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  1. Artikel ; Online: Hyponatremia and aging-related diseases: key player or innocent bystander? A systematic review.

    Fratangelo, Luigia / Nguyen, Sylvain / D'Amelio, Patrizia

    Systematic reviews

    2023  Band 12, Heft 1, Seite(n) 84

    Abstract: Background: Hyponatremia is frequent in older age; whether it is a key player, a surrogate marker, or an innocent bystander in age-related diseases is still unclear.: Objective: To understand the role of hyponatremia in falls, osteoporosis, fractures, ...

    Abstract Background: Hyponatremia is frequent in older age; whether it is a key player, a surrogate marker, or an innocent bystander in age-related diseases is still unclear.
    Objective: To understand the role of hyponatremia in falls, osteoporosis, fractures, and cognitive impairment in old patients.
    Method: Eligibility criteria for study inclusions were: written in English, peer-reviewed observational and intervention studies, clinical trial, prospective and retrospective controlled cohort studies, and case-controlled studies without limitations regarding the date of publication.
    Information sources: Protocol available on the International Prospective Register of Systematic Reviews (PROSPERO, CRD42021218389). MEDLINE, Embase, and PsycINFO were searched. Final search done on August 8, 2021. Risk-of-bias assessment: Risk-of-Bias Assessment tool for Non-randomized Studies (RoBANS) and the Bradford Hill's criteria for causality.
    Results: Includes studies: One-hundred thirty-five articles retained for the revision. Synthesis of results - Falls: Eleven studies were included. Strong association between hyponatremia and falls in all the studies was found. Osteoporosis and fractures: nineteen articles were included. The association between hyponatremia and osteoporosis is unclear. Cognitive impairment: Five articles were included. No association between hyponatremia and cognitive impairment was found.
    Discussion: Interpretation: Falls, osteoporosis, and fractures are multifactorial. Hyponatremia is not temporally related with the outcomes; we suggest that hyponatremia may be regarded as a marker of unhealthy aging and a confounder instead of a causal factor or an innocent bystander for falls and fractures. Concerning cognitive impairment, there are no evidence supporting a real role of hyponatremia to be regarded as an innocent bystander in neurodegeneration.
    Mesh-Begriff(e) Humans ; Aging ; Fractures, Bone ; Hyponatremia/complications ; Osteoporosis ; Retrospective Studies
    Sprache Englisch
    Erscheinungsdatum 2023-05-13
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Systematic Review
    ZDB-ID 2662257-9
    ISSN 2046-4053 ; 2046-4053
    ISSN (online) 2046-4053
    ISSN 2046-4053
    DOI 10.1186/s13643-023-02246-w
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Bone Deformities through the Prism of the International Classification of Functioning, Disability and Health in Ambulant Children with Cerebral Palsy: A Systematic Review.

    Bailly, Rodolphe / Pons, Christelle / Haes, Anne-Charlotte / Nguyen, Lisa / Thepaut, Matthias / Houx, Laëtitia / Lempereur, Mathieu / Brochard, Sylvain

    Children (Basel, Switzerland)

    2024  Band 11, Heft 2

    Abstract: 1) Aim: The aim of this study was to determine the relationship between lower limb bone deformities and body functions, activity, and participation in ambulant children with CP and whether changing bone morphology affects outcomes in these domains. (2) ... ...

