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  1. Artikel: Tandem MutSβ binding to long extruded DNA trinucleotide repeats underpins pathogenic expansions.

    Li, Jun / Wang, Huaibin / Yang, Wei

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Expansion of trinucleotide repeats causes Huntington's disease, Fragile X syndrome and over twenty other monogenic ... ...

    Abstract Expansion of trinucleotide repeats causes Huntington's disease, Fragile X syndrome and over twenty other monogenic disorders
    Sprache Englisch
    Erscheinungsdatum 2023-12-13
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2023.12.12.571350
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Impact on urban river water quality and pollution control of water environmental management projects based on SMS-Mike21 coupled simulation.

    Wei, Huaibin / Rao, Yiding / Liu, Jing / Wang, Yao / Cao, Yongxiao

    Scientific reports

    2024  Band 14, Heft 1, Seite(n) 6492

    Abstract: To explore the impact of expanding Nanyang Sewage Purification Center (NSPC) on the main sewage discharge area of Bai River, we constructed a 2D hydrodynamic-water quality model based on surface water modeling system (SMS) and Mike21. Simulating three ... ...

    Abstract To explore the impact of expanding Nanyang Sewage Purification Center (NSPC) on the main sewage discharge area of Bai River, we constructed a 2D hydrodynamic-water quality model based on surface water modeling system (SMS) and Mike21. Simulating three sewage discharge conditions in wet, normal, and dry season, we evaluated three indicators (COD, NH
    Sprache Englisch
    Erscheinungsdatum 2024-03-18
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-57201-z
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  3. Artikel: FAK loss reduces BRAF

    Gao, Chenxi / Ge, Huaibin / Kuan, Shih-Fan / Cai, Chunhui / Lu, Xinghua / Esni, Farzad / Schoen, Robert / Wang, Jing / Chu, Edward / Hu, Jing

    Research square

    2024  

    Abstract: ... ...

    Abstract BRAF
    Sprache Englisch
    Erscheinungsdatum 2024-01-05
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.21203/rs.3.rs-2531119/v2
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  4. Artikel ; Online: Characteristics of overlying strata and mechanisms of arch beam failure in shallowly buried thick bedrock coal seams

    Changxiang Wang / Huaibin Li / Meng Zhang / Changlong Liao / Shaojie Zhang

    Energy Science & Engineering, Vol 11, Iss 10, Pp 3317-

    A case study in western China

    2023  Band 3331

    Abstract: Abstract The Yangjiacun coal mine, located in western China, exhibits distinctive characteristics, such as its shallow depth, thick bedrock, thin loose layer, and unique roof strata breaking movement. In this research, a comprehensive analysis of ... ...

    Abstract Abstract The Yangjiacun coal mine, located in western China, exhibits distinctive characteristics, such as its shallow depth, thick bedrock, thin loose layer, and unique roof strata breaking movement. In this research, a comprehensive analysis of previous exploration data, subsequent mechanical testing, key stratum theory, natural equilibrium arch theory, and simulation tests and numerical simulations has been conducted to investigate the failure behavior of the overlying rock strata in the Yangjiacun Coal Mine. Specifically, the load‐bearing capacity of the key stratum structure in the bedrock and the morphological properties of the arch‐beam structure have been thoroughly examined. A mechanical model of the roof rock arch‐beam structure has been established, and an analytical formula for the limit size and stability criterion of the arch‐beam structure has been derived. The mining‐induced rock arch‐beam structure plays a crucial role in transferring the load of the upper strata to the surrounding goaf, thereby preventing subsidence and deformation of the overlying strata. However, the arch‐beam structure periodically experiences instability during the advancement of the working face, gradually progressing towards the upper layer until the main key stratum is breached and the arch‐beam structure collapses. Based on the characteristics of weathered rock and the arch‐beam failure model in the Yangjiacun Coal Mine, quantitative backfilling mining methods have been proposed to either compensate for the mining void created by coal extraction or limit the size of exposed key strata through strip mining, ensuring the stability of the R6 key stratum. This study represents a significant contribution to understanding the intricate failure behavior of overlying rock strata in coal mines and provides a valuable framework for the responsible and efficient extraction of coal resources in similar environments.
    Schlagwörter arch beam structure ; key layer structure ; shallow buried depth ; stability analysis ; Technology ; T ; Science ; Q
    Thema/Rubrik (Code) 950
    Sprache Englisch
    Erscheinungsdatum 2023-10-01T00:00:00Z
    Verlag Wiley
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: The Crucial Roles of Pitx3 in Midbrain Dopaminergic Neuron Development and Parkinson's Disease-Associated Neurodegeneration.

