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  1. Artikel ; Online: Retraction Note: Antibiotic growth promoters virginiamycin and bacitracin methylene disalicylate alter the chicken intestinal metabolome.

    Gadde, Ujvala Deepthi / Oh, Sungtaek / Lillehoj, Hyun S / Lillehoj, Erik P

    Scientific reports

    2021  Band 11, Heft 1, Seite(n) 2892

    Sprache Englisch
    Erscheinungsdatum 2021-01-28
    Erscheinungsland England
    Dokumenttyp Retraction of Publication
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-82285-2
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Mammalian Neuraminidases in Immune-Mediated Diseases: Mucins and Beyond.

    Lillehoj, Erik P / Luzina, Irina G / Atamas, Sergei P

    Frontiers in immunology

    2022  Band 13, Seite(n) 883079

    Abstract: Mammalian neuraminidases (NEUs), also known as sialidases, are enzymes that cleave off the terminal neuraminic, or sialic, acid resides from the carbohydrate moieties of glycolipids and glycoproteins. A rapidly growing body of literature indicates that ... ...

    Abstract Mammalian neuraminidases (NEUs), also known as sialidases, are enzymes that cleave off the terminal neuraminic, or sialic, acid resides from the carbohydrate moieties of glycolipids and glycoproteins. A rapidly growing body of literature indicates that in addition to their metabolic functions, NEUs also regulate the activity of their glycoprotein targets. The simple post-translational modification of NEU protein targets-removal of the highly electronegative sialic acid-affects protein folding, alters protein interactions with their ligands, and exposes or covers proteolytic sites. Through such effects, NEUs regulate the downstream processes in which their glycoprotein targets participate. A major target of desialylation by NEUs are mucins (MUCs), and such post-translational modification contributes to regulation of disease processes. In this review, we focus on the regulatory roles of NEU-modified MUCs as coordinators of disease pathogenesis in fibrotic, inflammatory, infectious, and autoimmune diseases. Special attention is placed on the most abundant and best studied NEU1, and its recently discovered important target, mucin-1 (MUC1). The role of the NEU1 - MUC1 axis in disease pathogenesis is discussed, along with regulatory contributions from other MUCs and other pathophysiologically important NEU targets.
    Mesh-Begriff(e) Animals ; Glycoproteins/metabolism ; Immune System Diseases ; Mammals/metabolism ; Mucins ; N-Acetylneuraminic Acid/metabolism ; Neuraminidase/metabolism
    Chemische Substanzen Glycoproteins ; Mucins ; Neuraminidase (EC 3.2.1.18) ; N-Acetylneuraminic Acid (GZP2782OP0)
    Sprache Englisch
    Erscheinungsdatum 2022-04-11
    Erscheinungsland Switzerland
    Dokumenttyp Systematic Review ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.883079
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Dietary Supplementation With Magnolia Bark Extract Alters Chicken Intestinal Metabolite Levels.

    Park, Inkyung / Oh, Sungtaek / Lillehoj, Erik P / Lillehoj, Hyun S

    Frontiers in veterinary science

    2020  Band 7, Seite(n) 157

    Abstract: Magnolia bark extract administered as a dietary supplement to poultry confers a performance and health benefit, but the mechanisms are unknown. Here, a metabolomics approach was used to identify changes in intestinal metabolite levels in chickens fed an ... ...

    Abstract Magnolia bark extract administered as a dietary supplement to poultry confers a performance and health benefit, but the mechanisms are unknown. Here, a metabolomics approach was used to identify changes in intestinal metabolite levels in chickens fed an unsupplemented diet or a diet supplemented with magnolia bark extract. Total body weight gains of chickens fed magnolia bark-supplemented diets were increased 2% (from 861 to 878 g/chicken), compared with chickens fed an unsupplemented diet. Compared with unsupplemented controls, the levels of 278 intestinal biochemicals (metabolites) were altered (165 increased, 113 decreased) in chickens given the magnolia-supplemented diet. Data for biochemicals of intestinal contents of chickens fed the unsupplemented diet clustered on the left side of the PCA score plot, while those of the magnolia-supplemented diet were separated and clustered on the right side. The biochemicals included changes in the levels of amino acids, fatty acids, peptides, and nucleosides, which provided a distinctive biochemical signature unique to the magnolia-supplemented group, compared with the unsupplemented group. These results provide the foundation for future studies to identify naturally-produced biochemicals that might be used to improve poultry growth performance.
    Sprache Englisch
    Erscheinungsdatum 2020-03-24
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2020.00157
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  4. Artikel ; Online: Retraction Note

