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  1. AU=Kurokawa Tomohiro
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  1. Article ; Online: Assessing the side effects and resistance in H. pylori treatment: a discussion on minocycline versus tetracycline therapy.

    Kurokawa, Tomohiro / Kurokawa, Tomoharu

    Journal of gastroenterology

    2024  Volume 59, Issue 4, Page(s) 357

    MeSH term(s) Humans ; Minocycline/adverse effects ; Bismuth/adverse effects ; Helicobacter pylori ; Anti-Bacterial Agents/adverse effects ; Tetracycline/adverse effects
    Chemical Substances Minocycline (FYY3R43WGO) ; Bismuth (U015TT5I8H) ; Anti-Bacterial Agents ; Tetracycline (F8VB5M810T)
    Language English
    Publishing date 2024-02-28
    Publishing country Japan
    Document type Letter ; Comment
    ZDB-ID 1186495-3
    ISSN 1435-5922 ; 0944-1174
    ISSN (online) 1435-5922
    ISSN 0944-1174
    DOI 10.1007/s00535-024-02084-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 620: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Letter to the Editor.

    Kurokawa, Tomohiro / Kurokawa, Tomoharu

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society

    2023  Volume 36, Issue 4, Page(s) 495

    Language English
    Publishing date 2023-12-18
    Publishing country Australia
    Document type Letter
    ZDB-ID 1171589-3
    ISSN 1443-1661 ; 0915-5635
    ISSN (online) 1443-1661
    ISSN 0915-5635
    DOI 10.1111/den.14730
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3854: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Chondroitin sulfate proteoglycan 4: An attractive target for antibody-based immunotherapy.

    Kurokawa, Tomohiro / Imai, Kohzoh

    Proceedings of the Japan Academy. Series B, Physical and biological sciences

    2024  Volume 100, Issue 5, Page(s) 293–308

    Abstract: Multifunctional molecules involved in tumor progression and metastasis have been identified as valuable targets for immunotherapy. Among these, chondroitin sulfate proteoglycan 4 (CSPG4), a significant tumor cell membrane-bound proteoglycan, has emerged ... ...

    Abstract Multifunctional molecules involved in tumor progression and metastasis have been identified as valuable targets for immunotherapy. Among these, chondroitin sulfate proteoglycan 4 (CSPG4), a significant tumor cell membrane-bound proteoglycan, has emerged as a promising target, especially in light of advances in chimeric antigen receptor (CAR) T-cell therapy. The profound bioactivity of CSPG4 and its role in pivotal processes such as tumor proliferation, migration, and neoangiogenesis underline its therapeutic potential. We reviewed the molecular intricacies of CSPG4, its functional attributes within tumor cells, and the latest clinical-translational advances targeting it. Strategies such as blocking monoclonal antibodies, conjugate therapies, bispecific antibodies, small-molecule inhibitors, CAR T-cell therapies, trispecific killer engagers, and ribonucleic acid vaccines against CSPG4 were assessed. CSPG4 overexpression in diverse tumors and its correlation with adverse prognostic outcomes emphasize its significance in cancer biology. These findings suggest that targeting CSPG4 offers a promising avenue for future cancer therapy, with potential synergistic effects when combined with existing treatments.
    MeSH term(s) Humans ; Immunotherapy/methods ; Neoplasms/therapy ; Neoplasms/immunology ; Animals ; Chondroitin Sulfate Proteoglycans/metabolism ; Chondroitin Sulfate Proteoglycans/immunology ; Proteoglycans/metabolism ; Proteoglycans/chemistry ; Molecular Targeted Therapy ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal/immunology ; Antigens ; Membrane Proteins
    Chemical Substances Chondroitin Sulfate Proteoglycans ; chondroitin sulfate proteoglycan 4 ; Proteoglycans ; CSPG4 protein, human ; Antibodies, Monoclonal ; Antigens ; Membrane Proteins
    Language English
    Publishing date 2024-05-10
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 161781-3
    ISSN 1349-2896 ; 0386-2208
    ISSN (online) 1349-2896
    ISSN 0386-2208
    DOI 10.2183/pjab.100.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

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    Z PRO 15: Show issues

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  4. Article: The epigenetic function of androgen receptor in prostate cancer progression.

