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  1. Artikel ; Online: Why do we need better omics in the breast cancer care?

    Gertych, Arkadiusz / Shiao, Stephen L

    EBioMedicine

    2021  Band 72, Seite(n) 103598

    Sprache Englisch
    Erscheinungsdatum 2021-09-23
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2021.103598
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  2. Artikel ; Online: Why do we need better omics in the breast cancer care?

    Arkadiusz Gertych / Stephen L. Shiao

    EBioMedicine, Vol 72, Iss , Pp 103598- (2021)

    2021  

    Schlagwörter Medicine ; R ; Medicine (General) ; R5-920
    Sprache Englisch
    Erscheinungsdatum 2021-10-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
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  3. Artikel ; Online: Activated T cell therapy targeting glioblastoma cancer stem cells.

    Miyaguchi, Ken / Wang, Hongqiang / Black, Keith L / Shiao, Stephen L / Wang, Rongfu / Yu, John S

    Scientific reports

    2023  Band 13, Heft 1, Seite(n) 196

    Abstract: Naïve T cells become effector T cells following stimulation by antigen-loaded dendritic cells (DCs) and sequential cytokine activation. We aimed to develop procedures to efficiently activate T cells with tumor-associated antigens (TAAs) to glioblastoma ( ... ...

    Abstract Naïve T cells become effector T cells following stimulation by antigen-loaded dendritic cells (DCs) and sequential cytokine activation. We aimed to develop procedures to efficiently activate T cells with tumor-associated antigens (TAAs) to glioblastoma (GBM) stem cells. To remove antigen presentation outside of the immunosuppressive tumor milieu, three different glioma stem cell (GSC) specific antigen sources to load DCs were compared in their ability to stimulate lymphocytes. An activated T cell (ATC) protocol including cytokine activation and expansion in culture to target GSCs was generated and optimized for a planned phase I clinical trial. We compared three different antigen-loading methods on DCs to effectively activate T cells, which were GBM patient-derived GSC-lysate, acid-eluate of GSCs and synthetic peptides derived from proteins expressed in GSCs. DCs derived from HLA-A2 positive blood sample were loaded with TAAs. Autologous T cells were activated by co-culturing with loaded DCs. Efficiency and cytotoxicity of ATCs were evaluated by targeting TAA-pulsed DCs or T2 cells, GSCs, or autologous PHA-blasts. Characteristics of ATCs were evaluated by Flow Cytometry and ELISpot assay, which showed increased number of ATCs secreting IFN-γ targeting GSCs as compared with non-activated T cells and unloaded target cells. Neither GSC-lysate nor acid-eluate loading showed enhancement in response of ATCs but the synthetic peptide pool showed significantly increased IFN-γ secretion and increased cytotoxicity towards target cells. These results demonstrate that ATCs activated using a TAA synthetic peptide pool efficiently enhance cytotoxicity specifically to target cells including GSC.
    Mesh-Begriff(e) Humans ; T-Lymphocytes, Cytotoxic ; Glioblastoma/therapy ; Glioblastoma/metabolism ; Interferon-gamma/metabolism ; Antigens, Neoplasm ; Peptides/metabolism ; Neoplastic Stem Cells/metabolism ; Cell- and Tissue-Based Therapy ; Dendritic Cells
    Chemische Substanzen Interferon-gamma (82115-62-6) ; Antigens, Neoplasm ; Peptides
    Sprache Englisch
    Erscheinungsdatum 2023-01-05
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-27184-w
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  4. Artikel ; Online: Chronic antigen in solid tumors drives a distinct program of T cell residence.

    Gavil, Noah V / Scott, Milcah C / Weyu, Eyob / Smith, Olivia C / O'Flanagan, Stephen D / Wijeyesinghe, Sathi / Lotfi-Emran, Sahar / Shiao, Stephen L / Vezys, Vaiva / Masopust, David

    Science immunology

    2023  Band 8, Heft 84, Seite(n) eadd5976

    Abstract: Analyses of healthy tissue reveal signatures that identify resident memory ... ...

