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  1. Artikel: Editorial: Micronutrients and critically ill patients.

    Lazzarin, Taline / Azevedo, Paula Schmidt / Cardoso, Barbara Rita / Suen, Vivian Marques Miguel / Minicucci, Marcos Ferreira

    Frontiers in medicine

    2024  Band 10, Seite(n) 1352808

    Sprache Englisch
    Erscheinungsdatum 2024-01-08
    Erscheinungsland Switzerland
    Dokumenttyp Editorial
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1352808
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Editorial

    Taline Lazzarin / Paula Schmidt Azevedo / Barbara Rita Cardoso / Vivian Marques Miguel Suen / Marcos Ferreira Minicucci

    Frontiers in Medicine, Vol

    Micronutrients and critically ill patients

    2024  Band 10

    Schlagwörter micronutrients ; critically ill patients ; mortality ; vitamins ; electrolyte ; Medicine (General) ; R5-920
    Sprache Englisch
    Erscheinungsdatum 2024-01-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Role of sulfonylurea administration in sepsis and septic shock patients: A systematic review.

    Lazzarin, Taline / Ballarin, Raquel Simões / Pereira, Filipe Welson Leal / Azevedo, Paula Schmidt / Tanni, Suzana Erico / Minicucci, Marcos Ferreira

    Clinics (Sao Paulo, Brazil)

    2023  Band 78, Seite(n) 100197

    Mesh-Begriff(e) Humans ; Shock, Septic ; Sepsis ; Hospital Mortality
    Sprache Englisch
    Erscheinungsdatum 2023-04-24
    Erscheinungsland United States
    Dokumenttyp Systematic Review ; Letter
    ZDB-ID 2182801-5
    ISSN 1980-5322 ; 1807-5932
    ISSN (online) 1980-5322
    ISSN 1807-5932
    DOI 10.1016/j.clinsp.2023.100197
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Methylene blue in sepsis and septic shock: a systematic review and meta-analysis.

    Ballarin, Raquel Simões / Lazzarin, Taline / Zornoff, Leonardo / Azevedo, Paula Schmidt / Pereira, Filipe Welson Leal / Tanni, Suzana Erico / Minicucci, Marcos Ferreira

    Frontiers in medicine

    2024  Band 11, Seite(n) 1366062

    Abstract: Background: Methylene blue is an interesting approach in reducing fluid overload and vasoactive drug administration in vasodilatory shock. The inhibition of guanylate cyclase induced by methylene blue infusion reduces nitric oxide production and ... ...

    Abstract Background: Methylene blue is an interesting approach in reducing fluid overload and vasoactive drug administration in vasodilatory shock. The inhibition of guanylate cyclase induced by methylene blue infusion reduces nitric oxide production and improves vasoconstriction. This systematic review and meta-analysis aimed to assess the effects of methylene blue administration compared to placebo on the hemodynamic status and clinical outcomes in patients with sepsis and septic shock.
    Methods: The authors specifically included randomized controlled trials that compared the use of methylene blue with placebo in adult patients with sepsis and septic shock. The outcomes were length of intensive care unit stay, hemodynamic parameters [vasopressor use], and days on mechanical ventilation. We also evaluated the abnormal levels of methemoglobinemia. This systematic review and meta-analysis were recorded in PROSPERO with the ID CRD42023423470.
    Results: During the initial search, a total of 1,014 records were identified, out of which 393 were duplicates. Fourteen citations were selected for detailed reading, and three were selected for inclusion. The studies enrolled 141 patients, with 70 of them in the methylene blue group and 71 of them in the control group. Methylene blue treatment was associated with a lower length of intensive care unit stay (MD -1.58; 95%CI -2.97, -0.20;
    Conclusion: Administering methylene blue to patients with sepsis and septic shock leads to reduced time to vasopressor discontinuation, length of intensive care unit stay, and days on mechanical ventilation.
    Systematic review registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023423470, CRD42023423470.
    Sprache Englisch
    Erscheinungsdatum 2024-04-18
    Erscheinungsland Switzerland
    Dokumenttyp Systematic Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2024.1366062
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Plasma Fibrinogen as a Predictor of Perioperative-Blood-Component Transfusion in Major-Nontraumatic-Orthopedic-Surgery Patients: A Cohort Study.

