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Artikel ; Online: A macro-micro FE and ANN framework to assess site-specific bone ingrowth around the porous beaded-coated implant: an example with BOX® tibial implant for total ankle replacement.

Minku / Ghosh, Rajesh

Medical & biological engineering & computing

2024

Abstract: The use of mechanoregulatory schemes based on finite element (FE) analysis for the evaluation of bone ingrowth around porous surfaces is a viable approach but requires significant computational time and effort. The aim of this study is to develop a ... ...

Abstract	The use of mechanoregulatory schemes based on finite element (FE) analysis for the evaluation of bone ingrowth around porous surfaces is a viable approach but requires significant computational time and effort. The aim of this study is to develop a combined macro-micro FE and artificial neural network (ANN) framework for rapid and accurate prediction of the site-specific bone ingrowth around the porous beaded-coated tibial implant for total ankle replacement (TAR). A macroscale FE model of the implanted tibia was developed based on CT data. Subsequently, a microscale FE model of the implant-bone interface was created for performing bone ingrowth simulations using mechanoregulatory algorithms. An ANN was trained for rapid and accurate prediction of bone ingrowth. The results predicted by ANN are well comparable to FE-predicted results. Predicted site-specific bone ingrowth using ANN around the implant ranges from 43.04 to 98.24%, with a mean bone ingrowth of around 74.24%. Results suggested that the central region exhibited the highest bone ingrowth, which is also well corroborated with the recent explanted study on BOX®. The proposed methodology has the potential to simulate bone ingrowth rapidly and effectively at any given site over any implant surface.
Sprache	Englisch
Erscheinungsdatum	2024-02-07
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	282327-5
ISSN	1741-0444 ; 0025-696X ; 0140-0118
ISSN (online)	1741-0444
ISSN	0025-696X ; 0140-0118
DOI	10.1007/s11517-024-03034-x
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Effect of silencing

Rajesh, Vavilapalli / Jangra, Sumit / Ghosh, Amalendu

Frontiers in microbiology

2023 Band 14, Seite(n) 1254246

Abstract: ... Thrips ... ...

Abstract	Thrips palmi
Sprache	Englisch
Erscheinungsdatum	2023-10-19
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2023.1254246
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Assessment of bone ingrowth around beaded coated tibial implant for total ankle replacement using mechanoregulatory algorithm.

Minku / Mukherjee, Kaushik / Ghosh, Rajesh

Computers in biology and medicine

2024 Band 175, Seite(n) 108551

Abstract: The long-term performance of porous coated tibial implants for total ankle replacement (TAR) primarily depends on the extent of bone ingrowth at the bone-implant interface. Although attempts were made for primary fixation for immediate post-operative ... ...

Abstract	The long-term performance of porous coated tibial implants for total ankle replacement (TAR) primarily depends on the extent of bone ingrowth at the bone-implant interface. Although attempts were made for primary fixation for immediate post-operative stability, no investigation was conducted on secondary fixation. The aim of this study is to assess bone ingrowth around the porous beaded coated tibial implant for TAR using a mechanoregulatory algorithm. A realistic macroscale finite element (FE) model of the implanted tibia was developed based on computer tomography (CT) data to assess implant-bone micromotions and coupled with microscale FE models of the implant-bone interface to predict bone ingrowth around tibial implant for TAR. The macroscale FE model was subjected to three near physiological loading conditions to evaluate the site-specific implant-bone micromotion, which were then incorporated into the corresponding microscale model to mimic the near physiological loading conditions. Results of the study demonstrated that the implant experienced tangential micromotion ranged from 0 to 71 μm with a mean of 3.871 μm. Tissue differentiation results revealed that bone ingrowth across the implant ranged from 44 to 96 %, with a mean of around 70 %. The average Young's modulus of the inter-bead tissue layer varied from 1444 to 4180 MPa around the different regions of the implant. The analysis postulates that when peak micromotion touches 30 μm around different regions of the implant, it leads to pronounced fibrous tissues on the implant surface. The highest amount of bone ingrowth was observed in the central regions, and poor bone ingrowth was seen in the anterior parts of the implant, which indicate improper osseointegration around this region. This macro-micro mechanical FE framework can be extended to improve the implant design to enhance the bone ingrowth and in future to develop porous lattice-structured implants to predict and enhance osseointegration around the implant.
Sprache	Englisch
Erscheinungsdatum	2024-04-30
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	127557-4
ISSN	1879-0534 ; 0010-4825
ISSN (online)	1879-0534
ISSN	0010-4825
DOI	10.1016/j.compbiomed.2024.108551
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: The role of the depth of resection of the distal tibia on biomechanical performance of the tibial component for TAR: A finite element analysis with three implant designs.

