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  1. AU=Zhu Ya AU=Zhu Ya
  2. AU="Manawadu, Dulka"
  3. AU="Masso-Welch, Patricia"
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  5. AU="Cobb, Benjamin G"
  6. AU="Blajer-Gołębiewska, Anna"
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  25. AU="Ghersi, Davina"
  26. AU="Ferrara, Gia"
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  28. AU="Ulbricht, J."
  29. AU="Kemp, E."
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  31. AU="Tam, Ka Cheung"
  32. AU="Richardson, Susan E"
  33. AU="Generoso, Erika Marie G"
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  35. AU="da Cruz, Luciana D"
  36. AU="Ratnayake, Jithendra"
  37. AU="Halesh, L H"
  38. AU=Babajanyan S G
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  43. AU="Leroux, Dominique"
  44. AU="Gallagher, Timothy J"
  45. AU=Baggish Aaron
  46. AU="Bush, Ashley I"
  47. AU="Carr, Kenneth D."
  48. AU="Spiro, Stephen"
  49. AU="Roberts, William Clifford"
  50. AU="Park, Hyungjong"
  51. AU="Das, Debasish"
  52. AU="Sanz-Magro, Adrián"
  53. AU="Fan, Shanhui"
  54. AU="Ellonen, Pekka"
  55. AU="Lambert, T"
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  1. Artikel: Theaflavoids A-C, new flavan-3-ols with potent α-glucosidase inhibitory activity from Yunnan black tea 'Jin-Ya'

    Li, Na / Chen, Min / Zhu, Hong-Tao / Zhang, Man / Wang, Dong / Yang, Chong-Ren / Zhang, Ying-Jun

    Lebensmittel-Wissenschaft + Technologie. 2022 Oct. 01, v. 168

    2022  

    Abstract: ... The extensive investigation on the chemical constituents of Yunnan black tea 'Jin-Ya', produced from the leaf ... only moderate activities. The results indicated that Yunnan black tea 'Jin-Ya' is an ideal drink ...

    Abstract Black tea, rich in various and complex polyphenols, is one of the most popular beverages in the world due to its pleasant aroma and health benefits, such as alleviate hyperglycemia and antioxidant. The extensive investigation on the chemical constituents of Yunnan black tea 'Jin-Ya', produced from the leaf buds of Camellia sinensis var. assamica, led to the isolation and identification of 16 flavonoids including three new flavan-3-ols, namely theaflavoids A-C (1–3). Most of the isolates displayed obvious inhibitory activity on α-glucosidase with IC₅₀ values ranging from 1.11 to 24.7 μM. Notably, the new theaflavoids 1–3 showed much stronger inhibitory activity (IC₅₀ = 1.34, 1.11, and 4.57 μM, respectively) than those of the positive controls (acarbose and quercetin, IC₅₀ = 228 and 9.38 μM, respectively). In addition, the isolated flavonol glycosides 5–16 were evaluated for their antioxidant activities by DPPH and ABTS ⁺ radical scavenging assays. Those with galloyl group in molecular exhibited comparable free radical scavenging activities to the positive controls (ascorbic acid and Trolox), while most of the flavonol glycosides showed only moderate activities. The results indicated that Yunnan black tea 'Jin-Ya' is an ideal drink with hypoglycemic and antioxidant property, and is worthy of regular consumption.
    Schlagwörter Camellia sinensis var. assamica ; acarbose ; antioxidant activity ; antioxidants ; ascorbic acid ; black tea ; flavanols ; free radicals ; glycosides ; hyperglycemia ; leaves ; odors ; polyphenols ; quercetin ; China
    Sprache Englisch
    Erscheinungsverlauf 2022-1001
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    ZDB-ID 241369-3
    ISSN 0460-1173 ; 0023-6438
    ISSN 0460-1173 ; 0023-6438
    DOI 10.1016/j.lwt.2022.113918
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  2. Artikel: Advances on plant miR169/NF-YA regulation modules.

