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  1. Artikel ; Online: Structural identification and anti-neuroinflammatory effects of a pectin-arabinoglucuronogalactan complex, AOPB-1-1, isolated from Asparagus officinalis.

    Yang, Junqiang / Liao, Yuechan / Cao, Chao / Yu, Qian / Zhang, Dawei / Yan, Chunyan

    International journal of biological macromolecules

    2024  Band 268, Heft Pt 1, Seite(n) 131593

    Abstract: Asparagus officinalis L. is a horticultural crop that contains a variety of bioactive compounds with anti-inflammatory effects. Aqueous extracts of A. officinalis can noticeably improve the learning and memory function of model mice. Herein, a pectin- ... ...

    Abstract Asparagus officinalis L. is a horticultural crop that contains a variety of bioactive compounds with anti-inflammatory effects. Aqueous extracts of A. officinalis can noticeably improve the learning and memory function of model mice. Herein, a pectin-arabinoglucuronogalactan complex (AOPB-1-1) with a relative molecular weight of 90.8 kDa was isolated from A. officinalis. The repeating structural unit of AOPB-1-1 was identified through monosaccharide composition, methylation analysis, uronic acid reduction, partial acid hydrolysis, and nuclear magnetic resonance spectroscopy. AOPB-1-1 contains the rhamnogalacturonan-I (RG-I) domain of pectin polysaccharides (PPs) and arabinoglucuronogalactan (AGG) regions. The backbone of the AGG region is composed of →3,6)-β-D-Galp-(1→ and →4)-β-D-Glcp-(1→ residues substituted at the 4-position to the →4)-α-D-GalAp-(1→ residues of the RG-I main chain. The anti-neuroinflammatory activity of AOPB-1-1 suggests that it can significantly reduce the content of inflammatory cytokines, including nitric oxide (NO), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) and inhibit the expression of inflammatory genes including cyclooxygenase-2 (COX2), nitric oxide synthase (iNOS), TNF-α, IL-6, and interleukin-1β (IL-1β) in LPS-stimulated BV2 cells. Furthermore, its inhibitory effects on TNF-α and IL-6 levels were even better than those of minocycline. The significant anti-neuroinflammatory activity of AOPB-1-1 suggests its applicability as a therapeutic option for the treatment of Alzheimer's disease.
    Sprache Englisch
    Erscheinungsdatum 2024-04-16
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2024.131593
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  2. Artikel ; Online: Which Specific Exercise Models Are Most Effective on Global Cognition in Patients with Cognitive Impairment? A Network Meta-Analysis.

    Yang, Junchao / Dong, Yunfeng / Yan, Shuting / Yi, Longyan / Qiu, Junqiang

    International journal of environmental research and public health

    2023  Band 20, Heft 4

    Abstract: 1) Introduction: Physical exercise interventions can impart significant cognitive benefits to older adults suffering from cognitive impairment (CI). However, the efficacy of these interventions can vary widely, depending on the type, intensity, duration ...

    Abstract (1) Introduction: Physical exercise interventions can impart significant cognitive benefits to older adults suffering from cognitive impairment (CI). However, the efficacy of these interventions can vary widely, depending on the type, intensity, duration and frequency of exercise. (2) Aim: To systematically review the efficacy of exercise therapy on global cognition in patients with CI using a network meta-analysis (NMA). (3) Methods: The PubMed, Embase, Sport Discus (EBSCO) and Cochrane Library databases were electronically searched to collect randomized controlled trials (RCTs) on exercise for patients with CI from inception to 7 August 2022. Two reviewers independently screened the literature, extracted data, and assessed the risk of bias of the included studies. The NMA was performed using the consistency model. (4) Results: A total of 29 RCTs comprising 2458 CI patients were included. The effects of different types of exercise on patients with CI were ranked as follows: multicomponent exercise (SMD = 0.84, 95% CI 0.31 to 1.36,
    Mesh-Begriff(e) Humans ; Aged ; Network Meta-Analysis ; Exercise ; Cognition ; Cognitive Dysfunction ; Exercise Therapy
    Sprache Englisch
    Erscheinungsdatum 2023-02-04
    Erscheinungsland Switzerland
    Dokumenttyp Meta-Analysis ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20042790
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Platelet-rich plasma alleviates neuropathic pain in osteoarthritis by downregulating microglial activation.

