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  1. Artikel ; Online: Reply to the Comment of Yu et al.

    Kang, Chang Hyun

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

    2019  Band 14, Heft 12, Seite(n) e281–e282

    Mesh-Begriff(e) Humans ; Lung Neoplasms ; Lymph Node Excision ; Propensity Score ; Thymus Neoplasms
    Sprache Englisch
    Erscheinungsdatum 2019-11-22
    Erscheinungsland United States
    Dokumenttyp Letter ; Comment
    ZDB-ID 2432037-7
    ISSN 1556-1380 ; 1556-0864
    ISSN (online) 1556-1380
    ISSN 1556-0864
    DOI 10.1016/j.jtho.2019.09.082
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 6664: Hefte anzeigen Standort:
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  2. Artikel: Potential Mechanisms of Shu Gan Jie Yu Capsule in the Treatment of Mild to Moderate Depression Based on Systemic Pharmacology and Current Evidence.

    Li, Taiping / Qiu, Tian / Zeng, Yanyan / Kang, Bing / Tang, Xianglong / Yang, Ning / Xiao, Hong

    Evidence-based complementary and alternative medicine : eCAM

    2022  Band 2022, Seite(n) 3321099

    Abstract: Background: Shu Gan Jie Yu (SGJY) capsule has a good effect on relieving depressive symptoms ...

    Abstract Background: Shu Gan Jie Yu (SGJY) capsule has a good effect on relieving depressive symptoms in China. However, the mechanism of action is still unclear. Therefore, systemic pharmacology and molecular docking approaches were used to clarify its corresponding antidepressant mechanisms.
    Methods: Traditional Chinese Medicine Database and Analysis Platform (TCMSP), the Encyclopedia of Traditional Chinese Medicine (ETCM), and Swiss Target Prediction servers were used to screen and predict the bioactive components of the
    Results: Seven active components and 45 intersection targets were included in the study. PPI network had genuinely uncovered the potential therapeutic targets, such as
    Conclusions: In this study, we have successfully predicted the biochemically active constituents, potential therapeutic targets, and comprehensively predicted the related drug-gene interaction of the
    Sprache Englisch
    Erscheinungsdatum 2022-08-22
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2022/3321099
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Buch: Gu dai han yu yu fa

    Kang, Ruicong

    2008  

    Verfasserangabe Kang rui cong
    Sprache Chinesisch
    Umfang 1, 2, 1, 2, 9, 458 S
    Ausgabenhinweis Di 1 ban
    Verlag Shang hai gu ji chu ban she
    Erscheinungsort Shang hai
    Dokumenttyp Buch
    ISBN 9787532548231 ; 7532548236
    Datenquelle Ehemaliges Sondersammelgebiet Küsten- und Hochseefischerei

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  4. Artikel ; Online: Potential Mechanisms of Shu Gan Jie Yu Capsule in the Treatment of Mild to Moderate Depression Based on Systemic Pharmacology and Current Evidence

    Taiping Li / Tian Qiu / Yanyan Zeng / Bing Kang / Xianglong Tang / Ning Yang / Hong Xiao

    Evidence-Based Complementary and Alternative Medicine, Vol

    2022  Band 2022

    Abstract: Background. Shu Gan Jie Yu (SGJY) capsule has a good effect on relieving depressive symptoms ...

