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Artikel ; Online: Roles for eosinophils and basophils in COVID-19?

Tabachnikova, Alexandra / Chen, Steven T

2020 Band 20, Heft 8, Seite(n) 461

Schlagwörter	covid19
Sprache	Englisch
Erscheinungsdatum	2020-06-22
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	2062776-2
ISSN	1474-1741 ; 1474-1733
ISSN (online)	1474-1741
ISSN	1474-1733
DOI	10.1038/s41577-020-0379-1
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Roles for eosinophils and basophils in COVID-19?

Tabachnikova, Alexandra / Chen, Steven T

Nat Rev Immunol

Schlagwörter	covid19
Verlag	WHO
Dokumenttyp	Artikel
Anmerkung	WHO #Covidence: #611260
Datenquelle	COVID19

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Artikel ; Online: Roles for eosinophils and basophils in COVID-19?

Tabachnikova, Alexandra / Chen, Steven T.

Nature Reviews Immunology

2020 Band 20, Heft 8, Seite(n) 461–461

Schlagwörter	Immunology ; covid19
Sprache	Englisch
Verlag	Springer Science and Business Media LLC
Erscheinungsland	us
Dokumenttyp	Artikel ; Online
ZDB-ID	2062776-2
ISSN	1474-1741 ; 1474-1733
ISSN (online)	1474-1741
ISSN	1474-1733
DOI	10.1038/s41577-020-0379-1
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel: Sex differences in symptomatology and immune profiles of Long COVID.

medRxiv : the preprint server for health sciences

2024

Abstract: Strong sex differences in the frequencies and manifestations of Long COVID (LC) have been reported with females significantly more likely than males to present with LC after acute SARS-CoV-2 ... ...

Abstract	Strong sex differences in the frequencies and manifestations of Long COVID (LC) have been reported with females significantly more likely than males to present with LC after acute SARS-CoV-2 infection
Sprache	Englisch
Erscheinungsdatum	2024-03-04
Erscheinungsland	United States
Dokumenttyp	Preprint
DOI	10.1101/2024.02.29.24303568
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Impact of COVID-19 vaccination on symptoms and immune phenotypes in vaccine-naïve individuals with Long COVID.

Grady, Connor B / Bhattacharjee, Bornali / Silva, Julio / Jaycox, Jillian / Lee, Lik Wee / Monteiro, Valter Silva / Sawano, Mitsuaki / Massey, Daisy / Caraballo, César / Gehlhausen, Jeff R / Tabachnikova, Alexandra / Mao, Tianyang / Lucas, Carolina / Peña-Hernandez, Mario A / Xu, Lan / Tzeng, Tiffany J / Takahashi, Takehiro / Herrin, Jeph / Güthe, Diana Berrent /

Akrami, Athena / Assaf, Gina / Davis, Hannah / Harris, Karen / McCorkell, Lisa / Schulz, Wade L / Grffin, Daniel / Wei, Hannah / Ring, Aaron M / Guan, Leying / Cruz, Charles Dela / Iwasaki, Akiko / Krumholz, Harlan M

medRxiv : the preprint server for health sciences

2024

Abstract: Background: Long COVID contributes to the global burden of disease. Proposed root cause hypotheses include the persistence of SARS-CoV-2 viral reservoir, autoimmunity, and reactivation of latent herpesviruses. Patients have reported various changes in ... ...