    Yan, Xiao / Ye, Yinshuang / Wang, Lin / Xue, Junqiang / Shen, Nana / Li, Tieshan

    BMC musculoskeletal disorders

    2024  Band 25, Heft 1, Seite(n) 331

    Abstract: Background: The development of neuropathic pain (NP) is one of the reasons why the pain is difficult to treat, and microglial activation plays an important role in NP. Recently, platelet-rich plasma (PRP) has emerged as a novel therapeutic method for ... ...

    Abstract Background: The development of neuropathic pain (NP) is one of the reasons why the pain is difficult to treat, and microglial activation plays an important role in NP. Recently, platelet-rich plasma (PRP) has emerged as a novel therapeutic method for knee osteoarthritis (KOA). However, it's unclarified whether PRP has analgesic effects on NP induced by KOA and the underlying mechanisms unknown.
    Purpose: To observe the analgesic effects of PRP on NP induced by KOA and explore the potential mechanisms of PRP in alleviating NP.
    Methods: KOA was induced in male rats with intra-articular injections of monosodium iodoacetate (MIA) on day 0. The rats received PRP or NS (normal saline) treatment at days 15, 17, and 19 after modeling. The Von Frey and Hargreaves tests were applied to assess the pain-related behaviors at different time points. After euthanizing the rats with deep anesthesia at days 28 and 42, the corresponding tissues were taken for subsequent experiments. The expression of activating transcription factor 3 (ATF3) in dorsal root ganglia (DRG) and ionized-calcium-binding adapter molecule-1(Iba-1) in the spinal dorsal horn (SDH) was detected by immunohistochemical staining. In addition, the knee histological assessment was performed by hematoxylin-eosin (HE) staining.
    Results: The results indicated that injection of MIA induced mechanical allodynia and thermal hyperalgesia, which could be reversed by PRP treatment. PRP downregulated the expression of ATF3 within the DRG and Iba-1 within the SDH. Furthermore, an inhibitory effect on cartilage degeneration was observed in the MIA + PRP group only on day 28.
    Conclusion: These results indicate that PRP intra-articular injection therapy may be a potential therapeutic agent for relieving NP induced by KOA. This effect could be attributed to downregulation of microglial activation and reduction in nerve injury.
    Mesh-Begriff(e) Animals ; Platelet-Rich Plasma ; Male ; Neuralgia/therapy ; Neuralgia/metabolism ; Microglia/metabolism ; Rats ; Rats, Sprague-Dawley ; Osteoarthritis, Knee/therapy ; Down-Regulation ; Activating Transcription Factor 3/metabolism ; Ganglia, Spinal/metabolism ; Disease Models, Animal ; Injections, Intra-Articular ; Calcium-Binding Proteins/metabolism ; Iodoacetic Acid/toxicity ; Microfilament Proteins
    Chemische Substanzen Atf3 protein, rat ; Activating Transcription Factor 3 ; Calcium-Binding Proteins ; Aif1 protein, rat ; Iodoacetic Acid (WF5188V710) ; Microfilament Proteins
    Sprache Englisch
    Erscheinungsdatum 2024-05-09
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2041355-5
    ISSN 1471-2474 ; 1471-2474
    ISSN (online) 1471-2474
    ISSN 1471-2474
    DOI 10.1186/s12891-024-07437-7
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Global scientific trends in continuous renal replacement therapy from 2000 to 2023: A bibliometric and visual analysis.

    Tao, ZhongBin / Feng, YanDong / Wang, Jie / Zhou, YongKang / Yang, JunQiang

    Blood purification

    2024  

    Abstract: Introduction: Continuous renal replacement therapy (CRRT) is one of the most widely used blood purification and organ support methods in the ICU. However, the development process, the current status, hotspots, and future trends of CRRT remain unclear.!## ...

