogenic bacteria belonging to ... ...

Abstract	Antibiotic and insecticidal bioactivities of the extracellular secondary metabolites produced by entomopathogenic bacteria belonging to genus
MeSH term(s)	Aedes/drug effects ; Aedes/physiology ; Animals ; Anopheles/drug effects ; Anopheles/physiology ; Culex/drug effects ; Culex/physiology ; DEET/pharmacology ; Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical/instrumentation ; Drug Evaluation, Preclinical/methods ; Feeding Behavior/drug effects ; Female ; Insect Repellents/administration & dosage ; Insect Repellents/chemistry ; Insect Repellents/pharmacology ; Oligopeptides/chemistry ; Piperidines/pharmacology ; Polyamines/chemistry ; Xenorhabdus/chemistry
Chemical Substances	Insect Repellents ; Oligopeptides ; Piperidines ; Polyamines ; fabclavine Ia ; DEET (134-62-3) ; picaridin (N51GQX0837)
Language	English
Publishing date	2019-01-16
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.aau6141
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Article ; Online: Dietary adaptation to high starch involves increased relative abundance of sucrase-isomaltase and its mRNA in nestling house sparrows.

Brun, Antonio / Magallanes, Melisa E / Barrett-Wilt, Gregory A / Karasov, William H / Caviedes-Vidal, Enrique

American journal of physiology. Regulatory, integrative and comparative physiology

2020 Volume 320, Issue 2, Page(s) R195–R202

Abstract: Dietary flexibility in digestive enzyme activity is widespread in vertebrates but mechanisms are poorly understood. When laboratory rats are switched to a higher carbohydrate diet, the activities of the apical intestinal α-glucosidases (AGs) increase ... ...

Abstract	Dietary flexibility in digestive enzyme activity is widespread in vertebrates but mechanisms are poorly understood. When laboratory rats are switched to a higher carbohydrate diet, the activities of the apical intestinal α-glucosidases (AGs) increase within 6-12 h, mainly by rapid increase in enzyme transcription, followed by rapid translation and translocation to the intestine's apical, brush-border membrane (BBM). We performed the first unified study of the overall process in birds, relying on activity, proteomic, and transcriptomic data from the same animals. Our avian model was nestling house sparrows (
MeSH term(s)	Adaptation, Physiological/drug effects ; Aging ; Animal Feed ; Animals ; Diet/veterinary ; Dietary Carbohydrates/pharmacology ; Gene Expression Regulation, Enzymologic/drug effects ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Sparrows/physiology ; Starch/administration & dosage ; Starch/pharmacology ; Sucrase-Isomaltase Complex/genetics ; Sucrase-Isomaltase Complex/metabolism
Chemical Substances	Dietary Carbohydrates ; RNA, Messenger ; Starch (9005-25-8) ; Sucrase-Isomaltase Complex (EC 3.2.1.-)
Language	English
Publishing date	2020-11-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603839-6
ISSN	1522-1490 ; 0363-6119
ISSN (online)	1522-1490
ISSN	0363-6119
DOI	10.1152/ajpregu.00181.2020
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Article ; Online: Identification of Molecular Targets of Dietary Grape-Mediated Chemoprevention of Ultraviolet B Skin Carcinogenesis: A Comparative Quantitative Proteomics Analysis.

Mintie, Charlotte A / Singh, Chandra K / Ndiaye, Mary A / Barrett-Wilt, Gregory A / Ahmad, Nihal

Journal of proteome research

2019 Volume 18, Issue 10, Page(s) 3741–3751

Abstract: We recently showed that dietary grape powder (GP) imparts considerable protection against ultraviolet B (UVB)-mediated skin carcinogenesis in SKH-1 mice. To determine molecular mechanisms of this response, we employed tandem mass tag (TMT) quantitative ... ...