    Abstract Analyses of healthy tissue reveal signatures that identify resident memory CD8
    Mesh-Begriff(e) Mice ; Animals ; CD8-Positive T-Lymphocytes ; Immunologic Memory ; Neoplasms ; Antigens ; Prognosis ; Tumor Microenvironment
    Chemische Substanzen Antigens
    Sprache Englisch
    Erscheinungsdatum 2023-06-02
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ISSN 2470-9468
    ISSN (online) 2470-9468
    DOI 10.1126/sciimmunol.add5976
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  5. Artikel ; Online: Advances in Combining Radiation and Immunotherapy in Breast Cancer.

    Nguyen, Anthony T / Shiao, Stephen L / McArthur, Heather L

    Clinical breast cancer

    2021  Band 21, Heft 2, Seite(n) 143–152

    Abstract: Breast irradiation has long been utilized in the adjuvant or metastatic setting to eliminate microscopic disease or to palliate existing disease, respectively. However, preclinical data have demonstrated that radiation can also alter the tumor ... ...

    Abstract Breast irradiation has long been utilized in the adjuvant or metastatic setting to eliminate microscopic disease or to palliate existing disease, respectively. However, preclinical data have demonstrated that radiation can also alter the tumor microenvironment and induce antitumor immune responses. As a result, multiple clinical studies have been undertaken and have reported synergy between radiation and immune checkpoint blockade across various cancer types. Given recent clinical successes with immune checkpoint blockade in both early-stage and metastatic breast cancer, there has been substantial interest in combining radiation and immunotherapy to enhance local and systemic immune responses. Herein, we review the preclinical rationale for combining radiotherapy and immunotherapy, the early clinical trials that have adopted this strategy in breast cancer, and the landscape of ongoing relevant clinical trials. Finally, we propose future directions based on promising preclinical studies that integrate radiation, checkpoint blockade, and novel agents for the treatment of breast cancer.
    Mesh-Begriff(e) Antibodies, Monoclonal/therapeutic use ; Antineoplastic Agents/therapeutic use ; Breast Neoplasms/immunology ; Breast Neoplasms/therapy ; Combined Modality Therapy ; Female ; Humans ; Immunotherapy/methods ; Lymphocyte Activation/immunology
    Chemische Substanzen Antibodies, Monoclonal ; Antineoplastic Agents
    Sprache Englisch
    Erscheinungsdatum 2021-03-16
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2106734-X
    ISSN 1938-0666 ; 1526-8209
    ISSN (online) 1938-0666
    ISSN 1526-8209
    DOI 10.1016/j.clbc.2021.03.007
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5800: Hefte anzeigen Standort:
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  6. Artikel ; Online: Association of x-ray velocimetry (XV) ventilation analysis compared to spirometry.

    Kirkness, Jason P / Dusting, Jonathan / Eikelis, Nina / Pirakalathanan, Piraveen / DeMarco, John / Shiao, Stephen L / Fouras, Andreas

    Frontiers in medical technology

    2023  Band 5, Seite(n) 1148310

    Abstract: Introduction: X-ray Velocimetry (XV) ventilation analysis is a 4-dimensional imaging-based method for quantifying regional ventilation, aiding in the assessment of lung function. We examined the performance characteristics of XV ventilation analysis by ... ...

    Abstract Introduction: X-ray Velocimetry (XV) ventilation analysis is a 4-dimensional imaging-based method for quantifying regional ventilation, aiding in the assessment of lung function. We examined the performance characteristics of XV ventilation analysis by examining correlation to spirometry and measurement repeatability.
    Methods: XV analysis was assessed in 27 patients receiving thoracic radiotherapy for non-lung cancer malignancies. Measurements were obtained pre-treatment and at 4 and 12-months post-treatment. XV metrics such as ventilation defect percent (VDP) and regional ventilation heterogeneity (VH) were compared to spirometry at each time point, using correlation analysis. Repeatability was assessed between multiple runs of the analysis algorithm, as well as between multiple breaths in the same patient. Change in VH and VDP in a case series over 12 months was used to determine effect size and estimate sample sizes for future studies.
    Results: VDP and VH were found to significantly correlate with FEV
    Conclusions: The performance and safety of XV analysis make it ideal for both clinical and research applications across most lung indications. Our results support continued research and provide a basis for powering future studies using XV as an endpoint to examine lung health and determine therapeutic efficacy.
    Sprache Englisch
    Erscheinungsdatum 2023-06-22
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ISSN 2673-3129
    ISSN (online) 2673-3129
    DOI 10.3389/fmedt.2023.1148310
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  7. Artikel ; Online: The role of macrophage phenotype in regulating the response to radiation therapy.