    Sawada, Takahiro / Kanemoto, Yoshiaki / Kurokawa, Tomohiro / Kato, Shigeaki

    Frontiers in cell and developmental biology

    2023  Volume 11, Page(s) 1083486

    Abstract: Androgen and androgen deprivation (castration) therapies, including androgen receptor antagonists, are clinically used to treat patients with prostate cancer. However, most hormone-dependent prostate cancer patients progress into a malignant state with ... ...

    Abstract Androgen and androgen deprivation (castration) therapies, including androgen receptor antagonists, are clinically used to treat patients with prostate cancer. However, most hormone-dependent prostate cancer patients progress into a malignant state with loss of hormone-dependency, known as castration (drug)-resistant prostate cancer (CRPC), after prolong androgen-based treatments. Even in the CRPC state with irreversible malignancy, androgen receptor (AR) expression is detectable. An epigenetic transition to CRPC induced by the action of AR-mediated androgen could be speculated in the patients with prostate cancer. Androgen receptors belongs to the nuclear receptor superfamily with 48 members in humans, and acts as a ligand-dependent transcriptional factor, leading to local chromatin reorganization for ligand-dependent gene regulation. In this review, we discussed the transcriptional/epigenetic regulatory functions of AR, with emphasis on the clinical applications of AR ligands, AR protein co-regulators, and AR RNA coregulator (enhancer RNA), especially in chromatin reorganization, in patients with prostate cancer.
    Language English
    Publishing date 2023-03-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.1083486
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Pneumocystis Pneumonia in Locally Advanced Breast Cancer Despite Prophylactic Use of Trimethoprim-Sulfamethoxazole During Prednisolone Treatment for a Pembrolizumab-Induced Immune-Related Adverse Event: A Case Report.

    Kaneda, Yudai / Gonda, Kenji / Asakura, Takanori / Wada, Masahiro / Sawano, Toyoaki / Kurokawa, Tomohiro / Tachibana, Kazunoshin / Ozaki, Akihiko

    Cureus

    2024  Volume 16, Issue 3, Page(s) e56868

    Abstract: Pneumocystis pneumonia (PCP) primarily affects immunosuppressed patients, with trimethoprim-sulfamethoxazole (TMP-SMX) commonly used for prophylaxis. However, there is insufficient information on PCP occurrence despite TMP-SMX prophylaxis. We encountered ...

    Abstract Pneumocystis pneumonia (PCP) primarily affects immunosuppressed patients, with trimethoprim-sulfamethoxazole (TMP-SMX) commonly used for prophylaxis. However, there is insufficient information on PCP occurrence despite TMP-SMX prophylaxis. We encountered a 57-year-old woman with locally advanced breast cancer developing PCP despite prophylactic intake of TMP-SMX, during treatment with prednisolone for Stevens-Johnson syndrome (SJS) induced by pembrolizumab. This case underscores the need to pay attention to the possibility of PCP development even during TMP-SMX prophylaxis. Dosage and duration adjustments according to the patient's condition and weight may be required.
    Language English
    Publishing date 2024-03-25
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.56868
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Opioid Prescription After Surgery.

