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  1. Artikel: Controllable physicochemical properties of WO

    Mandal, Rupam / Mandal, Aparajita / Dutta, Alapan / Sivakumar, Rengasamy / Srivastava, Sanjeev Kumar / Som, Tapobrata

    Beilstein journal of nanotechnology

    2024  Band 15, Seite(n) 350–359

    Abstract: In this work, various physicochemical properties are investigated in nanostructured ... ...

    Abstract In this work, various physicochemical properties are investigated in nanostructured WO
    Sprache Englisch
    Erscheinungsdatum 2024-04-02
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 2583584-1
    ISSN 2190-4286
    ISSN 2190-4286
    DOI 10.3762/bjnano.15.31
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Red to NIR-emissive anthracene-conjugated PMI dyes with dual functions: singlet-oxygen response and lipid-droplet imaging.

    Roy, Rupam / Khan, Aasif / Dutta, Tanoy / Koner, Apurba Lal

    Journal of materials chemistry. B

    2022  Band 10, Heft 28, Seite(n) 5352–5363

    Abstract: The rich chemistry of solution-processable red and near-infrared (NIR) organic emitters has emerged as an attractive and progressive research field because of their particular applications in organic optoelectronics and bioimaging. Also, one can see that ...

    Abstract The rich chemistry of solution-processable red and near-infrared (NIR) organic emitters has emerged as an attractive and progressive research field because of their particular applications in organic optoelectronics and bioimaging. Also, one can see that the research area of perylene monoimide-based red and NIR-emissive fluorophores is underexplored, which prompted us to design and synthesize three anthracene-conjugated PMI dyes exhibiting strong emission in the red and NIR window in solution. Three PMI-based fluorophores were synthesized
    Mesh-Begriff(e) Anthracenes ; Fluorescent Dyes/chemistry ; Lipids ; Oxygen ; Singlet Oxygen
    Chemische Substanzen Anthracenes ; Fluorescent Dyes ; Lipids ; Singlet Oxygen (17778-80-2) ; Oxygen (S88TT14065)
    Sprache Englisch
    Erscheinungsdatum 2022-07-20
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2702241-9
    ISSN 2050-7518 ; 2050-750X
    ISSN (online) 2050-7518
    ISSN 2050-750X
    DOI 10.1039/d2tb00349j
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  3. Artikel ; Online: QT Changes of Unforeseen Implications and Bedaquiline

    Samya Dutta / Chitrita Ghosh / Sandip Mukhopadhyay / Ta Rupam Kumar

    Journal of Clinical and Diagnostic Research, Vol 16, Iss 2, Pp OC24-OC

    An Observational Study

    2022  Band 28

    Abstract: Introduction: Bedaquiline (BDQ), a diarylquinoline class of antimicrobial, is one of the latest anti-mycobacterial agents to be developed in several decades. Despite the drug being a great hope for the Drug Resistant Tuberculosis (DR-TB) patients, ... ...

    Abstract Introduction: Bedaquiline (BDQ), a diarylquinoline class of antimicrobial, is one of the latest anti-mycobacterial agents to be developed in several decades. Despite the drug being a great hope for the Drug Resistant Tuberculosis (DR-TB) patients, previous studies have raised alarm about BDQ-induced QT prolongations of serious clinical implication. Unfortunately, knowledge about adverse drug reaction of BDQ on Indian patients remains limited. Therefore, dedicated research focused on safety of BDQ in Indian population can provide valuable insight. Aim: To assess the short-term safety of BDQ on Indian DR-TB patients. Materials and Methods: This prospective observational study was conducted over a period of one year on 49 DR-TB patients under BDQ therapy. Data of all the DR-TB patients from the first 14 days of BDQ therapy were enrolled in the study. All adverse events during this period were closely observed and recorded. Electrocardiography (ECG) were recorded daily during this period. From the observed QT value, a ‘corrected QT’ (QTc) value was calculated using Fridericia’s formula (QTcF). Values above 440 ms were noted as prolonged QTcF and values >500 ms were given a special consideration. Results: Total 49 patients were recruited in the present study, with mean age of 38.63±1.63 years. A total of 124 reports of adverse events or symptoms were recorded during the 14 days in-hospital period. Nausea was the most commonly reported complaint (n=33) followed by headache (n=30) and arthralgia (n=28). A total of 278 observations of prolonged QTcF values (>440 ms) was noted out of 686 ECG recordings. The mean QTcF values among day 1, day 7 and day 14 showed statistically significant difference {p=0.01, 95% CI (Confidence Interval)}. Moreover, a mean increase of 14.2% was observed in the QTcF values between day 1 and day 14. There were a total of 69 observations of QTcF value more than 500 ms. The incidence of such value was maximum on day 14 (n=9). The QTcF values were found to follow three distinct trends: a) ...
    Schlagwörter drug-resistant tuberculosis ; qt prolongation ; qt reduction ; Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-02-01T00:00:00Z
    Verlag JCDR Research and Publications Private Limited
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Development of recombinant subunit vaccine targeting InvH protein of Salmonella Typhimurium and evaluation of its immunoprotective efficacy against salmonellosis.

