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  1. Artikel: Effects of Different Taping Techniques in Individuals with Myofascial Pain Syndrome with a Trigger Point in the Trapezius Muscle: A Sham-controlled Randomized Study.

    Kardes, Kubra / Van Der Veer, Pinar / Tutuneken, Yunus Emre / Aykac, Hale Nur / Arslan, Esra / Aksoy, Aysenur / Buran Cirak, Yasemin

    Medeniyet medical journal

    2024  Band 39, Heft 1, Seite(n) 39–48

    Abstract: Objective: This study aimed to compare the effects of three different kinesio taping (KT) techniques in individuals with myofascial pain syndrome (MPS) who have a trigger point in the trapezius muscle.: Methods: The individuals included in our study ... ...

    Abstract Objective: This study aimed to compare the effects of three different kinesio taping (KT) techniques in individuals with myofascial pain syndrome (MPS) who have a trigger point in the trapezius muscle.
    Methods: The individuals included in our study were randomly divided into four groups: Group 1: Functional correlation technique, group 2: Fascia correlation technique, group 3: Star taping technique (STT), and group 4: Sham group. The visual analog scale was used to assess pain, cervical joint range of motion (ROM) with a universal goniometer, grip strength with a hand dynamometer, number of active trigger points by palpation, pressure-pain threshold with an algometer, quality of life with the Nottingham Health Profile and functional level with the Neck Disability index were evaluated before and after treatment.
    Results: There was no difference between the groups in terms of demographic data and pre-treatment outcome measures (p>0.05). There was a significant difference in the pain score between the groups after treatment (p<0.05). A statistically significant difference was found in the cervical flexion ROM of all groups after treatment (p<0.05). In pairwise comparisons, these differences were found due to group 3 (p<0.05).
    Conclusions: The three KT techniques are effective in reducing pain, increasing ROM, reducing the number of active trigger points, and increasing grip strength. Among these techniques, STT was found to be more effective in reducing pain and increasing cervical flexion ROM. KT is a method that can be used in the clinic for patients with MPS.
    Sprache Englisch
    Erscheinungsdatum 2024-03-21
    Erscheinungsland Turkey
    Dokumenttyp Journal Article
    ZDB-ID 3035195-9
    ISSN 2149-4606 ; 2149-2042
    ISSN (online) 2149-4606
    ISSN 2149-2042
    DOI 10.4274/MMJ.galenos.2024.59207
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Methylprednisolone use in children with severe pneumonia caused by severe acute respiratory syndrome coronavirus 2.

    Ozsurekci, Yasemin / Aykac, Kubra / Demir, Osman Oguz / Ilbay, Sare / Kesici, Selman / Karakaya, Jale / Cengiz, Ali Bulent

    Pediatrics international : official journal of the Japan Pediatric Society

    2023  Band 65, Heft 1, Seite(n) e15603

    Abstract: Background: This study aimed to evaluate the effectiveness and optimal use of corticosteroids in children with severe coronavirus disease 2019 (COVID-19) pneumonia, for which effective treatment is still lacking with respect to this population.: ... ...

