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  1. Artikel ; Online: Adverse childhood experience and persistent insomnia during emerging adulthood: do positive childhood experiences matter?

    Wu, Meng-Hsuan / Chiao, Chi / Lin, Wen-Hsu

    BMC public health

    2024  Band 24, Heft 1, Seite(n) 287

    Abstract: Background: Adverse childhood experiences (ACE) have been documented to have long-term impacts on sleep disturbances. However, less is known about how ACE co-occurs with positive childhood experiences (PCE) and modulate their effects on adult sleep ... ...

    Abstract Background: Adverse childhood experiences (ACE) have been documented to have long-term impacts on sleep disturbances. However, less is known about how ACE co-occurs with positive childhood experiences (PCE) and modulate their effects on adult sleep disturbances, particularly in the context of persistent insomnia. Building on resilience theory, this study aims to examine the interplay between ACE and PCE and their effects on persistent insomnia during emerging adulthood.
    Methods: A total of 2,841 emerging adults were recruited from the Taiwan Youth Project. Persistent insomnia during emerging adulthood was assessed using two adult surveys (mean age = 19.8 and 21.9). The ACE (10 items) and PCE (7 items) were obtained from the baseline survey (mean age = 13.8). A series of logistic regression analyses were conducted.
    Results: Among the emerging adults, 29.22% had persistent insomnia. Consistent with the compensatory model, ACE and PCE exerted opposing effects on persistent insomnia during emerging adulthood. In line with the protective model, the negative effect of ACE is mitigated when individuals have high PCE. However, consistent with the challenge model, the protective effect of PCE on persistent insomnia was inhibited in individuals with four or more ACE.
    Conclusions: PCE serves as a protective factor, shielding emerging adults from the adverse effects of ACE on persistent insomnia. It is essential to prioritize positive experiences during early life to promote lifelong sleep health.
    Mesh-Begriff(e) Adult ; Adolescent ; Humans ; Young Adult ; Sleep Initiation and Maintenance Disorders/epidemiology ; Adverse Childhood Experiences ; Sleep ; Drug-Related Side Effects and Adverse Reactions ; Protective Devices ; Sleep Wake Disorders
    Sprache Englisch
    Erscheinungsdatum 2024-01-24
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2041338-5
    ISSN 1471-2458 ; 1471-2458
    ISSN (online) 1471-2458
    ISSN 1471-2458
    DOI 10.1186/s12889-024-17774-w
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Thermosensation and Temperature Preference: From Molecules to Neuronal Circuits in

    Chiang, Meng-Hsuan / Lin, Yu-Chun / Wu, Tony / Wu, Chia-Lin

    Cells

    2023  Band 12, Heft 24

    Abstract: Temperature has a significant effect on all physiological processes of animals. Suitable temperatures promote responsiveness, movement, metabolism, growth, and reproduction in animals, whereas extreme temperatures can cause injury or even death. Thus, ... ...

    Abstract Temperature has a significant effect on all physiological processes of animals. Suitable temperatures promote responsiveness, movement, metabolism, growth, and reproduction in animals, whereas extreme temperatures can cause injury or even death. Thus, thermosensation is important for survival in all animals. However, mechanisms regulating thermosensation remain unexplored, mostly because of the complexity of mammalian neural circuits. The fruit fly
    Mesh-Begriff(e) Animals ; Temperature ; Drosophila/physiology ; Drosophila melanogaster/genetics ; Hot Temperature ; Behavior, Animal/physiology ; Mammals
    Sprache Englisch
    Erscheinungsdatum 2023-12-08
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12242792
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Treatment of Mammary Paget Disease: A systematic review and meta-analysis of real-world data.

    Lin, Cheng-Wei / Chiang, Meng-Hsuan / Tam, Ka-Wai

    International journal of surgery (London, England)

    2022  Band 107, Seite(n) 106964

    Abstract: Background: Because the lesions of mammary Paget disease (MPD) are often limited to the nipple-areolar complex, the extension of optimal tumor excision is inconclusive. Moreover, the risk of potential tumor upstaging is unknown; therefore, the ... ...