    Xu, Miao-yun / Zhu, Jia-xu / Zhang, Min / Wang, Lei

    Yi chuan = Hereditas

    2016  Band 38, Heft 8, Seite(n) 700–706

    Abstract: ... and experimental analyses suggest that miR169 targets members of the transcription factor NF-YA gene ... In addition, a comprehensive understanding the regulatory functions of the miR169/NF-YA module in plant ...

    Abstract Plant microRNAs (miRNAs) are a class of small non-coding RNAs which target and regulate the expression of genes involved in several growth, development, and metabolism processes. The miR169 family is the largest and most conserved miRNA family in plants. Recent researches have shown involvement of miR169 members in the regulation of plant responding to abiotic stress and development. Computational prediction and experimental analyses suggest that miR169 targets members of the transcription factor NF-YA gene family. In this review, we summarize the origins, evolution and diversity of miR169 family members. In addition, a comprehensive understanding the regulatory functions of the miR169/NF-YA module in plant with particular emphasis on stress-induced flowering is discussed.
    Mesh-Begriff(e) Flowers/genetics ; Gene Expression Regulation, Plant/genetics ; Genes, Plant/genetics ; MicroRNAs/genetics ; RNA, Plant/genetics ; Stress, Physiological/genetics ; Transcription Factors/genetics
    Chemische Substanzen MicroRNAs ; RNA, Plant ; Transcription Factors
    Sprache Englisch
    Erscheinungsdatum 2016
    Erscheinungsland China
    Dokumenttyp Journal Article ; Review
    ISSN 0253-9772
    ISSN 0253-9772
    DOI 10.16288/j.yczz.15-526
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: New Flavoalkaloids with Potent α-Glucosidase and Acetylcholinesterase Inhibitory Activities from Yunnan Black Tea 'Jin-Ya'.

    Li, Na / Zhu, Hong-Tao / Wang, Dong / Zhang, Man / Yang, Chong-Ren / Zhang, Ying-Jun

    Journal of agricultural and food chemistry

    2020  Band 68, Heft 30, Seite(n) 7955–7963

    Abstract: As a subgroup of flavoalkaloids, ...

    Abstract As a subgroup of flavoalkaloids,
    Mesh-Begriff(e) Acetylcholinesterase/chemistry ; Alkaloids/chemistry ; Camellia sinensis/chemistry ; China ; Enzyme Inhibitors/chemistry ; Glycosides/chemistry ; Humans ; Kinetics ; Molecular Structure ; Plant Extracts/chemistry ; Plant Leaves/chemistry ; alpha-Glucosidases/chemistry
    Chemische Substanzen Alkaloids ; Enzyme Inhibitors ; Glycosides ; Plant Extracts ; Acetylcholinesterase (EC 3.1.1.7) ; alpha-Glucosidases (EC 3.2.1.20)
    Sprache Englisch
    Erscheinungsdatum 2020-07-14
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.0c02401
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Artikel ; Online: Landslide Detection in the Linzhi–Ya’an Section along the Sichuan–Tibet Railway Based on InSAR and Hot Spot Analysis Methods

    Jinmin Zhang / Wu Zhu / Yiqing Cheng / Zhenhong Li

    Remote Sensing, Vol 13, Iss 3566, p

    2021  Band 3566

    Abstract: Construction of the 998.64-km Linzhi–Ya’an section of the Sichuan–Tibet Railway has been influenced ... images were collected to detect landslide disasters along the entire Linzhi–Ya’an section. Interferogram ... Finally, 517 landslide disasters along the Linzhi–Ya’an route were detected by integrating observed ...