    Abstract Background: This study aimed to evaluate the effectiveness and optimal use of corticosteroids in children with severe coronavirus disease 2019 (COVID-19) pneumonia, for which effective treatment is still lacking with respect to this population.
    Methods: We conducted a retrospective study and included patients (aged < 18 years) with severe COVID-19 pneumonia and/or acute respiratory distress syndrome (ARDS) who received standard doses (2-4 mg/kg/day) and high doses (>250 mg/day) of methylprednisolone (MPZ). We adjusted for patients on steroid treatments with a propensity score and compared the side effects of different MPZ doses and patient survival.
    Results: Fifty-nine patients were included: 61% were male, the median age was 8, interquartile range (IQR) 2-15) years. The overall survival was 84.4% in patients treated with standard-dose MPZ (n = 45, 76.3%) and 92.2% in patients treated with high-dose MPZ (n = 14, 23.7%; p = 0.67). The demographic, clinical, and laboratory data did not differ significantly after propensity score matching, apart from bradycardia, which was a prominent feature of the high-dose group. The clinical and radiological response rates on day 7 were higher and the need for invasive mechanical ventilation (IMV) was lower in the high-dose group.
    Conclusion: The patients with high-dose MPZ had better clinical and radiological responses than those with standard-dose MPZ, although the mortality rate did not differ between standard and high-dose regimens of MPZ.
    Mesh-Begriff(e) Humans ; Male ; Child ; Child, Preschool ; Adolescent ; Female ; SARS-CoV-2 ; COVID-19 ; Methylprednisolone/therapeutic use ; Retrospective Studies ; Respiratory Distress Syndrome/drug therapy ; Respiration, Artificial
    Chemische Substanzen Methylprednisolone (X4W7ZR7023)
    Sprache Englisch
    Erscheinungsdatum 2023-08-29
    Erscheinungsland Australia
    Dokumenttyp Journal Article
    ZDB-ID 1470376-2
    ISSN 1442-200X ; 1328-8067
    ISSN (online) 1442-200X
    ISSN 1328-8067
    DOI 10.1111/ped.15603
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  3. Artikel ; Online: Immunogenicity and Protective Capacity of CpG ODN Adjuvanted Alum Adsorbed Bivalent Meningococcal Outer Membrane Vesicle Vaccine.

    Canavar Yildirim, Tugce / Ozsurekci, Yasemin / Yildirim, Muzaffer / Evcili, Irem / Yazar, Volkan / Aykac, Kubra / Guler, Ulku / Salih, Bekir / Gursel, Mayda / Gursel, Ihsan

    International immunology

    2024  

    Abstract: Invasive meningococcal disease (IMD) is caused by Neisseria meningitidis, with the main serogroups responsible for the disease being A, B, C, W, X, and Y. To date, several vaccines targeting N.meningitidis have been developed albeit with a short-lived ... ...

    Abstract Invasive meningococcal disease (IMD) is caused by Neisseria meningitidis, with the main serogroups responsible for the disease being A, B, C, W, X, and Y. To date, several vaccines targeting N.meningitidis have been developed albeit with a short-lived protection. Given that MenW and MenB are the most common causes of IMD in Europe, Turkey, and Middle East, we aimed to develop an outer membrane vesicle (OMV) based bivalent vaccine as the heterologous antigen source. Herein, we compared the immunogenicity, and breadth of serum bactericidal assays (SBA) based protective coverage of OMV vaccine to X serotype with existing commercial meningococcal conjugate and polysaccharide (PS) vaccines in a murine model. BALB/c mice were immunized with preclinical batches of the W+B OMV vaccine, either adjuvanted with Alum, CpG ODN or their combinations and compared with a MenACYW conjugate vaccine (NimenrixTM, Pfizer) and a MenB OMV-based vaccine (Bexsero®, GSK), The immune responses were assessed through ELISA and SBA. Antibody responses and SBA titers were significantly higher in the W+B OMV vaccine when adjuvanted with Alum or CpG ODN, as compared to the control groups. Moreover, the SBA titers were not only significantly higher than those achieved with available conjugated ACYW vaccines but also on par with the 4CMenB vaccines. In conclusion, the W+B OMV vaccine demonstrated the capacity to elicit robust antibody responses, surpassing or matching the levels induced by licensed meningococcal vaccines. Consequently, the W+B OMV vaccine could potentially serve as a viable alternative or supplement to existing meningococcal vaccines.
    Sprache Englisch
    Erscheinungsdatum 2024-03-27
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1013745-2
    ISSN 1460-2377 ; 0953-8178
    ISSN (online) 1460-2377
    ISSN 0953-8178
    DOI 10.1093/intimm/dxae016
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  4. Artikel ; Online: MyD88 in osteoclast- and osteoblast-lineages differentially controls bone remodeling in homeostasis and malaria.