    Abstract Introduction: Continuous renal replacement therapy (CRRT) is one of the most widely used blood purification and organ support methods in the ICU. However, the development process, the current status, hotspots, and future trends of CRRT remain unclear.
    Method: The WoSCC database was used to analyze CRRT research evolution and theme trends. VOSviewer was used to construct co-authorship, co-occurrence, co-citation, and network visualizations. Citespace is used to detect bursts for co-occurrence items. Several important subtopics were reviewed and discussed in more detail.
    Results: Global publications increased from 56 in 2000 to 398 in 2023, a 710.71% increase. Blood Purification published the most manuscripts, followed by International Journal of Artificial Organs. The United States, the San Bortolo Hospital, and Bellomo, R were the most productive and impactful institution, country, and author respectively. Based on co-occurrence cluster analysis, five clusters emerged: (1) Clinical applications and management of CRRT; (2) Sepsis and CRRT; (3) CRRT anticoagulant management; (4) CRRT and antibiotic pharmacokinetics and pharmacodynamics; and (5) Comparison of CRRT and intermittent hemodialysis. COVID-19, initiation, ECOMO, cefepime, guidelines, cardiogenic shock, biomarker and outcome were the latest high-frequency keywords or strongest bursts, indicating the emerging frontiers of CRRT.
    Conclusions: There has been widespread publication and citation of CRRT research in the past two decades. We provide an overview of current trends, global collaboration patterns, basic knowledge, research hotspots, and emerging frontiers.
    Sprache Englisch
    Erscheinungsdatum 2024-02-04
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 605548-5
    ISSN 1421-9735 ; 0253-5068
    ISSN (online) 1421-9735
    ISSN 0253-5068
    DOI 10.1159/000536312
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  5. Artikel ; Online: Rutin Attenuates Oxidative Stress Via PHB2-Mediated Mitophagy in MPP

    Lai, Xiaoyi / Zhang, Yongjiang / Wu, Jiannan / Shen, Mengmeng / Yin, Shiyi / Yan, Junqiang

    Neurotoxicity research

    2023  Band 41, Heft 3, Seite(n) 242–255

    Abstract: Oxidative stress plays a crucial role in the occurrence and development of Parkinson's disease (PD). Rutin, a natural botanical ingredient, has been shown to have antioxidant properties. Therefore, the aim of this study was to investigate the ... ...

    Abstract Oxidative stress plays a crucial role in the occurrence and development of Parkinson's disease (PD). Rutin, a natural botanical ingredient, has been shown to have antioxidant properties. Therefore, the aim of this study was to investigate the neuroprotective effects of rutin on PD and the underlying mechanisms. MPP
    Mesh-Begriff(e) Humans ; Reactive Oxygen Species/metabolism ; Antioxidants/pharmacology ; Mitophagy ; 1-Methyl-4-phenylpyridinium/toxicity ; Rutin/pharmacology ; NF-E2-Related Factor 2/metabolism ; Neuroblastoma ; Oxidative Stress ; Cell Line, Tumor ; Parkinson Disease/drug therapy ; Microtubule-Associated Proteins/metabolism ; Apoptosis
    Chemische Substanzen Reactive Oxygen Species ; Antioxidants ; 1-Methyl-4-phenylpyridinium (R865A5OY8J) ; Rutin (5G06TVY3R7) ; NF-E2-Related Factor 2 ; Microtubule-Associated Proteins
    Sprache Englisch
    Erscheinungsdatum 2023-02-04
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2036826-4
    ISSN 1476-3524 ; 1029-8428
    ISSN (online) 1476-3524
    ISSN 1029-8428
    DOI 10.1007/s12640-023-00636-5
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  6. Artikel ; Online: Efficacy and Safety of Light Therapy as a Home Treatment for Motor and Non-Motor Symptoms of Parkinson Disease: A Meta-Analysis.

    Sun, Wenjie / Yan, Junqiang / Wu, Jiannan / Ma, Hongxia

    Medical science monitor : international medical journal of experimental and clinical research

    2022  Band 28, Seite(n) e935074

    Abstract: BACKGROUND Non-visual effects of the retina have been increasingly confirmed in developing Parkinson disease (PD). Light therapy (LT) has been proven to be an effective non-pharmacotherapy for improving the prognosis of PD, but the pathway of action is ... ...