    Abstract Background. Shu Gan Jie Yu (SGJY) capsule has a good effect on relieving depressive symptoms in China. However, the mechanism of action is still unclear. Therefore, systemic pharmacology and molecular docking approaches were used to clarify its corresponding antidepressant mechanisms. Methods. Traditional Chinese Medicine Database and Analysis Platform (TCMSP), the Encyclopedia of Traditional Chinese Medicine (ETCM), and Swiss Target Prediction servers were used to screen and predict the bioactive components of the SGJY capsule and their antidepressive targets. Mild to moderate depression (MMD) related genes were obtained from GeneCards and DisGeNET databases. A network of bioactive components-therapeutic targets of the SGJY capsule was established by STRING 11.5 and Cytoscape 3.9.0 software. Gene function and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed by utilizing Database for Annotation, Visualization, and Integrated Discovery (DAVID) platform. Active components were taken to dock with the hypothetical proteins by iGEMDOCK and SwissDock, and the docking details were visually displayed by UCSF Chimera software. Then, the related research literature of the SGJY capsule was reviewed, summarized, sorted, and analyzed, including experimental evidence and clinical experience. Results. Seven active components and 45 intersection targets were included in the study. PPI network had genuinely uncovered the potential therapeutic targets, such as AKT1, HSP90AA1, ESR1, EGFR, and PTGS2. KEGG pathway analysis showed that the mechanism of the SGJY capsule on MMD was mainly involved in the PI3K-Akt signaling pathway. Conclusions. In this study, we have successfully predicted the biochemically active constituents, potential therapeutic targets, and comprehensively predicted the related drug-gene interaction of the SGJY capsule for treating MMD and provided a basis for subsequent experiments.
    Schlagwörter Other systems of medicine ; RZ201-999
    Sprache Englisch
    Erscheinungsdatum 2022-01-01T00:00:00Z
    Verlag Hindawi Limited
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Simultaneous determination of sulfur compounds from the sulfur pathway in rat plasma by liquid chromatography tandem mass spectrometry: application to the study of the effect of Shao Fu Zhu Yu decoction.

    Zhang, Yue / Kang, An / Deng, Haishan / Shi, Le / Su, Shulan / Yu, Li / Xie, Tong / Shan, Jinjun / Wen, Hongmei / Chi, Yumei / Han, Shuying / Su, Ruilin / Song, Yilin / Chen, Xi / Shaikh, Armaan Basheer

    Analytical and bioanalytical chemistry

    2018  Band 410, Heft 16, Seite(n) 3743–3755

    Abstract: A sensitive, accurate, and time-saving approach was developed for the simultaneous quantification of eight sulfur compounds in the sulfur pathway, which could reflect the status of an organism, including oxidative stress, signal transduction, enzyme ... ...

    Abstract A sensitive, accurate, and time-saving approach was developed for the simultaneous quantification of eight sulfur compounds in the sulfur pathway, which could reflect the status of an organism, including oxidative stress, signal transduction, enzyme reaction, and so on. In order to overcome the instability of highly reactive sulfhydryl compounds, N-ethylmaleimide derivatization was adopted to effectively protect sulfhydryl-containing samples. Using isotope-labeled glutathione (GSH-
    Mesh-Begriff(e) Animals ; Antioxidants/pharmacology ; Chromatography, High Pressure Liquid/methods ; Drug Evaluation, Preclinical/methods ; Drugs, Chinese Herbal/pharmacology ; Female ; Limit of Detection ; Metabolic Networks and Pathways/drug effects ; Oxidative Stress/drug effects ; Rats ; Rats, Sprague-Dawley ; Sulfur Compounds/blood ; Sulfur Compounds/metabolism ; Tandem Mass Spectrometry/methods
    Chemische Substanzen Antioxidants ; Drugs, Chinese Herbal ; Shao-Fu-Zhu-Yu ; Sulfur Compounds
    Sprache Englisch
    Erscheinungsdatum 2018-06
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Validation Studies
    ZDB-ID 201093-8
    ISSN 1618-2650 ; 0016-1152 ; 0372-7920
    ISSN (online) 1618-2650
    ISSN 0016-1152 ; 0372-7920
    DOI 10.1007/s00216-018-1038-2
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Bonn

    Z 4' 69/97: Hefte anzeigen
    Archiv 3: Hefte anzeigen
    Z 9.4: Hefte anzeigen

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  6. Artikel ; Online: Effect of Xiao-tan-jie-yu Prescription on sleep quality of soldiers acute exposure to high altitude

    Yu-xing YANG / Xiao-yun LI / Pin-kang WEI / Hua-hua AN / Cai-juan LIN / Ya-ping HE / Jian-kui GUO / Yuan-wen QUAN

    Medical Journal of Chinese People's Liberation Army, Vol 41, Iss 10, Pp 869-

    2016  Band 873

    Abstract: Objective To observe the efficacy of Xiao-tan-jie-yu prescription (XTJYF) on sleep quality ...