    Alshaweesh, Jalal / Dash, Rashmi / Lee, Michelle S J / Kahyaoglu, Pinar / Erci, Ece / Xu, Mengling / Matsuo-Dapaah, Julia / Del Rosario Zorrilla, Camila / Aykac, Kubra / Ekemen, Suheyla / Kobiyama, Kouji / Ishii, Ken J / Coban, Cevayir

    International immunology

    2024  

    Abstract: Chronic bone loss is an under-recognized complication of malaria, the underlying mechanism of which remains incompletely understood. We have previously shown that persistent accumulation of Plasmodium products in the bone marrow leads to chronic ... ...

    Abstract Chronic bone loss is an under-recognized complication of malaria, the underlying mechanism of which remains incompletely understood. We have previously shown that persistent accumulation of Plasmodium products in the bone marrow leads to chronic inflammation in osteoblast (OB) and osteoclast (OC) precursors causing bone loss through MyD88, an adaptor molecule for diverse inflammatory signals. However, the specific contribution of MyD88 signaling in OB or OC precursors in malaria-induced bone loss remains elusive. To assess the direct cell-intrinsic role of MyD88 signaling in adult bone metabolism under physiological and infection conditions, we used the Lox-Cre system to specifically deplete MyD88 in the OB or OC lineages. Mice lacking MyD88 primarily in the maturing OBs showed a comparable decrease in trabecular bone density by microcomputed tomography (µCT) to that of controls after PyNL infection. In contrast, mice lacking MyD88 in OC precursors showed significantly less trabecular bone loss than controls, suggesting that malaria-mediated inflammatory mediators are primarily controlled by MyD88 in the OC lineage. Surprisingly, however, depletion of MyD88 in OB, but not in OC precursors, resulted in reduced bone mass with decreased bone formation rates in the trabecular areas of femurs under physiological conditions. Notably, IGF-1, a key molecule for OB differentiation, was significantly lower locally and systemically when MyD88 was depleted in OBs. Thus, our data demonstrate an indispensable intrinsic role for MyD88 signaling in OB differentiation and bone formation, while MyD88 signaling in OC lineages plays a partial role in controlling malaria-induced inflammatory mediators and following bone pathology. These findings may lead to the identification of novel targets for specific intervention of bone pathologies, particularly in malaria-endemic regions.
    Sprache Englisch
    Erscheinungsdatum 2024-04-20
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1013745-2
    ISSN 1460-2377 ; 0953-8178
    ISSN (online) 1460-2377
    ISSN 0953-8178
    DOI 10.1093/intimm/dxae023
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  5. Artikel ; Online: The comparison of COVID-19 vs seasonal influenza in children.

    Yayla, Burcu Ceylan Cura / Aykac, Kubra / Boluk, Oguz / Fidanci, Ilknur / Tasar, Medine Aysin / Pamuk, Utku / Karakoc, Ayse Esra / Karakaya, Jale / Ozsurekci, Yasemin

    Pediatrics international : official journal of the Japan Pediatric Society

    2023  Band 65, Heft 1, Seite(n) e15684

    Abstract: Background: Influenza in children has been well described, whereas there has been a paucity of pediatric data regarding COVID-19. It is crucial for clinicians to differentiate cases of COVID-19 from cases of influenza because of the upcoming influenza ... ...

