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Artikel ; Online: Baseline trait mindfulness moderates the efficacy of mindfulness interventions and active controls: A meta-analysis of 177 randomised controlled trials.

Sieder, Kathrin / Thiedmann, Phillip / Voracek, Martin / Tran, Ulrich S

Applied psychology. Health and well-being

2024

Abstract: Previous evidence suggests that benefits of mindfulness-based interventions (MBIs) may depend on individuals' baseline trait mindfulness (BTM) levels. This meta-analysis investigated moderating effects of BTM on changes in mental health outcomes and ... ...

Abstract	Previous evidence suggests that benefits of mindfulness-based interventions (MBIs) may depend on individuals' baseline trait mindfulness (BTM) levels. This meta-analysis investigated moderating effects of BTM on changes in mental health outcomes and trait mindfulness in randomised controlled trials (RCTs) of MBIs. A total of 177 primary studies (total N = 13,486), comparing the treatment effects of MBIs against active, treatment-as-usual (TAU) and waitlist control groups, were synthesised via three-level meta-analysis. Lower BTM was associated with larger changes in mental health outcomes (B = -0.14, 95% CI [-0.21, -0.06], p < .001) and trait mindfulness (B = -0.09 [-0.16, -0.02], p = .009) in MBIs and active controls combined. These associations were significantly larger than from those in TAU and waitlist controls. Moderating effects were less tangible for changes in trait mindfulness in MBIs and active controls individually and less tangible in various sensitivity analyses which, however, were confounded by client type across the RCTs. Individuals low in BTM may, by a small effect size, benefit more from MBIs and active control interventions. BTM may thus affect the evaluation of treatment efficacy. MBIs and active interventions could be offered specifically to persons low in BTM.
Sprache	Englisch
Erscheinungsdatum	2024-05-09
Erscheinungsland	England
Dokumenttyp	Journal Article ; Review
ZDB-ID	2483053-7
ISSN	1758-0854 ; 1758-0846
ISSN (online)	1758-0854
ISSN	1758-0846
DOI	10.1111/aphw.12550
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Survival outcomes for women with a solitary extracranial metastasis from breast cancer.

Dyer, Patrick / Xie, Jing / Tran, Phillip K / Byrne, Keelan

Breast (Edinburgh, Scotland)

2024 Band 75, Seite(n) 103730

Abstract: Background: Aggressive metastasis directed treatment of extracranial oligometastatic breast cancer with the aim of increasing disease-free survival has emerged as a new potential treatment paradigm, however there is currently a lack of data to assist in ...

Abstract	Background: Aggressive metastasis directed treatment of extracranial oligometastatic breast cancer with the aim of increasing disease-free survival has emerged as a new potential treatment paradigm, however there is currently a lack of data to assist in identifying the subset of patients who will potentially benefit most. This single-institute retrospective cohort study aimed to evaluate survival outcomes for patients with a solitary extracranial metastasis from breast cancer and to assess for significant prognostic factors. Methods and materials: Medical records of 70 female breast cancer patients with a solitary extracranial metastasis actively managed at the Peter MacCallum Cancer Centre (PMCC) Melbourne Campus between 2000 and 2019 were reviewed. Kaplan-Meier curves were used to estimate overall survival (OS), local progression free survival (LPFS) and distant progression free survival (DPFS). Results: Median follow-up period was 9.4 years. The study included 40 hormone receptor positive/HER2 negative (HR+HER2-), 14 hormone receptor positive/HER2 positive (HR+HER2+), 3 hormone receptor negative/HER2 positive (HR-HER2+), 9 triple negative (TNBC) and 4 unclassified breast cancer patients. 5-year OS rate for all patients was 46%, LPFS rate was 56% and DPFS was 20%. Tumour receptor group had a statistically significant association with OS and DPFS rates. TNBC patients had significantly poorer OS and DPFS rates in comparison to HR+HER2-patients. Conclusion: Among patients with a solitary extracranial metastasis from breast cancer, TNBC was associated with the poorest OS and DPFS rates. Identification of other significant prognostic factors for oligometastatic breast cancer patients may inform guidelines for metastasis directed treatments.
Mesh-Begriff(e)	Humans ; Female ; Breast Neoplasms/pathology ; Breast Neoplasms/mortality ; Breast Neoplasms/therapy ; Retrospective Studies ; Middle Aged ; Adult ; Aged ; Kaplan-Meier Estimate ; Prognosis ; Neoplasm Metastasis ; Progression-Free Survival ; Receptor, ErbB-2/metabolism ; Receptor, ErbB-2/analysis ; Survival Rate ; Disease-Free Survival ; Aged, 80 and over
Chemische Substanzen	ERBB2 protein, human
Sprache	Englisch
Erscheinungsdatum	2024-04-12
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article
ZDB-ID	1143210-x
ISSN	1532-3080 ; 0960-9776
ISSN (online)	1532-3080
ISSN	0960-9776
DOI	10.1016/j.breast.2024.103730
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Verfügbar in ZB MED Köln/Königswinter

Zs.A 3620: Hefte anzeigen			Standort: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Artikel ; Online: Childhood health conditions and insomnia among adults in mid-life.