    Abstract Background: Because the lesions of mammary Paget disease (MPD) are often limited to the nipple-areolar complex, the extension of optimal tumor excision is inconclusive. Moreover, the risk of potential tumor upstaging is unknown; therefore, the application of sentinel lymph node biopsy (SLNB) is required for analysis. We systematically reviewed the real-world data to evaluate the optimal treatment and potential predictors of poorer prognosis for MPD.
    Methods: The PubMed, Embase, and Cochrane Library databases were searched for relevant studies. Clinical studies were included if they evaluated the outcome of positive rates of SLNB, prognostic risk factors of MPD, and survival outcomes of treatments of interest for MPD, including mastectomy, breast-conserving surgery (BCS) with radiotherapy, and BCS alone.
    Results: A total of 38 studies with 24,062 patients were retrieved. Compared with BCS alone (21.2%), mastectomy (5.9%; P < 0.001) and BCS with radiotherapy (8; P = 0.001) had significantly lower local recurrence rates. Patients with palpable tumors (30.2%) had significantly worse prognoses than those with impalpable (3.4%) tumors in metastasis (P < 0.001), and significantly higher local recurrence rates were observed in patients with underlying invasive carcinoma (6.7%) than those with noninvasive carcinoma (4.5%; P = 0.032). The positive rate of SLNB was 17% (95% CI: 0.115-0.226).
    Conclusion: Except for MPD alone, BCS alone is not recommended for treating MPD with invasive ductal carcinoma and MPD with ductal carcinoma in situ. Moreover, a palpable mass, underlying invasive carcinoma, and positive lymph node status may lead to a poorer prognosis, which may be taken into consideration for the application of SLNB.
    Mesh-Begriff(e) Humans ; Female ; Paget's Disease, Mammary/surgery ; Mastectomy ; Breast Neoplasms/surgery ; Sentinel Lymph Node Biopsy ; Carcinoma, Intraductal, Noninfiltrating/pathology
    Sprache Englisch
    Erscheinungsdatum 2022-10-26
    Erscheinungsland England
    Dokumenttyp Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1016/j.ijsu.2022.106964
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Mapping land-use and land-cover changes through the integration of satellite and airborne remote sensing data.

    Lin, Meng-Hsuan / Lin, Ying-Tong / Tsai, Min-Lin / Chen, Yi-Ying / Chen, Yi-Chun / Wang, Hsueh-Ching / Wang, Chi-Kuei

    Environmental monitoring and assessment

    2024  Band 196, Heft 3, Seite(n) 246

    Abstract: An integrated, remotely sensed approach to assess land-use and land-cover change (LULCC) dynamics plays an important role in environmental monitoring, management, and policy development. In this study, we utilized the advantage of land-cover seasonality, ...

    Abstract An integrated, remotely sensed approach to assess land-use and land-cover change (LULCC) dynamics plays an important role in environmental monitoring, management, and policy development. In this study, we utilized the advantage of land-cover seasonality, canopy height, and spectral characteristics to develop a phenology-based classification model (PCM) for mapping the annual LULCC in our study areas. Monthly analysis of normalized difference vegetation index (NDVI) and near-infrared (NIR) values derived from SPOT images enabled the detection of temporal characteristics of each land type, serving as crucial indices for land type classification. The integration of normalized difference built-up index (NDBI) derived from Landsat images and airborne LiDAR canopy height into the PCM resulted in an overall performance of 0.85, slightly surpassing that of random forest analysis or principal component analysis. The development of PCM can reduce the time and effort required for manual classification and capture annual LULCC changes among five major land types: forests, built-up land, inland water, agriculture land, and grassland/shrubs. The gross change LULCC analysis for the Taoyuan Tableland demonstrated fluctuations in land types over the study period (2013 to 2022). A negative correlation (r =  - 0.79) in area changes between grassland/shrubs and agricultural land and a positive correlation (r = 0.47) between irrigation ponds and agricultural land were found. Event-based LULCC analysis for Taipei City demonstrated a balance between urbanization and urban greening, with the number of urbanization events becoming comparable to urban greening events when the spatial extent of LULCC events exceeds 1000 m
    Mesh-Begriff(e) Environmental Monitoring ; Remote Sensing Technology ; Agriculture ; Policy Making ; Ponds
    Sprache Englisch
    Erscheinungsdatum 2024-02-08
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 782621-7
    ISSN 1573-2959 ; 0167-6369
    ISSN (online) 1573-2959
    ISSN 0167-6369
    DOI 10.1007/s10661-024-12424-5
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Independent insulin signaling modulators govern hot avoidance under different feeding states.

