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  1. AU=Choi Jung-Ah AU=Choi Jung-Ah
  2. AU="William M. Trochim"
  3. AU="Castrillo, Gabriel"
  4. AU="Molina-Sánchez, José Raúl"
  5. AU="Maestre, Michael"
  6. AU="Kang, Adrian Ez"
  7. AU="Nolan, Mark"
  8. AU="Sangha, Sonia"
  9. AU="Shekhar, Nishant" AU="Shekhar, Nishant"
  10. AU="Barrington, Sally F"
  11. AU="Ríos, D Balaguer"
  12. AU="Aikaterini Emmanouilidi"
  13. AU="Rocha-Filho, Francisco Dário" AU="Rocha-Filho, Francisco Dário"
  14. AU="René F Ketting"
  15. AU="Mohammed, Shabber"
  16. AU="Frösen, Juhana"
  17. AU="Walter, Annette O"
  18. AU=de Groot Yorick J
  19. AU="Sánchez-González, Cristina"

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  1. Artikel ; Online: Middle East Respiratory Syndrome coronavirus vaccine development: updating clinical studies using platform technologies.

    Choi, Jung-Ah / Kim, Jae-Ouk

    Journal of microbiology (Seoul, Korea)

    2022  Band 60, Heft 3, Seite(n) 238–246

    Abstract: Middle East Respiratory Syndrome coronavirus (MERS-CoV), a contagious zoonotic virus, causes severe respiratory infection with a case fatality rate of approximately 35% in humans. Intermittent sporadic cases in communities and healthcare facility ... ...

    Abstract Middle East Respiratory Syndrome coronavirus (MERS-CoV), a contagious zoonotic virus, causes severe respiratory infection with a case fatality rate of approximately 35% in humans. Intermittent sporadic cases in communities and healthcare facility outbreaks have continued to occur since its first identification in 2012. The World Health Organization has declared MERS-CoV a priority pathogen for worldwide research and vaccine development due to its epidemic potential and the insufficient countermeasures available. The Coalition for Epidemic Preparedness Innovations is supporting vaccine development against emerging diseases, including MERS-CoV, based on platform technologies using DNA, mRNA, viral vector, and protein subunit vaccines. In this paper, we review the usefulness and structure of a spike glycoprotein as a MERS-CoV vaccine candidate molecule, and provide an update on the status of MERS-CoV vaccine development. Vaccine candidates based on both DNA and viral vectors coding MERS-CoV spike gene have completed early phase clinical trials. A harmonized approach is required to assess the immunogenicity of various candidate vaccine platforms. Platform technologies accelerated COVID-19 vaccine development and can also be applied to developing vaccines against other emerging viral diseases.
    Mesh-Begriff(e) Antibodies, Viral ; COVID-19 ; COVID-19 Vaccines ; Humans ; Middle East Respiratory Syndrome Coronavirus/genetics ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/genetics ; Viral Vaccines/genetics
    Chemische Substanzen Antibodies, Viral ; COVID-19 Vaccines ; Spike Glycoprotein, Coronavirus ; Viral Vaccines ; spike protein, SARS-CoV-2
    Sprache Englisch
    Erscheinungsdatum 2022-01-28
    Erscheinungsland Korea (South)
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2012399-1
    ISSN 1976-3794 ; 1225-8873
    ISSN (online) 1976-3794
    ISSN 1225-8873
    DOI 10.1007/s12275-022-1547-8
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  2. Artikel: Predicting Maximum Oxygen Uptake from Non-Exercise and Submaximal Exercise Tests in Paraplegic Men with Spinal Cord Injury.

    Lee, Bum-Suk / Bae, Jae-Hyuk / Choi, Yu-Jin / Lee, Jung-Ah

    Healthcare (Basel, Switzerland)

    2023  Band 11, Heft 5

    Abstract: This study aimed to develop prediction equations for maximum oxygen uptake ( ... ...