    Choudhury, Mridusmita / Borah, Probodh / Sarma, Hridip Kumar / Deka, Dipak / Dutta, Rupam / Hazarika, Girin / Deka, Naba Kumar

    Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology

    2023  Band 54, Heft 4, Seite(n) 3257–3264

    Abstract: Salmonella Typhimurium is the most prevalent non-host specific Salmonella serovars and a major concern for both human and animal health systems worldwide contributing to significant economic loss. Type 3 secretion system (T3SS) of Salmonella plays an ... ...

    Abstract Salmonella Typhimurium is the most prevalent non-host specific Salmonella serovars and a major concern for both human and animal health systems worldwide contributing to significant economic loss. Type 3 secretion system (T3SS) of Salmonella plays an important role in bacterial adherence and entry into the host epithelial cells. The product of invH gene of Salmonella is an important component of the needle complex of the type 3 secretion system. Hence, the present study was undertaken to clone and express the 15 kDa InvH surface protein of Salmonella Typhimurium in an E. coli host and to evaluate its immune potency in mice. The purified recombinant InvH (r-InvH) protein provoked a significant (p < 0.01) rise in IgG in the inoculated mice. The immunized mice were completely (100%) protected against the challenge dose of 107.5 LD50, while protection against challenge with the same dose of heterologous serovars was 90%. The bacterin-vaccinated group showed homologous protection of 60% against all three serovars. Findings in this study suggest the potential of the r-InvH protein of S. Typhimurium as an effective vaccine candidate against Salmonella infections.
    Mesh-Begriff(e) Animals ; Mice ; Humans ; Salmonella typhimurium/genetics ; Salmonella typhimurium/metabolism ; Type III Secretion Systems/metabolism ; Escherichia coli/genetics ; Bacterial Proteins/metabolism ; Salmonella Infections/prevention & control ; Salmonella Food Poisoning ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Vaccines, Subunit/genetics ; Vaccines, Subunit/metabolism ; Salmonella Infections, Animal/microbiology ; Vaccines, Attenuated
    Chemische Substanzen Type III Secretion Systems ; Bacterial Proteins ; Recombinant Proteins ; Vaccines, Subunit ; Vaccines, Attenuated
    Sprache Englisch
    Erscheinungsdatum 2023-10-04
    Erscheinungsland Brazil
    Dokumenttyp Journal Article
    ZDB-ID 2017175-4
    ISSN 1678-4405 ; 1517-8382
    ISSN (online) 1678-4405
    ISSN 1517-8382
    DOI 10.1007/s42770-023-01136-6
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Novel Mutations Reduce Expression of Meiotic Regulators SYCE1 and BOLL in Testis of Azoospermic Men from West Bengal, India.

    Pal, Samudra / Paladhi, Pranab / Dutta, Saurav / Mullick, Rupam Basu / Bose, Gunja / Ghosh, Papiya / Chattopadhyay, Ratna / Ghosh, Sujay

    Reproductive sciences (Thousand Oaks, Calif.)

    2023  Band 31, Heft 4, Seite(n) 1069–1088

    Abstract: We investigated the polymorphisms/mutations in synaptonemal complex central element protein 1 (SYCE1) and CDC25A mRNA-binding protein (BOLL) to test whether they increase the risk of azoospermia among Bengali-speaking men from West Bengal, India. Sanger' ... ...