    Meng-Hsuan Chiang / Yu-Chun Lin / Sheng-Fu Chen / Peng-Shiuan Lee / Tsai-Feng Fu / Tony Wu / Chia-Lin Wu

    PLoS Biology, Vol 21, Iss 10, p e

    2023  Band 3002332

    Abstract: Thermosensation is critical for the survival of animals. However, mechanisms through which nutritional status modulates thermosensation remain unclear. Herein, we showed that hungry Drosophila exhibit a strong hot avoidance behavior (HAB) compared to ... ...

    Abstract Thermosensation is critical for the survival of animals. However, mechanisms through which nutritional status modulates thermosensation remain unclear. Herein, we showed that hungry Drosophila exhibit a strong hot avoidance behavior (HAB) compared to food-sated flies. We identified that hot stimulus increases the activity of α'β' mushroom body neurons (MBns), with weak activity in the sated state and strong activity in the hungry state. Furthermore, we showed that α'β' MBn receives the same level of hot input from the mALT projection neurons via cholinergic transmission in sated and hungry states. Differences in α'β' MBn activity between food-sated and hungry flies following heat stimuli are regulated by distinct Drosophila insulin-like peptides (Dilps). Dilp2 is secreted by insulin-producing cells (IPCs) and regulates HAB during satiety, whereas Dilp6 is secreted by the fat body and regulates HAB during the hungry state. We observed that Dilp2 induces PI3K/AKT signaling, whereas Dilp6 induces Ras/ERK signaling in α'β' MBn to regulate HAB in different feeding conditions. Finally, we showed that the 2 α'β'-related MB output neurons (MBONs), MBON-α'3 and MBON-β'1, are necessary for the output of integrated hot avoidance information from α'β' MBn. Our results demonstrate the presence of dual insulin modulation pathways in α'β' MBn, which are important for suitable behavioral responses in Drosophila during thermoregulation under different feeding states.
    Schlagwörter Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 590
    Sprache Englisch
    Erscheinungsdatum 2023-10-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Probiotic

    Ho, Shuk-Man / Tsai, Wan-Hua / Lai, Chih-Ho / Chiang, Meng-Hsuan / Lee, Wang-Po / Wu, Hui-Yu / Bai, Pei-Yi / Wu, Tony / Wu, Chia-Lin

    Gut microbes

    2024  Band 16, Heft 1, Seite(n) 2316533

    Abstract: Probiotics are live microorganisms that offer potential benefits to their hosts and can occasionally influence behavioral responses. However, the detailed mechanisms by which probiotics affect the behavior of their hosts and the underlying biogenic ... ...

    Abstract Probiotics are live microorganisms that offer potential benefits to their hosts and can occasionally influence behavioral responses. However, the detailed mechanisms by which probiotics affect the behavior of their hosts and the underlying biogenic effects remain unclear. Lactic acid bacteria, specifically
    Mesh-Begriff(e) Animals ; Drosophila ; Lactobacillus ; Drosophila melanogaster ; Mushroom Bodies ; Gastrointestinal Microbiome ; Brain ; Lactate Dehydrogenases
    Chemische Substanzen Lactate Dehydrogenases (EC 1.1.-)
    Sprache Englisch
    Erscheinungsdatum 2024-02-19
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2575755-6
    ISSN 1949-0984 ; 1949-0984
    ISSN (online) 1949-0984
    ISSN 1949-0984
    DOI 10.1080/19490976.2024.2316533
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: The risk factors and clinical outcomes in hepatitis B seropositive and seronegative renal transplant patients.

    Tsai, Yu-Lien / Chung, Meng-Hsuan / Lin, Niang-Cheng / Chen, Cheng-Yen / Lin, Yao-Ping / Tsai, Ming-Tsun / Tsai, Hsin-Lin / Chen, Yee-An / Ou, Shuo-Ming / Chu, Chi-Jen / Wu, Tsai-Hung / Tsai, Chang-Youh

    American journal of nephrology

    2024  

    Abstract: Introduction: Hepatitis B virus (HBV) infection is prevalent in Asia including Taiwan. We retrospectively evaluated the risk of HBV reactivation and clinical outcomes in HBV+ and HBV- kidney transplant recipients.: Methods: Patients who underwent ... ...