    Abstract This study aimed to develop prediction equations for maximum oxygen uptake (VO
    Sprache Englisch
    Erscheinungsdatum 2023-03-05
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare11050763
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  3. Artikel ; Online: High-Resolution Finger MRI: What Should You Look for in Trauma of the Fingers?

    Lee, Kyoung Yeon / Rim, Jiwon / Choi, Jung-Ah / Khil, Eun Kyung

    Journal of the Korean Society of Radiology

    2023  Band 84, Heft 5, Seite(n) 1031–1046

    Abstract: The fingers are among the most commonly injured structures in traumatic injuries resulting from sports and work. Finger injuries encompass a broad spectrum of injuries to bone and soft tissues, including tendons, ligaments, and cartilage. The high ... ...

    Abstract The fingers are among the most commonly injured structures in traumatic injuries resulting from sports and work. Finger injuries encompass a broad spectrum of injuries to bone and soft tissues, including tendons, ligaments, and cartilage. The high resolution of 3T MRI with dedicated surface coils allows for optimal assessment of the intricate soft tissue structures of the fingers. There have been several reports on detailed MRI features of the basic anatomy and common pathological findings of the finger and hand. Understanding the normal anatomy and familiarization with common traumatic lesions of the ligaments, tendons, and pulleys of the fingers on high-resolution MRI will allow radiologists to perform accurate preoperative evaluations of traumatic hand lesions. The purpose of this study is to review the normal hand anatomy and common traumatic lesions of the finger on high-resolution MRI and correlate them with surgical findings.
    Sprache Englisch
    Erscheinungsdatum 2023-09-25
    Erscheinungsland Korea (South)
    Dokumenttyp Journal Article ; Review
    ISSN 2951-0805
    ISSN (online) 2951-0805
    DOI 10.3348/jksr.2022.0123
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  4. Artikel: Middle East Respiratory Syndrome coronavirus vaccine development: updating clinical studies using platform technologies

    Choi, Jung-ah / Kim, Jae-Ouk

    journal of microbiology. 2022 Mar., v. 60, no. 3

    2022  

    Abstract: Middle East Respiratory Syndrome coronavirus (MERS-CoV), a contagious zoonotic virus, causes severe respiratory infection with a case fatality rate of approximately 35% in humans. Intermittent sporadic cases in communities and healthcare facility ... ...

    Abstract Middle East Respiratory Syndrome coronavirus (MERS-CoV), a contagious zoonotic virus, causes severe respiratory infection with a case fatality rate of approximately 35% in humans. Intermittent sporadic cases in communities and healthcare facility outbreaks have continued to occur since its first identification in 2012. The World Health Organization has declared MERS-CoV a priority pathogen for worldwide research and vaccine development due to its epidemic potential and the insufficient countermeasures available. The Coalition for Epidemic Preparedness Innovations is supporting vaccine development against emerging diseases, including MERS-CoV, based on platform technologies using DNA, mRNA, viral vector, and protein subunit vaccines. In this paper, we review the usefulness and structure of a spike glycoprotein as a MERS-CoV vaccine candidate molecule, and provide an update on the status of MERS-CoV vaccine development. Vaccine candidates based on both DNA and viral vectors coding MERS-CoV spike gene have completed early phase clinical trials. A harmonized approach is required to assess the immunogenicity of various candidate vaccine platforms. Platform technologies accelerated COVID-19 vaccine development and can also be applied to developing vaccines against other emerging viral diseases.
    Schlagwörter COVID-19 infection ; DNA ; Middle East respiratory syndrome coronavirus ; World Health Organization ; genes ; glycoproteins ; health services ; immunogenicity ; mortality ; pathogens ; protein subunits ; respiratory tract diseases ; vaccine development ; viruses
    Sprache Englisch
    Erscheinungsverlauf 2022-03
    Umfang p. 238-246.
    Erscheinungsort The Microbiological Society of Korea
    Dokumenttyp Artikel
    Anmerkung Review
    ZDB-ID 2012399-1
    ISSN 1225-8873
    ISSN 1225-8873
    DOI 10.1007/s12275-022-1547-8
    Datenquelle NAL Katalog (AGRICOLA)