    Ujvala Deepthi Gadde / Sungtaek Oh / Hyun S. Lillehoj / Erik. P. Lillehoj

    Scientific Reports, Vol 11, Iss 1, Pp 1-

    Antibiotic growth promoters virginiamycin and bacitracin methylene disalicylate alter the chicken intestinal metabolome

    2021  Band 1

    Abstract: Editor's Note: this Article has been retracted; the Retraction Note is available at https://doi.org/10.1038/s41598-021-82285-2 . ...

    Abstract Editor's Note: this Article has been retracted; the Retraction Note is available at https://doi.org/10.1038/s41598-021-82285-2 .
    Schlagwörter Medicine ; R ; Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2021-01-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

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  5. Artikel ; Online: Dietary Supplementation With Magnolia Bark Extract Alters Chicken Intestinal Metabolite Levels

    Inkyung Park / Sungtaek Oh / Erik. P. Lillehoj / Hyun S. Lillehoj

    Frontiers in Veterinary Science, Vol

    2020  Band 7

    Abstract: Magnolia bark extract administered as a dietary supplement to poultry confers a performance and health benefit, but the mechanisms are unknown. Here, a metabolomics approach was used to identify changes in intestinal metabolite levels in chickens fed an ... ...

    Abstract Magnolia bark extract administered as a dietary supplement to poultry confers a performance and health benefit, but the mechanisms are unknown. Here, a metabolomics approach was used to identify changes in intestinal metabolite levels in chickens fed an unsupplemented diet or a diet supplemented with magnolia bark extract. Total body weight gains of chickens fed magnolia bark-supplemented diets were increased 2% (from 861 to 878 g/chicken), compared with chickens fed an unsupplemented diet. Compared with unsupplemented controls, the levels of 278 intestinal biochemicals (metabolites) were altered (165 increased, 113 decreased) in chickens given the magnolia-supplemented diet. Data for biochemicals of intestinal contents of chickens fed the unsupplemented diet clustered on the left side of the PCA score plot, while those of the magnolia-supplemented diet were separated and clustered on the right side. The biochemicals included changes in the levels of amino acids, fatty acids, peptides, and nucleosides, which provided a distinctive biochemical signature unique to the magnolia-supplemented group, compared with the unsupplemented group. These results provide the foundation for future studies to identify naturally-produced biochemicals that might be used to improve poultry growth performance.
    Schlagwörter phytochemical ; intestine ; metabolomics ; growth ; chicken ; magnolia ; Veterinary medicine ; SF600-1100
    Thema/Rubrik (Code) 590
    Sprache Englisch
    Erscheinungsdatum 2020-03-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

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  6. Artikel: Dietary Antibiotic Growth Promoters Down-Regulate Intestinal Inflammatory Cytokine Expression in Chickens Challenged With LPS or Co-infected With

    Oh, Sungtaek / Lillehoj, Hyun S / Lee, Youngsub / Bravo, David / Lillehoj, Erik P

    Frontiers in veterinary science

    2019  Band 6, Seite(n) 420

    Abstract: Subtherapeutic levels of dietary antibiotics increase growth performance in domestic animals, but the mechanisms are poorly understood. Here, 1-week-old broiler chickens were challenged with LPS (experiment 1), or co-infected ... ...

    Abstract Subtherapeutic levels of dietary antibiotics increase growth performance in domestic animals, but the mechanisms are poorly understood. Here, 1-week-old broiler chickens were challenged with LPS (experiment 1), or co-infected with
    Sprache Englisch
    Erscheinungsdatum 2019-11-22
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2019.00420
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Antibiotic growth promoters virginiamycin and bacitracin methylene disalicylate alter the chicken intestinal metabolome.

    Gadde, Ujvala Deepthi / Oh, Sungtaek / Lillehoj, Hyun S / Lillehoj, Erik P

    Publikation ZURÜCKGEZOGEN

    Scientific reports

    2018  Band 8, Heft 1, Seite(n) 3592

    Abstract: Although dietary antibiotic growth promoters have long been used to increase growth performance in commercial food animal production, the biochemical details associated with these effects remain poorly defined. A metabolomics approach was used to ... ...