    Pagnussatt Neto, Eugenio / Lopes da Costa, Paula Daniele / Gurgel, Sanderland J Tavares / Schmidt Azevedo, Paula / Modolo, Norma S Pinheiro / do Nascimento Junior, Paulo

    Diagnostics (Basel, Switzerland)

    2023  Band 13, Heft 5

    Abstract: There is a trend towards increased perioperative bleeding in patients with plasma fibrinogen levels < 200 mg/ ... ...

    Abstract There is a trend towards increased perioperative bleeding in patients with plasma fibrinogen levels < 200 mg/dL
    Sprache Englisch
    Erscheinungsdatum 2023-03-04
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13050976
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: FRAIL scale as a screening tool and a predictor of mortality in non-dialysis dependent patients.

    Rodrigues, Hellen Christina Neves / Sousa, Amanda Goulart de Oliveira / Preto, Vitória Rodrigues Morais / Ferro, Camila Moura Batista / Sugizaki, Clara Sandra de Araújo / Freitas, Ana Tereza Vaz de Souza / Minicucci, Marcos Ferreira / Azevedo, Paula Schmidt / Peixoto, Maria do Rosário Gondim / Costa, Nara Aline

    Journal of nephrology

    2024  

    Abstract: Background: This study aimed to compare the diagnostic yield of the FRAIL scale with respect to the physical frailty phenotype measure and their association with mortality in non-dialysis-dependent patients.: Methods: In this prospective cohort study, ...

    Abstract Background: This study aimed to compare the diagnostic yield of the FRAIL scale with respect to the physical frailty phenotype measure and their association with mortality in non-dialysis-dependent patients.
    Methods: In this prospective cohort study, non-dialysis dependent patients with chronic kidney disease (CKD) stages 3b-5 seen in the nephrology outpatient clinics of two university hospitals were included. The presence of frailty was evaluated by physical frailty phenotype measure and the FRAIL scale. Patients were evaluated for six months, and mortality was recorded. The Kappa test was used to evaluate the diagnostic properties between the methods, and logistic regression to test the association between frailty and mortality.
    Results: One hundred fifty-three patients were evaluated; average age was 65 (56-70) years, 50.9% were women, and the all-cause mortality rate was 2.6%. Forty-six patients were classified as living with frailty according to the physical frailty phenotype while 36 patients were rated frail by the FRAIL scale. In adults < 60 years of age, the FRAIL scale showed good accuracy (84.9%) and specificity (93.2%) but had low sensitivity (41.3%) and moderate agreement (Kappa = 0.41; p < 0.001) compared to the definition of the physical frailty phenotype. The adjusted logistic regression model showed that the patients with frailty assessed by the FRAIL scale had a greater chance of mortality than the non-frail patients (OR: 6.8; CI95%:1.477-31.513; p = 0.014).
    Conclusion: Physical frailty phenotype identifies more patients as having pre-frailty and frailty in non-dialysis dependent patients as compared to the FRAIL scale. However, the FRAIL scale is a simple bedside tool that can be useful for screening for frailty and whose results were associated with mortality.
    Sprache Englisch
    Erscheinungsdatum 2024-03-26
    Erscheinungsland Italy
    Dokumenttyp Journal Article
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-024-01900-3
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Serum urea increase during hospital stay is associated with worse outcomes after in-hospital cardiac arrest.

    Barros, João Carlos Clarck / Ferreira, Gustavo Martins / Souza, Isabelle de Almeida / Shalova, Asiya / Azevedo, Paula Schmidt / Polegato, Bertha Furlan / Zornoff, Leonardo / de Paiva, Sergio Alberto Rupp / Favero, Edson Luiz / Lazzarin, Taline / Minicucci, Marcos Ferreira

    The American journal of the medical sciences

    2024  

    Abstract: Background: Evaluate the association between serum urea at admission and during hospital stay with return of spontaneous circulation (ROSC) and in-hospital mortality in patients with in-hospital cardiac arrest (IHCA).: Methods: This retrospective ... ...