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  5. Artikel ; Online: High-Resolution Finger MRI

    Kyoung Yeon Lee / Jiwon Rim / Jung-Ah Choi / Eun Kyung Khil

    Journal of the Korean Society of Radiology, Vol 84, Iss 5, Pp 1031-

    What Should You Look for in Trauma of the Fingers?

    2023  Band 1046

    Abstract: The fingers are among the most commonly injured structures in traumatic injuries resulting from sports and work. Finger injuries encompass a broad spectrum of injuries to bone and soft tissues, including tendons, ligaments, and cartilage. The high ... ...

    Abstract The fingers are among the most commonly injured structures in traumatic injuries resulting from sports and work. Finger injuries encompass a broad spectrum of injuries to bone and soft tissues, including tendons, ligaments, and cartilage. The high resolution of 3T MRI with dedicated surface coils allows for optimal assessment of the intricate soft tissue structures of the fingers. There have been several reports on detailed MRI features of the basic anatomy and common pathological findings of the finger and hand. Understanding the normal anatomy and familiarization with common traumatic lesions of the ligaments, tendons, and pulleys of the fingers on high-resolution MRI will allow radiologists to perform accurate preoperative evaluations of traumatic hand lesions. The purpose of this study is to review the normal hand anatomy and common traumatic lesions of the finger on high-resolution MRI and correlate them with surgical findings.
    Schlagwörter fingers ; anatomy ; finger injuries ; diagnostic imaging ; magnetic resonance imaging ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2023-09-01T00:00:00Z
    Verlag The Korean Society of Radiology
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Predicting Maximum Oxygen Uptake from Non-Exercise and Submaximal Exercise Tests in Paraplegic Men with Spinal Cord Injury

    Bum-Suk Lee / Jae-Hyuk Bae / Yu-Jin Choi / Jung-Ah Lee

    Healthcare, Vol 11, Iss 763, p

    2023  Band 763

    Abstract: This study aimed to develop prediction equations for maximum oxygen uptake (VO 2 max) based on non-exercise (anthropometric) and submaximal exercise (anthropometric and physiological) variables in paraplegic men with a spinal cord injury. All ... ...

    Abstract This study aimed to develop prediction equations for maximum oxygen uptake (VO 2 max) based on non-exercise (anthropometric) and submaximal exercise (anthropometric and physiological) variables in paraplegic men with a spinal cord injury. All participants were tested on an arm ergometer using a maximal graded exercise test. Anthropometric variables such as age, height, weight, body fat, body mass index, body fat percentage, and arm muscle mass and physiological variables such as VO 2 , VCO 2 , and heart rate at 3 and 6 min of graded exercise tests were included in the multiple linear regression analysis. The prediction equations revealed the following. Regarding non-exercise variables, VO 2 max was correlated with age and weight (equation R = 0.771, R 2 = 0.595, SEE= 3.187). Regarding submaximal variables, VO 2 max was correlated with weight and VO 2 and VCO 2 at 6 min (equation R = 0.892, R 2 = 0.796, SEE = 2.309). In conclusion, our prediction equations can be used as a cardiopulmonary function evaluation tool to estimate VO 2 max simply and conveniently using the anthropometric and physiological characteristics of paraplegic men with spinal cord injuries.
    Schlagwörter maximum oxygen uptake ; prediction equation ; non-exercise test ; submaximal test ; spinal cord injury ; Medicine ; R
    Thema/Rubrik (Code) 796
    Sprache Englisch
    Erscheinungsdatum 2023-03-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: The new HLA-DQA1*03:50Q allele discovered by next-generation sequencing in a Korean family.

