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  1. Artikel ; Online: The Role of Radiotherapy in the Contemporary Management of Patients With Sarcoma: Opportunities to Improve Patient Outcomes.

    Kirsch, David G

    Seminars in radiation oncology

    2024  Band 34, Heft 2, Seite(n) 145–146

    Mesh-Begriff(e) Humans ; Sarcoma/radiotherapy ; Soft Tissue Neoplasms/radiotherapy ; Radiotherapy, Adjuvant
    Sprache Englisch
    Erscheinungsdatum 2024-03-20
    Erscheinungsland United States
    Dokumenttyp Editorial
    ZDB-ID 1146999-7
    ISSN 1532-9461 ; 1053-4296
    ISSN (online) 1532-9461
    ISSN 1053-4296
    DOI 10.1016/j.semradonc.2024.02.004
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Treating the Unknown: First Refine the Diagnosis.

    Kirsch, David G

    International journal of radiation oncology, biology, physics

    2021  Band 112, Heft 1, Seite(n) 37–38

    Sprache Englisch
    Erscheinungsdatum 2021-12-14
    Erscheinungsland United States
    Dokumenttyp Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2021.05.128
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Radiation Therapy as a Treatment for COVID-19?

    Kirsch, David G

    International journal of radiation oncology, biology, physics

    2020  Band 108, Heft 5, Seite(n) 1140–1142

    Mesh-Begriff(e) COVID-19 ; Humans ; Lung ; Pandemics ; SARS-CoV-2
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-07-23
    Erscheinungsland United States
    Dokumenttyp Editorial ; Comment
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2020.07.025
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Relationship between the tumor microenvironment and the efficacy of the combination of radiotherapy and immunotherapy.

    Su, Chang / Himes, Jonathon E / Kirsch, David G

    International review of cell and molecular biology

    2023  Band 378, Seite(n) 201–232

    Abstract: Activating and recruiting the immune system is critical for successful cancer treatment. Since the discovery of immune checkpoint inhibitors, immunotherapy has become the standard of care for many types of cancers. However, many patients fail to respond ... ...

    Abstract Activating and recruiting the immune system is critical for successful cancer treatment. Since the discovery of immune checkpoint inhibitors, immunotherapy has become the standard of care for many types of cancers. However, many patients fail to respond to immunotherapy. Further research is needed to understand the mechanisms of resistance and adjuvant therapies that can help sensitize patients to immunotherapies. Here, we will discuss how radiotherapy can change the tumor microenvironment and work synergistically with immunotherapy. We will examine different pre-clinical models focusing on their limitations and their unique advantages in studying the efficacy of treatments and the tumor microenvironment. We will also describe emerging findings from clinical trials testing the combination of immunotherapy and radiotherapy.
    Mesh-Begriff(e) Humans ; Tumor Microenvironment ; Immunotherapy
    Sprache Englisch
    Erscheinungsdatum 2023-04-17
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 2427220-6
    ISSN 1937-6448 ; 0074-7696
    ISSN 1937-6448 ; 0074-7696
    DOI 10.1016/bs.ircmb.2023.03.006
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Current Opportunities and Future Vision of Precision Medicine in Radiation Oncology.

    Kirsch, David G

    International journal of radiation oncology, biology, physics

    2018  Band 101, Heft 2, Seite(n) 267–270

    Mesh-Begriff(e) Forecasting ; Humans ; Mutation ; Neoplasms/genetics ; Neoplasms/radiotherapy ; Precision Medicine/methods ; Precision Medicine/trends ; Radiation Oncology/methods ; Radiation Oncology/trends ; Radiotherapy Dosage
    Sprache Englisch
    Erscheinungsdatum 2018-04-26
    Erscheinungsland United States
    Dokumenttyp Editorial ; Research Support, N.I.H., Extramural
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2017.04.005
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Radiation Therapy as a Treatment for COVID-19?

    Kirsch, David G.

