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  1. Artikel ; Online: H

    Xu, Jun / Zhong, Yali / Wang, Weixin / Gao, Rui / Wang, Yini / Tong, Fei / Sun, Jiahui / Hong, Miaofang / Qiao, Lingyan / Qiao, Weiwei / Mei, Qibing / Wu, Jianming

    Nanoscale

    2024  Band 16, Heft 3, Seite(n) 1282–1290

    Abstract: As emerging nanosystems, nanomotors have been applied in the active treatment of many diseases. In this paper, Pt@chitosan-loaded melatonin asymmetrical nanomaterials embedded with L-serine (S, kidney injury molecule 1-targeting agent) were constructed ... ...

    Abstract As emerging nanosystems, nanomotors have been applied in the active treatment of many diseases. In this paper, Pt@chitosan-loaded melatonin asymmetrical nanomaterials embedded with L-serine (S, kidney injury molecule 1-targeting agent) were constructed to alleviate acute kidney injury (AKI). The Janus nanocarriers arrived at the renal injury site
    Mesh-Begriff(e) Humans ; Hydrogen Peroxide ; Melatonin ; Nanostructures ; Permeability ; Acute Kidney Injury/drug therapy
    Chemische Substanzen Hydrogen Peroxide (BBX060AN9V) ; Melatonin (JL5DK93RCL)
    Sprache Englisch
    Erscheinungsdatum 2024-01-18
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/d3nr04808j
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: H

    Wang, Weixin / Fu, Renquan / Gao, Rui / Luo, Lei / Wang, Zhongchao / Xue, Yingli / Sun, Jiahui / Pan, Min / Hong, Miaofang / Qiao, Lingyan / Qiao, Weiwei / Mei, Qibing / Wu, Jianming / Wang, Yini / Zhong, Yali / Liu, Jin / Tong, Fei

    ACS biomaterials science & engineering

    2024  

    Abstract: ... the nanoparticles release H ...

    Abstract Disruption of the symbiosis of extra/intratumoral metabolism is a good strategy for treating tumors that shuttle resources from the tumor microenvironment. Here, we report a precision treatment strategy for enhancing pyruvic acid and intratumoral acidosis to destroy tumoral metabolic symbiosis to eliminate tumors; this approach is based on PEGylated gold and lactate oxidase-modified aminated dendritic mesoporous silica with lonidamine and ferrous sulfide loading (PEG-Au@DMSNs/FeS/LND@LOX). In the tumor microenvironment, LOX oxidizes lactic acid to produce pyruvate, which represses tumor cell proliferation by inhibiting histone gene expression and induces ferroptosis by partial histone monoubiquitination. In acidic tumor conditions, the nanoparticles release H
    Sprache Englisch
    Erscheinungsdatum 2024-05-12
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2373-9878
    ISSN (online) 2373-9878
    DOI 10.1021/acsbiomaterials.3c01665
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: H

    Cai, Wanqian / Zhang, Chongbiao / Wu, Yourong / Wang, Wei / Lin, Mei / Lin, Tengfei / Lin, Cong / Gao, Min / Zhao, Chunlin / Wu, Xiao

    RSC advances

    2023  Band 13, Heft 17, Seite(n) 11720–11727

    Abstract: As emerging contaminants, antineoplastic drugs are widely used, but their residues in water may cause long-term genotoxicity to aquatic organisms and human beings. Here, waste moxa ash was selected as biomass raw material and modified by ball milling to ... ...

    Abstract As emerging contaminants, antineoplastic drugs are widely used, but their residues in water may cause long-term genotoxicity to aquatic organisms and human beings. Here, waste moxa ash was selected as biomass raw material and modified by ball milling to obtain carbon-based materials with excellent adsorption performance, which were used to remove the antineoplastic drug mitoxantrone (MTX) from water. The experimental results indicate that moxa ash modified by ball milling in hydrogen peroxide exhibits ultrafast removal of MTX (the removal efficiency reaches 97.66% in 1 min and 99.72% in 30 min). The pseudo-second-order kinetics and Freundlich isotherm models accurately describe the MTX adsorption process, and the mechanism of adsorption probably involves pore filling, hydrogen bond, π-π interaction and electrostatic attraction. Not only that, moxa ash also has the ability to remove dyes such as malachite green (97.81%) and methylene blue (99.97%). In this study, a simple and environmentally friendly process was used to convert waste moxa ash into an effective MTX adsorbent, providing a feasible solution for controlling MTX pollution and identifying a circular and economic way to reuse the waste.
    Sprache Englisch
    Erscheinungsdatum 2023-04-14
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra00988b
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: H

    Liu, Xiang-Mei / Wang, Yu-Ling / Ren, Shu-Wei / Cao, Jun-Tao / Liu, Yan-Ming

    The Analyst

    2022  Band 147, Heft 11, Seite(n) 2508–2514

    Abstract: ... ratiometric sensor based on the bidirectional regulation of two independent co-reaction systems by H ...