    Choi, Sooin / Bang, Hae In / Chae, Soobin / Young, Im Hwa / Kim, Jung-Ah

    HLA

    2023  Band 102, Heft 6, Seite(n) 770–772

    Abstract: DQA1*03:50Q differs from DQA1*03:02:01:01 by a three-nucleotide insertion at gDNA position 3968 in exon 2. ...

    Abstract DQA1*03:50Q differs from DQA1*03:02:01:01 by a three-nucleotide insertion at gDNA position 3968 in exon 2.
    Mesh-Begriff(e) Humans ; Alleles ; Sequence Analysis, DNA ; HLA-DQ alpha-Chains/genetics ; High-Throughput Nucleotide Sequencing ; Republic of Korea
    Chemische Substanzen HLA-DQA1 antigen ; HLA-DQ alpha-Chains
    Sprache Englisch
    Erscheinungsdatum 2023-08-22
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2845111-9
    ISSN 2059-2310 ; 2059-2302
    ISSN (online) 2059-2310
    ISSN 2059-2302
    DOI 10.1111/tan.15210
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Utility of Preoperative Shear-Wave Elastography of the Supraspinatus Muscle for Predicting Successful Rotator Cuff Repair: A Prospective Observational Study With MRI Correlation.

    Jeong, Jeung Yeol / Khil, Eun Kyung / Kim, A Yeon / Lee, Seun Ah / Choi, Jung-Ah

    AJR. American journal of roentgenology

    2022  Band 218, Heft 6, Seite(n) 1051–1060

    Abstract: BACKGROUND. ...

    Abstract BACKGROUND.
    Mesh-Begriff(e) Aged ; Elasticity Imaging Techniques/methods ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Muscular Atrophy ; Prospective Studies ; Rotator Cuff/diagnostic imaging ; Rotator Cuff/pathology ; Rotator Cuff/surgery ; Rotator Cuff Injuries/diagnostic imaging ; Rotator Cuff Injuries/pathology ; Rotator Cuff Injuries/surgery ; Rupture/pathology
    Sprache Englisch
    Erscheinungsdatum 2022-01-19
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Observational Study
    ZDB-ID 82076-3
    ISSN 1546-3141 ; 0361-803X ; 0092-5381
    ISSN (online) 1546-3141
    ISSN 0361-803X ; 0092-5381
    DOI 10.2214/AJR.21.27129
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  9. Artikel ; Online: Novel MRI signs of ruptured disc in the cervical spine with intraoperative comparisons.

    Khil, Eun Kyung / Choi, Il / Lee, Seun Ah / Seo, Woorim / Choi, Jung-Ah

    European radiology

    2022  Band 33, Heft 2, Seite(n) 1475–1485

    Abstract: Objectives: To evaluate the diagnostic performance of two novel MRI signs for extruded disc (ED) and uncontained ED (ruptured disc, RD) in the cervical spine using intraoperative findings as reference.: Methods: This retrospective study included ... ...

