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Artikel: Correlation of Fibroscan with FIB-4 index and APRI for Assessment of Liver Fibrosis in patients with Nonalcoholic Fatty Liver Disease.

Soni, Abhilasha / Tripathi, B K

The Journal of the Association of Physicians of India

2020 Band 68, Heft 1, Seite(n) 97

Mesh-Begriff(e)	Aspartate Aminotransferases ; Biomarkers ; Biopsy ; Elasticity Imaging Techniques ; Humans ; Liver Cirrhosis ; Non-alcoholic Fatty Liver Disease ; Severity of Illness Index
Chemische Substanzen	Biomarkers ; Aspartate Aminotransferases (EC 2.6.1.1)
Sprache	Englisch
Erscheinungsdatum	2020-01-24
Erscheinungsland	India
Dokumenttyp	Journal Article
ZDB-ID	800766-4
ISSN	0004-5772
ISSN	0004-5772
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Effect of Exercise on β-Endorphin and Its Receptors in Myasthenia Gravis Patients.

Tripathi, Gyanesh M / Misra, Usha K / Kalita, Jayantee / Singh, Varun K / Tripathi, Abhilasha

Molecular neurobiology

2023 Band 60, Heft 6, Seite(n) 3010–3019

Abstract: This is a prospective observational study evaluating the change in β-endorphin (BE) and its receptors following exercise in patients with myasthenia gravis (MG) and their association with clinical improvement. Fifteen patients with mild to moderate MG, ... ...

Abstract	This is a prospective observational study evaluating the change in β-endorphin (BE) and its receptors following exercise in patients with myasthenia gravis (MG) and their association with clinical improvement. Fifteen patients with mild to moderate MG, aged 16-70 years, who were able to do 6-Minute Walk Test (6-MWT) and had MG Quality of Life-15 (MGQoL-15) ≤ 45 without any contraindication for exercise were included. The patients walked 30 min daily for 3 months. The primary outcome at 3 months was > 50% improvement in MGQoL-15 from the baseline, and the secondary outcomes were MG Activities of Daily Living (MGADL), Hospital Anxiety and Depression Scale (HADS), number of steps, and distance covered on 6-MWT and adverse events. Plasma BE level, μ-opioid receptor (MOR), and δ-opioid receptor (DOR) were measured on admission and at 1 and 3 months. Twelve age- and gender-matched healthy controls who were not on regular exercise were included for comparison of BE, MOR, and DOR levels. Plasma BE level (P = 0.007) and DOR expression (P = 0.001) were lower in MG patients compared to the healthy controls. After 3 months of exercise, 6 patients improved. Plasma BE, MOR, and DOR levels increased in the first and decreased in the third month. MGQoL-15 (P < 0.001), HADS (P < 0.0001), number of steps (P < 0.007), distance (P = 0.030), and MGADL (P < 0.001) significantly improved compared to baseline. At 3 months, MGQoL-15 was associated with HADS score (P = 0.001), reduced depression (P = 0.013), MGADL (P = 0.035), and distance travelled on the 6-WMW test (P = 0.050). The improvement in depression was associated with higher BE level.
Mesh-Begriff(e)	Humans ; beta-Endorphin ; Quality of Life ; Activities of Daily Living ; Receptors, Opioid, mu/metabolism ; Myasthenia Gravis ; Exercise
Chemische Substanzen	beta-Endorphin (60617-12-1) ; Receptors, Opioid, mu
Sprache	Englisch
Erscheinungsdatum	2023-02-13
Erscheinungsland	United States
Dokumenttyp	Observational Study ; Journal Article
ZDB-ID	645020-9
ISSN	1559-1182 ; 0893-7648
ISSN (online)	1559-1182
ISSN	0893-7648
DOI	10.1007/s12035-023-03247-5
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: A Comparative Study of Diagnosis and Treatment of Pott's Spine Amongst Specialists and Super Specialists in India.

Warrier, Siddharth / Chaudhary, Sarvesh K / Kalita, Jayantee / Tripathi, Abhilasha / Misra, Usha K

Neurology India

2023 Band 70, Heft Supplement, Seite(n) S200–S205

Abstract: Background and objective: There is a paucity of guidelines about the diagnosis and management of Pott's spine. In this study, we report the pattern of practice of diagnosis and treatment of Pott's spine among the specialists and super-specialists in ... ...