    Abstract We investigated the polymorphisms/mutations in synaptonemal complex central element protein 1 (SYCE1) and CDC25A mRNA-binding protein (BOLL) to test whether they increase the risk of azoospermia among Bengali-speaking men from West Bengal, India. Sanger's dideoxy sequencing was used to genotype 140 azoospermic individuals who tested negative for Y chromosome microdeletion and 120 healthy controls. In both cases and controls, qRT-PCR was used to determine the expression summary of SYCE1 and BOLL. The perceived harmful consequences of identified mutations were inferred using in silico analysis. Suitable statistical approaches were used to conduct the association study. We found SYCE1 177insT (ON245141), 10650T > G (ON257012), 10093insT (ON257013), 10653insG (ON292504), rs10857748A > G, rs10857749G > A, and rs10857750T > A and BOLL 7708T > A (ON245141insT), rs72918816T > C, and rs700655C > T variants with the prevalence of azoospermia. Data from qRT-PCR and in silico studies projected that the variations would either disrupt the transcript's natural splice junctions or cause probable damage to the structure of the genes' proteins. SYCE1 gene variants [177insT (ON245141), 10650T > G (ON257012), 10093insT (ON257013), 10653insG (ON292504), rs10857748A > G, rs10857749G > A, rs10857750T > A] and BOLL gene variants [7708T > A (ON245141insT), rs72918816T > C, rs700655C > T] reduce the expression of respective gene in testicular tissue among azoospermic male as revealed from qRT-PCR result. These genetic variations could be utilized as screening tools for male infertility to determine the best course of treatment in routine ART practise.
    Mesh-Begriff(e) Humans ; Male ; Azoospermia/metabolism ; India ; Infertility, Male/metabolism ; Mutation ; Testis/metabolism
    Chemische Substanzen SYCP1 protein, human ; BOLL protein, human
    Sprache Englisch
    Erscheinungsdatum 2023-11-13
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2276411-2
    ISSN 1933-7205 ; 1933-7191
    ISSN (online) 1933-7205
    ISSN 1933-7191
    DOI 10.1007/s43032-023-01393-8
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  6. Artikel ; Online: Analysis of codon usage of severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) and its adaptability in dog.

    Dutta, Rupam / Buragohain, Lukumoni / Borah, Probodh

    Virus research

    2020  Band 288, Seite(n) 198113

    Abstract: Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) is recognized as one of the life-threatening viruses causing the most destructive pandemic in this century. The genesis of this virus is still unknown. To elucidate its molecular evolution and ...

    Abstract Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) is recognized as one of the life-threatening viruses causing the most destructive pandemic in this century. The genesis of this virus is still unknown. To elucidate its molecular evolution and regulation of gene expression, the knowledge of codon usage is a pre-requisite. In this study, an attempt was made to document the genome-wide codon usage profile and the various factors influencing the codon usage patterns of SARS-CoV-2 in human and dog. The SARS-CoV-2 genome showed relative abundance of A and U nucleotides and relative synonymous codon usage analysis revealed that the preferred synonymous codons mostly end with A/U. The analysis of ENc-GC3s, Neutrality and Parity rule 2 plots indicated that natural selection and other undefined factors dominate the overall codon usage bias in SARS-CoV-2 whereas the impact of mutation pressure is comparatively minor. The codon adaptation index and relative codon deoptimization index of SARS-CoV-2 deciphered that human is more favoured host for adaptation compared to dog. These results enhance our understanding of the factors involved in evolution of the novel human SARS-CoV-2 and its adaptability in dog.
    Mesh-Begriff(e) Adaptation, Biological/genetics ; Animals ; Betacoronavirus/genetics ; COVID-19 ; Cats ; Cattle ; Chiroptera ; Codon Usage ; Coronavirus Infections/virology ; Dog Diseases/virology ; Dogs ; Evolution, Molecular ; Genome, Viral ; Horses ; Host Specificity ; Humans ; Mutation ; Pandemics ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Selection, Genetic ; Swine
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-08-07
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605780-9
    ISSN 1872-7492 ; 0168-1702
    ISSN (online) 1872-7492
    ISSN 0168-1702
    DOI 10.1016/j.virusres.2020.198113
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  7. Artikel: Analysis of codon usage of severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) and its adaptability in dog

    Dutta, Rupam / Buragohain, Lukumoni / Borah, Probodh

    Virus research. 2020 Oct. 15, v. 288

    2020  

    Abstract: Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) is recognized as one of the life-threatening viruses causing the most destructive pandemic in this century. The genesis of this virus is still unknown. To elucidate its molecular evolution and ...

    Abstract Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) is recognized as one of the life-threatening viruses causing the most destructive pandemic in this century. The genesis of this virus is still unknown. To elucidate its molecular evolution and regulation of gene expression, the knowledge of codon usage is a pre-requisite. In this study, an attempt was made to document the genome-wide codon usage profile and the various factors influencing the codon usage patterns of SARS-CoV-2 in human and dog. The SARS-CoV-2 genome showed relative abundance of A and U nucleotides and relative synonymous codon usage analysis revealed that the preferred synonymous codons mostly end with A/U. The analysis of ENc-GC3s, Neutrality and Parity rule 2 plots indicated that natural selection and other undefined factors dominate the overall codon usage bias in SARS-CoV-2 whereas the impact of mutation pressure is comparatively minor. The codon adaptation index and relative codon deoptimization index of SARS-CoV-2 deciphered that human is more favoured host for adaptation compared to dog. These results enhance our understanding of the factors involved in evolution of the novel human SARS-CoV-2 and its adaptability in dog.
    Schlagwörter Severe acute respiratory syndrome coronavirus 2 ; codon usage ; dogs ; gene expression regulation ; humans ; mutation ; natural selection ; nucleotides ; pandemic ; viruses
    Sprache Englisch
    Erscheinungsverlauf 2020-1015
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ZDB-ID 605780-9
    ISSN 1872-7492 ; 0168-1702
    ISSN (online) 1872-7492
    ISSN 0168-1702
    DOI 10.1016/j.virusres.2020.198113
    Datenquelle NAL Katalog (AGRICOLA)