    Abstract Construction of the 998.64-km Linzhi–Ya’an section of the Sichuan–Tibet Railway has been influenced by landslide disasters, threatening the safety of Sichuan–Tibet railway projects. Landslide identification and deformation analysis in this area are urgently needed. In this context, it was the first time that 164 advanced land-observing satellite-2 (ALOS-2) phased array type L-band synthetic aperture radar-2 (PALSAR-2) images were collected to detect landslide disasters along the entire Linzhi–Ya’an section. Interferogram stacking and small baseline interferometry methods were used to derive the deformation rate and time-series deformation from 2014–2020. After that, the hot spot analysis method was introduced to conduct spatial clustering analysis of the annual deformation rate, and the effective deformation area was quickly extracted. Finally, 517 landslide disasters along the Linzhi–Ya’an route were detected by integrating observed deformation, Google Earth optical images, and external geological data. The main factors controlling the spatial landslide distribution were analyzed. In the vertical direction, the spatial landslide distribution was mainly concentrated in the elevation range of 3000–5000 m, the slope range of 10–40°, and the aspect of northeast and east. In the horizontal direction, landslides were concentrated near rivers, and were also closely related to earthquake-prone areas, fault zones, and high-precipitation areas. In short, rainfall, freeze–thaw weathering, seismic activity, and fault zones are the main factors inducing landslides along this route. This research provides scientific support for the construction and operation of the Linzhi–Ya’an section of the Sichuan–Tibet Railway.
    Schlagwörter landslide detection ; Sichuan–Tibet Railway ; interferometric synthetic aperture radar (InSAR) ; hot spot analysis ; Science ; Q
    Thema/Rubrik (Code) 550
    Sprache Englisch
    Erscheinungsdatum 2021-09-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel: Landslide Detection in the Linzhi–Ya’an Section along the Sichuan–Tibet Railway Based on InSAR and Hot Spot Analysis Methods

    Zhang, Jinmin / Zhu, Wu / Cheng, Yiqing / Li, Zhenhong

    Remote Sensing. 2021 Sept. 08, v. 13, no. 18

    2021  

    Abstract: Construction of the 998.64-km Linzhi–Ya’an section of the Sichuan–Tibet Railway has been influenced ... images were collected to detect landslide disasters along the entire Linzhi–Ya’an section. Interferogram ... Finally, 517 landslide disasters along the Linzhi–Ya’an route were detected by integrating observed ...

    Abstract Construction of the 998.64-km Linzhi–Ya’an section of the Sichuan–Tibet Railway has been influenced by landslide disasters, threatening the safety of Sichuan–Tibet railway projects. Landslide identification and deformation analysis in this area are urgently needed. In this context, it was the first time that 164 advanced land-observing satellite-2 (ALOS-2) phased array type L-band synthetic aperture radar-2 (PALSAR-2) images were collected to detect landslide disasters along the entire Linzhi–Ya’an section. Interferogram stacking and small baseline interferometry methods were used to derive the deformation rate and time-series deformation from 2014–2020. After that, the hot spot analysis method was introduced to conduct spatial clustering analysis of the annual deformation rate, and the effective deformation area was quickly extracted. Finally, 517 landslide disasters along the Linzhi–Ya’an route were detected by integrating observed deformation, Google Earth optical images, and external geological data. The main factors controlling the spatial landslide distribution were analyzed. In the vertical direction, the spatial landslide distribution was mainly concentrated in the elevation range of 3000–5000 m, the slope range of 10–40°, and the aspect of northeast and east. In the horizontal direction, landslides were concentrated near rivers, and were also closely related to earthquake-prone areas, fault zones, and high-precipitation areas. In short, rainfall, freeze–thaw weathering, seismic activity, and fault zones are the main factors inducing landslides along this route. This research provides scientific support for the construction and operation of the Linzhi–Ya’an section of the Sichuan–Tibet Railway.
    Schlagwörter Internet ; deformation ; freeze-thaw cycles ; geophysics ; interferometry ; landslides ; railroads ; rain ; time series analysis
    Sprache Englisch
    Erscheinungsverlauf 2021-0908
    Erscheinungsort Multidisciplinary Digital Publishing Institute
    Dokumenttyp Artikel
    ZDB-ID 2513863-7
    ISSN 2072-4292
    ISSN 2072-4292
    DOI 10.3390/rs13183566
    Datenquelle NAL Katalog (AGRICOLA)