Sheehan, Connor / Cantu, Phillip / Powell, Danielle / Tran, Sydney

Aging and health research

2023 Band 3, Heft 1

Abstract: Background: Little is known regarding the influence of childhood health broadly and childhood health conditions specifically on insomnia throughout adulthood.: Methods: Health and Retirement Study (HRS) Baby Boomers born 1954-1965 were investigated. ... ...

Abstract	Background: Little is known regarding the influence of childhood health broadly and childhood health conditions specifically on insomnia throughout adulthood. Methods: Health and Retirement Study (HRS) Baby Boomers born 1954-1965 were investigated. We fitted regression models predicting self-reported insomnia based on twenty-three retrospectively reported specific childhood health conditions (e.g., measles) and general childhood health measures and adjusted for demographics, childhood socioeconomic status, and adult socioeconomic status. Results: Nearly all the measures of childhood health significantly increased insomnia symptoms in adulthood. In a model where all measures were included, we found that respiratory disorders, headaches, stomach problems, and concussions were particularly strong predictors of insomnia. Conclusions: Our findings extend past work illustrating the "long arm" of childhood conditions for health, showing that specific health conditions in childhood may indelibly imprint insomnia risk.
Sprache	Englisch
Erscheinungsdatum	2023-02-02
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article
ISSN	2667-0321
ISSN (online)	2667-0321
DOI	10.1016/j.ahr.2023.100124
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Distribution of Pt single atom coordination environments on anatase TiO

Zang, Wenjie / Lee, Jaeha / Tieu, Peter / Yan, Xingxu / Graham, George W / Tran, Ich C / Wang, Peikui / Christopher, Phillip / Pan, Xiaoqing

Nature communications

2024 Band 15, Heft 1, Seite(n) 998

Abstract: Single-atom catalysts (SACs) offer efficient metal utilization and distinct reactivity compared to supported metal nanoparticles. Structure-function relationships for SACs often assume that active sites have uniform coordination environments at ... ...

Abstract	Single-atom catalysts (SACs) offer efficient metal utilization and distinct reactivity compared to supported metal nanoparticles. Structure-function relationships for SACs often assume that active sites have uniform coordination environments at particular binding sites on support surfaces. Here, we investigate the distribution of coordination environments of Pt SAs dispersed on shape-controlled anatase TiO
Sprache	Englisch
Erscheinungsdatum	2024-02-02
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-45367-z
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Photosynthesis and other factors affecting the establishment and maintenance of cnidarian-dinoflagellate symbiosis.

Tran, Cawa / Rosenfield, Gabriel R / Cleves, Phillip A / Krediet, Cory J / Paul, Maitri R / Clowez, Sophie / Grossman, Arthur R / Pringle, John R

Philosophical transactions of the Royal Society of London. Series B, Biological sciences

2024 Band 379, Heft 1901, Seite(n) 20230079

Abstract: Coral growth depends on the partnership between the animal hosts and their intracellular, photosynthetic dinoflagellate symbionts. In this study, we used the sea ... ...

Abstract	Coral growth depends on the partnership between the animal hosts and their intracellular, photosynthetic dinoflagellate symbionts. In this study, we used the sea anemone
Mesh-Begriff(e)	Animals ; Symbiosis ; Dinoflagellida ; Anthozoa ; Sea Anemones ; Photosynthesis ; Larva
Sprache	Englisch
Erscheinungsdatum	2024-03-18
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	208382-6
ISSN	1471-2970 ; 0080-4622 ; 0264-3839 ; 0962-8436
ISSN (online)	1471-2970
ISSN	0080-4622 ; 0264-3839 ; 0962-8436
DOI	10.1098/rstb.2023.0079
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Towards comprehensive evaluation of the FLEXotendon glove-III: a case series evaluation in pediatric clinical cases and able-bodied adults.

Tran, Phillip / Elliott, Drew / Herrin, Kinsey / Desai, Jaydev P

Biomedical engineering letters

2023 Band 13, Heft 3, Seite(n) 485–494

Abstract: Injuries involving the nervous system, such as a brachial plexus palsy or traumatic brain injury, can lead to impairment in the functionality of the hand. Assistive robotics have been proposed as a possible method to improve patient outcomes in ... ...