Abstract	Background and objective: There is a paucity of guidelines about the diagnosis and management of Pott's spine. In this study, we report the pattern of practice of diagnosis and treatment of Pott's spine among the specialists and super-specialists in India. Subject and methods: Response to a 22-item questionnaire regarding the diagnosis and treatment of Pott's spine has been reported. The responses were compared between medical and surgical specialists, residents and consultants, and specialists and super-specialists. There were 84 responders: 42 physicians and 42 surgeons; 48 residents and 36 faculty or consultants; 53 specialists and 31 super-specialists. Results: Thirty-eight responders rarely recommended biopsy whereas others recommended biopsy more frequently, especially the surgeons (P < 0.007). Twenty-five responders recommended immobilization even in an asymptomatic patient whereas 38 would immobilize those with neurological involvement only. All but 4 responders would repeat imaging at different time points. The response of medical treatment was judged at 1 month by 53, and 3 months by 26 responders. Surgery was recommended in a minority of patients-in those with neurological involvement or abscess. Surgeons more frequently biopsied, immobilized the patients, and recommended surgery compared to the physicians. The residents also recommended biopsy and recommended immobilization more frequently compared to consultants or faculty members. Super-specialists more frequently recommended biopsy compared to specialists. Conclusion: There is marked variation in investigations and treatment of Pott's spine patients, suggesting the need for consensus or evidence-based guidelines.
Mesh-Begriff(e)	Humans ; India/epidemiology ; Medicine/statistics & numerical data ; Specialties, Surgical/statistics & numerical data ; Spine/diagnostic imaging ; Spine/surgery ; Surgeons/statistics & numerical data ; Surveys and Questionnaires ; Tuberculosis, Spinal/diagnosis ; Tuberculosis, Spinal/epidemiology ; Tuberculosis, Spinal/therapy
Sprache	Englisch
Erscheinungsdatum	2023-01-26
Erscheinungsland	India
Dokumenttyp	Comparative Study ; Journal Article
ZDB-ID	415522-1
ISSN	1998-4022 ; 0028-3886
ISSN (online)	1998-4022
ISSN	0028-3886
DOI	10.4103/0028-3886.360937
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: A Study of Dopaminergic Pathway in Neurologic Wilson Disease with Movement Disorder.

Kalita, Jayantee / Tripathi, Abhilasha / Jadhav, Mahesh / Thakur, Ravindra S / Patel, Devendra K

Molecular neurobiology

2023 Band 60, Heft 6, Seite(n) 3496–3506

Abstract: Movement disorder (MD) is an important manifestation of neurologic Wilson disease (NWD), but there is a paucity of information on dopaminergic pathways. We evaluate dopamine and its receptors in patients with NWD and correlate the changes with MD and MRI ...

Abstract	Movement disorder (MD) is an important manifestation of neurologic Wilson disease (NWD), but there is a paucity of information on dopaminergic pathways. We evaluate dopamine and its receptors in patients with NWD and correlate the changes with MD and MRI changes. Twenty patients with NWD having MD were included. The severity of dystonia was assessed using BFM (Burke-Fahn-Marsden) score. The neurological severity of NWD was categorized as grades I to III based on the sum score of 5 neurological signs and activity of daily living. Dopamine concentration in plasma and CSF was measured using liquid chromatography-mass spectrometry, and D1 and D2 receptor expression at mRNA by reverse transcriptase polymerase chain reaction in patients and 20 matched controls. The median age of the patients was 15 years and 7 (35%) were females. Eighteen (90%) patients had dystonia and 2 (10%) had chorea. The CSF dopamine concentration (0.08 ± 0.02 vs 0.09 ± 0.017 pg/ml; p = 0.42) in the patients and controls was comparable, but D2 receptor expression was reduced in the patients (0.41 ± 0.13 vs 1.39 ± 1.04; p = 0.01). Plasma dopamine level correlated with BFM score (r = 0.592, p < 0.01) and D2 receptor expression with the severity of chorea (r = 0.447, p < 0.05). The neurological severity of WD correlated with plasma dopamine concentration (p = 0.006). Dopamine and its receptors were not related to MRI changes. The central nervous system dopaminergic pathway is not enhanced in NWD, which may be due to structural damage to the corpus striatum and/or substantia nigra.
Mesh-Begriff(e)	Female ; Humans ; Adolescent ; Male ; Dopamine/metabolism ; Hepatolenticular Degeneration/metabolism ; Dystonia/metabolism ; Chorea/metabolism ; Movement Disorders ; Receptors, Dopamine D2/metabolism ; Corpus Striatum/metabolism ; Receptors, Dopamine D1/metabolism ; Substantia Nigra/metabolism ; Carrier Proteins/metabolism
Chemische Substanzen	Dopamine (VTD58H1Z2X) ; Receptors, Dopamine D2 ; Receptors, Dopamine D1 ; Carrier Proteins
Sprache	Englisch
Erscheinungsdatum	2023-03-07
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	645020-9
ISSN	1559-1182 ; 0893-7648
ISSN (online)	1559-1182
ISSN	0893-7648
DOI	10.1007/s12035-023-03276-0
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Oxidative stress and ER stress are related to severity of tubercular infection.