    Abstract Background: Influenza in children has been well described, whereas there has been a paucity of pediatric data regarding COVID-19. It is crucial for clinicians to differentiate cases of COVID-19 from cases of influenza because of the upcoming influenza season in the new pandemic era.
    Methods: This retrospective study included pediatric patients who were diagnosed with laboratory-confirmed COVID-19 between March and September 2020, or seasonal influenza between October 2019 and March 2020.
    Results: A total of 315 children were included in this study; 151 were diagnosed with influenza and 164 had confirmed COVID-19. The median age of patients with COVID-19 was 10 years (interquartile range [IQR]: 3-15 years), whereas the median age of patients with influenza was 4 years (IQR: 1-6 years) (p = 0.001). In the COVID-19 group, 6.3% of patients had underlying diseases, the most frequent being neurological conditions (3%). In the influenza group, 20.9% of patients had an underlying disease, the most frequent being asthma (14.5%). Fever (odds ratio [OR]: 20.476; 95% confidence interval [CI]: 2.438-171.995; p = 0.005), dyspnea/tachypnea (OR 13.950; 95% CI: 2.607-74.634; p = 0.002), and increased C-reactive protein (CRP) (OR: 7.650; 95% CI: 2.094-27.955; p = 0.002) were main predictors of influenza diagnosis in comparison to COVID-19. Lymphopenia was detected in 43.2% of patients with influenza and 19.9% of patients with COVID-19 (p = 0.001).
    Conclusions: The accurate differentiation between "influenza or COVID-19" seems possible by evaluating a combination of factors including cough, fever, vomiting, leucopenia, lymphopenia, pneumonia, in pediatric patients with high CRP as well as age.
    Mesh-Begriff(e) Child ; Humans ; Child, Preschool ; Adolescent ; Infant ; COVID-19/diagnosis ; COVID-19/epidemiology ; Influenza, Human/diagnosis ; Influenza, Human/epidemiology ; Seasons ; Retrospective Studies ; SARS-CoV-2 ; Lymphopenia/epidemiology
    Sprache Englisch
    Erscheinungsdatum 2023-12-01
    Erscheinungsland Australia
    Dokumenttyp Journal Article
    ZDB-ID 1470376-2
    ISSN 1442-200X ; 1328-8067
    ISSN (online) 1442-200X
    ISSN 1328-8067
    DOI 10.1111/ped.15684
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  6. Artikel ; Online: Pneumococcal carriage in children with COVID-19.

    Aykac, Kubra / Ozsurekci, Yasemin / Cura Yayla, Burcu Ceylan / Evren, Kubra / Lacinel Gurlevik, Sibel / Oygar, Pembe Derin / Yucel, Mihriban / Karakoc, Ayse Esra / Alp, Alpaslan / Cengiz, Ali Bulent / Ceyhan, Mehmet

    Human vaccines & immunotherapeutics

    2021  Band 17, Heft 6, Seite(n) 1628–1634

    Abstract: ... ...

    Abstract Background
    Mesh-Begriff(e) COVID-19/complications ; COVID-19/microbiology ; Carrier State/epidemiology ; Carrier State/microbiology ; Child ; Humans ; Nasopharynx/microbiology ; Pandemics ; Pneumococcal Infections/epidemiology ; Retrospective Studies ; Streptococcus pneumoniae ; Turkey
    Sprache Englisch
    Erscheinungsdatum 2021-01-15
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2664176-8
    ISSN 2164-554X ; 2164-5515
    ISSN (online) 2164-554X
    ISSN 2164-5515
    DOI 10.1080/21645515.2020.1849516
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  7. Artikel ; Online: Evaluation of medication errors in pediatric patients using antibiotics.

    Özdemir, Nesligül / Kara, Emre / Büyükçam, Ayşe / Aykaç, Kübra / Çeliker, Ayçe / Demirkan, Kutay / Kara, Ateş

    The Turkish journal of pediatrics

    2022  Band 63, Heft 6, Seite(n) 970–977

    Abstract: Background: Medication errors are frequently seen in pediatric patients. Medication error studies on pediatric cases were found to not only be limited but also the collaboration of clinical pharmacists and physicians on this topic was not published in ... ...

