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  1. Artikel ; Online: Microbiote intestinal : quels tests en pratique ?

    Sokol, Harry

    La Revue du praticien

    2020  Band 69, Heft 7, Seite(n) 783

    Titelübersetzung Gut microbiota: what tests in practice?
    Mesh-Begriff(e) Gastrointestinal Microbiome
    Sprache Französisch
    Erscheinungsdatum 2020-03-31
    Erscheinungsland France
    Dokumenttyp Journal Article
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Microbiote intestinal : 10 messages « vrai/faux ».

    Sokol, Harry

    La Revue du praticien

    2020  Band 69, Heft 7, Seite(n) 804

    Titelübersetzung Gut microbiota : 10 «true / false» messages.
    Mesh-Begriff(e) Gastrointestinal Microbiome
    Sprache Französisch
    Erscheinungsdatum 2020-03-31
    Erscheinungsland France
    Dokumenttyp Journal Article
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Antibiotics: a trigger for inflammatory bowel disease?

    Sokol, Harry

    The lancet. Gastroenterology & hepatology

    2020  Band 5, Heft 11, Seite(n) 956–957

    Mesh-Begriff(e) Anti-Bacterial Agents/adverse effects ; Case-Control Studies ; Colitis, Ulcerative/drug therapy ; Humans ; Inflammatory Bowel Diseases/drug therapy ; Sweden
    Chemische Substanzen Anti-Bacterial Agents
    Sprache Englisch
    Erscheinungsdatum 2020-08-17
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Comment
    ISSN 2468-1253
    ISSN (online) 2468-1253
    DOI 10.1016/S2468-1253(20)30208-9
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Définition et rôles du microbiote intestinal.

    Sokol, Harry

    La Revue du praticien

    2020  Band 69, Heft 7, Seite(n) 776–782

    Abstract: Definition and roles of the gut microbiota. The gut microbiota is the set of microorganisms that colonize our digestive tract. A human being hosts 1013 bacteria in his gastro-intestinal tract, as much as human cells in his body. The microbiota contains ... ...

    Titelübersetzung Definition and roles of the gut microbiota.
    Abstract Definition and roles of the gut microbiota. The gut microbiota is the set of microorganisms that colonize our digestive tract. A human being hosts 1013 bacteria in his gastro-intestinal tract, as much as human cells in his body. The microbiota contains bacteria but also fungi, viruses and protists. The microbiota settles gradually after birth is considered adult around the age of 3 years. The microbiota can be modulated by many environmental factors and by the genetics of the host. An unbalanced microbiota (dysbiotic) is observed in many human diseases and plays a role in many of them, with however unequal weight from one disease to another. The microbiota could, in the near future, serve as a diagnostic and prognostic biomarker. It is already considered a potential therapeutic tool or target.
    Mesh-Begriff(e) Gastrointestinal Microbiome ; Gastrointestinal Tract ; Humans
    Sprache Französisch
    Erscheinungsdatum 2020-03-31
    Erscheinungsland France
    Dokumenttyp Journal Article
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Targeting the gut microbiota in inflammatory bowel diseases: where are we?

    Benech, Nicolas / Sokol, Harry

    Current opinion in microbiology

    2023  Band 74, Seite(n) 102319

    Abstract: The gut microbiota is now recognized to be a key driver of mucosal inflammation in inflammatory bowel disease (IBD). Robust functional and compositional alterations of the gut microbiota have been described in IBD with a reduction in bacterial diversity, ...

    Abstract The gut microbiota is now recognized to be a key driver of mucosal inflammation in inflammatory bowel disease (IBD). Robust functional and compositional alterations of the gut microbiota have been described in IBD with a reduction in bacterial diversity, a reduction in some anti-inflammatory anaerobic bacteria, and an increase in bacteria with pro-inflammatory potential. However, despite 15 years of active research, therapeutical applications are still lacking. Recent studies have shed new light on how targeting the gut microbiota can be beneficial in IBD with fecal microbiota transplantation, next-generation probiotics, and phage therapy. Given the similarities in dysfunction and structure of the gut microbiota between IBD and other chronic conditions associated with intestinal inflammation, such as celiac disease, Familial Mediterranean Fever, or common variable immunodeficiency, common therapeutic strategies targeting the host-microbiota symbiosis may be applied in these different conditions.
    Mesh-Begriff(e) Humans ; Gastrointestinal Microbiome ; Inflammatory Bowel Diseases/therapy ; Inflammatory Bowel Diseases/microbiology ; Microbiota ; Fecal Microbiota Transplantation ; Bacteria/genetics ; Inflammation
    Sprache Englisch
    Erscheinungsdatum 2023-04-15
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1418474-6
    ISSN 1879-0364 ; 1369-5274
    ISSN (online) 1879-0364
    ISSN 1369-5274
    DOI 10.1016/j.mib.2023.102319
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Understanding and predicting the efficacy of FMT.