    Shi, Xiaoshan / Shiao, Stephen L

    Translational research : the journal of laboratory and clinical medicine

    2017  Band 191, Seite(n) 64–80

    Abstract: Increasing experimental and clinical evidence has revealed a critical role for myeloid cells in the development and progression of cancer. The ability of monocytes and macrophages to regulate inflammation allows them to manipulate the tumor ... ...

    Abstract Increasing experimental and clinical evidence has revealed a critical role for myeloid cells in the development and progression of cancer. The ability of monocytes and macrophages to regulate inflammation allows them to manipulate the tumor microenvironment to support the growth and development of malignant cells. Recent studies have shown that macrophages can exist in several functional states depending on the microenvironment they encounter in the tissue. These functional phenotypes influence not only the genesis and propagation of tumors, but also the efficacy of cancer therapies, particularly radiation. Early classification of the macrophage phenotypes, or "polarization states," identified 2 major states, M1 and M2, that have cytotoxic and wound repair capacity, respectively. In the context of tumors, classically activated or M1 macrophages driven by interferon-gamma support antitumor immunity while alternatively activated or M2 macrophages generated in part from interleukin-4 exposure hinder antitumor immunity by suppressing cytotoxic responses against a tumor. In this review, we discuss the role that the functional phenotype of a macrophage population plays in tumor development. We will then focus specifically on how macrophages and myeloid cells regulate the tumor response to radiation therapy.
    Mesh-Begriff(e) Animals ; Cell Polarity ; Humans ; Macrophages/drug effects ; Macrophages/radiation effects ; Molecular Targeted Therapy/methods ; Neoplasms/drug therapy ; Neoplasms/immunology ; Neoplasms/pathology ; Neoplasms/radiotherapy ; Radiotherapy
    Sprache Englisch
    Erscheinungsdatum 2017-11-20
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2246684-8
    ISSN 1878-1810 ; 1532-6543 ; 1931-5244
    ISSN (online) 1878-1810 ; 1532-6543
    ISSN 1931-5244
    DOI 10.1016/j.trsl.2017.11.002
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs 42: Hefte anzeigen Standort:
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  8. Artikel ; Online: Targeting Innate Immunity to Enhance the Efficacy of Radiation Therapy.

    Dar, Tahir B / Henson, Regina M / Shiao, Stephen L

    Frontiers in immunology

    2019  Band 9, Seite(n) 3077

    Abstract: Radiation continues to play a major role in the treatment of almost every cancer type. Traditional radiation studies focused on its ability to damage DNA, but recent evidence has demonstrated that a key mechanism driving the efficacy of ... ...

    Abstract Radiation continues to play a major role in the treatment of almost every cancer type. Traditional radiation studies focused on its ability to damage DNA, but recent evidence has demonstrated that a key mechanism driving the efficacy of radiation
    Mesh-Begriff(e) Adaptive Immunity/drug effects ; Adaptive Immunity/radiation effects ; Antineoplastic Agents, Immunological/pharmacology ; Antineoplastic Agents, Immunological/therapeutic use ; Chemoradiotherapy/methods ; Clinical Trials as Topic ; Dendritic Cells/drug effects ; Dendritic Cells/immunology ; Dendritic Cells/radiation effects ; Humans ; Immunity, Innate/drug effects ; Immunity, Innate/radiation effects ; Killer Cells, Natural/drug effects ; Killer Cells, Natural/immunology ; Killer Cells, Natural/radiation effects ; Macrophages/drug effects ; Macrophages/immunology ; Macrophages/radiation effects ; Molecular Targeted Therapy/methods ; Neoplasms/immunology ; Neoplasms/therapy ; Treatment Outcome ; Tumor Microenvironment/drug effects ; Tumor Microenvironment/immunology ; Tumor Microenvironment/radiation effects
    Chemische Substanzen Antineoplastic Agents, Immunological
    Sprache Englisch
    Erscheinungsdatum 2019-01-14
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2018.03077
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  9. Artikel: Impact of the immune system and immunotherapy in colorectal cancer.