Abstract	Background: Long COVID contributes to the global burden of disease. Proposed root cause hypotheses include the persistence of SARS-CoV-2 viral reservoir, autoimmunity, and reactivation of latent herpesviruses. Patients have reported various changes in Long COVID symptoms after COVID-19 vaccinations, leaving uncertainty about whether vaccine-induced immune responses may alleviate or worsen disease pathology. Methods: In this prospective study, we evaluated changes in symptoms and immune responses after COVID-19 vaccination in 16 vaccine-naïve individuals with Long COVID. Surveys were administered before vaccination and then at 2, 6, and 12 weeks after receiving the first vaccine dose of the primary series. Simultaneously, SARS-CoV-2-reactive TCR enrichment, SARS-CoV-2-specific antibody responses, antibody responses to other viral and self-antigens, and circulating cytokines were quantified before vaccination and at 6 and 12 weeks after vaccination. Results: Self-report at 12 weeks post-vaccination indicated 10 out of 16 participants had improved health, 3 had no change, 1 had worse health, and 2 reported marginal changes. Significant elevation in SARS-CoV-2-specific TCRs and Spike protein-specific IgG were observed 6 and 12 weeks after vaccination. No changes in reactivities were observed against herpes viruses and self-antigens. Within this dataset, higher baseline sIL-6R was associated with symptom improvement, and the two top features associated with non-improvement were high IFN-β and CNTF, among soluble analytes. Conclusions: Our study showed that in this small sample, vaccination improved the health or resulted in no change to the health of most participants, though few experienced worsening. Vaccination was associated with increased SARS-CoV-2 Spike protein-specific IgG and T cell expansion in most individuals with Long COVID. Symptom improvement was observed in those with baseline elevated sIL-6R, while elevated interferon and neuropeptide levels were associated with a lack of improvement.
Sprache	Englisch
Erscheinungsdatum	2024-01-12
Erscheinungsland	United States
Dokumenttyp	Preprint
DOI	10.1101/2024.01.11.24300929
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: No evidence of fetal defects or anti-syncytin-1 antibody induction following COVID-19 mRNA vaccination.

Lu-Culligan, Alice / Tabachnikova, Alexandra / Pérez-Then, Eddy / Tokuyama, Maria / Lee, Hannah J / Lucas, Carolina / Silva Monteiro, Valter / Miric, Marija / Brache, Vivian / Cochon, Leila / Muenker, M Catherine / Mohanty, Subhasis / Huang, Jiefang / Kang, Insoo / Dela Cruz, Charles / Farhadian, Shelli / Campbell, Melissa / Yildirim, Inci / Shaw, Albert C /

Ma, Shuangge / Vermund, Sten H / Ko, Albert I / Omer, Saad B / Iwasaki, Akiko

PLoS biology

2022 Band 20, Heft 5, Seite(n) e3001506

Abstract: The impact of Coronavirus Disease 2019 (COVID-19) mRNA vaccination on pregnancy and fertility has become a major topic of public interest. We investigated 2 of the most widely propagated claims to determine (1) whether COVID-19 mRNA vaccination of mice ... ...

Abstract	The impact of Coronavirus Disease 2019 (COVID-19) mRNA vaccination on pregnancy and fertility has become a major topic of public interest. We investigated 2 of the most widely propagated claims to determine (1) whether COVID-19 mRNA vaccination of mice during early pregnancy is associated with an increased incidence of birth defects or growth abnormalities; and (2) whether COVID-19 mRNA-vaccinated human volunteers exhibit elevated levels of antibodies to the human placental protein syncytin-1. Using a mouse model, we found that intramuscular COVID-19 mRNA vaccination during early pregnancy at gestational age E7.5 did not lead to differences in fetal size by crown-rump length or weight at term, nor did we observe any gross birth defects. In contrast, injection of the TLR3 agonist and double-stranded RNA mimic polyinosinic-polycytidylic acid, or poly(I:C), impacted growth in utero leading to reduced fetal size. No overt maternal illness following either vaccination or poly(I:C) exposure was observed. We also found that term fetuses from these murine pregnancies vaccinated prior to the formation of the definitive placenta exhibit high circulating levels of anti-spike and anti-receptor-binding domain (anti-RBD) antibodies to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) consistent with maternal antibody status, indicating transplacental transfer in the later stages of pregnancy after early immunization. Finally, we did not detect increased levels of circulating anti-syncytin-1 antibodies in a cohort of COVID-19 vaccinated adults compared to unvaccinated adults by ELISA. Our findings contradict popular claims associating COVID-19 mRNA vaccination with infertility and adverse neonatal outcomes.
Mesh-Begriff(e)	Animals ; Antibodies, Viral ; COVID-19/prevention & control ; Female ; Fetus ; Gene Products, env ; Humans ; Mice ; Placenta/metabolism ; Pregnancy ; Pregnancy Proteins ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; SARS-CoV-2 ; Vaccination
Chemische Substanzen	Antibodies, Viral ; Gene Products, env ; Pregnancy Proteins ; RNA, Messenger ; syncytin
Sprache	Englisch
Erscheinungsdatum	2022-05-24
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2126776-5
ISSN	1545-7885 ; 1544-9173
ISSN (online)	1545-7885
ISSN	1544-9173
DOI	10.1371/journal.pbio.3001506
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Impact of COVID-19 vaccination on symptoms and immune phenotypes in vaccine-naïve individuals with Long COVID