Tripathi, Abhilasha / Kalita, Jayantee / Kant, Surya / Misra, Usha K

Microbial pathogenesis

2022 Band 172, Seite(n) 105764

Abstract: To report the markers of oxidative stress and endoplasmic reticulum (ER) stress in tuberculosis of differing severity. Ninety patients with tuberculosis, 30 each with pulmonary tuberculosis (PTB), Pott's spine (PS) and tuberculous meningitis (TBM) were ... ...

Abstract	To report the markers of oxidative stress and endoplasmic reticulum (ER) stress in tuberculosis of differing severity. Ninety patients with tuberculosis, 30 each with pulmonary tuberculosis (PTB), Pott's spine (PS) and tuberculous meningitis (TBM) were included. The diagnosis and severity of the respective group was based on pre-defined criteria. Six-months outcome and complications (Hyponatremia, paradoxical worsening and Drug induced hepatitis(DIH)) were recorded. Serum Melanodehyde (MDA) , glutathione (GSH), total antioxidant capacity (TAC), ER stress markers ATF-4,GRP-78 and CHOP, were measured using spectrophotometry and real time PCR. The oxidative and ER stress markers were correlated with different subgroups, severity of TBM, complications and outcome. The severity of TBM correlated with alteration in oxidative and ER stress markers. MDA was related to hyponatremia (P = 0.045), paradoxical worsening (P = 0.035) and DIH (P = 0.038), TAC correlated with paradoxical worsening (P = 0.047) and DIH (P = 0.015). In PS, MDA correlated with paradoxical worsening (P = 0.032) and DIH (P = 0.032); and in PTB, MDA correlated with hyponatremia (P = 0.025) and DIH (P = 0.037). Changes in stress marker levels were more marked in TBM compared to PS and PTB. Outcome of TBM correlated with MDA (P = 0.002), PS to MDA(P = 0.004), TAC(P = 0.05) CHOP(P = 0.004), GRP78(P = 0.001), ATF4(P = 0.045) and PTB to MDA(P = 0.0450), TAC(P = 0.014), CHOP(P = 0.025) and GRP78(P = 0.035). Oxidative and ER stress markers seem to be related to severity of TB, its complications and outcome.
Mesh-Begriff(e)	Humans ; Antioxidants ; Hyponatremia ; Oxidative Stress ; Endoplasmic Reticulum Stress ; Tuberculosis, Meningeal ; Glutathione/metabolism ; Biomarkers
Chemische Substanzen	Antioxidants ; Glutathione (GAN16C9B8O) ; Biomarkers
Sprache	Englisch
Erscheinungsdatum	2022-09-07
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	632772-2
ISSN	1096-1208 ; 0882-4010
ISSN (online)	1096-1208
ISSN	0882-4010
DOI	10.1016/j.micpath.2022.105764
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: A study of glutamate excitotoxicity in seizures related to tuberculous meningitis.

Tripathi, Abhilasha / Kalita, Jayantee / Misra, Usha K

Epilepsy research

2021 Band 178, Seite(n) 106789

Abstract: Background and purpose: Glutamate is a neurotransmitter that regulates approximately half of the nervous system, along with the sensory system. Glutamate excitotoxicity is related to seizures but its role in TBM-related seizure has not been reported to ... ...