    Abstract BACKGROUND Non-visual effects of the retina have been increasingly confirmed in developing Parkinson disease (PD). Light therapy (LT) has been proven to be an effective non-pharmacotherapy for improving the prognosis of PD, but the pathway of action is unclear, and there is a lack of a unified and standardized LT regimen. We aimed to evaluate the efficacy and safety of various LT measures in improving motor and non-motor symptoms in patients with idiopathic PD via a meta-analysis. MATERIAL AND METHODS CENTRAL, EMBASE, CINAHL, PEDro, and PubMed were searched for randomized controlled trials (RCTs) investigating the efficacy of LT for PD. Cochrane's Risk of bias tool and the GRADE approach were used to assess evidence quality. A meta-analysis and subgroup analyses evaluated the differences in efficacy produced by the different LT protocols. Trial sequential analysis (TSA) verified the analyses outcome and quantified the statistical relevance of the data.[color=#0e101a] [/color] RESULTS Patients receiving LT had significantly better scores for motor function (MD=-4.68, 95% Cl -8.25 to -1.12, P=0.01) compared with the control group exposed to dim-red light. In addition, in terms of non-motor symptoms, depression (SMD=-0.27, 95% Cl -0.52 to -0.02, P=0.04) and sleep disturbance-related scores (MD=3.45, 95% Cl 0.12 to 6.78, P=0.04) similarly showed significant optimization after receiving LT. CONCLUSIONS The results of this meta-analysis show strong evidence that LT has significant efficacy on motor and non-motor function in PD patients.
    Mesh-Begriff(e) Humans ; Parkinson Disease/diagnosis ; Parkinson Disease/therapy ; Phototherapy/methods ; Phototherapy/standards ; Prognosis ; Symptom Assessment/methods ; Treatment Outcome
    Sprache Englisch
    Erscheinungsdatum 2022-01-07
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Meta-Analysis
    ZDB-ID 1439041-3
    ISSN 1643-3750 ; 1234-1010
    ISSN (online) 1643-3750
    ISSN 1234-1010
    DOI 10.12659/MSM.935074
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  7. Artikel: Oral pyruvate prevents high-intensity interval exercise-induced metabolic acidosis in rats by promoting lactate dehydrogenase reaction.

    Che, Kaixuan / Yang, Yanping / Zhang, Jun / Feng, Lin / Xie, Yan / Li, Qinlong / Qiu, Junqiang

    Frontiers in nutrition

    2023  Band 10, Seite(n) 1096986

    Abstract: Introduction: There is no denying the clinical benefits of exogenous pyruvate in the treatment of pathological metabolic acidosis. However, whether it can prevent exercise physiological metabolic acidosis, delay the occurrence of exercise fatigue, and ... ...

    Abstract Introduction: There is no denying the clinical benefits of exogenous pyruvate in the treatment of pathological metabolic acidosis. However, whether it can prevent exercise physiological metabolic acidosis, delay the occurrence of exercise fatigue, and improve the beneficial effects of exercise and its internal mechanism remain unclear.
    Methods: We randomly divided 24 male SD rats into 3 groups: one group was a control without exercise (CC,
    Results: Pyruvate supplementation significantly reversed the decrease of pHe, BE, HCO
    Discussion: This study provides compelling evidence that oral pyruvate attenuates HIIE-induced intracellular and extracellular acidification, possibly due to increased activity of LDHA, which promotes the absorption of H
    Sprache Englisch
    Erscheinungsdatum 2023-04-06
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2023.1096986
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  8. Artikel ; Online: Effects of three weeks base training at moderate simulated altitude with or without hypoxic residence on exercise capacity and physiological adaptations in well-trained male runners.

    Yi, Longyan / Wu, Jian / Yan, Bing / Wang, Yang / Zou, Menghui / Zhang, Yimin / Li, Feifei / Qiu, Junqiang / Girard, Olivier

    PeerJ

    2024  Band 12, Seite(n) e17166

    Abstract: Objectives: To test the hypothesis that 'live high-base train high-interval train low' (HiHiLo) altitude training, compared to 'live low-train high' (LoHi), yields greater benefits on performance and physiological adaptations.: Methods: Sixteen young ...

    Abstract Objectives: To test the hypothesis that 'live high-base train high-interval train low' (HiHiLo) altitude training, compared to 'live low-train high' (LoHi), yields greater benefits on performance and physiological adaptations.
    Methods: Sixteen young male middle-distance runners (age, 17.0 ± 1.5 y; body mass, 58.8 ± 4.9 kg; body height, 176.3 ± 4.3 cm; training years, 3-5 y; training distance per week, 30-60 km.wk
    Results: Peak oxygen uptake and running performance did not differ before and after the intervention in either group (all
    Conclusions: Well-trained runners undertaking base training at moderate simulated altitude for 3 weeks, with or without hypoxic residence, showed no performance improvement, also with unchanged time-domain heart rate variability and exercise-induced arterial hypoxemia responses.
    Mesh-Begriff(e) Male ; Humans ; Adolescent ; Altitude ; Exercise Tolerance ; Oxygen Consumption/physiology ; Hypoxia ; Adaptation, Physiological ; Oxygen
    Chemische Substanzen Oxygen (S88TT14065)
    Sprache Englisch
    Erscheinungsdatum 2024-03-29
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2703241-3
    ISSN 2167-8359 ; 2167-8359
    ISSN (online) 2167-8359
    ISSN 2167-8359
    DOI 10.7717/peerj.17166
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  9. Artikel ; Online: Nur77 increases mitophagy and decreases aggregation of α-synuclein by modulating the p-c-Abl/p-PHB2 Y121 in α-synuclein PFF SH-SY5Y cells and mice.