    Abstract (1) Aim: The aim of this study was to determine the relationship between lower limb bone deformities and body functions, activity, and participation in ambulant children with CP and whether changing bone morphology affects outcomes in these domains. (2) Methods: A systematic literature search (PROSPERO CRD42020208416) of studies reporting correlations between measures of lower limb bone deformities and measures of body function, activity or participation, or post-surgical outcomes in these domains was conducted from 1990 to 2023 in Medline, Scopus, and Cochrane Library. We assessed study quality with the Checklist for Case Series (CCS) and a quality assessment developed by Quebec University Hospital. Meta-analysis was not possible; therefore, descriptive synthesis was performed. (3) Results: A total of 12 of 3373 screened articles were included. No studies evaluated the relationships between bone deformities and activity or participation, or the effect of isolated bone surgery on these domains. Correlations between bone deformities and body functions were poor-to-moderate. Internal hip rotation during gait improved after femoral derotation osteotomy. (4) Conclusions: A shift in paradigm is urgently required for the research and management of bone deformities in children with CP to include the activity and participation domains of the ICF, as well as consider more psychological aspects such as self-image.
    Sprache Englisch
    Erscheinungsdatum 2024-02-16
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children11020257
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Circulating tumor cells in Waldenström macroglobulinemia.

    Boccon-Gibod, Clémentine / Sourdeau, Elise / Morel, Pierre / Chapiro, Elise / Nguyen-Khac, Florence / Bravetti, Clotilde / Davi, Frédéric / Morel, Véronique / Gauthier, Nicolas / Grenier, Adrien / Boussen, Inès / Choquet, Sylvain / Leblond, Véronique / Le Garff-Tavernier, Magali / Baron, Marine / Roos-Weil, Damien

    Leukemia

    2024  Band 38, Heft 4, Seite(n) 903–907

    Mesh-Begriff(e) Humans ; Waldenstrom Macroglobulinemia/pathology ; Neoplastic Cells, Circulating ; Mutation ; Cell Proliferation
    Sprache Englisch
    Erscheinungsdatum 2024-02-09
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 807030-1
    ISSN 1476-5551 ; 0887-6924
    ISSN (online) 1476-5551
    ISSN 0887-6924
    DOI 10.1038/s41375-024-02156-3
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2295: Hefte anzeigen Standort:
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  4. Artikel ; Online: Efficacy of eculizumab in transplantation-associated thrombotic microangiopathy: results of the French nationwide study on behalf of the SFGM-TC and the CNR-MAT.

    Peyre, Marion / Sicre de Fontbrune, Flore / Berceanu, Ana / Benjemia, Lise / Castelle, Martin / D'Aveni, Maud / Marçais, Ambroise / Kaphan, Eleonore / Bulabois, Claude-Eric / Sirvent, Anne / Rohrlich, Pierre-Simon / Coiteux, Valerie / Chantepie, Sylvain / Nguyen-Quoc, Stéphanie / Peffault de Latour, Régis / Coppo, Paul

    Bone marrow transplantation

    2024  

    Sprache Englisch
    Erscheinungsdatum 2024-04-11
    Erscheinungsland England
    Dokumenttyp Letter
    ZDB-ID 632854-4
    ISSN 1476-5365 ; 0268-3369 ; 0951-3078
    ISSN (online) 1476-5365
    ISSN 0268-3369 ; 0951-3078
    DOI 10.1038/s41409-024-02279-2
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 2168: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Artikel: Growth Performance and Disease Resistance against

    Hoa, Tran Thi Tuyet / Fagnon, Mahougnon Siméon / Thy, Dang Thuy Mai / Chabrillat, Thibaut / Trung, Nguyen Bao / Kerros, Sylvain

    Animals : an open access journal from MDPI

    2023  Band 13, Heft 21

    Abstract: Acute Hepatopancreatic Necrosis Disease (AHPND) is a serious and emerging disease caused by a group of strains ... ...

    Abstract Acute Hepatopancreatic Necrosis Disease (AHPND) is a serious and emerging disease caused by a group of strains of
    Sprache Englisch
    Erscheinungsdatum 2023-10-25
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani13213320
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Buch ; Online: A Conditional Randomization Test for Sparse Logistic Regression in High-Dimension

    Nguyen, Binh T. / Thirion, Bertrand / Arlot, Sylvain

    2022  

    Abstract: Identifying the relevant variables for a classification model with correct confidence levels is a central but difficult task in high-dimension. Despite the core role of sparse logistic regression in statistics and machine learning, it still lacks a good ... ...

