Artikel ; Online: Understanding hypergammaglobulinemia in experimental or natural visceral leishmaniasis.
2024 Band 46, Heft 1, Seite(n) e13021
Abstract: Nonspecific hypergammaglobulinemia (HGG) occurs in symptomatic human visceral leishmaniasis (VL) caused by L. L. infantum. This study assessed this finding in experimental infection in hamsters and natural infection in dogs. The serum concentration of ... ...
Abstract | Nonspecific hypergammaglobulinemia (HGG) occurs in symptomatic human visceral leishmaniasis (VL) caused by L. L. infantum. This study assessed this finding in experimental infection in hamsters and natural infection in dogs. The serum concentration of proteins, albumin and globulins was determined through the biuret and bromocresol green reaction, where the HGG was better expressed through the albumin/globulin (A/G) ratio. HGG was associated with a higher concentration of specific anti-glycan antibodies (BSA-G)/promastigote soluble extract (PSE) and the presence of circulating immune complexes (IC) by dissociative enzyme-linked immunoassay (ELISA). The study found monovalent IC in 37.9% (PSE) and 50% (BSA-G) of sera from infected hamsters, with increased frequency as the disease progressed. HGG was found in >60% of the samples in dogs with VL, associated with higher levels of specific immunoglobulin (Ig)A and IgM, but not IgG, determined using the PSE and BSA-G ELISA. HGG was associated with the presence of monovalent IC in 58.9% (PSE) and 63.4% (BSA-G) positive dog samples. HGG may result not only from the nonspecific activation of B cells, with greater production of specific and nonspecific antibodies, but also due to lower IgG excretion due to the presence of soluble monovalent IC. HGG correlates to the progression of VL and may be a marker for manifested disease. |
---|---|
Mesh-Begriff(e) | Cricetinae ; Humans ; Animals ; Dogs ; Leishmaniasis, Visceral ; Hypergammaglobulinemia ; Enzyme-Linked Immunosorbent Assay ; Antibodies, Protozoan ; Dog Diseases ; Leishmania infantum ; Antigen-Antibody Complex ; Albumins |
Chemische Substanzen | Antibodies, Protozoan ; Antigen-Antibody Complex ; Albumins |
Sprache | Englisch |
Erscheinungsdatum | 2024-01-26 |
Erscheinungsland | England |
Dokumenttyp | Journal Article |
ZDB-ID | 424444-8 |
ISSN | 1365-3024 ; 0141-9838 |
ISSN (online) | 1365-3024 |
ISSN | 0141-9838 |
DOI | 10.1111/pim.13021 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
Zusatzmaterialien
Kategorien
Verfügbar in ZB MED Köln/Königswinter
Zs.A 1509: Hefte anzeigen | Standort: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
Über subito bestellen
Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.