    Yin, Shiyi / Shen, Mengmeng / Zhang, Yongjiang / Wu, Jiannan / Song, Run / Lai, Xiaoyi / Tian, Zhenzhen / Wang, Tingting / Jin, Weina / Yan, Junqiang

    European journal of medicinal chemistry

    2024  Band 268, Seite(n) 116251

    Abstract: Parkinson's disease (PD) is characterized by the progressive death of dopamine (DA) neurons and the pathological accumulation of α-synuclein (α-syn) fibrils. In our previous study, simulated PHB2 phosphorylation was utilized to clarify the regulatory ... ...

    Abstract Parkinson's disease (PD) is characterized by the progressive death of dopamine (DA) neurons and the pathological accumulation of α-synuclein (α-syn) fibrils. In our previous study, simulated PHB2 phosphorylation was utilized to clarify the regulatory role of c-Abl in PHB2-mediated mitophagy in PD models. In this investigation, we employed an independently patented PHB2Y121 phosphorylated antibody in the PD model to further verify that the c-Abl inhibitor STI571 can impede PHB2Y121 phosphorylation, decrease the formation of α-Syn polymers, and improve autophagic levels. The specific involvement of Nur77 in PD pathology has remained elusive. We also investigate the contribution of Nur77, a nuclear transcription factor, to α-syn and mitophagy in PD. Our findings demonstrate that under α-syn, Nur77 translocates from the cytoplasm to the mitochondria, improving PHB-mediated mitophagy by regulating c-Abl phosphorylation. Moreover, Nur77 overexpression alleviates the expression level of pS129-α-syn and the loss of DA neurons in α-syn PFF mice, potentially associated with the p-c-Abl/p-PHB2 Y121 axis. This study provides initial in vivo and in vitro evidence that Nur77 protects PD DA neurons by modulating the p-c-Abl/p-PHB2 Y121 axis, and STI571 holds promise as a treatment for PD.
    Mesh-Begriff(e) Mice ; Humans ; Animals ; alpha-Synuclein/metabolism ; Mitophagy ; Imatinib Mesylate ; Neuroblastoma/pathology ; Parkinson Disease/metabolism ; Dopaminergic Neurons/metabolism
    Chemische Substanzen alpha-Synuclein ; Imatinib Mesylate (8A1O1M485B)
    Sprache Englisch
    Erscheinungsdatum 2024-02-23
    Erscheinungsland France
    Dokumenttyp Journal Article
    ZDB-ID 188597-2
    ISSN 1768-3254 ; 0009-4374 ; 0223-5234
    ISSN (online) 1768-3254
    ISSN 0009-4374 ; 0223-5234
    DOI 10.1016/j.ejmech.2024.116251
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  10. Artikel ; Online: Targeting DAD1 gene with CRISPR-Cas9 system transmucosally delivered by fluorinated polylysine nanoparticles for bladder cancer intravesical gene therapy.

    Tang, Dongdong / Yan, Yang / Li, Yangyang / Li, Yuqing / Tian, Junqiang / Yang, Li / Ding, Hui / Bashir, Ghassan / Zhou, Houhong / Ding, Qiuxia / Tao, Ran / Zhang, Shaohua / Wang, Zhiping / Wu, Song

    Theranostics

    2024  Band 14, Heft 1, Seite(n) 203–219

    Abstract: Background: ...

    Abstract Background:
    Mesh-Begriff(e) Mice ; Animals ; Humans ; Urinary Bladder/pathology ; Polylysine/metabolism ; CRISPR-Cas Systems/genetics ; Urinary Bladder Neoplasms/therapy ; Urinary Bladder Neoplasms/drug therapy ; Nanoparticles ; Genetic Therapy
    Chemische Substanzen Polylysine (25104-18-1)
    Sprache Englisch
    Erscheinungsdatum 2024-01-01
    Erscheinungsland Australia
    Dokumenttyp Journal Article
    ZDB-ID 2592097-2
    ISSN 1838-7640 ; 1838-7640
    ISSN (online) 1838-7640
    ISSN 1838-7640
    DOI 10.7150/thno.88550
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