Abstract	Background and purpose: Glutamate is a neurotransmitter that regulates approximately half of the nervous system, along with the sensory system. Glutamate excitotoxicity is related to seizures but its role in TBM-related seizure has not been reported to our best knowledge. It is proposed to report plasma glutamate level and its receptors in TBM patients with seizures and correlate with the type of seizures, Magnetic Resonance Imaging (MRI) findings, and outcome. Methods: TBM was diagnosed clinically with MRI as well as cerebrospinal fluid examination. TBM-related seizures have been categorized into early (< 1 month) or late (> 1 month) seizures. Six months outcome was defined using modified Rankin Scale as good (mRS ≤ 2) or poor (mRS > 2). Plasma glutamate was measured by ELISA, along with NR1, NR2A, and NR2B receptors using Real Time Polymerase Chain Reaction (RT-PCR) and have been correlated with seizure, MRI abnormalities, and outcome. Results: A total of 29 (53.7%) patients developed seizures (early-09, late-20). Glutamate (P < 0.0001), NR1 (p ≤ 0.0001), NR2A (p ≤ 0.0001), and NR2B (p ≤ 0.0001) were higher than the controls. In TBM patients with seizures, plasma glutamate (p = 0.01), NR1 (p = 0.03) and NR2A (p = 0.001) were significantly higher than those without seizures. Plasma glutamate level and all three receptor genes expression were higher during seizures and improved on cessation of seizure compared to the baseline. These markers correlated well with MRI findings and determined the outcome. ROC curve was used to estimate the diagnostic accuracy of the markers. The result indicated that NR2A gene was the best predictor followed by glutamate and NR1 gene. Conclusion: Our results highlight the role of glutamate and its receptors in TBM-related seizures and outcomes.
Mesh-Begriff(e)	Glutamic Acid/metabolism ; Humans ; Magnetic Resonance Imaging ; Seizures/diagnostic imaging ; Tuberculosis, Meningeal
Chemische Substanzen	Glutamic Acid (3KX376GY7L)
Sprache	Englisch
Erscheinungsdatum	2021-10-25
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632939-1
ISSN	1872-6844 ; 0920-1211
ISSN (online)	1872-6844
ISSN	0920-1211
DOI	10.1016/j.eplepsyres.2021.106789
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Role of Caspase- 3, TNF-α, and IL6 mRNA Expression in Intracranial Tuberculoma.

Kalita, Jayantee / Tripathi, Abhilasha / Shukla, Ruchi / Misra, Usha K / Kumar, Sunil

Molecular neurobiology

2022 Band 59, Heft 8, Seite(n) 4869–4878

Abstract: The development of tuberculoma is a process of inflammation, necrosis, and apoptosis. Therefore, the pro-inflammatory cytokines and apoptosis biomarkers are likely to play an important role. In this study, we report the expression of TNFα, IL6, and ... ...

Abstract	The development of tuberculoma is a process of inflammation, necrosis, and apoptosis. Therefore, the pro-inflammatory cytokines and apoptosis biomarkers are likely to play an important role. In this study, we report the expression of TNFα, IL6, and caspase-3 at the mRNA level in the patients with tuberculous meningitis (TBM) and compare these biomarkers in the patients with and without tuberculoma. A total of 134 patients with TBM and 35 matched healthy controls were included. The clinical, cerebrospinal fluid (CSF), and cranial magnetic resonance imaging (MRI) findings were noted. The mRNA expression of TNFα, IL6, and caspase-3 in peripheral blood mononuclear cells was evaluated by reverse transcriptase polymerase chain reaction. On cranial MRI, 89 (64.2%) patients had tuberculoma, and their level of consciousness, severity of meningitis, CSF findings, and blood counts were not significantly different from those without tuberculoma. Patients with tuberculoma had a higher expression of TNFα and IL6 compared to the controls, but had lower expression compared to the patients without tuberculoma. TNFα expression positively correlated with the expression of caspase-3, but not with IL6. Twenty-five (18.6%) patients died: 12 (13.5%) in tuberculoma and 13 (28.9%) in the non-tuberculoma group. Death was related to higher expression of TNFα and caspase-3. The lower expression of TNFα and IL6 in intracranial tuberculoma suggests that these patients are unlikely to be benefited with TNFα blockers.
Mesh-Begriff(e)	Biomarkers ; Caspase 3 ; Humans ; Interleukin-6/genetics ; Leukocytes, Mononuclear ; RNA, Messenger/analysis ; RNA, Messenger/genetics ; Tuberculoma, Intracranial/cerebrospinal fluid ; Tuberculosis, Meningeal/cerebrospinal fluid ; Tuberculosis, Meningeal/genetics ; Tumor Necrosis Factor-alpha/genetics
Chemische Substanzen	Biomarkers ; Interleukin-6 ; RNA, Messenger ; Tumor Necrosis Factor-alpha ; Caspase 3 (EC 3.4.22.-)
Sprache	Englisch
Erscheinungsdatum	2022-06-02
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	645020-9
ISSN	1559-1182 ; 0893-7648
ISSN (online)	1559-1182
ISSN	0893-7648
DOI	10.1007/s12035-022-02901-8
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Renin, antidiuretic hormone (ADH), and ADH receptor levels in cerebral salt wasting associated with tuberculous meningitis.