    Lavelle, Aonghus / Sokol, Harry

    Nature medicine

    2022  Band 28, Heft 9, Seite(n) 1759–1760

    Mesh-Begriff(e) Fecal Microbiota Transplantation ; Feces ; Treatment Outcome
    Sprache Englisch
    Erscheinungsdatum 2022-09-15
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-022-01991-0
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Specific gut microbiota taxa as a key source of variability in colitis model.

    Benech, Nicolas / Sokol, Harry

    Nature reviews. Gastroenterology & hepatology

    2022  Band 19, Heft 8, Seite(n) 491–492

    Mesh-Begriff(e) Animals ; Colitis ; Disease Models, Animal ; Gastrointestinal Microbiome ; Humans ; Mice ; Mice, Inbred C57BL
    Sprache Englisch
    Erscheinungsdatum 2022-06-11
    Erscheinungsland England
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 2493722-8
    ISSN 1759-5053 ; 1759-5045
    ISSN (online) 1759-5053
    ISSN 1759-5045
    DOI 10.1038/s41575-022-00644-4
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: CARD9, VAV3, and infection risk in IgA nephropathy.

    Gleeson, Patrick J / Sokol, Harry / Monteiro, Renato C

    Kidney international

    2023  Band 103, Heft 5, Seite(n) 996–997

    Mesh-Begriff(e) Humans ; CARD Signaling Adaptor Proteins ; Glomerulonephritis, IGA/complications ; Glomerulonephritis, IGA/genetics ; Glomerulonephritis, IGA/microbiology ; Infections/genetics ; Proto-Oncogene Proteins c-vav/genetics
    Chemische Substanzen CARD Signaling Adaptor Proteins ; CARD9 protein, human ; Proto-Oncogene Proteins c-vav ; VAV3 protein, human
    Sprache Englisch
    Erscheinungsdatum 2023-04-21
    Erscheinungsland United States
    Dokumenttyp Letter
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2023.02.013
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Fecal microbiota transplantation for recurrent C. difficile infection can be the best therapeutic option in severely immunocompromised patients depending on a case-by-case assessment of the benefit/risk ratio.

    Benech, Nicolas / Cassir, Nadim / Galperine, Tatiana / Alric, Laurent / Scanzi, Julien / Sokol, Harry

    Gastroenterology

    2024  

    Sprache Englisch
    Erscheinungsdatum 2024-04-26
    Erscheinungsland United States
    Dokumenttyp Letter
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2024.04.022
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Gut dysbiosis in Crohn's disease: Never so close to solving the chicken-and-egg enigma: Commentary to "Gut microbiome composition is associated with future onset of Crohn's disease in healthy first-degree relatives, by Raygoza Garay JA et al., Gastroenterology 2023".

    Grellier, Nathan / Sokol, Harry / Seksik, Philippe

    Clinics and research in hepatology and gastroenterology

    2023  Band 48, Heft 2, Seite(n) 102272

    Abstract: Crohn's disease (CD) is a chronic disease of the digestive tract whose pathogenesis remains not fully understood. Several studies have implicated the gut microbiota as a key player in the onset of gut inflammation. However, most of the data is based on ... ...

    Abstract Crohn's disease (CD) is a chronic disease of the digestive tract whose pathogenesis remains not fully understood. Several studies have implicated the gut microbiota as a key player in the onset of gut inflammation. However, most of the data is based on case-control studies comparing patients with established disease with controls, usually healthy individuals. The study by Raygoza Garay and colleagues shows for the first time that changes in the composition of the gut microbiota precede CD onset by up to five years. The authors developed a microbiome risk score using a machine-learning model that included bacterial composition and clinical variables from a large cohort of healthy first-degree relatives of patients with CD. This study provides strong evidence that the alterations of the gut microbiota is causal in CD pathogenesis and suggest that early intervention targeting it may be an appropriate preventive strategy.
    Mesh-Begriff(e) Humans ; Crohn Disease/complications ; Gastrointestinal Microbiome ; Gastroenterology ; Dysbiosis/complications ; Dysbiosis/microbiology
    Sprache Englisch
    Erscheinungsdatum 2023-12-23
    Erscheinungsland France
    Dokumenttyp Editorial
    ZDB-ID 2594333-9
    ISSN 2210-741X ; 2210-7401
    ISSN (online) 2210-741X
    ISSN 2210-7401
    DOI 10.1016/j.clinre.2023.102272
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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