Abstract	Injuries involving the nervous system, such as a brachial plexus palsy or traumatic brain injury, can lead to impairment in the functionality of the hand. Assistive robotics have been proposed as a possible method to improve patient outcomes in rehabilitation. The work presented here evaluates the FLEXotendon Glove-III, a 5 degree-of-freedom, voice-controlled, tendon-driven soft robotic hand exoskeleton, with two human subjects with hand impairments and four able-bodied subjects. The FLEXotendon Glove-III was evaluated on four unimpaired subjects, in conjunction with EMG sensor data, to determine the quantitative performance of the glove in applied pinch force, perturbation resistance, and exertion reduction. The exoskeleton system was also evaluated on two subjects with hand impairments, using two standardized hand function tests, the Jebsen-Taylor Hand Function Test and the Toronto Rehabilitation Institute Hand Function Test. The subjects were also presented with three qualitative questionnaires, the Capabilities of Upper Extremities Questionnaire, the Quebec User Evaluation of Satisfaction with Assistive Technology, and the Orthotics Prosthetics User Survey-Satisfaction module. From the previous design, minor design changes were made to the exoskeleton. The quick connect system was redesigned for improved performance, the number of motors was reduced to decrease overall footprint, and the entire system was placed into a compact acrylic case that can be placed into a backpack for increased portability.
Sprache	Englisch
Erscheinungsdatum	2023-04-28
Erscheinungsland	Germany
Dokumenttyp	Journal Article
ZDB-ID	2602422-6
ISSN	2093-985X ; 2093-9868
ISSN (online)	2093-985X
ISSN	2093-9868
DOI	10.1007/s13534-023-00280-0
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: "It's like a safety net for when things go wrong": key stakeholder and program user perspectives on a peer-led safe space program in Sydney, Australia.

Wadds, Phillip / Doran, Christopher M / Shakeshaft, Anthony / Tran, Dam Anh

Harm reduction journal

2023 Band 20, Heft 1, Seite(n) 129

Abstract: Background: Safe Spaces are a harm reduction approach commonly utilised in nightlife and festival settings to address alcohol and other drug-related harms. Despite increasing use, there has been little independent evaluation of safe space programs. This ...

Abstract	Background: Safe Spaces are a harm reduction approach commonly utilised in nightlife and festival settings to address alcohol and other drug-related harms. Despite increasing use, there has been little independent evaluation of safe space programs. This study aimed to explore (1) program user satisfaction with and use of a safe space program implemented in Sydney, Australia (The Take Kare Safe Space (TKSS)), and (2) the strengths and weaknesses of TKSS from the perspective of key stakeholders. Methods: Semi-structured, in-depth, interviews lasting between 30 min to 1 h were conducted with 38 key program stakeholders, including staff from police (n = 4), ambulance (n = 4), a local hospital accident and emergency room (n = 4), local council (n = 2), city 'rangers' (n = 2), the TKSS program (n = 4), licensed venues and other nightlife service providers (n = 4), and program users (n = 14). Purposive sampling was used to identify key stakeholders to participate in interviews. Results: Stakeholders stated that the TKSS program had a number of core benefits, including that it filled a service gap in nightlife settings; improved the efficiency and effectiveness of emergency services and other stakeholders operating in nightlife precincts; provided welfare services through proactive and non-judgmental interventions; and facilitated a means to de-escalate conflict without engaging police. Perceived weaknesses of the program included a lack of public awareness about the program; staff and volunteer levels; and misunderstandings regarding the scope and function of the TKSS program by some stakeholders. Conclusion: This study demonstrates the complex relationships that exist around the delivery of harm reduction in nightlife settings. In particular, it highlights the relative lack of servicing of public nightlife settings and the value of safe spaces/peer-to-peer safety ambassador programs in linking up care and filling this service gap. Further, it documents the extended benefit across key stakeholder groups of delivering proactive and non-judgemental harm reduction services and, in doing so, provides critical evidence around their efficacy in reducing AOD-related harms in the night-time economy.
Mesh-Begriff(e)	Humans ; Australia ; Emergency Service, Hospital ; Ethanol ; Harm Reduction ; Peer Group
Chemische Substanzen	Ethanol (3K9958V90M)
Sprache	Englisch
Erscheinungsdatum	2023-09-09
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2146691-9
ISSN	1477-7517 ; 1477-7517
ISSN (online)	1477-7517
ISSN	1477-7517
DOI	10.1186/s12954-023-00854-2
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Evaluation of the FLEXotendon glove-III through a human subject case study.

Tran, Phillip / Elliott, Drew / Herrin, Kinsey / Bhatia, Shovan / Desai, Jaydev P

Biomedical engineering letters

2023 Band 13, Heft 2, Seite(n) 153–163

Abstract: Cervical spinal cord injury (SCI) can significantly impair an individual's hand functionality due to the disruption of nerve signals from the brain to the upper extremity. Robotic assistive hand exoskeletons have been proposed as a potential technology ... ...