    International Journal of Radiation Oncology*Biology*Physics ; ISSN 0360-3016

    2020  

    Schlagwörter Cancer Research ; Oncology ; Radiation ; Radiology Nuclear Medicine and imaging ; covid19
    Sprache Englisch
    Verlag Elsevier BV
    Erscheinungsland us
    Dokumenttyp Artikel ; Online
    DOI 10.1016/j.ijrobp.2020.07.025
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Radiotherapy Combined with Intralesional Immunostimulatory Agents for Soft Tissue Sarcomas.

    Su, Chang / Kim, Soo Kyoung / Wang, Charles X / Kirsch, David G / Monjazeb, Arta M

    Seminars in radiation oncology

    2024  Band 34, Heft 2, Seite(n) 243–257

    Abstract: Immunotherapy has shifted the treatment paradigm for many types of cancer. Unfortunately, the most commonly used immunotherapies, such as immune checkpoint inhibitors (ICI), have yielded limited benefit for most types of soft tissue sarcoma (STS). ... ...

    Abstract Immunotherapy has shifted the treatment paradigm for many types of cancer. Unfortunately, the most commonly used immunotherapies, such as immune checkpoint inhibitors (ICI), have yielded limited benefit for most types of soft tissue sarcoma (STS). Radiotherapy (RT) is a mainstay of sarcoma therapy and can induce immune modulatory effects. Combining immunotherapy and RT in STS may be a promising strategy to improve sarcoma response to RT and increase the efficacy of immunotherapy. Most combination strategies have employed immunotherapies, such as ICI, that derepress immune suppressive networks. These have yielded only modest results, possibly due to the limited immune stimulatory effects of RT. Combining RT with immune stimulatory agents has yielded promising preclinical and clinical results but can be limited by the toxic nature of systemic administration of immune stimulants. Using intralesional immune stimulants may generate stronger RT immune modulation and less systemic toxicity, which may be a feasible strategy in accessible tumors such as STS. In this review, we summarize the immune modulatory effects of RT, the mechanism of action of various immune stimulants, including toll-like receptor agonists, and data for combinatorial strategies utilizing these agents.
    Mesh-Begriff(e) Humans ; Sarcoma/drug therapy ; Sarcoma/radiotherapy ; Immunotherapy/methods ; Immune Checkpoint Inhibitors/therapeutic use
    Chemische Substanzen Immune Checkpoint Inhibitors
    Sprache Englisch
    Erscheinungsdatum 2024-02-15
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1146999-7
    ISSN 1532-9461 ; 1053-4296
    ISSN (online) 1532-9461
    ISSN 1053-4296
    DOI 10.1016/j.semradonc.2024.01.001
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Dissecting the Functional Significance of DNA Polymerase Mutations in Cancer.

    Wisdom, Amy J / Kirsch, David G

    Cancer research

    2020  Band 80, Heft 24, Seite(n) 5459–5461

    Abstract: DNA polymerase mutations can cause hypermutant cancers, but the mechanisms of tumorigenesis and the impact of various DNA polymerase mutations on treatment response is poorly understood. In this issue ... ...

    Abstract DNA polymerase mutations can cause hypermutant cancers, but the mechanisms of tumorigenesis and the impact of various DNA polymerase mutations on treatment response is poorly understood. In this issue of
    Mesh-Begriff(e) Animals ; DNA Polymerase II/genetics ; Immune Checkpoint Inhibitors ; Immunotherapy ; Mice ; Mutation ; Neoplasms/genetics ; Neoplasms/therapy ; Tumor Microenvironment
    Chemische Substanzen Immune Checkpoint Inhibitors ; DNA Polymerase II (EC 2.7.7.7)
    Sprache Englisch
    Erscheinungsdatum 2020-11-18
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-20-3241
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Safely combining trabectedin with radiotherapy to treat myxoid liposarcoma.

    Chen, Mark / Kirsch, David G

    EClinicalMedicine

    2019  Band 9, Seite(n) 5–6

    Sprache Englisch
    Erscheinungsdatum 2019-03-31
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 2589-5370
    ISSN (online) 2589-5370
    DOI 10.1016/j.eclinm.2019.03.015
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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