Grady, Connor B / Bhattacharjee, Bornali / Silva, Julio / Jaycox, Jillian / Lee, Lik Wee / Monteiro, Valter Silva / Sawano, Mitsuaki / Massey, Daisy / Caraballo, César / Gehlhausen, Jeff R. / Tabachnikova, Alexandra / Mao, Tianyang / Lucas, Carolina / Peña-Hernandez, Mario A. / Xu, Lan / Tzeng, Tiffany J. / Takahashi, Takehiro / Herrin, Jeph / Güthe, Diana Berrent /

medRxiv

Abstract	Background: Long COVID contributes to the global burden of disease. Proposed root cause hypotheses include the persistence of SARS-CoV-2 viral reservoir, autoimmunity, and reactivation of latent herpesviruses. Patients have reported various changes in Long COVID symptoms after COVID-19 vaccinations, leaving uncertainty about whether vaccine-induced immune responses may alleviate or worsen disease pathology. Methods: In this prospective study, we evaluated changes in symptoms and immune responses after COVID-19 vaccination in 16 vaccine-naïve individuals with Long COVID. Surveys were administered before vaccination and then at 2, 6, and 12 weeks after receiving the first vaccine dose of the primary series. Simultaneously, SARS-CoV-2-reactive TCR enrichment, SARS-CoV-2-specific antibody responses, antibody responses to other viral and self-antigens, and circulating cytokines were quantified before vaccination and at 6 and 12 weeks after vaccination. Results: Self-report at 12 weeks post-vaccination indicated 10 out of 16 participants had improved health, 3 had no change, 1 had worse health, and 2 reported marginal changes. Significant elevation in SARS-CoV-2-specific TCRs and Spike protein-specific IgG were observed 6 and 12 weeks after vaccination. No changes in reactivities were observed against herpes viruses and self-antigens. Within this dataset, higher baseline sIL-6R was associated with symptom improvement, and the two top features associated with non-improvement were high IFN-β and CNTF, among soluble analytes. Conclusions: Our study showed that in this small sample, vaccination improved the health or resulted in no change to the health of most participants, though few experienced worsening. Vaccination was associated with increased SARS-CoV-2 Spike protein-specific IgG and T cell expansion in most individuals with Long COVID. Symptom improvement was observed in those with baseline elevated sIL-6R, while elevated interferon and neuropeptide levels were associated with a lack of improvement.
Schlagwörter	covid19
Sprache	Englisch
Erscheinungsdatum	2024-01-12
Verlag	Cold Spring Harbor Laboratory Press
Dokumenttyp	Artikel ; Online
DOI	10.1101/2024.01.11.24300929
Datenquelle	COVID19

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Artikel: Distinguishing features of Long COVID identified through immune profiling.

Klein, Jon / Wood, Jamie / Jaycox, Jillian / Lu, Peiwen / Dhodapkar, Rahul M / Gehlhausen, Jeff R / Tabachnikova, Alexandra / Tabacof, Laura / Malik, Amyn A / Kamath, Kathy / Greene, Kerrie / Monteiro, Valter Silva / Peña-Hernandez, Mario / Mao, Tianyang / Bhattacharjee, Bornali / Takahashi, Takehiro / Lucas, Carolina / Silva, Julio / Mccarthy, Dayna /

Breyman, Erica / Tosto-Mancuso, Jenna / Dai, Yile / Perotti, Emily / Akduman, Koray / Tzeng, Tiffany J / Xu, Lan / Yildirim, Inci / Krumholz, Harlan M / Shon, John / Medzhitov, Ruslan / Omer, Saad B / van Dijk, David / Ring, Aaron M / Putrino, David / Iwasaki, Akiko

medRxiv : the preprint server for health sciences

2022

Abstract: SARS-CoV-2 infection can result in the development of a constellation of persistent sequelae following acute disease called post-acute sequelae of COVID-19 (PASC) or Long ... ...

Abstract	SARS-CoV-2 infection can result in the development of a constellation of persistent sequelae following acute disease called post-acute sequelae of COVID-19 (PASC) or Long COVID
Sprache	Englisch
Erscheinungsdatum	2022-08-10
Erscheinungsland	United States
Dokumenttyp	Preprint
DOI	10.1101/2022.08.09.22278592
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Impact of circulating SARS-CoV-2 variants on mRNA vaccine-induced immunity.