    Abstract Background: Evaluate the association between serum urea at admission and during hospital stay with return of spontaneous circulation (ROSC) and in-hospital mortality in patients with in-hospital cardiac arrest (IHCA).
    Methods: This retrospective study included patients over 18 years with IHCA attended from May 2018 to December 2022. The exclusion criteria were the absence of exams to calculate delta urea and the express order of "do-not-resuscitate". Data were collected from the electronic medical records. Serum admission urea and urea 24 hours before IHCA were also collected and used to calculate delta urea.
    Results: A total of 504 patients were evaluated; 125 patients were excluded due to the absence of variables to calculate delta urea and 5 due to "do-not-resuscitate" order. Thus, we included 374 patients in the analysis. The mean age was 65.0 ± 14.5 years, 48.9% were male, 45.5% had ROSC, and in-hospital mortality was 91.7%. In logistic regression models, ROSC was associated with lower urea levels 24 hours before IHCA (OR: 0.996; CI95%: 0.992-1.000; p: 0.032). In addition, increased levels of urea 24 hours before IHCA (OR: 1.020; CI95%: 1.008-1.033; p: 0.002) and of delta urea (OR: 1.001; CI95%: 1.001-1.019; p: 0.023) were associated with in-hospital mortality. ROC curve analysis showed that the area under the ROC curve for mortality prediction was higher for urea 24 hours before IHCA (Cutoff > 120.1 mg/dL) than for delta urea (Cutoff > 34.83 mg/dL).
    Conclusions: In conclusion, increased serum urea levels during hospital stay were associated with worse prognosis in IHCA.
    Sprache Englisch
    Erscheinungsdatum 2024-04-27
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 82078-7
    ISSN 1538-2990 ; 0002-9629
    ISSN (online) 1538-2990
    ISSN 0002-9629
    DOI 10.1016/j.amjms.2024.04.016
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Plasma Fibrinogen as a Predictor of Perioperative-Blood-Component Transfusion in Major-Nontraumatic-Orthopedic-Surgery Patients

    Eugenio Pagnussatt Neto / Paula Daniele Lopes da Costa / Sanderland J. Tavares Gurgel / Paula Schmidt Azevedo / Norma S. Pinheiro Modolo / Paulo do Nascimento Junior

    Diagnostics, Vol 13, Iss 976, p

    A Cohort Study

    2023  Band 976

    Abstract: There is a trend towards increased perioperative bleeding in patients with plasma fibrinogen levels < 200 mg/dL −1 . This study aimed to assess whether there is an association between preoperative fibrinogen levels and perioperative blood-product ... ...

    Abstract There is a trend towards increased perioperative bleeding in patients with plasma fibrinogen levels < 200 mg/dL −1 . This study aimed to assess whether there is an association between preoperative fibrinogen levels and perioperative blood-product transfusion up to 48 h after major orthopedic surgery. This cohort study included 195 patients who underwent primary or revision hip arthroplasty for nontraumatic etiologies. Plasma fibrinogen, blood count, coagulation tests, and platelet count were measured preoperatively. A plasma fibrinogen level of 200 mg/dL −1 was the cutoff value used to predict blood transfusion. The mean (SD) plasma fibrinogen level was 325 (83) mg/dL −1 . Only thirteen patients had levels < 200 mg/dL −1 , and only one of them received a blood transfusion, with an absolute risk of 7.69% (1/13; 95%CI: 1.37–33.31%). Preoperative plasma fibrinogen levels were not associated with the need for blood transfusion ( p = 0.745). The sensitivity and the positive predictive value of plasma fibrinogen < 200 mg/dL −1 as a predictor of blood transfusion were 4.17% (95%CI: 0.11–21.12%) and 7.69% (95%CI: 1.12–37.99%), respectively. Test accuracy was 82.05% (95%CI: 75.93–87.17%), but positive and negative likelihood ratios were poor. Therefore, preoperative plasma fibrinogen level in hip-arthroplasty patients was not associated with the need for blood-product transfusion.
    Schlagwörter anesthesia ; blood transfusion ; blood-coagulation tests ; fibrinogen ; orthopedic surgeries ; Medicine (General) ; R5-920
    Sprache Englisch
    Erscheinungsdatum 2023-03-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Association of Outdoor Relative Humidity and Temperature on In-Hospital Cardiac Arrest Prognosis.