    Markman, Janet L / Shiao, Stephen L

    Journal of gastrointestinal oncology

    2015  Band 6, Heft 2, Seite(n) 208–223

    Abstract: The development of cancer is a multi-step process involving the gradual loss of regulation over the growth and functional capabilities of normal cells. Much research has been focused on the numerous cell intrinsic factors that govern this process; ... ...

    Abstract The development of cancer is a multi-step process involving the gradual loss of regulation over the growth and functional capabilities of normal cells. Much research has been focused on the numerous cell intrinsic factors that govern this process; however, recent attention has turned to understanding the cell extrinsic factors in the tumor microenvironment that appear equally critical to the progression and treatment of cancer. One critical component of the tumor microenvironment is the immune system and it has become increasingly evident that the immune system plays an integral role in preventing and promoting the development of cancer. Understanding the immune cell types and pathways involved in this process has enabled the development of novel biomarkers for prognosis and accelerated the development of immune-based therapeutics, both of which have the potential to forever change the treatment paradigms for colorectal cancer (CRC). In this review, we discuss the impact of the immune system on the initiation, progression and treatment of cancer, specifically focusing on CRC.
    Sprache Englisch
    Erscheinungsdatum 2015-02-25
    Erscheinungsland China
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2594644-4
    ISSN 2219-679X ; 2078-6891
    ISSN (online) 2219-679X
    ISSN 2078-6891
    DOI 10.3978/j.issn.2078-6891.2014.077
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  10. Buch ; Online: Improvements to Pan-STARRS1 Astrometry Using Gaia

    Lubow, Stephen H. / White, Richard L. / Shiao, Bernie

    2020  

    Abstract: We use the Gaia DR2 catalog to improve the astrometric accuracy of about 1.7 billion objects in Pan-STARRS1 Data Release 2 (PS1 DR2). We also obtain proper motions for these PS1 objects. The cross match between Gaia and PS1 reveals residuals that are ... ...

    Abstract We use the Gaia DR2 catalog to improve the astrometric accuracy of about 1.7 billion objects in Pan-STARRS1 Data Release 2 (PS1 DR2). We also obtain proper motions for these PS1 objects. The cross match between Gaia and PS1 reveals residuals that are correlated on a scale of about 1 arcmin. We apply a spatially adaptive correction algorithm for all PS1 objects having more than two detections to reduce these residuals and align the object positions to Gaia. For point-like PS1 objects that cross match to Gaia, the algorithm reduces PS1/Gaia residuals by 33% in position (median value of 13.5 mas reduced to 9.0 mas) and by 24% in proper motion (median value of 6.3 mas/yr reduced to 4.8 mas/yr). The residuals for the corrected positions are smallest for objects with the most point-like morphologies and with intermediate magnitudes of about 17 mag. The residual errors in declination are systematically larger than those in right ascension; the declination errors increase with zenith angle in proportion to the air mass of the observations. Declination positional residuals at a given declination generally vary with color and are consistent with the effects of differential atmospheric refraction. In principle, these residuals could be reduced further by taking into account object color.

    Comment: 22 pages, 31 figures
    Schlagwörter Astrophysics - Astrophysics of Galaxies ; Astrophysics - Instrumentation and Methods for Astrophysics ; Astrophysics - Solar and Stellar Astrophysics
    Thema/Rubrik (Code) 572 ; 520
    Erscheinungsdatum 2020-10-19
    Erscheinungsland us
    Dokumenttyp Buch ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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