Nature

2021 Band 600, Heft 7889, Seite(n) 523–529

Abstract: The emergence of SARS-CoV-2 variants with mutations in major neutralizing antibody-binding sites can affect humoral immunity induced by infection or ... ...

Abstract	The emergence of SARS-CoV-2 variants with mutations in major neutralizing antibody-binding sites can affect humoral immunity induced by infection or vaccination
Mesh-Begriff(e)	2019-nCoV Vaccine mRNA-1273/immunology ; Adult ; Aged ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; BNT162 Vaccine/immunology ; COVID-19/epidemiology ; COVID-19/virology ; Female ; Health Personnel/statistics & numerical data ; Humans ; Immunity, Humoral ; Male ; Middle Aged ; Mutation ; Retrospective Studies ; SARS-CoV-2/classification ; SARS-CoV-2/immunology ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/immunology ; T-Lymphocytes/immunology ; Vaccines, Synthetic/immunology ; mRNA Vaccines/immunology
Chemische Substanzen	Antibodies, Neutralizing ; Antibodies, Viral ; Spike Glycoprotein, Coronavirus ; Vaccines, Synthetic ; mRNA Vaccines ; spike protein, SARS-CoV-2 ; 2019-nCoV Vaccine mRNA-1273 (EPK39PL4R4) ; BNT162 Vaccine (N38TVC63NU)
Sprache	Englisch
Erscheinungsdatum	2021-10-11
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-021-04085-y
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Shift of lung macrophage composition is associated with COVID-19 disease severity and recovery.

Chen, Steven T / Park, Matthew D / Del Valle, Diane Marie / Buckup, Mark / Tabachnikova, Alexandra / Simons, Nicole W / Mouskas, Konstantinos / Lee, Brian / Geanon, Daniel / D'Souza, Darwin / Dawson, Travis / Marvin, Robert / Nie, Kai / Thompson, Ryan C / Zhao, Zhen / LeBerichel, Jessica / Chang, Christie / Jamal, Hajra / Chaddha, Udit /

Mathews, Kusum / Acquah, Samuel / Brown, Stacey-Ann / Reiss, Michelle / Harkin, Timothy / Feldmann, Marc / Powell, Charles A / Hook, Jaime L / Kim-Schulze, Seunghee / Rahman, Adeeb H / Brown, Brian D / Beckmann, Noam D / Gnjatic, Sacha / Kenigsberg, Ephraim / Charney, Alexander W / Merad, Miriam

bioRxiv : the preprint server for biology

2022

Abstract: Though it has been 2 years since the start of the Coronavirus Disease 19 (COVID-19) pandemic, COVID-19 continues to be a worldwide health crisis. Despite the development of preventive vaccines, very little progress has been made to identify curative ... ...

Abstract	Though it has been 2 years since the start of the Coronavirus Disease 19 (COVID-19) pandemic, COVID-19 continues to be a worldwide health crisis. Despite the development of preventive vaccines, very little progress has been made to identify curative therapies to treat COVID-19 and other inflammatory diseases which remain a major unmet need in medicine. Our study sought to identify drivers of disease severity and death to develop tailored immunotherapy strategies to halt disease progression. Here we assembled the Mount Sinai COVID-19 Biobank which was comprised of ~600 hospitalized patients followed longitudinally during the peak of the pandemic. Moderate disease and survival were associated with a stronger antigen (Ag) presentation and effector T cell signature, while severe disease and death were associated with an altered Ag presentation signature, increased numbers of circulating inflammatory, immature myeloid cells, and extrafollicular activated B cells associated with autoantibody formation. Strikingly, we found that in severe COVID-19 patients, lung tissue resident alveolar macrophages (AM) were not only severely depleted, but also had an altered Ag presentation signature, and were replaced by inflammatory monocytes and monocyte-derived macrophages (MoMΦ). Notably, the size of the AM pool correlated with recovery or death, while AM loss and functionality were restored in patients that recovered. These data therefore suggest that local and systemic myeloid cell dysregulation is a driver of COVID-19 severity and that modulation of AM numbers and functionality in the lung may be a viable therapeutic strategy for the treatment of critical lung inflammatory illnesses.
Sprache	Englisch
Erscheinungsdatum	2022-01-12
Erscheinungsland	United States
Dokumenttyp	Preprint
DOI	10.1101/2022.01.11.475918
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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