Jyoti / Ghosh, Rajesh

Medical engineering & physics

2023 Band 119, Seite(n) 104034

Abstract: The depth of resection of the tibia bone in total ankle replacement (TAR) may influence implant-bone micromotion and stress shielding. High implant-bone micromotion and stress-shielding lead to aseptic loosening of the tibial component for TAR. The aim ... ...

Abstract	The depth of resection of the tibia bone in total ankle replacement (TAR) may influence implant-bone micromotion and stress shielding. High implant-bone micromotion and stress-shielding lead to aseptic loosening of the tibial component for TAR. The aim was to improve the outcomes of the different designs of TAR (STAR, Mobility, and Salto) with the variation of the depth of resection of the distal tibia bone. Finite element (FE) models of the implanted tibia with the depth of resection varying from 6 mm to 16 mm and of the intact tibia was prepared. The value of micromotion increased as the depth of resection increased. The micromotion increased in the proximal anterior-posterior portion of the pegs for STAR, the posterior part of the stem for Mobility, and the proximal lateral portion of the keel for Salto with the increase in the depth of resection. Whereas, the stresses (von Mises) decreased in some regions and increased in some regions depending upon the implant design. But overall stresses decreased in the tibia bone. Furthermore, the mean stress shielding increased in all the designs as the depth of resection increased. This in silico study indicated that the depth of resection should be given more importance during TAR surgery. The ideal depth of resection should be minimum i.e., 6 mm based on this FE study.
Mesh-Begriff(e)	Finite Element Analysis ; Tibia/surgery ; Arthroplasty, Replacement, Ankle ; Prostheses and Implants
Sprache	Englisch
Erscheinungsdatum	2023-08-07
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	1181080-4
ISSN	1873-4030 ; 1350-4533
ISSN (online)	1873-4030
ISSN	1350-4533
DOI	10.1016/j.medengphy.2023.104034
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Ni

Chakrabortty, Rajesh / Ghosh, Suman / Ganesh, Venkataraman

Organic letters

2024 Band 26, Heft 4, Seite(n) 792–797

Abstract: In the present work, we demonstrate a regioselective [2 + 2 + 2] cyclotrimerization of 1,3-diynes catalyzed by ... ...

Abstract	In the present work, we demonstrate a regioselective [2 + 2 + 2] cyclotrimerization of 1,3-diynes catalyzed by Ni
Sprache	Englisch
Erscheinungsdatum	2024-01-22
Erscheinungsland	United States
Dokumenttyp	Journal Article
ISSN	1523-7052
ISSN (online)	1523-7052
DOI	10.1021/acs.orglett.3c03863
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: A combined FE-hybrid MCDM framework for improving the performance of the conical stem tibial design for TAR with the addition of pegs.

Jyoti / Ghosh, Rajesh

Computer methods and programs in biomedicine

2023 Band 237, Seite(n) 107574

Abstract: Background and objectives: The conical stemmed design of the tibial component for total ankle replacement (TAR) (example Mobility design) uses a single intramedullary stem for primary fixation. Tibial component loosening is a common mode of failure for ... ...