Tripathi, Abhilasha / Kumar, Mritunjai / Kalita, Jayantee / Kant, Surya / Misra, Usha K

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

2022 Band 43, Heft 5, Seite(n) 3361–3369

Abstract: Background: To evaluate serum antidiuretic hormone (ADH), its receptors, and renin levels in cerebral salt wasting (CSW) in tuberculous meningitis (TBM).: Methods: Patients diagnosed with definite (n = 30) or probable TBM (n = 47) who developed ... ...

Abstract	Background: To evaluate serum antidiuretic hormone (ADH), its receptors, and renin levels in cerebral salt wasting (CSW) in tuberculous meningitis (TBM). Methods: Patients diagnosed with definite (n = 30) or probable TBM (n = 47) who developed hyponatremia (CSW, SIADH, or miscellaneous causes) were included. Sequential measurement of serum ADH, ADH-R, and renin activity by enzyme-linked immunosorbent assay was done and correlated with serum sodium level, urinary output, and fluid balance. Results: Out of 79 TBM patients, CSW was observed in 36, SIADH in four, and miscellaneous hyponatremia in eight patients. CSW patients had a longer hospital stay (P < 0.001), lower GCS score (P < 0.007), higher MRC grade (P < 0.007), and a lower serum Na (P < 0.001) compared to non-CSW TBM patients. In severe CSW patients, serum ADH and ADH-R were correlated with hyponatremia and returned to baseline on correction; however, serum renin levels remained elevated. Serum ADH was related to hyponatremia but ADH-R and renin were not. ADH-R and renin levels did not significantly differ in CSW and SIADH. Conclusion: CSW is the commonest cause of hyponatremia in TBM and correlates with disease severity. ADH is related to hyponatremia, but ADH receptor and renin are not.
Mesh-Begriff(e)	Humans ; Hyponatremia/blood ; Hyponatremia/diagnosis ; Inappropriate ADH Syndrome/blood ; Renin/blood ; Tuberculosis, Meningeal/blood ; Tuberculosis, Meningeal/diagnosis ; Vasopressins/blood
Chemische Substanzen	Vasopressins (11000-17-2) ; Renin (EC 3.4.23.15)
Sprache	Englisch
Erscheinungsdatum	2022-01-05
Erscheinungsland	Italy
Dokumenttyp	Journal Article
ZDB-ID	2016546-8
ISSN	1590-3478 ; 1590-1874
ISSN (online)	1590-3478
ISSN	1590-1874
DOI	10.1007/s10072-021-05681-6
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Treatment response and complications during management of Pott's spine.

Misra, Usha K / Warrier, Siddharth / Kalita, Jayantee / Tripathi, Abhilasha / Kumar, Sunil

Journal of neuroimmunology

2022 Band 373, Seite(n) 577979

Abstract: The global incidence of TB in 2016 was 10.4 million and India accounts for a quarter of the global burden of TB. It is estimated that there are 2.79 million people with TB in India. About 10% of extra pulmonary TB involves bone and joints. Spinal TB ... ...