    Abstract Background: Medication errors are frequently seen in pediatric patients. Medication error studies on pediatric cases were found to not only be limited but also the collaboration of clinical pharmacists and physicians on this topic was not published in Turkey. This study aimed to identify drug-related problems, especially in antibiotics.
    Methods: This study was a point prevalence study with pediatric inpatients that used at least one antibiotic at a pediatric tertiary care reference hospital on November 16, 2016. Medications of patients were evaluated by clinical pharmacists in terms of drug-related problems and by physicians in terms of correct indications.
    Results: Eighty-nine hospitalized patients were using antibiotics at the time of the study. The median age was 42 months (range: 1-226 months), and 49 (55.1%) of the patients were male. Clinical pharmacists detected a total of 210 potential drug-drug interactions in 46 (51.7%) patients. Approximately 48.5% of the patients in pediatric wards and 52.4% of the patients in surgical wards had at least one potential drug-drug interaction. A total of 39 medication errors were identified in 36 patients` drug orders. Most of the errors (51.3%) were due to dosing and administration time errors (35.9%). The number of errors per patient in surgical services was higher (0.47) than the pediatric services (0.42). Forty-three percent of errors were antimicrobial-related, and 70.5% of them were classified as dosing errors.
    Conclusions: Evaluation of patients` drug usage by a clinical pharmacist in terms of drug-related problems such as drug interactions, side effects and prescribing errors leads to better pharmaceutical care.
    Mesh-Begriff(e) Adolescent ; Anti-Bacterial Agents/adverse effects ; Child ; Child, Preschool ; Drug-Related Side Effects and Adverse Reactions ; Female ; Humans ; Infant ; Male ; Medication Errors ; Pharmacists ; Pharmacy Service, Hospital
    Chemische Substanzen Anti-Bacterial Agents
    Sprache Englisch
    Erscheinungsdatum 2022-01-13
    Erscheinungsland Turkey
    Dokumenttyp Journal Article
    ZDB-ID 123487-0
    ISSN 2791-6421 ; 0041-4301
    ISSN (online) 2791-6421
    ISSN 0041-4301
    DOI 10.24953/turkjped.2021.06.004
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  8. Artikel ; Online: Characteristics and Management of Children With COVID-19 in a Tertiary Care Hospital in Turkey.

    Yayla, Burcu Ceylan Cura / Aykac, Kubra / Ozsurekci, Yasemin / Ceyhan, Mehmet

    Clinical pediatrics

    2020  Band 60, Heft 3, Seite(n) 170–177

    Abstract: Introduction: Limited data are available for pediatric patients with coronavirus disease 2019 (COVID-19), especially with regard to disease management strategies.: Objective: To assess the children with COVID-19.: Method: We conducted a ... ...

    Abstract Introduction: Limited data are available for pediatric patients with coronavirus disease 2019 (COVID-19), especially with regard to disease management strategies.
    Objective: To assess the children with COVID-19.
    Method: We conducted a retrospective review of the medical records of pediatric patients on March 11 and May 23, 2020.
    Results: We evaluated 77 COVID-19 pediatric patients, of whom 45.5% were male, with a median age of 8 years (interquartile range [IQR] = 2-13), and 6.4% had underlying diseases. Patients were classified according to severity, with the percentages of asymptomatic, mild, moderate, and critical/severe cases determined to be 24.7%, 41.6%, 29.9%, and 3.9%, respectively. Extracorporeal membrane oxygenation and mechanic ventilation were only required for 1 patient. Targeted therapies were used in 3 patients.
    Conclusion: The disease course of COVID-19 appears to be milder in children than in adults, and the treatment course primarily consists of supportive care.
    Mesh-Begriff(e) Adolescent ; Amides ; Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; COVID-19/pathology ; COVID-19/physiopathology ; Child ; Child, Preschool ; Female ; Humans ; Hydroxychloroquine ; Immunoglobulins, Intravenous/therapeutic use ; Lung/pathology ; Lung/physiopathology ; Male ; Pediatrics/methods ; Pyrazines ; Retrospective Studies ; SARS-CoV-2 ; Severity of Illness Index ; Tertiary Care Centers ; Treatment Outcome ; Turkey
    Chemische Substanzen Amides ; Antiviral Agents ; Immunoglobulins, Intravenous ; Pyrazines ; Hydroxychloroquine (4QWG6N8QKH) ; favipiravir (EW5GL2X7E0)
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-10-09
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 207678-0
    ISSN 1938-2707 ; 0009-9228
    ISSN (online) 1938-2707
    ISSN 0009-9228
    DOI 10.1177/0009922820966306
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  9. Artikel ; Online: Frequency and safety of COVID-19 vaccination in children with multisystem inflammatory syndrome: a telephonic interview-based analysis.