Abstract	Background and objectives: The conical stemmed design of the tibial component for total ankle replacement (TAR) (example Mobility design) uses a single intramedullary stem for primary fixation. Tibial component loosening is a common mode of failure for TAR. Primary causes of loosening are lack of bone ingrowth due to excessive micromotion at the implant-bone interface and bone resorption due to stress shielding after implantation. The fixation feature of the conical stemmed design can be modified with the addition of small pegs to avoid loosening. The aim of the study is to select the improved design for conical stemmed TAR using a combined Finite Element (FE) hybrid Multi-Criteria Decision-Making (MCDM) framework. Methods: The geometry and material properties of the bone for FE modeling were extracted from the CT data. Thirty-two design alternatives with varying pegs in number (one, two, four, eight), location (anterior, posterior, medial, lateral, anterior-posterior, medial-lateral, equally spaced), and height (5 mm, 4 mm, 3 mm, 2 mm) were prepared. All models were analyzed for dorsiflexion, neutral, and plantarflexion loading. The proximal part of the tibia was fixed. The implant-bone interface coefficient of friction was taken as 0.5. The implant-bone micromotion, stress shielding, volume of bone resection, and surgical simplicity were the important criteria considered for evaluating the performance of TAR. The designs were compared using a hybrid MCDM method of WASPAS, TOPSIS, EDAS, and VIKOR. The weight calculations were based on fuzzy AHP and the final ranks on the Degree of Membership method. Results: The addition of pegs decreased the mean implant-bone micromotions and increased stress shielding. There was a marginal decrease in micromotion and a marginal increase in stress shielding when the peg heights were increased. The results of hybrid MCDM indicated that the most preferable alternative designs were two pegs of 4 mm height in the AP direction to the main stem, two pegs of 4 mm height in the ML direction, and one peg of 3 mm height in the A direction. Conclusions: Outcomes of this study suggest that the addition of pegs can reduce the implant-bone micromotions. Modified three designs would be useful by considering implant-bone micromotions, stress shielding, volume of bone resection, and surgical simplicity.
Mesh-Begriff(e)	Tibia/surgery ; Arthroplasty, Replacement, Ankle ; Prosthesis Design ; Arthroplasty, Replacement, Knee/methods ; Finite Element Analysis ; Stress, Mechanical
Sprache	Englisch
Erscheinungsdatum	2023-04-27
Erscheinungsland	Ireland
Dokumenttyp	Journal Article
ZDB-ID	632564-6
ISSN	1872-7565 ; 0169-2607
ISSN (online)	1872-7565
ISSN	0169-2607
DOI	10.1016/j.cmpb.2023.107574
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Ni-Catalyzed Diastereoconvergent Intramolecular Alkene-Aldehyde Reductive Coupling: A Route to

Ghosh, Sudipta / Rooj, Arnab / Chakrabortty, Rajesh / Ganesh, Venkataraman

Organic letters

2024

Abstract: We demonstrate for the first time a nickel-catalyzed diastereoconvergent reductive coupling of a heteroatom-attached allyl moiety with aldehydes, viz., ...

Abstract	We demonstrate for the first time a nickel-catalyzed diastereoconvergent reductive coupling of a heteroatom-attached allyl moiety with aldehydes, viz.,
Sprache	Englisch
Erscheinungsdatum	2024-04-26
Erscheinungsland	United States
Dokumenttyp	Journal Article
ISSN	1523-7052
ISSN (online)	1523-7052
DOI	10.1021/acs.orglett.4c01428
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: A new mathematical model of compressive stress-strain behaviour of low viscosity and high viscosity bone cement with different strain rates.

Chaurasiya, Sonalal Prasad / Ghosh, Rajesh

Medical engineering & physics

2023 Band 117, Seite(n) 104001

Abstract: A new mathematical model of compressive stress-strain behaviour of low viscosity (LV) and high viscosity (HV) bone cement has been proposed to capture large uniaxial deformation under constant applied strain rate by incorporating three-term power law. ... ...

