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  1. Artikel ; Online: Flavonols as potential antiviral drugs targeting SARS-CoV-2 proteases (3CL

    Mouffouk, Chaima / Mouffouk, Soumia / Mouffouk, Sara / Hambaba, Leila / Haba, Hamada

    European journal of pharmacology

    2020  Band 891, Seite(n) 173759

    Abstract: The novel coronavirus outbreak (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) represents the actual greatest global public health crisis. The lack of efficacious drugs and vaccines against this viral infection created a ...

    Abstract The novel coronavirus outbreak (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) represents the actual greatest global public health crisis. The lack of efficacious drugs and vaccines against this viral infection created a challenge for scientific researchers in order to find effective solutions. One of the promising therapeutic approaches is the search for bioactive molecules with few side effects that display antiviral properties in natural sources like medicinal plants and vegetables. Several computational and experimental studies indicated that flavonoids especially flavonols and their derivatives constitute effective viral enzyme inhibitors and possess interesting antiviral activities. In this context, the present study reviews the efficacy of many dietary flavonols as potential antiviral drugs targeting the SARS-CoV-2 enzymes and proteins including Chymotrypsin-Like Protease (3CL
    Mesh-Begriff(e) Angiotensin-Converting Enzyme 2/metabolism ; Antiviral Agents/pharmacology ; COVID-19/metabolism ; Coronavirus 3C Proteases/metabolism ; Coronavirus RNA-Dependent RNA Polymerase/metabolism ; Drug Development ; Flavonols/pharmacology ; Humans ; Phytochemicals/pharmacology ; SARS-CoV-2/drug effects ; SARS-CoV-2/physiology ; Spike Glycoprotein, Coronavirus/metabolism ; COVID-19 Drug Treatment
    Chemische Substanzen Antiviral Agents ; Flavonols ; Phytochemicals ; Spike Glycoprotein, Coronavirus ; Coronavirus RNA-Dependent RNA Polymerase (EC 2.7.7.48) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; 3C-like protease, SARS coronavirus (EC 3.4.22.-) ; 3C-like proteinase, SARS-CoV-2 (EC 3.4.22.-) ; Coronavirus 3C Proteases (EC 3.4.22.28)
    Sprache Englisch
    Erscheinungsdatum 2020-11-27
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Review
    ZDB-ID 80121-5
    ISSN 1879-0712 ; 0014-2999
    ISSN (online) 1879-0712
    ISSN 0014-2999
    DOI 10.1016/j.ejphar.2020.173759
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: In vitro photoprotective, hemostatic, anti-inflammatory and antioxidant activities of the species Linaria scariosa Desf

    Mouffouk, Chaima / Mouffouk, Soumia / Oulmi, Kafia / Mouffouk, Sara / Haba, Hamada

    SAAB South African journal of botany. 2020 May, v. 130

    2020  

    Abstract: Recently, plant-derived extracts gained considerable attention as skincare agents, because of their capacity to exert a broad spectrum of biological activities, including their power to absorb ultraviolet radiation, their antioxidant, anti-inflammatory ... ...

    Abstract Recently, plant-derived extracts gained considerable attention as skincare agents, because of their capacity to exert a broad spectrum of biological activities, including their power to absorb ultraviolet radiation, their antioxidant, anti-inflammatory and hemostatic properties. In this context, the study focused on the evaluation of in vitro pharmacological activities of the methanolic extract obtained from the species Linaria scariosa. The plant is used by the local populations of Aures region (Algeria) for wound healing and its traditional applications will be validated. The quantification of the total phenolic and flavonoid content was performed spectrophotometrically using Folin-Ciocalteu and trichloroaluminum methods. The antioxidant activity was determined by four different assays including ferric reducing antioxidant power, total antioxidant capacity, ferric thiocyanate assay and the antioxidant activity by potentiometric method. Furthemore, the in vitro anti-inflammatory activity was assessed by albumin denaturation method, the photoprotective effect was evaluated by the measurment of sun protection factor (SPF) and the hemostatic activity was carried out by the determination of plasma re-calcification time (PRT). Result of the phytochemical screening from the methanolic extract was found to contain several secondary metabolites known for their biological properties. Moderate contents of polyphenols and flavonoids were estimated. The MeOH extract possessed moderate antioxidant activity for various tested assays and had the ability to inhibit thermally-induced protein denaturation in a dose-dependent manner with a percentage of 40.98% at 500 μg/ml. Moreover, this plant extract significantly shortened the clotting time compared to the control group and had a higher capacity to absorb UV radiations with a sun protection factor estimated at 38.46 ± 0.22. The methanolic extract from L. scariosa could be used in cosmetic formulations and as a skincare agent.
    Schlagwörter Linaria ; albumins ; anti-inflammatory activity ; antioxidant activity ; antioxidants ; chemical constituents of plants ; denaturation ; dose response ; flavonoids ; methanol ; plant extracts ; polyphenols ; protein denaturation ; radiation resistance ; screening ; secondary metabolites ; thiocyanates ; tissue repair ; ultraviolet radiation ; Algeria
    Sprache Englisch
    Erscheinungsverlauf 2020-05
    Umfang p. 383-388.
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ZDB-ID 2126918-X
    ISSN 0254-6299
    ISSN 0254-6299
    DOI 10.1016/j.sajb.2020.01.003
    Datenquelle NAL Katalog (AGRICOLA)

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  3. Artikel ; Online: Accuracy of serum markers, progesterone and vitamins measurements for early screening of abortions in the eastern region of Algeria (Batna)

    Sara Mouffouk / Mouloud Yahia / Chaima Mouffouk / Hanane Boukrous / Aicha Saaidia / Fairouz Douha / Naima Achi

    Journal of Biological Research, Vol 90, Iss

    2018  Band 2

    Abstract: Spontaneous abortion is an involuntary interruption of pregnancy before 22 weeks of gestation. According to the Algerian National Institute of Public Health the percentage of women suffering from permanent complications during pregnancy is approximately ... ...

    Abstract Spontaneous abortion is an involuntary interruption of pregnancy before 22 weeks of gestation. According to the Algerian National Institute of Public Health the percentage of women suffering from permanent complications during pregnancy is approximately 15%. The aim of this study is the determination of some biochemical analytes, including folic acid, vitamin B12, alphafoetoproteine, beta human chorionic gonadotropin (β-hCG), progesterone and oestradiol (uE3), which are involved in the detection of pregnancy failures. This case-control study was carried out on women in the process of abortion and a control group with viable pregnancies in the East region of Algeria (Batna) during the year 2015. In the present investigation, 69 pregnant women during the first and second trimester were recruited during the first and second trimesters as cases (with miscarriages) and the control group (n=69) was constituted of women who had normal ultrasound. The average concentration of alpha-fetoprotein is significantly low during the first trimester, but it is very high during the second trimester between cases and controls. The median values of β- hCG, uE3 and progesterone decrease very significantly. The mean concentration of serum folate and vitamin B12 did not change significantly between cases and controls in the first and second trimesters. The results of this study revealed that, spontaneous abortions are associated with changes in serum markers and progesterone, which could form an important part in the early diagnosis of non-viable pregnancies. However, vitamins levels have no significant effects on these pregnancies.
    Schlagwörter Serum markers ; progesterone ; vitamins (B9 ; B12) ; abortion ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 630
    Sprache Englisch
    Erscheinungsdatum 2018-02-01T00:00:00Z
    Verlag PAGEPress Publications
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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