    Aykac, Kubra / Ozturk, Kubra / Demir, Osman Oguz / Gumus, Dilan Demir / Aslan, Sevgi / Cem, Ela / Celebi, Miray Yilmaz / Karabacak, Mustafa Dogan / Alkan, Gulsum / Aksoy, Fatma Dilsad / Yayla, Burcu Ceylan Cura / Kepenekli, Eda / Celebi, Solmaz / Emiroglu, Melike / Devrim, Ilker / Cengiz, Ali Bulent / Ceyhan, Mehmet / Ozsurekci, Yasemin

    World journal of pediatrics : WJP

    2022  Band 18, Heft 10, Seite(n) 700–705

    Mesh-Begriff(e) COVID-19/complications ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Child ; Connective Tissue Diseases ; Humans ; SARS-CoV-2 ; Systemic Inflammatory Response Syndrome ; Vaccination/adverse effects
    Chemische Substanzen COVID-19 Vaccines
    Sprache Englisch
    Erscheinungsdatum 2022-08-16
    Erscheinungsland Switzerland
    Dokumenttyp Letter
    ZDB-ID 2236681-7
    ISSN 1867-0687 ; 1708-8569
    ISSN (online) 1867-0687
    ISSN 1708-8569
    DOI 10.1007/s12519-022-00604-7
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  10. Artikel ; Online: Oxidative Stress Related Diseases in Newborns.

    Ozsurekci, Yasemin / Aykac, Kubra

    Oxidative medicine and cellular longevity

    2016  Band 2016, Seite(n) 2768365

    Abstract: We review oxidative stress-related newborn disease and the mechanism of oxidative damage. In addition, we outline diagnostic and therapeutic strategies and future directions. Many reports have defined oxidative stress as an imbalance between an enhanced ... ...

    Abstract We review oxidative stress-related newborn disease and the mechanism of oxidative damage. In addition, we outline diagnostic and therapeutic strategies and future directions. Many reports have defined oxidative stress as an imbalance between an enhanced reactive oxygen/nitrogen species and the lack of protective ability of antioxidants. From that point of view, free radical-induced damage caused by oxidative stress seems to be a probable contributing factor to the pathogenesis of many newborn diseases, such as respiratory distress syndrome, bronchopulmonary dysplasia, periventricular leukomalacia, necrotizing enterocolitis, patent ductus arteriosus, and retinopathy of prematurity. We share the hope that the new understanding of the concept of oxidative stress and its relation to newborn diseases that has been made possible by new diagnostic techniques will throw light on the treatment of those diseases.
    Mesh-Begriff(e) Antioxidants ; Female ; Humans ; Infant, Newborn ; Infant, Premature, Diseases/etiology ; Male ; Oxidative Stress/physiology ; Respiratory Distress Syndrome, Newborn/etiology
    Chemische Substanzen Antioxidants
    Sprache Englisch
    Erscheinungsdatum 2016-06-15
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2455981-7
    ISSN 1942-0994 ; 1942-0994
    ISSN (online) 1942-0994
    ISSN 1942-0994
    DOI 10.1155/2016/2768365
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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