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  1. Buch ; Online: Severe Eosinophilic Disorders: Mechanisms and Clinical Management

    Ueki, Shigeharu / Akuthota, Praveen / Sabbadini Neves, Josiane

    2019  

    Schlagwörter Medicine ; Immunology ; Asthma ; Eosinophils ; Eosinophilic disorders ; Extracellular traps ; Hypereosinophilia ; IL-5 ; Degranulation ; Rhinitis
    Umfang 1 electronic resource (138 pages)
    Verlag Frontiers Media SA
    Dokumenttyp Buch ; Online
    Anmerkung English ; Open Access
    HBZ-ID HT021230812
    ISBN 9782889631797 ; 2889631796
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  2. Artikel: Asthma Exacerbations: Patient Features and Potential Long-Term Implications.

    Akuthota, Praveen

    Advances in experimental medicine and biology

    2023  Band 1426, Seite(n) 253–263

    Abstract: Asthma exacerbations occur in the context of a complex interplay between external exposures and host factors. Respiratory tract viral infections, in particular rhinovirus, are dominant initiators of exacerbations, with allergens and other inhalation ... ...

    Abstract Asthma exacerbations occur in the context of a complex interplay between external exposures and host factors. Respiratory tract viral infections, in particular rhinovirus, are dominant initiators of exacerbations, with allergens and other inhalation exposures as additional key contributors. The presence of underlying type II inflammation, with associated biomarker elevations, is a major driver of exacerbation risk and mechanism, as evidenced by the consistent reduction of exacerbations seen with biologics targeting these pathways. Several genetic polymorphisms are associated with exacerbations, and while they may individually have small effects, they are cumulatively important and magnified by environmental exposures. A history of exacerbations predicts future exacerbations with potentially negative implications on long-term lung health.
    Mesh-Begriff(e) Humans ; Asthma/genetics ; Asthma/complications ; Lung ; Virus Diseases/complications ; Allergens ; Inflammation/complications ; Rhinovirus/genetics ; Picornaviridae Infections/complications
    Chemische Substanzen Allergens
    Sprache Englisch
    Erscheinungsdatum 2023-07-18
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 410187-X
    ISSN 0065-2598
    ISSN 0065-2598
    DOI 10.1007/978-3-031-32259-4_12
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Corticosteroid-sparing effect of biologics in patients with allergic bronchopulmonary aspergillosis.

    Darragh, Keara / Akuthota, Praveen

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2024  Band 132, Heft 5, Seite(n) 650–652

    Mesh-Begriff(e) Humans ; Aspergillosis, Allergic Bronchopulmonary/drug therapy ; Male ; Female ; Adrenal Cortex Hormones/therapeutic use ; Biological Products/therapeutic use ; Middle Aged ; Adult ; Treatment Outcome
    Chemische Substanzen Adrenal Cortex Hormones ; Biological Products
    Sprache Englisch
    Erscheinungsdatum 2024-01-15
    Erscheinungsland United States
    Dokumenttyp Letter ; Journal Article
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2024.01.010
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Approach to non-type 2 asthma.

    Adrish, Muhammad / Akuthota, Praveen

    Respiratory medicine

    2023  Band 216, Seite(n) 107327

    Mesh-Begriff(e) Humans ; Asthma ; Neutrophils ; Inflammation ; Phenotype ; Sputum ; Eosinophils
    Sprache Englisch
    Erscheinungsdatum 2023-06-10
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1003348-8
    ISSN 1532-3064 ; 0954-6111
    ISSN (online) 1532-3064
    ISSN 0954-6111
    DOI 10.1016/j.rmed.2023.107327
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Bronchial Epithelial Cell CC16 mRNA: Novel Asthma Biomarker or the Same Book with a New Cover?

    Desai, Brinda / Akuthota, Praveen

    American journal of respiratory and critical care medicine

    2022  Band 207, Heft 4, Seite(n) 385–386

    Mesh-Begriff(e) Humans ; RNA, Messenger/metabolism ; Asthma/diagnosis ; Asthma/genetics ; Asthma/metabolism ; Biomarkers/metabolism ; Epithelial Cells/metabolism
    Chemische Substanzen RNA, Messenger ; Biomarkers
    Sprache Englisch
    Erscheinungsdatum 2022-09-28
    Erscheinungsland United States
    Dokumenttyp Editorial ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202209-1768ED
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Type 2 Biomarkers in Asthma: Yet Another Reflection of Heterogeneity.