    Abstract Objective To observe the efficacy of Xiao-tan-jie-yu prescription (XTJYF) on sleep quality of the soldiers who acutely exposed to western area of high altitude. Methods In this prospective, completely randomized, parallel, placebo-controlled study, 550 soldiers acutely exposed to western area of high altitude were investigated by the Pittsburgh Sleep Quality Index (PSQI), 100 soldiers with sleep disorder were selected and divided into two groups (50 each): treatment group received TCM XTJYF therapy and control group was treated with placebo. After 2 weeks' treatment, PSQI total score and respective factor scores before and after treatment were assessed, and clinical therapeutic efficacy and adverse reactions were observed. Results The PSQI total score and respective factor scores of these soldiers were significantly higher than those of normal adults, but significantly lower than those of insomnia patients, while their sleep disorder factor score was significantly higher compared with insomnia patients. XTJYF reduced the total score and some factor scores (subjective sleep quality, time for initiating sleep, total sleep time, and sleep efficiency) for PSQI in the soldiers with sleep disorder, and the overall response rate was 91.49% which is higher than those in the placebo control group (P<0.05 or 0.01), without toxic side effects. Conclusions The sleep quality of soldiers who acutely exposed to western area of high altitude in China is not high, and XTJYF may safely and effectively improve the sleep quality. DOI:10.11855/j.issn.0577-7402.2016.10.15
    Schlagwörter altitude ; sleep disorders ; Xiao-tan-jie-yu prescription ; military personnel ; Medicine ; R ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 150
    Sprache Chinesisch
    Erscheinungsdatum 2016-10-01T00:00:00Z
    Verlag Editorial Board of Medical Journal of Chinese People's Liberation Army
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Buch ; Konferenzbeitrag: Lu xun yu "zuo lian"

    Tan, Guilin / Wu, Kang

    zhong guo lu xun yan jiu hui li shi hui 2010 nian nian hui lun wen ji

    2011  

    Titelvarianten Zhong guo lu xun yan jiu hui li shi hui 2010 nian nian hui lun wen ji ; 中国鲁迅研究会理事会2010年年会论文集
    Körperschaft Lu Xun yu zuo lian xue shu yan tao hui :
    Zhongguo zuo yi zuo jia lian meng
    Veranstaltung/Kongress Lu Xun yu zuo lian xue shu yan tao hui (2010, ChangshaChina)
    Verfasserangabe Tan gui lin, wu kang zhu bian
    Schlagwörter Authors, Chinese ; Chinese literature/History and criticism
    Sprache Chinesisch
    Umfang 2, 357 p., [1] p. of plates, ill, 24 cm
    Ausgabenhinweis Di 1 ban
    Verlag Hu nan shi fan da xue chu ban she
    Erscheinungsort Chang sha
    Dokumenttyp Buch ; Konferenzbeitrag
    Anmerkung Includes bibliographical references
    ISBN 7564805420 ; 9787564805425
    Datenquelle Ehemaliges Sondersammelgebiet Küsten- und Hochseefischerei

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  8. Artikel ; Online: Qian Yang Yu Yin Granule-containing serum inhibits angiotensin II-induced proliferation, reactive oxygen species production, and inflammation in human mesangial cells via an NADPH oxidase 4-dependent pathway.

    Ding, Kang / Wang, Yan / Jiang, Weimin / Zhang, Yu / Yin, Hongping / Fang, Zhuyuan

    BMC complementary and alternative medicine

    2015  Band 15, Seite(n) 81

    Abstract: Background: Qian Yang Yu Yin Granule (QYYYG), a traditional Chinese herbal medicine, has been ...