    Wang, Xin / Chen, Xi / Liu, Guangdong / Cai, Huaibin / Le, Weidong

    International journal of molecular sciences

    2023  Band 24, Heft 10

    Abstract: The degeneration of midbrain dopaminergic (mDA) neurons, particularly in the substantia nigra pars compacta (SNc), is one of the most prominent pathological hallmarks of Parkinson's disease (PD). To uncover the pathogenic mechanisms of mDA neuronal death ...

    Abstract The degeneration of midbrain dopaminergic (mDA) neurons, particularly in the substantia nigra pars compacta (SNc), is one of the most prominent pathological hallmarks of Parkinson's disease (PD). To uncover the pathogenic mechanisms of mDA neuronal death during PD may provide therapeutic targets to prevent mDA neuronal loss and slow down the disease's progression. Paired-like homeodomain transcription factor 3 (Pitx3) is selectively expressed in the mDA neurons as early as embryonic day 11.5 and plays a critical role in mDA neuron terminal differentiation and subset specification. Moreover, Pitx3-deficient mice exhibit some canonical PD-related features, including the profound loss of SNc mDA neurons, a dramatic decrease in striatal dopamine (DA) levels, and motor abnormalities. However, the precise role of Pitx3 in progressive PD and how this gene contributes to mDA neuronal specification during early stages remains unclear. In this review, we updated the latest findings on Pitx3 by summarizing the crosstalk between Pitx3 and its associated transcription factors in mDA neuron development. We further explored the potential benefits of Pitx3 as a therapeutic target for PD in the future. To better understand the transcriptional network of Pitx3 in mDA neuron development may provide insights into Pitx3-related clinical drug-targeting research and therapeutic approaches.
    Mesh-Begriff(e) Animals ; Mice ; Dopamine ; Dopaminergic Neurons/metabolism ; Homeodomain Proteins/genetics ; Homeodomain Proteins/metabolism ; Mesencephalon/metabolism ; Parkinson Disease/genetics ; Parkinson Disease/pathology ; Transcription Factors/genetics ; Transcription Factors/metabolism
    Chemische Substanzen Dopamine (VTD58H1Z2X) ; Homeodomain Proteins ; Transcription Factors ; homeobox protein PITX3
    Sprache Englisch
    Erscheinungsdatum 2023-05-11
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24108614
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Effects of Valproic Acid Therapy on Rats with Spinal Cord Injury: A Systematic Review and Meta-Analysis.

    Yang, Qinglin / Zhang, Huaibin / Jin, Zhuanmei / Zhang, Baolin / Wang, Yongping

    World neurosurgery

    2023  Band 182, Seite(n) 12–28

    Abstract: Objective: To systematically evaluate the efficacy of valproic acid (VPA) in rats with spinal cord injury (SCI) to reduce the risk of clinical conversion and provide a valuable reference for future animal and clinical studies.: Methods: We searched ... ...