Abstract	A new mathematical model of compressive stress-strain behaviour of low viscosity (LV) and high viscosity (HV) bone cement has been proposed to capture large uniaxial deformation under constant applied strain rate by incorporating three-term power law. The modeling capacity of the proposed model has been validated using uniaxial compressive test under eight different low strain rates ranging from 1.39 × 10
Mesh-Begriff(e)	Bone Cements ; Polymethyl Methacrylate ; Viscosity ; Pressure ; Models, Theoretical ; Compressive Strength
Chemische Substanzen	Bone Cements ; Polymethyl Methacrylate (9011-14-7)
Sprache	Englisch
Erscheinungsdatum	2023-06-01
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	1181080-4
ISSN	1873-4030 ; 1350-4533
ISSN (online)	1873-4030
ISSN	1350-4533
DOI	10.1016/j.medengphy.2023.104001
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Comparative studies on the aggregate formation of synthesized zwitterionic gemini and monomeric surfactants in the presence of the amphiphilic antipsychotic drug chlorpromazine hydrochloride in aqueous solution: an experimental and theoretical approach.

Banik, Rajesh / Das, Sourav / Ghosh, Asitanga / Ghosh, Soumen

Soft matter

2023 Band 19, Heft 41, Seite(n) 7995–8010

Abstract: The formation of aggregates, which are widely used in the field of biochemistry and the medical industry, was studied with different compositions of alkyl betaine gemini surfactant ( ... ...

Abstract	The formation of aggregates, which are widely used in the field of biochemistry and the medical industry, was studied with different compositions of alkyl betaine gemini surfactant (C
Mesh-Begriff(e)	Surface-Active Agents/chemistry ; Antipsychotic Agents/chemistry ; Chlorpromazine/chemistry ; Water/chemistry ; Chemical Phenomena
Chemische Substanzen	Surface-Active Agents ; Antipsychotic Agents ; Chlorpromazine (U42B7VYA4P) ; Water (059QF0KO0R)
Sprache	Englisch
Erscheinungsdatum	2023-10-25
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	2191476-X
ISSN	1744-6848 ; 1744-683X
ISSN (online)	1744-6848
ISSN	1744-683X
DOI	10.1039/d3sm00907f
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Influence of obesity on load-transfer mechanism, contact mechanics, and longevity of cemented acetabular cup.

Kumar, Ajay / Mondal, Subrata / Ghosh, Rajesh

Journal of orthopaedics

2024 Band 55, Seite(n) 118–123

Abstract: Objective: This investigation aimed to assess the impact of obesity on the load-transfer mechanism, longevity, and contact mechanics of cemented acetabular cups.: Methods: Three obesity scenarios were considered: obese case-I (100-110 kg), obese case- ...

Abstract	Objective: This investigation aimed to assess the impact of obesity on the load-transfer mechanism, longevity, and contact mechanics of cemented acetabular cups. Methods: Three obesity scenarios were considered: obese case-I (100-110 kg), obese case-II (120-130 kg), and obese case-III (140-150 kg). Utilising six finite element models, the effects of different bodyweights on load transfer, contact mechanics, and cup longevity during normal walking conditions were assessed. Muscle forces and hip joint reaction forces were adjusted and linearly calibrated based on obesity cases. Results: Elevated stresses in cortical and cancellous bones, as well as the cement mantle, were observed in obese cases, suggesting a heightened risk of loosening and failure of the cemented fixation of the acetabular cup. Additionally, increased contact pressure and micromotion between articulating surfaces were noted in obese individuals, with a gradual escalation from obese case-I to obese case-III. Conclusions: These findings highlight the significant negative impact of obesity on the performance of cemented acetabular cups, emphasizing the importance of considering bodyweight variations in the design and assessment of orthopaedic implants for optimal functionality and durability.
Sprache	Englisch
Erscheinungsdatum	2024-04-16
Erscheinungsland	India
Dokumenttyp	Journal Article
ZDB-ID	2240839-3
ISSN	0972-978X
ISSN	0972-978X
DOI	10.1016/j.jor.2024.04.012
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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