Abstract	We recently showed that dietary grape powder (GP) imparts considerable protection against ultraviolet B (UVB)-mediated skin carcinogenesis in SKH-1 mice. To determine molecular mechanisms of this response, we employed tandem mass tag (TMT) quantitative global proteomics approach on skin tumors from mice exposed to 180 mJ/cm
MeSH term(s)	Animals ; Chemoprevention/methods ; Diet ; Drug Delivery Systems ; Mice ; Oxidative Stress ; Proteolysis ; Proteomics/methods ; Skin Neoplasms/etiology ; Skin Neoplasms/prevention & control ; Tandem Mass Spectrometry ; Ubiquitination ; Ultraviolet Rays/adverse effects ; Vitis/chemistry
Language	English
Publishing date	2019-09-23
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2078618-9
ISSN	1535-3907 ; 1535-3893
ISSN (online)	1535-3907
ISSN	1535-3893
DOI	10.1021/acs.jproteome.9b00442
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Article ; Online: A Fast and Accurate Method to Identify and Quantify Enzymes in Brush-Border Membranes: In Situ Hydrolysis Followed by Nano LC-MS/MS.

Brun, Antonio / Magallanes, Melisa E / Martínez Del Rio, Carlos / Barrett-Wilt, Gregory A / Karasov, William H / Caviedes-Vidal, Enrique

Methods and protocols

2020 Volume 3, Issue 1

Abstract: A simple method for the identification of brush-border membrane α-glucosidases is described. The proteins were first solubilized and separated in a gel under native, non-denaturing, conditions. The gel was then incubated in substrate solutions (maltose ... ...

Abstract	A simple method for the identification of brush-border membrane α-glucosidases is described. The proteins were first solubilized and separated in a gel under native, non-denaturing, conditions. The gel was then incubated in substrate solutions (maltose or sucrose), and the product (glucose) exposed in situ by the oxidation of o-dianisidine, which yields a brown-orange color. Nano-liquid chromatography coupled to mass spectrometry analyses of proteins (nano LC-MS/MS) present in the colored bands excised from the gels, was used to confirm the presence of the enzymes. The stain is inexpensive and the procedure permits testing several substrates in the same gel. Once enzymes are identified, their abundance, relative to that of other proteins in the brush border, can be semi-quantified using nano LC-MS/MS.
Language	English
Publishing date	2020-02-10
Publishing country	Switzerland
Document type	Journal Article
ISSN	2409-9279
ISSN (online)	2409-9279
DOI	10.3390/mps3010015
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Article ; Online: Co-culture with mouse embryonic fibroblasts improves maintenance of metabolic function of human small hepatocyte progenitor cells.

Sengupta, Srikumar / Johnson, Brian / Seirup, Morten / Ardalani, Hamisha / Duffin, Bret / Barrett-Wilt, Gregory A / Stewart, Ron / Thomson, James A

Current research in toxicology

2020 Volume 1, Page(s) 70–84

Abstract: Derivation and culture of small hepatocyte progenitor cells (SHPCs) capable of ... ...

Abstract	Derivation and culture of small hepatocyte progenitor cells (SHPCs) capable of proliferating
Language	English
Publishing date	2020-08-26
Document type	Journal Article
ISSN	2666-027X
ISSN (online)	2666-027X
DOI	10.1016/j.crtox.2020.08.001
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Article ; Online: A tail of two voltages: Proteomic comparison of the three electric organs of the electric eel.

Traeger, Lindsay L / Sabat, Grzegorz / Barrett-Wilt, Gregory A / Wells, Gregg B / Sussman, Michael R

Science advances

2017 Volume 3, Issue 7, Page(s) e1700523

Abstract: The electric eel ( ...

Abstract	The electric eel (
MeSH term(s)	Animals ; Electric Organ/metabolism ; Electrophorus/physiology ; Phosphopeptides/metabolism ; Phosphoproteins/metabolism ; Phosphorylation ; Potassium Channels/metabolism ; Proteome ; Proteomics/methods
Chemical Substances	Phosphopeptides ; Phosphoproteins ; Potassium Channels ; Proteome
Language	English
Publishing date	2017-07-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.1700523
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