    Abstract Potential-resolved electrochemiluminescence (ECL) ratiometric analysis has become a research hotspot in bioassays by virtue of its good accuracy, versatility and specificity. Current ECL ratiometry mainly focuses on the competition for the co-reactant or quantitative analysis using a variable signal and a changeless signal; the disorganized change or small difference between the two signals may affect the accuracy and sensitivity of detection. In this study, we have developed a novel ECL ratiometric sensor based on the bidirectional regulation of two independent co-reaction systems by H
    Mesh-Begriff(e) Biosensing Techniques ; Electrochemical Techniques ; Electrodes ; Humans ; Hydrogen Peroxide ; Limit of Detection ; Luminescent Measurements
    Chemische Substanzen Hydrogen Peroxide (BBX060AN9V)
    Sprache Englisch
    Erscheinungsdatum 2022-05-30
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 210747-8
    ISSN 1364-5528 ; 0003-2654
    ISSN (online) 1364-5528
    ISSN 0003-2654
    DOI 10.1039/d2an00601d
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: H

    Chen, Jianqiang / Jin, Xiangxiang / Shen, Zhe / Mei, Yanan / Zhu, Jufan / Zhang, Xiaodan / Liang, Guang / Zheng, Xiaohui

    Medical oncology (Northwood, London, England)

    2021  Band 38, Heft 6, Seite(n) 59

    Abstract: ... we investigated the anticancer activity of TMPyP4 in A549 and PANC cells cultured in H ...

    Abstract Cancer is one of the diseases that threatens human health and is a leading cause of mortality worldwide. High levels of reactive oxygen species (ROS) have been observed in cancer tissues compared with normal tissues in vivo, and it is not yet known how this influences chemotherapeutic drug action. Cationic porphyrin 5,10,15,20-tetra-(N-methyl-4-pyridyl) porphyrin (TMPyP4) is a photosensitizer used in photodynamic therapy (PDT) and a telomerase inhibitor used in the treatment of telomerase-positive cancer. Here, we investigated the anticancer activity of TMPyP4 in A549 and PANC cells cultured in H
    Mesh-Begriff(e) A549 Cells ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Cell Line, Tumor ; Comet Assay ; DNA Damage ; Hepatocytes/drug effects ; Humans ; Hydrogen Peroxide/administration & dosage ; Membrane Potential, Mitochondrial/drug effects ; Mitochondria/drug effects ; Mitochondria/genetics ; Mitochondria/metabolism ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/metabolism ; Pancreatic Neoplasms/pathology ; Porphyrins/administration & dosage ; Reactive Oxygen Species/metabolism ; Tumor Microenvironment/drug effects
    Chemische Substanzen Porphyrins ; Reactive Oxygen Species ; tetra(4-N-methylpyridyl)porphine (38673-65-3) ; Hydrogen Peroxide (BBX060AN9V)
    Sprache Englisch
    Erscheinungsdatum 2021-04-21
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1201189-7
    ISSN 1559-131X ; 0736-0118 ; 1357-0560
    ISSN (online) 1559-131X
    ISSN 0736-0118 ; 1357-0560
    DOI 10.1007/s12032-021-01505-x
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: H

    Mei, Qiong / Yang, Yong / Ye, Shenhai / Liang, Weifang / Wang, Xuming / Zhou, Jie / Yu, Chulang / Yan, Chengqi / Chen, Jianping

    Plants (Basel, Switzerland)

    2019  Band 8, Heft 9

    Abstract: Oryza meyeriana is a wild species of rice with high resistance to Xanthomonas oryzae pv. oryzae (Xoo), but the detailed resistance mechanism is unclear. Ribulose-1, 5-bisphosphate carboxylase/oxygenase (Rubisco) activase (RCA) is an important enzyme that ...

    Abstract Oryza meyeriana is a wild species of rice with high resistance to Xanthomonas oryzae pv. oryzae (Xoo), but the detailed resistance mechanism is unclear. Ribulose-1, 5-bisphosphate carboxylase/oxygenase (Rubisco) activase (RCA) is an important enzyme that regulates photosynthesis by activating Rubisco. We have previously reported that
    Sprache Englisch
    Erscheinungsdatum 2019-09-16
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants8090351
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: H

    Chen, Mei-Kuang / Du, Yi / Sun, Linlin / Hsu, Jennifer L / Wang, Yu-Han / Gao, Yuan / Huang, Jiaxing / Hung, Mien-Chie

    The Journal of biological chemistry

    2019  Band 294, Heft 21, Seite(n) 8516–8528

    Abstract: ... anticancer agents, such as ionizing irradiation and chemotherapy drugs. The ROS H ...