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  6. Artikel: New Flavoalkaloids with Potent α-Glucosidase and Acetylcholinesterase Inhibitory Activities from Yunnan Black Tea ‘Jin-Ya’

    Li, Na / Zhu, Hong-Tao / Wang, Dong / Zhang, Man / Yang, Chong-Ren / Zhang, Ying-Jun

    Journal of agricultural and food chemistry. 2020 July 06, v. 68, no. 30

    2020  

    Abstract: ... ols in ‘Jin-Ya’, which is a Yunnan black tea produced only from the buds of the tea plant ...

    Abstract As a subgroup of flavoalkaloids, N-ethyl-2-pyrrolidinone substituted flavan-3-ols are reported to possess various biological activities that may play important roles in the beneficial healthcare functions of tea. The HPLC and LC-MS analyses showed the existence of N-ethyl-2-pyrrolidinone substituted flavan-3-ols in ‘Jin-Ya’, which is a Yunnan black tea produced only from the buds of the tea plant Camellia sinensis var. assamica. Further phytochemical study on this precious black tea led to the identification of 8 flavoalkaloids, 1–8, along with 11 known flavan-3-ols (9–14) and flavonol glycosides (15–19). The new compounds, (−)-6-(5″S)-N-ethyl-2-pyrrolidinone-epiafzelechin (1), (−)-8-(5″R)-N-ethyl-2-pyrrolidinone-epiafzelechin-3-O-gallate (2a), and (−)-8-(5″S)-N-ethyl-2-pyrrolidinone-epiafzelechin-3-O-gallate (2b), were identified based on extensive spectroscopic analysis. Flavoalkaloids 2–6 showed inhibitory activity on α-glucosidase with IC₅₀ values ranging from 2.09 to 8.47 μM, compared to those of quercetin and acarbose (IC₅₀ = 6.87 and 228.9 μM, respectively). Moreover, compounds 2, 3, and 6 displayed an inhibitory effect on acetyl-cholinesterase with IC₅₀ values of 14.23, 33.79, and 34.82 μM, respectively, compared to tacrine (IC₅₀ = 0.223 μM).
    Schlagwörter Camellia sinensis var. assamica ; acarbose ; acetylcholinesterase ; black tea ; flavanols ; food chemistry ; glycosides ; health services ; quercetin ; spectral analysis ; China
    Sprache Englisch
    Erscheinungsverlauf 2020-0706
    Umfang p. 7955-7963.
    Erscheinungsort American Chemical Society
    Dokumenttyp Artikel
    Anmerkung NAL-AP-2-clean
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.0c02401
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  7. Artikel: NF-Ya activates multiple hematopoietic stem cell (HSC) regulatory genes and promotes HSC self-renewal.

    Zhu, Jiang / Zhang, Yi / Joe, Gerard J / Pompetti, Richard / Emerson, Stephen G

    Proceedings of the National Academy of Sciences of the United States of America

    2005  Band 102, Heft 33, Seite(n) 11728–11733

    Abstract: ... that NF-Ya, the regulatory and DNA-binding subunit of the trimeric transcription factor NF-Y, plays ... a central, integrating role in several of these HSC pathways. NF-Ya is preferentially expressed in HSC ... enriched bone marrow subpopulations, and NF-Ya mRNA rapidly declines with HSC differentiation ...