    Abstract Identifying the relevant variables for a classification model with correct confidence levels is a central but difficult task in high-dimension. Despite the core role of sparse logistic regression in statistics and machine learning, it still lacks a good solution for accurate inference in the regime where the number of features $p$ is as large as or larger than the number of samples $n$. Here, we tackle this problem by improving the Conditional Randomization Test (CRT). The original CRT algorithm shows promise as a way to output p-values while making few assumptions on the distribution of the test statistics. As it comes with a prohibitive computational cost even in mildly high-dimensional problems, faster solutions based on distillation have been proposed. Yet, they rely on unrealistic hypotheses and result in low-power solutions. To improve this, we propose \emph{CRT-logit}, an algorithm that combines a variable-distillation step and a decorrelation step that takes into account the geometry of $\ell_1$-penalized logistic regression problem. We provide a theoretical analysis of this procedure, and demonstrate its effectiveness on simulations, along with experiments on large-scale brain-imaging and genomics datasets.
    Schlagwörter Statistics - Machine Learning ; Computer Science - Machine Learning ; Mathematics - Statistics Theory
    Erscheinungsdatum 2022-05-29
    Erscheinungsland us
    Dokumenttyp Buch ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Hybrid Peptide-Alkoxyamine Drugs: A Strategy for the Development of a New Family of Antiplasmodial Drugs.

    Embo-Ibouanga, Ange W / Nguyen, Michel / Paloque, Lucie / Coustets, Mathilde / Joly, Jean-Patrick / Augereau, Jean-Michel / Vanthuyne, Nicolas / Bikanga, Raphaël / Coquin, Naomie / Robert, Anne / Audran, Gérard / Boissier, Jérôme / Mellet, Philippe / Benoit-Vical, Françoise / Marque, Sylvain R A

    Molecules (Basel, Switzerland)

    2024  Band 29, Heft 6

    Abstract: The emergence and spread of drug- ... ...

    Abstract The emergence and spread of drug-resistant
    Mesh-Begriff(e) Humans ; Antimalarials/chemistry ; Cytostatic Agents/therapeutic use ; Malaria/drug therapy ; Malaria, Falciparum/drug therapy ; Plasmodium falciparum ; Peptides/pharmacology ; Peptides/therapeutic use
    Chemische Substanzen Antimalarials ; Cytostatic Agents ; Peptides
    Sprache Englisch
    Erscheinungsdatum 2024-03-21
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules29061397
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.MO 81: Hefte anzeigen

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  8. Artikel ; Online: Growth Performance and Disease Resistance against Vibrio parahaemolyticus of Whiteleg Shrimp ( Litopenaeus vannamei ) Fed Essential Oil Blend (Phyto AquaBiotic)

    Tran Thi Tuyet Hoa / Mahougnon Siméon Fagnon / Dang Thuy Mai Thy / Thibaut Chabrillat / Nguyen Bao Trung / Sylvain Kerros

    Animals, Vol 13, Iss 21, p

    2023  Band 3320

    Abstract: Acute Hepatopancreatic Necrosis Disease (AHPND) is a serious and emerging disease caused by a group of strains of Vibrio parahaemolyticus and affects farmed shrimp, particularly whiteleg shrimps ( Liptopenaeus vannamei ). The objective of this study is ... ...