    Abstract Reactive oxygen species (ROS) are cellular by-products produced from metabolism and also anticancer agents, such as ionizing irradiation and chemotherapy drugs. The ROS H
    Mesh-Begriff(e) Active Transport, Cell Nucleus/drug effects ; Breast Neoplasms/enzymology ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Cell Membrane/enzymology ; Cell Membrane/genetics ; Cell Membrane/pathology ; Cell Nucleus/enzymology ; Cell Nucleus/genetics ; Cell Nucleus/pathology ; Coatomer Protein/genetics ; Coatomer Protein/metabolism ; DNA Damage ; DNA Repair ; Female ; Humans ; Hydrogen Peroxide/pharmacology ; Proto-Oncogene Proteins c-met/genetics ; Proto-Oncogene Proteins c-met/metabolism ; SEC Translocation Channels/genetics ; SEC Translocation Channels/metabolism ; Signal Transduction/drug effects
    Chemische Substanzen COPG1 protein, human ; Coatomer Protein ; SEC Translocation Channels ; SEC61B protein, human ; Hydrogen Peroxide (BBX060AN9V) ; MET protein, human (EC 2.7.10.1) ; Proto-Oncogene Proteins c-met (EC 2.7.10.1)
    Sprache Englisch
    Erscheinungsdatum 2019-04-08
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1074/jbc.RA118.005953
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: H

    Meng, Xiang-Min / Huang, Xu / Lu, Hong-Li / Zhang, Chun-Mei / Kim, Young-Chul / Chen, Jie / Xu, Wen-Xie

    Experimental physiology

    2017  Band 102, Heft 7, Seite(n) 779–790

    Abstract: ... the relationship between H ...

    Abstract New findings: What is the central question of this study? The present study investigated the relationship between H
    Sprache Englisch
    Erscheinungsdatum 2017-07-01
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1016295-1
    ISSN 1469-445X ; 0958-0670
    ISSN (online) 1469-445X
    ISSN 0958-0670
    DOI 10.1113/EP086288
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: H

    Liang, Xin / Chen, Yu-Lin / Jiang, Xiao-Jing / Wang, Sheng-Mei / Zhang, Ji-Wen / Gui, Shuang-Ying

    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

    2017  Band 100, Seite(n) 155–162

    Abstract: The main objective of this study was to develop reversed hexagonal (H ...

    Abstract The main objective of this study was to develop reversed hexagonal (H
    Mesh-Begriff(e) Administration, Cutaneous ; Analgesics/administration & dosage ; Analgesics/blood ; Analgesics/pharmacokinetics ; Analgesics/therapeutic use ; Animals ; Anti-Inflammatory Agents/administration & dosage ; Anti-Inflammatory Agents/blood ; Anti-Inflammatory Agents/pharmacokinetics ; Anti-Inflammatory Agents/therapeutic use ; Biological Availability ; Drug Delivery Systems ; Edema/drug therapy ; Fatty Alcohols/chemistry ; Female ; Liquid Crystals/chemistry ; Male ; Mice ; Pain/drug therapy ; Rats, Wistar ; Salicylates/administration & dosage ; Salicylates/blood ; Salicylates/pharmacokinetics ; Salicylates/therapeutic use ; Skin/drug effects ; Skin/metabolism ; Skin Absorption ; Skin Irritancy Tests
    Chemische Substanzen Analgesics ; Anti-Inflammatory Agents ; Fatty Alcohols ; Salicylates ; 3,7,11,15-tetramethyl-1,2,3-hexadecanetriol (8LVI07A72W) ; methyl salicylate (LAV5U5022Y)
    Sprache Englisch
    Erscheinungsdatum 2017-03-30
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 1154366-8
    ISSN 1879-0720 ; 0928-0987
    ISSN (online) 1879-0720
    ISSN 0928-0987
    DOI 10.1016/j.ejps.2016.12.033
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Methane-H

    Wang, Yong / Zhao, Wenru / Chen, Xiaofeng / Ji, Yinjie / Zhu, Xilei / Chen, Xiaomai / Mei, Donghai / Shi, Hui / Lercher, Johannes A

    Journal of the American Chemical Society

    2024  Band 146, Heft 12, Seite(n) 8630–8640

    Abstract: H ...

    Abstract H
    Sprache Englisch
    Erscheinungsdatum 2024-03-15
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.4c00738
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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