    Abstract Hematopoietic stem cell (HSC) self-renewal and differentiation are influenced through multiple pathways, including homeobox transcription factors, signaling through beta-catenin and Notch-1, telomerase, and p27. How these multiple pathways interact and are orchestrated is currently unknown. We now report that NF-Ya, the regulatory and DNA-binding subunit of the trimeric transcription factor NF-Y, plays a central, integrating role in several of these HSC pathways. NF-Ya is preferentially expressed in HSC-enriched bone marrow subpopulations, and NF-Ya mRNA rapidly declines with HSC differentiation. Overexpression of NF-Ya in primitive hematopoietic cells activates the transcription of multiple HOX4 paralogs, as well as Notch-1, LEF-1, and telomerase RNA. HSCs overexpressing NF-Ya are biased toward primitive hematopoiesis in vitro and show strikingly increased in vivo repopulating abilities after single or sequential bone marrow transplantation. Thus, NF-Ya is a potent cellular regulator of HSC self-renewal.
    Mesh-Begriff(e) Animals ; CCAAT-Binding Factor/genetics ; CCAAT-Binding Factor/metabolism ; Cell Proliferation ; Cells, Cultured ; Female ; Gene Expression Regulation/genetics ; Hematopoietic Stem Cells/cytology ; Hematopoietic Stem Cells/metabolism ; Homeodomain Proteins/genetics ; Male ; Mice ; Phenotype ; Promoter Regions, Genetic/genetics ; Regeneration ; Transcription Factors/genetics ; Transcription Factors/metabolism
    Chemische Substanzen CCAAT-Binding Factor ; Homeodomain Proteins ; Hoxb4 protein, mouse ; NFYA protein, human ; Transcription Factors
    Sprache Englisch
    Erscheinungsdatum 2005-08-16
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.0503405102
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1148: Hefte anzeigen Standort:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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  8. Buch ; Dissertation / Habilitation: Complex effects of iPLA2β deficiency on hepatic lipid metabolism in methionine-choline-deficient diet-induced fatty liver

    Zhu, Xingya

    2018  

    Verfasserangabe vorgelegt von Xingya Zhu
    Sprache Englisch
    Umfang 82 Seiten, Illustrationen, Diagramme, 30 cm
    Erscheinungsort Heidelberg
    Erscheinungsland Deutschland
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Dissertation, Ruprecht-Karls-Universität Heidelberg, 2019
    Anmerkung Im Titel ist "2" tiefgestellt
    HBZ-ID HT020239884
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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    SignaturLeihstatusStandort
    2019 E 1144 bestellbar zur Ausleihe Magazin

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  9. Buch: Zhongguo dong Ya fei huang fa sheng yu zhi li

    Zhu, Enlin

    1999  

    Verfasserangabe Zhu Enlin zhu bian
    Schlagwörter Migratory locust ; Migratory locust/Control
    Sprache Chinesisch
    Umfang 2, 3, 7, 576 p. :, ill. (some col.), maps ;, 27 cm.
    Ausgabenhinweis Di 1 ban.
    Verlag Zhongguo nong ye chu ban she ; Xin hua shu dian Beijing fa xing suo fa xing
    Erscheinungsort Beijing Shi
    Dokumenttyp Buch
    ISBN 7109056163 ; 9787109056169
    Datenquelle NAL Katalog (AGRICOLA)

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  10. Buch: Ya ge

    Wang, Fumin / Zhu, Yixiong / Gordis, Robert / Ting, Simon

    The song of songs

    1959  

    Titelübersetzung Bible. <Song of Solomon.> <engl.>. Gordis., 1960.
    Titelvarianten Bible. <Song of Solomon.> . Revised Standard., 1960. ; Song of songs
    Verfasserangabe [Ying yi zhe Gedisi yu biao zhun xiu zheng ban xue zhe; Han yi zhe Wang Fumin; cha hua zhe Zhu Yixiong]
    Sprache Chinesisch ; Englisch
    Umfang 4, 1, 175 p., [8] leaves of plates, col. ill
    Dokumenttyp Buch
    Anmerkung Title in Hebrew, Chinese, English, Greek, and Latin
    Datenquelle Ehemaliges Sondersammelgebiet Küsten- und Hochseefischerei

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