    Abstract Although dietary antibiotic growth promoters have long been used to increase growth performance in commercial food animal production, the biochemical details associated with these effects remain poorly defined. A metabolomics approach was used to characterize and identify the biochemical compounds present in the intestine of broiler chickens fed a standard, unsupplemented diet or a diet supplemented with the antibiotic growth promoters, virginiamycin or bacitracin methylene disalicylate. Compared with unsupplemented controls, the levels of 218 biochemicals were altered (156 increased, 62 decreased) in chickens given the virginiamycin-supplemented diet, while 119 were altered (96 increased, 23 decreased) with the bacitracin-supplemented diet. When compared between antibiotic-supplemented groups, 79 chemicals were altered (43 increased, 36 decreased) in virginiamycin- vs. bacitracin-supplemented chickens. The changes in the levels of intestinal biochemicals provided a distinctive biochemical signature unique to each antibiotic-supplemented group. These biochemical signatures were characterized by increases in the levels of metabolites of amino acids (e.g. 5-hydroxylysine, 2-aminoadipate, 5-hydroxyindoleaceate, 7-hydroxyindole sulfate), fatty acids (e.g. oleate/vaccenate, eicosapentaenoate, 16-hydroxypalmitate, stearate), nucleosides (e.g. inosine, N
    Mesh-Begriff(e) Amino Acids/metabolism ; Analysis of Variance ; Animal Feed/analysis ; Animals ; Anti-Bacterial Agents/metabolism ; Anti-Bacterial Agents/pharmacology ; Bacitracin/metabolism ; Bacitracin/pharmacology ; Chickens/growth & development ; Dietary Supplements ; Fatty Acids/metabolism ; Gastrointestinal Microbiome/drug effects ; Intestines/physiology ; Metabolome/physiology ; Niacinamide/metabolism ; Nucleosides/metabolism ; Salicylates/metabolism ; Salicylates/pharmacology ; Virginiamycin/metabolism ; Virginiamycin/pharmacology
    Chemische Substanzen Amino Acids ; Anti-Bacterial Agents ; Fatty Acids ; Nucleosides ; Salicylates ; Virginiamycin (11006-76-1) ; Bacitracin (1405-87-4) ; Niacinamide (25X51I8RD4) ; bacitracin methylenedisalicylic acid (JGV6OJ52FT)
    Sprache Englisch
    Erscheinungsdatum 2018-02-26
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Retracted Publication
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-018-22004-6
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: Dietary Supplementation With

    Park, Inkyung / Zimmerman, Noah P / Smith, Alexandra H / Rehberger, Thomas G / Lillehoj, Erik P / Lillehoj, Hyun S

    Frontiers in veterinary science

    2020  Band 7, Seite(n) 123

    Abstract: Direct-fed microbials (DFMs) are dietary supplements containing live microorganisms which confer a performance and health benefit to the host, but the mechanisms are unclear. Here, a metabolomics approach was used to identify changes in intestinal ... ...

    Abstract Direct-fed microbials (DFMs) are dietary supplements containing live microorganisms which confer a performance and health benefit to the host, but the mechanisms are unclear. Here, a metabolomics approach was used to identify changes in intestinal metabolite levels in chickens fed an unsupplemented diet or a diet supplemented with
    Sprache Englisch
    Erscheinungsdatum 2020-03-04
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2020.00123
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  9. Artikel ; Online: The sialidase NEU1 directly interacts with the juxtamembranous segment of the cytoplasmic domain of mucin-1 to inhibit downstream PI3K-Akt signaling.

    Hyun, Sang W / Imamura, Akihiro / Ishida, Hideharu / Piepenbrink, Kurt H / Goldblum, Simeon E / Lillehoj, Erik P

    The Journal of biological chemistry

    2021  Band 297, Heft 5, Seite(n) 101337

    Abstract: The extracellular domain (ED) of the membrane-spanning sialoglycoprotein, mucin-1 (MUC1), is an in vivo substrate for the lysosomal sialidase, neuraminidase-1 (NEU1). Engagement of the MUC1-ED by its cognate ligand, Pseudomonas aeruginosa-expressed ... ...