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  8. Artikel: Red to NIR-emissive anthracene-conjugated PMI dyes with dual functions: singlet-oxygen response and lipid-droplet imaging

    Roy, Rupam / Khan, Aasif / Dutta, Tanoy / Koner, Apurba Lal

    Journal of materials chemistry B. 2022 July 20, v. 10, no. 28

    2022  

    Abstract: The rich chemistry of solution-processable red and near-infrared (NIR) organic emitters has emerged as an attractive and progressive research field because of their particular applications in organic optoelectronics and bioimaging. Also, one can see that ...

    Abstract The rich chemistry of solution-processable red and near-infrared (NIR) organic emitters has emerged as an attractive and progressive research field because of their particular applications in organic optoelectronics and bioimaging. Also, one can see that the research area of perylene monoimide-based red and NIR-emissive fluorophores is underexplored, which prompted us to design and synthesize three anthracene-conjugated PMI dyes exhibiting strong emission in the red and NIR window in solution. Three PMI-based fluorophores were synthesized via conjoining anthracene and donor moieties (-Ph, -N,N-PhNMe₂) with a PMI core via an acetylene linkage at the peri-position, which helped to attain extensive electronic conjugation, which was reflected in red and NIR-emission in solution. The key molecular features to be highlighted here are: all three dyes are strongly emissive in solution, as unveiled by the excellent absolute fluorescence QYs; and they possess tuneable emission properties, guided by the donor strength and a profound Stokes shift (100–200 nm). The three fluorescent dyes demonstrated appreciable singlet-oxygen (¹O₂) sensitivity when photoirradiated with methylene blue (MB) in solution, showing a substantial blue-shift in emission in a ratiometric manner. Further, the treatment of dye–MB solution with α-tocopherol (¹O₂ scavenger) validated the presence of ¹O₂ as the only oxidizing species generated by MB in solution. Computational investigations gave insight into the twisting of donor moieties in their ground-state optimized geometries, the modulation of the FMO energy gap, and the thermodynamic feasibility of the ¹O₂ reaction. Finally, via taking advantage of the red and NIR-emission, we successfully utilized one of the fluorophores as a lipid-droplet marker for bioimaging in HepG2 cells.
    Schlagwörter acetylene ; alpha-tocopherol ; anthracenes ; bioimaging ; energy ; fluorescence ; fluorescent dyes ; methylene blue ; photoirradiation ; singlet oxygen ; thermodynamics
    Sprache Englisch
    Erscheinungsverlauf 2022-0720
    Umfang p. 5352-5363.
    Erscheinungsort The Royal Society of Chemistry
    Dokumenttyp Artikel
    ZDB-ID 2702241-9
    ISSN 2050-7518 ; 2050-750X
    ISSN (online) 2050-7518
    ISSN 2050-750X
    DOI 10.1039/d2tb00349j
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  9. Artikel ; Online: Effect of Microheterogeneity of Different Aqueous Binary Mixtures on the Proton Transfer Dynamics of [2,2′-Bipyridyl]-3,3′-diol

    Rupam Dutta / Arghajit Pyne / Dipankar Mondal / Nilmoni Sarkar

    ACS Omega, Vol 3, Iss 1, Pp 314-

    A Femtosecond Fluorescence Upconversion Study

    2018  Band 328

    Schlagwörter Chemistry ; QD1-999
    Sprache Englisch
    Erscheinungsdatum 2018-01-01T00:00:00Z
    Verlag American Chemical Society
    Dokumenttyp Artikel ; Online
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  10. Artikel ; Online: Analysis of codon usage of severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) and its adaptability in dog

    Dutta, Rupam / Buragohain, Lukumoni / Borah, Probodh

    Virus Research

    2020  Band 288, Seite(n) 198113

    Schlagwörter Cancer Research ; Virology ; Infectious Diseases ; covid19
    Sprache Englisch
    Verlag Elsevier BV
    Erscheinungsland us
    Dokumenttyp Artikel ; Online
    ZDB-ID 605780-9
    ISSN 1872-7492 ; 0168-1702
    ISSN (online) 1872-7492
    ISSN 0168-1702
    DOI 10.1016/j.virusres.2020.198113
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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