    Abstract Acute Hepatopancreatic Necrosis Disease (AHPND) is a serious and emerging disease caused by a group of strains of Vibrio parahaemolyticus and affects farmed shrimp, particularly whiteleg shrimps ( Liptopenaeus vannamei ). The objective of this study is to assess the effect of dietary supplementation with two dosages of an essential oil mixture (Phyto AquaBiotic, abbreviated as PAB) on growth performance and mortality reduction after challenge against V. parahaemolyticus . PAB was mixed with basal diets at rates of 0, 1 and 2 g/kg and fed for 42 days. Each tank was stocked with 100 individuals with experimentation performed in triplicate. The results showed an improvement in growth performance in a dose-dependent manner, specifically regarding daily weight gain, specific growth rate and total biomass, which were significantly improved compared to control ( p < 0.05). Further, PAB significantly reduced mortalities when challenged against Vibrio parahaemolyticus ( p < 0.05) and decreased Vibrio spp. count in the hepatopancreas of infected shrimp. Overall, PAB was efficient in reducing mortalities in cases of disease outbreaks at a rate of 2 g/kg.
    Schlagwörter essential oil mixture ; AHPND ; Vibrio parahaemolyticus ; Liptopenaeus vannamei ; growth performance ; survival ; Veterinary medicine ; SF600-1100 ; Zoology ; QL1-991
    Thema/Rubrik (Code) 630
    Sprache Englisch
    Erscheinungsdatum 2023-10-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: SPITFIR(e)

    Sylvain Prigent / Hoai-Nam Nguyen / Ludovic Leconte / Cesar Augusto Valades-Cruz / Bassam Hajj / Jean Salamero / Charles Kervrann

    Scientific Reports, Vol 13, Iss 1, Pp 1-

    a supermaneuverable algorithm for fast denoising and deconvolution of 3D fluorescence microscopy images and videos

    2023  Band 21

    Abstract: Abstract Modern fluorescent microscopy imaging is still limited by the optical aberrations and the photon budget available in the specimen. A direct consequence is the necessity to develop flexible and “off-road” algorithms in order to recover structural ...

    Abstract Abstract Modern fluorescent microscopy imaging is still limited by the optical aberrations and the photon budget available in the specimen. A direct consequence is the necessity to develop flexible and “off-road” algorithms in order to recover structural details and improve spatial resolution, which is critical when restraining the illumination to low levels in order to limit photo-damages. Here, we report SPITFIR(e) a flexible method designed to accurately and quickly restore 2D–3D fluorescence microscopy images and videos (4D images). We designed a generic sparse-promoting regularizer to subtract undesirable out-of-focus background and we developed a primal-dual algorithm for fast optimization. SPITFIR(e) is a ”swiss-knife” method for practitioners as it adapts to any microscopy techniques, to various sources of signal degradation (noise, blur), to variable image contents, as well as to low signal-to-noise ratios. Our method outperforms existing state-of-the-art algorithms, and is more flexible than supervised deep-learning methods requiring ground truth datasets. The performance, the flexibility, and the ability to push the spatiotemporal resolution limit of sub-diffracted fluorescence microscopy techniques are demonstrated on experimental datasets acquired with various microscopy techniques from 3D spinning-disk confocal up to lattice light sheet microscopy.
    Schlagwörter Medicine ; R ; Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2023-01-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: Nkx2-5

    Choquet, Caroline / Sicard, Pierre / Vahdat, Juliette / Nguyen, Thi Hong Minh / Kober, Frank / Varlet, Isabelle / Bernard, Monique / Richard, Sylvain / Kelly, Robert G / Lalevée, Nathalie / Miquerol, Lucile

    Journal of cardiovascular development and disease

    2023  Band 10, Heft 5

    Abstract: The ventricular conduction or His-Purkinje system (VCS) mediates the rapid propagation and precise delivery of electrical activity essential for the synchronization of heartbeats. Mutations in the transcription ... ...

    Abstract The ventricular conduction or His-Purkinje system (VCS) mediates the rapid propagation and precise delivery of electrical activity essential for the synchronization of heartbeats. Mutations in the transcription factor
    Sprache Englisch
    Erscheinungsdatum 2023-04-27
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2777082-5
    ISSN 2308-3425 ; 2308-3425
    ISSN (online) 2308-3425
    ISSN 2308-3425
    DOI 10.3390/jcdd10050194
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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