    Abstract Introduction: Hepatitis B virus (HBV) infection is prevalent in Asia including Taiwan. We retrospectively evaluated the risk of HBV reactivation and clinical outcomes in HBV+ and HBV- kidney transplant recipients.
    Methods: Patients who underwent kidney transplantation between January 2004 and December 2021 were reviewed. The outcomes of interest included risks of HBV reactivation and patient/graft survival.
    Results: We identified 337 patients (47.5 ± 12 years) were enrolled in our final cohort. Fifty-two (15.4%) had HBsAg positive at the time of transplantation. Seventeen developed viral reactivations, with 41.2% of them accompanied by active hepatitis. The graft survival, acute rejection rate, and cancer development after kidney transplantation did not differ in terms of HBsAg status. The Cox multivariate analysis indicated the HBV reactivation risk was increased by a lack of pre-transplant anti-HBV medication [hazard ratio (HR), 5.95; 95% confidence interval (CI), 1.31-27.02; P = 0.021 or an absence of lifelong antiviral therapy [HR, 3.14; 95% CI, 1.01-9.74; P = 0.047] Conclusion: Individuals, independent of HBsAg status, had similar prognosis in terms of patient and graft survival, acute rejection rate, and cancer development. The absence of either pre-transplant anti-HBV medication or lifelong antiviral therapy was significantly associated with an increased risk of HBV reactivation.
    Sprache Englisch
    Erscheinungsdatum 2024-03-18
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 604540-6
    ISSN 1421-9670 ; 0250-8095
    ISSN (online) 1421-9670
    ISSN 0250-8095
    DOI 10.1159/000538231
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: NMR assignments of the macro domain from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

    Lin, Meng-Hsuan / Huang, Yi-Ping / Chang, Chi-Fon / Hsu, Chun-Hua

    Biomolecular NMR assignments

    2021  Band 15, Heft 1, Seite(n) 137–142

    Abstract: SARS-CoV-2 is a novel pathogen causing pneumonia named COVID-19 and leading to a severe pandemic since the end of 2019. The genome of SARS-CoV-2 contains a macro domain that may play an important role in regulating ADP-ribosylation in host cells and ... ...

    Abstract SARS-CoV-2 is a novel pathogen causing pneumonia named COVID-19 and leading to a severe pandemic since the end of 2019. The genome of SARS-CoV-2 contains a macro domain that may play an important role in regulating ADP-ribosylation in host cells and initiating viral replication. Here, we report the
    Mesh-Begriff(e) Carbon Isotopes ; Genome, Viral ; Hydrogen ; Hydrogen-Ion Concentration ; Magnetic Resonance Spectroscopy ; Nitrogen Isotopes ; Protein Binding ; Protein Domains ; Protein Structure, Secondary ; SARS-CoV-2/chemistry ; Temperature ; Viral Nonstructural Proteins/chemistry ; Viral Proteins/chemistry
    Chemische Substanzen Carbon Isotopes ; Nitrogen Isotopes ; Nitrogen-15 ; Viral Nonstructural Proteins ; Viral Proteins ; Hydrogen (7YNJ3PO35Z) ; Carbon-13 (FDJ0A8596D)
    Sprache Englisch
    Erscheinungsdatum 2021-01-24
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2388861-1
    ISSN 1874-270X ; 1874-2718
    ISSN (online) 1874-270X
    ISSN 1874-2718
    DOI 10.1007/s12104-020-09996-x
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Independent insulin signaling modulators govern hot avoidance under different feeding states.

    Chiang, Meng-Hsuan / Lin, Yu-Chun / Chen, Sheng-Fu / Lee, Peng-Shiuan / Fu, Tsai-Feng / Wu, Tony / Wu, Chia-Lin

    PLoS biology

    2023  Band 21, Heft 10, Seite(n) e3002332

    Abstract: Thermosensation is critical for the survival of animals. However, mechanisms through which nutritional status modulates thermosensation remain unclear. Herein, we showed that hungry Drosophila exhibit a strong hot avoidance behavior (HAB) compared to ... ...