    Abstract Objective: To systematically evaluate the efficacy of valproic acid (VPA) in rats with spinal cord injury (SCI) to reduce the risk of clinical conversion and provide a valuable reference for future animal and clinical studies.
    Methods: We searched scientific databases, including PubMed, Ovid-Embase, Web of Science, and Scopus databases. The relevant literature was searched from the establishment date of the database to June 28, 2023. The search results were screened, data were extracted, and the quality of the literature was evaluated independently by 2 reviewers.
    Results: Among 656 nonduplicated references, 14 articles were included for meta-analysis. The summary results showed that the overall Basso, Beattie and Bresnahan scores of the VPA intervention group were significantly higher than those in the control group at 1-6 weeks after VPA intervention. Subgroup analysis showed that the injury model, administration dose, rat strain, country of study, or follow-up duration had no significant effect on the efficacy of VPA on rats with SCI. In addition, mesh analysis showed that high doses of the VPA group had a better effect on SCI rats, compared with the low dose group and the medium dose group.
    Conclusions: To date, this is the first systematic evaluation of the potential effects of VPA on motor recovery in rats with SCI. We concluded that VPA can promote motor recovery in rats with SCI, and higher doses of VPA seem to be more effective in rats with SCI. However, the limited quality and sample of included studies reduced the application of this meta-analysis. In the future, more high-quality, direct comparative studies are needed to explore this issue in depth.
    Mesh-Begriff(e) Rats ; Animals ; Valproic Acid/therapeutic use ; Spinal Cord Injuries/drug therapy ; Spinal Cord ; Recovery of Function ; Disease Models, Animal
    Chemische Substanzen Valproic Acid (614OI1Z5WI)
    Sprache Englisch
    Erscheinungsdatum 2023-11-03
    Erscheinungsland United States
    Dokumenttyp Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2023.10.135
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  7. Artikel ; Online: Correction: Elaborating the interplay between the detecting unit and emitting unit in infrared quantum dot up-conversion photodetectors.

    Xua, Qiulei / Yang, Xinxin / Liu, Jiao Jiao / Li, Fei / Chang, Ruiguang / Wang, Lei / Wang, A Qiang / Wu, Zhenghui / Shen, Huaibin / Du, Zuliang

    Nanoscale

    2024  Band 16, Heft 2, Seite(n) 941

    Abstract: Correction for 'Elaborating the interplay between the detecting unit and emitting unit in infrared quantum dot up-conversion photodetectors' by Qiulei ... ...

    Abstract Correction for 'Elaborating the interplay between the detecting unit and emitting unit in infrared quantum dot up-conversion photodetectors' by Qiulei Xu
    Sprache Englisch
    Erscheinungsdatum 2024-01-03
    Erscheinungsland England
    Dokumenttyp Published Erratum
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/d3nr90227g
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  8. Artikel ; Online: lncRNA HAGLR modulates myocardial ischemia–reperfusion injury in mice through regulating miR-133a-3p/MAPK1 axis

    Wang Zi / Luo Wenqi / Zhong Peng / Feng Yifan / Wang Huaibin

    Open Medicine, Vol 17, Iss 1, Pp 1299-

    2022  Band 1307

    Abstract: Acute myocardial infarction is one of the leading causes of morbidity worldwide, but the underlying mechanism responsible for myocardial ischemia–reperfusion (I/R) injury remains elusive. lncRNA plays roles in inflammatory response, cell apoptosis and ... ...

    Abstract Acute myocardial infarction is one of the leading causes of morbidity worldwide, but the underlying mechanism responsible for myocardial ischemia–reperfusion (I/R) injury remains elusive. lncRNA plays roles in inflammatory response, cell apoptosis and regulation of myocardial ischemia. However, whether lncRNA HAGLR could regulate myocardial I/R injury and the molecular mechanism need to be further investigated. lncRNA has been shown to bind to miRNAs and compete with endogenous RNAs. miR-133a-3p has been shown to regulate cardiomyocyte apoptosis and ischemic myocardial injury. In this work, it has shown that knockdown of HAGLR could suppress inflammatory response and cell apoptosis induced by I/R and, thus, alleviate myocardial I/R injury. HAGLR promoted myocardial I/R injury by inhibiting miR-133a-3p to promote MAPK1 expression.
    Schlagwörter myocardial ischemia–reperfusion injury ; haglr ; mir-133a-3p ; mapk1 ; Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-07-01T00:00:00Z
    Verlag De Gruyter
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Spatiotemporally Controlled Photolabeling of Genetically Unmodified Proteins in Live Cells.