    Abstract The extracellular domain (ED) of the membrane-spanning sialoglycoprotein, mucin-1 (MUC1), is an in vivo substrate for the lysosomal sialidase, neuraminidase-1 (NEU1). Engagement of the MUC1-ED by its cognate ligand, Pseudomonas aeruginosa-expressed flagellin, increases NEU1-MUC1 association and NEU1-mediated MUC1-ED desialylation to unmask cryptic binding sites for its ligand. However, the mechanism(s) through which intracellular NEU1 might physically interact with its surface-expressed MUC1-ED substrate are unclear. Using reciprocal coimmunoprecipitation and in vitro binding assays in a human airway epithelial cell system, we show here that NEU1 associates with the MUC1-cytoplasmic domain (CD) but not with the MUC1-ED. Prior pharmacologic inhibition of the NEU1 catalytic activity using the NEU1-selective sialidase inhibitor, C9-butyl amide-2-deoxy-2,3-dehydro-N-acetylneuraminic acid, did not diminish NEU1-MUC1-CD association. In addition, glutathione-S-transferase (GST) pull-down assays using the deletion mutants of the MUC1-CD mapped the NEU1-binding site to the membrane-proximal 36 aa of the MUC1-CD. In a cell-free system, we found that the purified NEU1 interacted with the immobilized GST-MUC1-CD and the purified MUC1-CD associated with the immobilized 6XHis-NEU1, indicating that the NEU1-MUC1-CD interaction was direct and independent of its chaperone protein, protective protein/cathepsin A. However, the NEU1-MUC1-CD interaction was not required for the NEU1-mediated MUC1-ED desialylation. Finally, we demonstrated that overexpression of either WT NEU1 or a catalytically dead NEU1 G68V mutant diminished the association of the established MUC1-CD binding partner, PI3K, to MUC1-CD and reduced downstream Akt kinase phosphorylation. These results indicate that NEU1 associates with the juxtamembranous region of the MUC1-CD to inhibit PI3K-Akt signaling independent of NEU1 catalytic activity.
    Mesh-Begriff(e) A549 Cells ; Amino Acid Substitution ; HEK293 Cells ; Humans ; Mucin-1/genetics ; Mucin-1/metabolism ; Mutation, Missense ; Neuraminidase/genetics ; Neuraminidase/metabolism ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Protein Domains ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction
    Chemische Substanzen MUC1 protein, human ; Mucin-1 ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; NEU1 protein, human (EC 3.2.1.18) ; Neuraminidase (EC 3.2.1.18)
    Sprache Englisch
    Erscheinungsdatum 2021-10-22
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2021.101337
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: "Dietary supplementation with magnolia bark extract alters chicken intestinal metabolite levels"

    Park, Inkyung / Oh, Sungtaek / Lillehoj, Erik P. / Lillehoj, Hyun S.

    Frontiers in veterinary science. 2020 Mar. 24, v. 7, no. 5

    2020  

    Abstract: Magnolia bark extract administered as a dietary supplement to poultry confers a performance and health benefit, but the mechanisms are unknown. Here, a metabolomics approach was used to identify changes in intestinal metabolite levels in chickens fed an ... ...

    Abstract Magnolia bark extract administered as a dietary supplement to poultry confers a performance and health benefit, but the mechanisms are unknown. Here, a metabolomics approach was used to identify changes in intestinal metabolite levels in chickens fed an unsupplemented diet or a diet supplemented with magnolia bark extract. Body weight gains of chickens fed magnolia bark-supplemented diets were increased, compared with chickens fed an unsupplemented diet. Compared with unsupplemented controls, the levels of 278 intestinal metabolites were altered (165 increased, 113 decreased) in chickens given the magnolia-supplemented diet. These included changes in the levels of amino acids, fatty acids, peptides, and nucleosides, which provided a distinctive biochemical signature unique to the magnolia-supplemented group, compared with the unsupplemented group. These results provide the foundation for future studies to identify naturally-produced biochemicals that might be used to improve poultry growth performance.
    Schlagwörter Magnolia ; amino acids ; bark extracts ; chickens ; fatty acids ; feed supplements ; growth performance ; intestines ; liveweight gain ; metabolites ; metabolome ; metabolomics ; nucleosides ; peptides ; phytochemicals ; poultry feeding
    Sprache Englisch
    Erscheinungsverlauf 2020-0324
    Dokumenttyp Artikel ; Online
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2020.00157
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