Abstract	Cervical spinal cord injury (SCI) can significantly impair an individual's hand functionality due to the disruption of nerve signals from the brain to the upper extremity. Robotic assistive hand exoskeletons have been proposed as a potential technology to facilitate improved patient rehabilitation outcomes, but few exoskeleton studies utilize standardized hand function tests and questionnaires to produce quantitative data regarding exoskeleton performance. This work presents the human subject case study evaluation of the FLEXotendon Glove-III, a 5 degree-of-freedom voice-controlled, tendon-driven soft robotic assistive hand exoskeleton for individuals with SCI. The exoskeleton system was evaluated in a case study with two individuals with SCI through two standardized hand function tests namely, the Jebsen-Taylor Hand Function Test and the Toronto Rehabilitation Institute Hand Function Test and three questionnaires (Capabilities of Upper Extremities Questionnaire, Orthotics Prosthetics Users Survey, Quebec User Evaluation of Satisfaction with Assistive Technology). Minor design changes were made to the exoskeleton: integrated fingertip force sensors to sense excessive grasp force, a quick connect system to expedite the exoskeleton glove swapping process between users, compact tendon tension sensors to measure tendon force for admittance control, and a redesigned smartphone app to encompass all aspects of exoskeleton use.
Sprache	Englisch
Erscheinungsdatum	2023-01-27
Erscheinungsland	Germany
Dokumenttyp	Journal Article
ZDB-ID	2602422-6
ISSN	2093-985X ; 2093-9868
ISSN (online)	2093-985X
ISSN	2093-9868
DOI	10.1007/s13534-023-00262-2
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Querying Recombination Junctions of Replication-Competent Adeno-Associated Viruses in Gene Therapy Vector Preparations with Single Molecule, Real-Time Sequencing.

Yip, Mitchell / Chen, Jing / Zhi, Yan / Tran, Ngoc Tam / Namkung, Suk / Pastor, Eric / Gao, Guangping / Tai, Phillip W L

Viruses

2023 Band 15, Heft 6

Abstract: Clinical-grade preparations of adeno-associated virus (AAV) vectors used for gene therapy typically undergo a series of diagnostics to determine titer, purity, homogeneity, and the presence of DNA contaminants. One type of contaminant that remains poorly ...

Abstract	Clinical-grade preparations of adeno-associated virus (AAV) vectors used for gene therapy typically undergo a series of diagnostics to determine titer, purity, homogeneity, and the presence of DNA contaminants. One type of contaminant that remains poorly investigated is replication-competent (rc)AAVs. rcAAVs form through recombination of DNA originating from production materials, yielding intact, replicative, and potentially infectious virus-like virions. They can be detected through the serial passaging of lysates from cells transduced by AAV vectors in the presence of wildtype adenovirus. Cellular lysates from the last passage are subjected to qPCR to detect the presence of the
Mesh-Begriff(e)	Dependovirus/genetics ; Genetic Vectors/genetics ; Plasmids ; Genome, Viral ; Genetic Therapy
Sprache	Englisch
Erscheinungsdatum	2023-05-24
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15061228
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Iron and Alzheimer's Disease: From Pathology to Imaging.

Tran, Dean / DiGiacomo, Phillip / Born, Donald E / Georgiadis, Marios / Zeineh, Michael

Frontiers in human neuroscience

2022 Band 16, Seite(n) 838692

Abstract: Alzheimer's disease (AD) is a debilitating brain disorder that afflicts millions worldwide with no effective treatment. Currently, AD progression has primarily been characterized by abnormal accumulations of β-amyloid within plaques and phosphorylated ... ...

Abstract	Alzheimer's disease (AD) is a debilitating brain disorder that afflicts millions worldwide with no effective treatment. Currently, AD progression has primarily been characterized by abnormal accumulations of β-amyloid within plaques and phosphorylated tau within neurofibrillary tangles, giving rise to neurodegeneration due to synaptic and neuronal loss. While β-amyloid and tau deposition are required for clinical diagnosis of AD, presence of such abnormalities does not tell the complete story, and the actual mechanisms behind neurodegeneration in AD progression are still not well understood. Support for abnormal iron accumulation playing a role in AD pathogenesis includes its presence in the early stages of the disease, its interactions with β-amyloid and tau, and the important role it plays in AD related inflammation. In this review, we present the existing evidence of pathological iron accumulation in the human AD brain, as well as discuss the imaging tools and peripheral measures available to characterize iron accumulation and dysregulation in AD, which may help in developing iron-based biomarkers or therapeutic targets for the disease.
Sprache	Englisch
Erscheinungsdatum	2022-07-13
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Review
ZDB-ID	2425477-0
ISSN	1662-5161
ISSN	1662-5161
DOI	10.3389/fnhum.2022.838692
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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