    Abstract Objectives: To evaluate the diagnostic performance of two novel MRI signs for extruded disc (ED) and uncontained ED (ruptured disc, RD) in the cervical spine using intraoperative findings as reference.
    Methods: This retrospective study included patients who underwent cervical spine MRI and surgery for disc pathology with intraoperative confirmation of RD from September 1, 2016, to January 31, 2021. Two radiologists determined whether the disc was extruded or ruptured with and without the aid of two novel MRI signs suggesting RD (sign 1: blurred margin of the disc; sign 2: mushroom-shaped disc). The diagnostic performance was analyzed using surgical findings as reference. Intra- and interobserver agreements were measured for each MRI sign.
    Results: A total of 91 patients totaling 131 discs were enrolled (mean age: 56.02 ± 12.93; range: 26-88; 62 men and 29 women), of whom 62 were surgically confirmed with RD. When the diagnosis was based exclusively on existing ED definitions, ED was diagnosed with 62.9-79.0% sensitivity and 80.2% accuracy, whereas RD was diagnosed with 35.5-45.2% sensitivity and 67.9-71.0% accuracy. However, when the two novel MRI signs were used as an aid in the diagnosis, ED was diagnosed with 95.2-96.8% sensitivity and 84.0-88.5% accuracy, while RD was diagnosed with 95.2-96.8% sensitivity and 84.0-89.3% accuracy. Intra- and interobserver agreement was substantial (k = 00.77-0.86, 0.69-0.79, respectively, p < 0.001).
    Conclusions: The detection of two novel MRI signs on preoperative MRI can lead to a more accurate RD diagnosis.
    Key points: • The diagnostic sensitivity of MRI for cervical ruptured disc is very low (about 35-45 %) using the standardized definition of lumbar disc nomenclature. • Two novel MRI signs can lead to a more accurate diagnosis of the surgically confirmed ruptured disc in the cervical spine. • These two novel MRI signs showed substantial intra-and interobserver reliabilities.
    Mesh-Begriff(e) Male ; Humans ; Female ; Adult ; Middle Aged ; Aged ; Retrospective Studies ; Lumbosacral Region ; Cervical Vertebrae/diagnostic imaging ; Cervical Vertebrae/surgery ; Cervical Vertebrae/pathology ; Magnetic Resonance Imaging ; Neck/pathology ; Intervertebral Disc Displacement ; Intervertebral Disc/pathology
    Sprache Englisch
    Erscheinungsdatum 2022-09-06
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 1085366-2
    ISSN 1432-1084 ; 0938-7994 ; 1613-3749
    ISSN (online) 1432-1084
    ISSN 0938-7994 ; 1613-3749
    DOI 10.1007/s00330-022-09124-4
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  10. Artikel ; Online: In Vitro Growth of Preantral Follicle and Maturation of Intrafollicular Oocyte from Aged Mice

    Jung-Ah Yoon / Jung-Kyu Choi

    Journal of Animal Reproduction and Biotechnology, Vol 34, Iss 1, Pp 35-

    2019  Band 39

    Abstract: This study aimed to recover the ovarian function through in vitro culture of preantral follicles from aged mice. First, we isolated the preantral follicles from ovaries of sixty-seven-week old B6D2F1 mice with decreased fecundity to know how many ... ...

    Abstract This study aimed to recover the ovarian function through in vitro culture of preantral follicles from aged mice. First, we isolated the preantral follicles from ovaries of sixty-seven-week old B6D2F1 mice with decreased fecundity to know how many follicles were present in them, which was 6 preantral follicles including 2 primary, 2 early secondary and late secondary follicles from 8 aged mice. It was confirmed that a few follicles (~2) were present in aged mice through histological analysis compared to adult mice as control. The 9 days of in vitro culture of preantal follicles showed in vitro growth and induced maturation after treatment with hCG (2.5 IU/mL) and EGF (5 ng/mL). Cumulus cells in the cumulus-oocyte complexes (COCs) were removed using hyaluronidase and oocytes at the germinal vesicle (GV) and GV breakdown (GVBD) were obtained from preantral follicle culture of aged mice in vitro. In conclusion, these observations demonstrated that there still were a few preantral follicles in the ovaries of 67 week-old mice, which we were able to culture in vitro and oocytes were obtained from them. This study proposed an in vitro culture system using preantral follicle as a therapeutic strategy for fertility preservation in humans for assisted reproductive medicine.
    Schlagwörter aged mice ; fertility preservation ; in vitro culture ; Biotechnology ; TP248.13-248.65 ; Medicine (General) ; R5-920 ; Internal medicine ; RC31-1245
    Thema/Rubrik (Code) 570
    Sprache Englisch
    Erscheinungsdatum 2019-03-01T00:00:00Z
    Verlag The Korean Society of Animal Reproduction and Biotechnology
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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