Abstract	The global incidence of TB in 2016 was 10.4 million and India accounts for a quarter of the global burden of TB. It is estimated that there are 2.79 million people with TB in India. About 10% of extra pulmonary TB involves bone and joints. Spinal TB accounts for half the cases of skeletal TB. The incidence of spinal TB is 1-4% of total TB cases, then it is estimated that only in India approximately 60,000 spinal TB cases exist. To report the pattern of recovery and predictors of outcome of Pott's spine. The intervention comprised of four drug antitubercular treatment, rest, immobilization, and ultrasonography or computerized tomography guided aspiration or biopsy as indicated outcome measures were six months Nurick grade, and mRS and complications like drug induced hepatitis (DIH) and paradoxical worsening. Seventy-three patients with Pott's spine, median age 36 (11-73) years, 32 (43.8%) females were included. The neurological signs were present in 44 (64.4%) patients. At six months, median Nurick grade improved from 4 to 2 and;and 70% patients had a good outcome as defined by mRS.The predictors of poor outcome were weight loss, non-ambulatory state on admission and paradoxical worsening. It is concluded that neurological involvement in Pott's spine was present in 64% patients, paradoxical worsening (deterioration in symptoms after one month of ATT) in 11% and DIH in 16%. Weight loss, non-ambulatory state on admission and paradoxical worsening predicted poor outcome.
Mesh-Begriff(e)	Female ; Humans ; Adult ; Male ; Tuberculosis, Spinal/diagnostic imaging ; Tuberculosis, Spinal/therapy ; Tuberculosis, Spinal/complications ; Antitubercular Agents/therapeutic use ; Decompression, Surgical ; Tomography, X-Ray Computed ; Weight Loss
Chemische Substanzen	Antitubercular Agents
Sprache	Englisch
Erscheinungsdatum	2022-10-10
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article
ZDB-ID	8335-5
ISSN	1872-8421 ; 0165-5728
ISSN (online)	1872-8421
ISSN	0165-5728
DOI	10.1016/j.jneuroim.2022.577979
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Oxidative stress and ER stress are related to severity of tubercular infection

Tripathi, Abhilasha / Kalita, Jayantee / Kant, Surya / Misra, Usha K.

Microbial pathogenesis. 2022 Nov., v. 172

2022

Abstract	To report the markers of oxidative stress and endoplasmic reticulum (ER) stress in tuberculosis of differing severity. Ninety patients with tuberculosis, 30 each with pulmonary tuberculosis (PTB), Pott's spine (PS) and tuberculous meningitis (TBM) were included. The diagnosis and severity of the respective group was based on pre-defined criteria. Six-months outcome and complications (Hyponatremia, paradoxical worsening and Drug induced hepatitis(DIH)) were recorded. Serum Melanodehyde (MDA) , glutathione (GSH), total antioxidant capacity (TAC), ER stress markers ATF-4,GRP-78 and CHOP, were measured using spectrophotometry and real time PCR. The oxidative and ER stress markers were correlated with different subgroups, severity of TBM, complications and outcome. The severity of TBM correlated with alteration in oxidative and ER stress markers. MDA was related to hyponatremia (P = 0.045), paradoxical worsening (P = 0.035) and DIH (P = 0.038), TAC correlated with paradoxical worsening (P = 0.047) and DIH (P = 0.015). In PS, MDA correlated with paradoxical worsening (P = 0.032) and DIH (P = 0.032); and in PTB, MDA correlated with hyponatremia (P = 0.025) and DIH (P = 0.037). Changes in stress marker levels were more marked in TBM compared to PS and PTB. Outcome of TBM correlated with MDA (P = 0.002), PS to MDA(P = 0.004), TAC(P = 0.05) CHOP(P = 0.004), GRP78(P = 0.001), ATF4(P = 0.045) and PTB to MDA(P = 0.0450), TAC(P = 0.014), CHOP(P = 0.025) and GRP78(P = 0.035). Oxidative and ER stress markers seem to be related to severity of TB, its complications and outcome.
Schlagwörter	antioxidant activity ; blood serum ; drugs ; endoplasmic reticulum ; glutathione ; hepatitis ; hyponatremia ; meningitis ; oxidative stress ; pathogenesis ; quantitative polymerase chain reaction ; spectroscopy ; tuberculosis
Sprache	Englisch
Erscheinungsverlauf	2022-11
Erscheinungsort	Elsevier Ltd
Dokumenttyp	Artikel
ZDB-ID	632772-2
ISSN	1096-1208 ; 0882-4010
ISSN (online)	1096-1208
ISSN	0882-4010
DOI	10.1016/j.micpath.2022.105764
Datenquelle	NAL Katalog (AGRICOLA)

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