    Kurokawa, Yuko / Kurokawa, Tomohiro / Tanimoto, Tetsuya

    JAMA surgery

    2019  Volume 154, Issue 7, Page(s) 675

    MeSH term(s) Analgesics, Opioid ; Drug Prescriptions ; Humans ; Michigan ; Pain, Postoperative ; Practice Patterns, Physicians'
    Chemical Substances Analgesics, Opioid
    Language English
    Publishing date 2019-08-14
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2701841-6
    ISSN 2168-6262 ; 2168-6254
    ISSN (online) 2168-6262
    ISSN 2168-6254
    DOI 10.1001/jamasurg.2019.0573
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.72: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Regulation of Diacylglycerol Content in Olfactory Neurons Determines Forgetting or Retrieval of Olfactory Memory in

    Arai, Mary / Kurokawa, Itsuki / Arakane, Hoshinosuke / Kitazono, Tomohiro / Ishihara, Takeshi

    The Journal of neuroscience : the official journal of the Society for Neuroscience

    2022  Volume 42, Issue 43, Page(s) 8039–8053

    Abstract: Proper management of memories by forgetting and retrieval is essential for animals to adapt their behavior to changing environments. To elucidate the mechanisms underlying forgetting, we use olfactory learning to an attractive odorant, diacetyl, ... ...

    Abstract Proper management of memories by forgetting and retrieval is essential for animals to adapt their behavior to changing environments. To elucidate the mechanisms underlying forgetting, we use olfactory learning to an attractive odorant, diacetyl, in
    MeSH term(s) Animals ; Caenorhabditis elegans/physiology ; Caenorhabditis elegans Proteins/metabolism ; Calcium/metabolism ; Diacylglycerol Kinase/genetics ; Diacylglycerol Kinase/metabolism ; Diglycerides/metabolism ; Diacetyl ; Smell/physiology ; GTP-Binding Proteins ; Sensory Receptor Cells/metabolism ; Olfactory Receptor Neurons/physiology
    Chemical Substances Caenorhabditis elegans Proteins ; Calcium (SY7Q814VUP) ; Diacylglycerol Kinase (EC 2.7.1.107) ; Diglycerides ; Diacetyl (K324J5K4HM) ; GTP-Binding Proteins (EC 3.6.1.-)
    Language English
    Publishing date 2022-09-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 604637-x
    ISSN 1529-2401 ; 0270-6474
    ISSN (online) 1529-2401
    ISSN 0270-6474
    DOI 10.1523/JNEUROSCI.0090-22.2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1668: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Comment on "Long Term Outcome of Surgery Versus Conservative Management for Recurrent and Ongoing Complaints After an Episode of Diverticulitis. 5-year Follow-up Results of a Multicenter Randomized Control Trial (DIRECT-trial)".

    Kanemoto, Yoshiaki / Kurokawa, Tomohiro / Tanimoto, Tetsuya

    Annals of surgery

    2020  Volume 274, Issue 1, Page(s) e105–e106

    MeSH term(s) Conservative Treatment ; Diverticulitis ; Diverticulitis, Colonic/surgery ; Follow-Up Studies ; Humans ; Longitudinal Studies
    Language English
    Publishing date 2020-01-23
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 340-2
    ISSN 1528-1140 ; 0003-4932
    ISSN (online) 1528-1140
    ISSN 0003-4932
    DOI 10.1097/SLA.0000000000003787
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.35/1: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Differential gene regulation by a synthetic vitamin D receptor ligand and active vitamin D in human cells

    Miho Iwaki / Yoshiaki Kanemoto / Takahiro Sawada / Koki Nojiri / Tomohiro Kurokawa / Rino Tsutsumi / Kazuo Nagasawa / Shigeaki Kato

    PLoS ONE, Vol 18, Iss

    2023  Volume 12

    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  10. Article ; Online: Combination of Surgery With Extensive Intraoperative Peritoneal Lavage for Patients With Advanced Gastric Cancer.

    Kanemoto, Yoshiaki / Kurokawa, Tomohiro / Tanimoto, Tetsuya

    JAMA surgery

    2019  Volume 154, Issue 12, Page(s) 1163–1164

    MeSH term(s) Gastrectomy ; Humans ; Peritoneal Lavage ; Stomach Neoplasms/surgery
    Language English
    Publishing date 2019-09-09
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2701841-6
    ISSN 2168-6262 ; 2168-6254
    ISSN (online) 2168-6262
    ISSN 2168-6254
    DOI 10.1001/jamasurg.2019.2661
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.72: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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