    Lugogo, Njira L / Akuthota, Praveen

    The journal of allergy and clinical immunology. In practice

    2021  Band 9, Heft 3, Seite(n) 1276–1277

    Mesh-Begriff(e) Asthma/diagnosis ; Biomarkers/metabolism ; Humans ; Inflammation ; Prevalence
    Chemische Substanzen Biomarkers
    Sprache Englisch
    Erscheinungsdatum 2021-03-08
    Erscheinungsland United States
    Dokumenttyp Editorial ; Comment
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2020.12.032
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Estimated Ventricular Size: A New Predictor of Asthma Severity and Exacerbation Rate?

    Barry, Jeffrey R / Akuthota, Praveen

    Chest

    2020  Band 157, Heft 2, Seite(n) 243–244

    Mesh-Begriff(e) Asthma ; Cohort Studies ; Humans
    Sprache Englisch
    Erscheinungsdatum 2020-02-04
    Erscheinungsland United States
    Dokumenttyp Editorial ; Comment
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2019.10.019
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: How Sex and Age of Asthma Onset Influence Difficult Asthma Heterogeneity.

    Akuthota, Praveen / Busse, William W

    The journal of allergy and clinical immunology. In practice

    2020  Band 8, Heft 10, Seite(n) 3407–3408

    Mesh-Begriff(e) Asthma/epidemiology ; Humans ; Phenotype
    Sprache Englisch
    Erscheinungsdatum 2020-11-06
    Erscheinungsland United States
    Dokumenttyp Editorial ; Comment
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2020.07.041
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Eosinophils and eosinophilic immune dysfunction in health and disease.

    Jackson, David J / Akuthota, Praveen / Roufosse, Florence

    European respiratory review : an official journal of the European Respiratory Society

    2022  Band 31, Heft 163

    Abstract: The functions ascribed to eosinophils have classically been limited to host defence against certain parasitic infections and potentially deleterious effects in the setting of specific diseases that are associated with elevated eosinophil counts in blood ... ...

    Abstract The functions ascribed to eosinophils have classically been limited to host defence against certain parasitic infections and potentially deleterious effects in the setting of specific diseases that are associated with elevated eosinophil counts in blood and/or tissue. The ability to induce eosinophil depletion either experimentally in animal models or through targeted therapies in humans has extended our understanding of the roles played by eosinophils in health and homeostasis as well as in disease pathogenesis. When associated with human disease aetiology, the eosinophil takes on a pathogenic rather than a protective role. This maladaptive response, called "eosinophilic immune dysfunction" herein, appears central to exacerbation pathogenesis and disease control in severe asthma and may be involved in the aetiology of other eosinophil-related conditions ranging from organ-system-limited diseases such as phenotypic subsets of chronic obstructive pulmonary disease and chronic rhinosinusitis with nasal polyposis to more broadly systemic diseases such as eosinophilic granulomatosis with polyangiitis and hypereosinophilic syndrome. In this review, we describe the evidence supporting eosinophilic functions related to health and homeostasis and explore the contribution of eosinophilic immune dysfunction to human disease.
    Mesh-Begriff(e) Animals ; Asthma ; Churg-Strauss Syndrome ; Eosinophilia ; Eosinophils ; Granulomatosis with Polyangiitis ; Humans
    Sprache Englisch
    Erscheinungsdatum 2022-01-25
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1077620-5
    ISSN 1600-0617 ; 0905-9180
    ISSN (online) 1600-0617
    ISSN 0905-9180
    DOI 10.1183/16000617.0150-2021
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Introducing the Severe Asthma Series of Invited Reviews.

    Akuthota, Praveen / Jackson, David J / Wechsler, Michael E

    Chest

    2021  Band 160, Heft 4, Seite(n) 1151–1152

    Mesh-Begriff(e) Asthma/epidemiology ; Humans
    Sprache Englisch
    Erscheinungsdatum 2021-10-01
    Erscheinungsland United States
    Dokumenttyp Editorial ; Comment
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2021.08.056
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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