    Abstract Background: Qian Yang Yu Yin Granule (QYYYG), a traditional Chinese herbal medicine, has been indicated for renal damage in hypertension for decades in China, but little remains known regarding its underlying molecular mechanism. Therefore, we performed the current study in order to investigate the underlying molecular mechanism of QYYYG in the treatment of hypertensive renal damage.
    Methods: We hypothesize that QYYYG relieves hypertensive renal injury through an angiotensin II (Ang II)-nicotinamide adenine dinucleotide phosphate (NAPDH)-oxidase (NOX)-reactive oxygen species (ROS) pathway. In this study, we investigated the effects of QYYYG-containing serum (QYGS) in human mesangial cells (HMCs) against Ang II-induced cell proliferation, ROS production, and inflammation through the seropharmacological method.
    Results: We found that QYGS could inhibit cell proliferation in Ang II-treated HMCs. In addition, QYGS considerably suppressed production of ROS, decreased mRNA and protein expression of NAPDH-oxidase 4 (NOX4), p22 (phox) , and activated Ras-related C3 botulinum toxin substrate 1 (GTP-Rac1); as well as counteracted the up-regulation of inflammatory markers including tumor necrosis factor-α (TNF-α), nuclear factor-κB (NF-κB) p65, and interleukin 6 (IL-6). These effects were further confirmed in HMCs transfected with specific small interfering RNA (siRNA) targeting NOX4.
    Conclusions: Taken together, these results suggest that a NOX4-dependent pathway plays an important role in regulating the inhibitory effect of QYGS. Our findings provide new insights into the molecular mechanisms of QYYYG and their role in the treatment of hypertensive nephropathy.
    Mesh-Begriff(e) Angiotensin II/metabolism ; Animals ; Cell Proliferation/drug effects ; China ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Hypertension, Renal/drug therapy ; Hypertension, Renal/metabolism ; Inflammation/drug therapy ; Inflammation/metabolism ; Mesangial Cells/drug effects ; Mesangial Cells/metabolism ; NADPH Oxidases/metabolism ; NF-kappa B/metabolism ; Phytotherapy ; Polygonum ; RNA, Small Interfering/pharmacology ; Rats, Wistar ; Reactive Oxygen Species/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Up-Regulation/drug effects
    Chemische Substanzen Drugs, Chinese Herbal ; NF-kappa B ; RNA, Small Interfering ; Reactive Oxygen Species ; TNF protein, human ; Tumor Necrosis Factor-alpha ; Angiotensin II (11128-99-7) ; NADPH Oxidases (EC 1.6.3.-)
    Sprache Englisch
    Erscheinungsdatum 2015-03-25
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2050429-9
    ISSN 1472-6882 ; 1472-6882
    ISSN (online) 1472-6882
    ISSN 1472-6882
    DOI 10.1186/s12906-015-0619-2
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: Simultaneous determination of sulfur compounds from the sulfur pathway in rat plasma by liquid chromatography tandem mass spectrometry: application to the study of the effect of Shao Fu Zhu Yu decoction

    Zhang, Yue / An Kang / Armaan Basheer Shaikh / Haishan Deng / Hongmei Wen / Jinjun Shan / Le Shi / Li Yu / Ruilin Su / Shulan Su / Shuying Han / Tong Xie / Xi Chen / Yilin Song / Yumei Chi

    Analytical and bioanalytical chemistry. 2018 June, v. 410, no. 16

    2018  

    Abstract: ... traditional Chinese medicine, Shao Fu Zhu Yu decoction. The results suggested that Shao Fu Zhu Yu decoction might protect ... and applied to the study of the effect of Shao Fu Zhu Yu decoction. ...

    Abstract A sensitive, accurate, and time-saving approach was developed for the simultaneous quantification of eight sulfur compounds in the sulfur pathway, which could reflect the status of an organism, including oxidative stress, signal transduction, enzyme reaction, and so on. In order to overcome the instability of highly reactive sulfhydryl compounds, N-ethylmaleimide derivatization was adopted to effectively protect sulfhydryl-containing samples. Using isotope-labeled glutathione (GSH-13C2, 15N), the validated method was demonstrated to offer satisfactory linearity, accuracy, and precision. Separation was done by UHPLC, using a BEH amide column. Accordingly, 0.1% formic acid acetonitrile was selected as the precipitant. A tandem mass spectrometer was coupled to the chromatographic system and afforded a detection limit of 0.2 ng/mL. Good linearity was maintained over a wide concentration range (r2 > 0.994), and the accuracy was in the range of 86.6–114% for all the studied compounds. The precision, expressed in RSD%, ranged from 1.1% to 9.4% as intraday variability and less than 13% as interday precision for all of the analytes. The approach was applied to study the potential therapeutic mechanism of a well-known traditional Chinese medicine, Shao Fu Zhu Yu decoction. The results suggested that Shao Fu Zhu Yu decoction might protect against oxidative damage by increasing the concentrations of sulfhydryl compounds. Graphical abstract An approach to quantitatively determining sulfur compounds in the sulfur pathway simultaneously wasestablished and applied to the study of the effect of Shao Fu Zhu Yu decoction.
    Schlagwörter acetonitrile ; derivatization ; enzymatic reactions ; formic acid ; glutathione ; isotope labeling ; nitrogen ; Oriental traditional medicine ; oxidative stress ; rats ; signal transduction ; spectrometers ; stable isotopes ; sulfur ; tandem mass spectrometry ; therapeutics ; ultra-performance liquid chromatography
    Sprache Englisch
    Erscheinungsverlauf 2018-06
    Umfang p. 3743-3755.
    Erscheinungsort Springer Berlin Heidelberg
    Dokumenttyp Artikel
    ISSN 1618-2642
    DOI 10.1007/s00216-018-1038-2
    Datenquelle NAL Katalog (AGRICOLA)

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  10. Artikel ; Online: Xue-fu-Zhu-Yu decoction protects rats against retinal ischemia by downregulation of HIF-1α and VEGF via inhibition of RBP2 and PKM2.