    Lazzarin, Taline / Fávero Junior, Edson Luiz / Delai, Caroline Casagrande / Pinheiro, Victor Rocha / Ballarin, Raquel Simões / Rischini, Felipe Antonio / Polegato, Bertha Furlan / Azevedo, Paula Schmidt / de Paiva, Sergio Alberto Rupp / Zornoff, Leonardo / da Cunha, Antônio Ribeiro / do Valle, Adriana Polachini / Minicucci, Marcos Ferreira

    Global heart

    2023  Band 18, Heft 1, Seite(n) 52

    Mesh-Begriff(e) Humans ; Temperature ; Humidity ; Heart Arrest ; Prognosis ; Hospitals ; Retrospective Studies
    Sprache Englisch
    Erscheinungsdatum 2023-09-28
    Erscheinungsland England
    Dokumenttyp Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2629633-0
    ISSN 2211-8179 ; 2211-8160
    ISSN (online) 2211-8179
    ISSN 2211-8160
    DOI 10.5334/gh.1266
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Reduced mobility is associated with adverse outcomes after in-hospital cardiac arrest.

    Lazzarin, Taline / Fávero Junior, Edson Luiz / Rischini, Felipe Antonio / Azevedo, Paula Schmidt / Polegato, Bertha Furlan / Paiva, Sergio Alberto Rupp de / Zornoff, Leonardo / Minicucci, Marcos Ferreira

    Revista da Associacao Medica Brasileira (1992)

    2023  Band 69, Heft 12, Seite(n) e20230947

    Abstract: Objective: In-hospital cardiac arrest is a critical medical emergency. Knowledge of prognostic factors could assist in cardiopulmonary resuscitation decision-making. Frailty and functional status are emerging risk factors and may play a role in ... ...

    Abstract Objective: In-hospital cardiac arrest is a critical medical emergency. Knowledge of prognostic factors could assist in cardiopulmonary resuscitation decision-making. Frailty and functional status are emerging risk factors and may play a role in prognostication. The objective was to evaluate the association between reduced mobility and in-hospital cardiac arrest outcomes.
    Methods: This retrospective cohort study included patients over 18 years of age with in-hospital cardiac arrest in Botucatu, Brazil, from April 2018 to December 2021. Exclusion criteria were patients with a do-not-resuscitate order or patients with recurrent in-hospital cardiac arrest. Reduced mobility was defined as the need for a bed bath 48 h before in-hospital cardiac arrest. The outcomes of no return of spontaneous circulation and in-hospital mortality were evaluated.
    Results: A total of 387 patients were included in the analysis. The mean age was 65.4±14.8 years; 53.7% were males and 75.4% had reduced mobility. Among the evaluated outcomes, the no return of spontaneous circulation rate was 57.1%, and in-hospital mortality was 94.3%. In multivariate analysis, reduced mobility was associated with no return of spontaneous circulation when adjusted by age, gender, initial shockable rhythm, duration of cardiopulmonary resuscitation, and epinephrine administration. However, in multiple logistic regression, there was no association between reduced mobility and in-hospital mortality.
    Conclusion: In patients with in-hospital cardiac arrest, reduced mobility is associated with no return of spontaneous circulation. However, there is no relation to in-hospital mortality.
    Mesh-Begriff(e) Male ; Humans ; Adolescent ; Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Female ; Retrospective Studies ; Out-of-Hospital Cardiac Arrest ; Emergency Medical Services ; Cardiopulmonary Resuscitation ; Hospitals
    Sprache Englisch
    Erscheinungsdatum 2023-10-30
    Erscheinungsland Brazil
    Dokumenttyp Journal Article
    ZDB-ID 731969-1
    ISSN 1806-9282 ; 0104-4230 ; 0004-5241 ; 0102-843X
    ISSN (online) 1806-9282
    ISSN 0104-4230 ; 0004-5241 ; 0102-843X
    DOI 10.1590/1806-9282.20230947
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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