    Yu, Huaibin / Wang, Shuangshuang / Fu, Yu / Wagner, Manfred / Weil, Tanja / Liu, Shaoqin / Zhao, Weining / Zhong, Fangrui / Wu, Yuzhou

    Analytical chemistry

    2024  Band 96, Heft 5, Seite(n) 1932–1940

    Abstract: Selective labeling of the protein of interest (POI) in genetically unmodified live cells is crucial for understanding protein functions and kinetics in their natural habitat. In particular, spatiotemporally controlled installation of the labels on a POI ... ...

    Abstract Selective labeling of the protein of interest (POI) in genetically unmodified live cells is crucial for understanding protein functions and kinetics in their natural habitat. In particular, spatiotemporally controlled installation of the labels on a POI under light control without affecting their original activity is in high demand but is a tremendous challenge. Here, we describe a novel ligand-directed photoclick strategy for spatiotemporally controlled labeling of endogenous proteins in live cells. It was realized with a designer labeling reagent skillfully integrating the photochemistries of 2-nitrophenylpropyloxycarbonyl and 3-hydroxymethyl-2-naphthol with an affinity ligand. Highly electrophilic
    Mesh-Begriff(e) Ligands ; Proteins/chemistry ; Naphthols/chemistry ; Fluorescein
    Chemische Substanzen 3-(hydroxymethyl)-2-naphthol ; Ligands ; Proteins ; Naphthols ; Fluorescein (TPY09G7XIR)
    Sprache Englisch
    Erscheinungsdatum 2024-01-19
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.3c04099
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  10. Artikel ; Online: Comprehensive bioinformation analysis of differentially expressed genes in recurrent pregnancy loss.

    Wang, Huaibin / Liu, Zhao / Meng, Lijun / Zhang, Xiujun

    Human fertility (Cambridge, England)

    2022  Band 26, Heft 5, Seite(n) 1015–1022

    Abstract: Recurrent pregnancy loss (RPL) occurs frequently, and its causes are complex. The aetiology of nearly 50% of RPL cases is still unknown. This study aimed to ascertain differentially expressed genes (DEGs) and pathways by comprehensive bioinformatics ... ...

    Abstract Recurrent pregnancy loss (RPL) occurs frequently, and its causes are complex. The aetiology of nearly 50% of RPL cases is still unknown. This study aimed to ascertain differentially expressed genes (DEGs) and pathways by comprehensive bioinformatics analysis. We downloaded the gene expression microarray of GSE165004 from the Gene Expression Omnibus (GEO). Gene ontology (GO) analysis and Kyoto Encyclopaedia of Gene and Genome (KEGG) pathway enrichment analyses were performed on selected genes by using the R Programming Language. A protein-protein interaction (PPI) network was constructed with the Retrieval of Interacting Genes (STRING). Our analysis revealed that 1,869 genes were differentially expressed in RPL and control groups. GO analysis revealed that the interferon type 1 and the glycoprotein-related biological processes played irreplaceable roles, meanwhile KEGG enrichment analysis also revealed that the cAMP signalling pathway and the prolactin signalling pathway played important roles. In the following study, we found that there were many DEGs in the RPL group that were closely related to endometrial decidualization, such as IL17RD, IL16, SOX4, CREBBP, and POFUT1 as well as Notch1 and RBPJ in the Notch signalling pathway family were down-regulated in the RPL group. The results provided valuable information on the pathogenesis of RPL.
    Mesh-Begriff(e) Female ; Pregnancy ; Humans ; Gene Expression Profiling/methods ; Computational Biology/methods ; SOXC Transcription Factors
    Chemische Substanzen SOX4 protein, human ; SOXC Transcription Factors
    Sprache Englisch
    Erscheinungsdatum 2022-03-21
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2086960-5
    ISSN 1742-8149 ; 1464-7273
    ISSN (online) 1742-8149
    ISSN 1464-7273
    DOI 10.1080/14647273.2022.2045636
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