    Tan, Shu-Qiu / Geng, Xue / Liu, Jorn-Hon / Pan, Wynn Hwai-Tzong / Wang, Li-Xiang / Liu, Hui-Kang / Hu, Lei / Chao, Hsiao-Ming

    BMC complementary and alternative medicine

    2017  Band 17, Heft 1, Seite(n) 365

    Abstract: ... investigates the protective effects and mechanisms of Xue-Fu-Zhu-Yu decoction (XFZYD) with respect to retinal ...

    Abstract Background: Retinal ischemia-related eye diseases result in visual dysfunction. This study investigates the protective effects and mechanisms of Xue-Fu-Zhu-Yu decoction (XFZYD) with respect to retinal ischemia.
    Methods: Retinal ischemia (I) was induced in Wistar rats by a high intraocular pressure (HIOP) of 120 mmHg for 1 h, which was followed by reperfusion of the ischemic eye; the fellow untreated eye acted as a control. Electroretinogram (ERG), biochemistry and histopathology investigations were performed.
    Results: Significant ischemic changes occurred after ischemia including decreased ERG b-wave ratios, less numerous retinal ganglion cells (RGCs), reduced inner retinal thickness, fewer choline acetyltransferase (ChAT) labeled amacrine cell bodies, increased glial fibrillary acidic protein (GFAP) immunoreactivity and increased vimentin Müller immunolabeling. These were accompanied by significant increases in the mRNA/protein concentrations of vascular endothelium growth factor, hypoxia-inducible factor-1α, pyruvate kinase M2 and retinoblastoma-binding protein 2. The ischemic changes were concentration-dependently and significantly altered when XFZYD was given for seven consecutive days before or after retina ischemia, compared to vehicle. These alterations included enhanced ERG b-wave amplitudes, more numerous RGCs, enhanced inner retinal thickness, a greater number of ChAT immunolabeled amacrine cell bodies and decreased GFAP/vimentin immunoreactivity. Furthermore, decreased mRNA levels of VEGF, HIF-1α, PKM2, and RBP2 were also found. Reduced protein concentrations of VEGF, HIF-1α, PKM2, and RBP2 were also demonstrated. Furthermore, there was an inhibition of the ischemia-associated increased ratios (target protein/β-actin) in the protein levels of VEGF, HIF-1α, PKM2, and RBP2, which were induced by Shikonin, JIB-04 or Avastin.
    Conclusion: XFZYD would seem to protect against well-known retinal ischemic changes via a synergistic inhibition of RBP2 and PKM2, as well as down-regulation of HIF-1α and a reduction in VEGF secretion.
    Mesh-Begriff(e) Animals ; Down-Regulation ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Electroretinography ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Ischemia/drug therapy ; Ischemia/metabolism ; Male ; Phytotherapy ; Pyruvate Kinase/metabolism ; Rats, Wistar ; Retina/drug effects ; Retina/metabolism ; Retina/pathology ; Retinal Diseases/drug therapy ; Retinal Diseases/metabolism ; Retinoblastoma-Binding Protein 2/metabolism ; Vascular Endothelial Growth Factor A/metabolism
    Chemische Substanzen Drugs, Chinese Herbal ; Hypoxia-Inducible Factor 1, alpha Subunit ; Vascular Endothelial Growth Factor A ; Xue-Fu-Zhu-Yu decoction ; Retinoblastoma-Binding Protein 2 (EC 1.14.11.27) ; Pyruvate Kinase (EC 2.7.1.40)
    Sprache Englisch
    Erscheinungsdatum 2017-07-14
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2050429-9
    ISSN 1472-6882 ; 1472-6882
    ISSN (online) 1472-6882
    ISSN 1472-6882
    DOI 10.1186/s12906-017-1857-2
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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