    Abstract Thermosensation is critical for the survival of animals. However, mechanisms through which nutritional status modulates thermosensation remain unclear. Herein, we showed that hungry Drosophila exhibit a strong hot avoidance behavior (HAB) compared to food-sated flies. We identified that hot stimulus increases the activity of α'β' mushroom body neurons (MBns), with weak activity in the sated state and strong activity in the hungry state. Furthermore, we showed that α'β' MBn receives the same level of hot input from the mALT projection neurons via cholinergic transmission in sated and hungry states. Differences in α'β' MBn activity between food-sated and hungry flies following heat stimuli are regulated by distinct Drosophila insulin-like peptides (Dilps). Dilp2 is secreted by insulin-producing cells (IPCs) and regulates HAB during satiety, whereas Dilp6 is secreted by the fat body and regulates HAB during the hungry state. We observed that Dilp2 induces PI3K/AKT signaling, whereas Dilp6 induces Ras/ERK signaling in α'β' MBn to regulate HAB in different feeding conditions. Finally, we showed that the 2 α'β'-related MB output neurons (MBONs), MBON-α'3 and MBON-β'1, are necessary for the output of integrated hot avoidance information from α'β' MBn. Our results demonstrate the presence of dual insulin modulation pathways in α'β' MBn, which are important for suitable behavioral responses in Drosophila during thermoregulation under different feeding states.
    Mesh-Begriff(e) Animals ; Drosophila/metabolism ; Drosophila melanogaster/metabolism ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Insulin/metabolism ; Mushroom Bodies/physiology ; Phosphatidylinositol 3-Kinases/metabolism ; Signal Transduction
    Chemische Substanzen Drosophila Proteins ; Insulin ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; ILP2 protein, Drosophila ; Ilp6 protein, Drosophila
    Sprache Englisch
    Erscheinungsdatum 2023-10-17
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2126776-5
    ISSN 1545-7885 ; 1544-9173
    ISSN (online) 1545-7885
    ISSN 1544-9173
    DOI 10.1371/journal.pbio.3002332
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Retina-TransNet: A Gradient-Guided Few-Shot Retinal Vessel Segmentation Net.

    Shao, Hao-Chiang / Chen, Chih-Ying / Chang, Meng-Hsuan / Yu, Chih-Han / Lin, Chia-Wen / Yang, Ju-Wen

    IEEE journal of biomedical and health informatics

    2023  Band 27, Heft 10, Seite(n) 4902–4913

    Abstract: Due to the high labor cost of physicians, it is difficult to collect a rich amount of manually-labeled medical images for developing learning-based computer-aided diagnosis (CADx) systems or segmentation algorithms. To tackle this issue, we reshape the ... ...

    Abstract Due to the high labor cost of physicians, it is difficult to collect a rich amount of manually-labeled medical images for developing learning-based computer-aided diagnosis (CADx) systems or segmentation algorithms. To tackle this issue, we reshape the image segmentation task as an image-to-image (I2I) translation problem and propose a retinal vascular segmentation network, which can achieve good cross-domain generalizability even with a small amount of training data. We devise primarily two components to facilitate this I2I-based segmentation method. The first is the constraints provided by the proposed gradient-vector-flow (GVF) loss, and, the second is a two-stage Unet (2Unet) generator with a skip connection. This configuration makes 2Unet's first-stage play a role similar to conventional Unet, but forces 2Unet's second stage to learn to be a refinement module. Extensive experiments show that by re-casting retinal vessel segmentation as an image-to-image translation problem, our I2I translator-based segmentation subnetwork achieves better cross-domain generalizability than existing segmentation methods. Our model, trained on one dataset, e.g., DRIVE, can produce segmentation results stably on datasets of other domains, e.g., CHASE-DB1, STARE, HRF, and DIARETDB1, even in low-shot circumstances.
    Mesh-Begriff(e) Humans ; Algorithms ; Retina/diagnostic imaging ; Retinal Vessels/diagnostic imaging ; Fundus Oculi ; Diagnosis, Computer-Assisted ; Image Processing, Computer-Assisted/methods
    Sprache Englisch
    Erscheinungsdatum 2023-10-05
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2695320-1
    ISSN 2168-2208 ; 2168-2194
    ISSN (online) 2168-2208
    ISSN 2168-2194
    DOI 10.1109/JBHI.2023.3298710
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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