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  1. Buch: Xin yi gai xia gong li yi yuan cai wu guan li yao dian, jie xi, li ju

    Li, Lebo

    Points, analysis and examples on financial management of public hospital under the new medical reform

    2014  

    Titelvarianten Points, analysis and examples on financial management of public hospital under the new medical reform
    Verfasserangabe Li Lebo zhu
    Mesh-Begriff(e) Financial Management, Hospital/organization & administration ; Hospitals, Public/economics ; Health Care Reform/economics
    Schlagwörter China
    Sprache Chinesisch
    Umfang 3, 2, 282 pages :, illustrations
    Ausgabenhinweis Di 1 ban.
    Dokumenttyp Buch
    ISBN 9787517801627 ; 7517801627
    Datenquelle Katalog der US National Library of Medicine (NLM)

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  2. Buch: Da bai cai si ji you zhi gao xiao zai pei

    Liang, Zuzhen / Li, Yuhong / Li, Wenlan

    (Shu cai gao Chan zai pei ji shu cong shu)

    2001  

    Verfasserangabe Liang Zuzhen, Li Yuhong, Li Wenlan bian zhu
    Serientitel Shu cai gao Chan zai pei ji shu cong shu
    Schlagwörter Chinese cabbage.
    Sprache Chinesisch
    Umfang 2, 90 p. ;, 19 cm.
    Ausgabenhinweis Di 1 ban.
    Verlag Guangxi ke xue ji shu chu ban she ; Guangxi xin hua shu dian fa xing
    Erscheinungsort Naning shi
    Dokumenttyp Buch
    ISBN 7806660143 ; 9787806660140
    Datenquelle NAL Katalog (AGRICOLA)

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  3. Buch: Qin cai you zhi gao xiao zai pei

    Tang, Xuejun / Li, Yeyong / Liu, Chunchang

    (San nong gong cheng shu ku ; Shu cai gao chan zai pei ji shu cong shu)

    2000  

    Verfasserangabe Tang Xuejun, Li Yeyong, Liu Chunchang bian zhu
    Serientitel San nong gong cheng shu ku
    Shu cai gao chan zai pei ji shu cong shu
    Schlagwörter Celery.
    Sprache Chinesisch
    Umfang 69 p. :, ill. ;, 21 cm.
    Ausgabenhinweis Di 1 ban.
    Verlag Giangxi ke xue ji xhu chu ban she ; Guangxi xin hua shu dian fa xing
    Erscheinungsort Nanning shi
    Dokumenttyp Buch
    ISBN 7806199934 ; 9787806199930
    Datenquelle NAL Katalog (AGRICOLA)

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  4. Artikel ; Online: A CD6 homolog of Nile tilapia (Oreochromis niloticus) conserved binding bacteria involved in the regulation of Streptococcus agalactiae induced inflammation.

    Wang, Zhiwen / Xie, Caixia / Li, Yuan / Cai, Jia / Jian, Jichang / Xia, Liqun / Lu, Yishan

    Fish & shellfish immunology

    2024  Band 146, Seite(n) 109360

    Abstract: As a lymphocyte-specific surface receptor belonging to the cysteine-rich superfamily of scavenger receptors, CD6 acts as a pattern recognition receptor for microbial components and is involved in the regulation of inflammatory responses. However, the ... ...

    Abstract As a lymphocyte-specific surface receptor belonging to the cysteine-rich superfamily of scavenger receptors, CD6 acts as a pattern recognition receptor for microbial components and is involved in the regulation of inflammatory responses. However, the characteristics and functions of CD6 molecules in lower vertebrates represented by teleost fish are unknown. In this study, a CD6 homolog (designated OnCD6) was characterized from Nile tilapia (Oreochromis niloticus), and establishing its role as a PRRs that participates in immune recognition. OnCD6 contains an open reading frame of 1872 bp that encodes a peptide of 623 amino acids, and contains two conserved SR domain. Multiple sequence alignment revealed that OnCD6 shares a relatively high level of identity with those of other species. Transcriptional expression analysis revealed that OnCD6 was constitutively expressed in immunes tissues such as head kidney and thymus. The expression level of OnCD6 in mainly immune tissues were found significantly upregulated after the injection of Streptococcus agalactiae (S. agalactiae). Moreover, OnCD6 protein was located in the head kidney and brain, mainly over the plasma membrane of lymphocytes in these immune tissues. In vitro experiments showed that CD6 extracellular protein bound to and aggregated several Gram-positive and -negative bacterial strains through the recognition of bacterial surface conserved components LPS and LTA etc. In vivo experiments demonstrated that overexpression OnCD6 before S. agalactiae challenge significantly improved tilapia survival, and this was concomitant with reduced bacterial load and pro-inflammatory cytokines (IL-1β and TNF-α). Taken together, our results illustrated the function of CD6 molecular pattern recognition receptors (PRRs) is conserved and plays an important role in antibacterial infection.
    Mesh-Begriff(e) Animals ; Streptococcus agalactiae/physiology ; Cichlids ; Amino Acid Sequence ; Cytokines/metabolism ; Inflammation ; Fish Diseases ; Fish Proteins/chemistry ; Streptococcal Infections/veterinary ; Gene Expression Regulation
    Chemische Substanzen Cytokines ; Fish Proteins
    Sprache Englisch
    Erscheinungsdatum 2024-01-05
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1067738-0
    ISSN 1095-9947 ; 1050-4648
    ISSN (online) 1095-9947
    ISSN 1050-4648
    DOI 10.1016/j.fsi.2024.109360
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Paternal genetic structure analysis of the modern Han populations based on Y-SNP and Y-STR.

    Xin, Zhu / Xin, Jin / Jun, Liu / Lan, Yang / Li-Xin, Zou / Cai-Xia, Li / Jiang, Huang / Li, Jiang

    Yi chuan = Hereditas

    2024  Band 46, Heft 2, Seite(n) 149–167

    Abstract: ... with the Gelao and Li ethnic groups. In summary, this study presented a systematic analysis of haplogroup ...

    Abstract The Han populations represent the largest ethnic group in China. Previous studies have primarily focused on investigating their genetic origins, migration and integration, as well as paternal genetic relationships within specific regional Han populations. However, a comprehensive analysis of the global paternal genetic structure of Han populations is lacking. In this study, we performed Y-chromosome sequencing on 362 unrelated male samples from Chinese Han individuals collected from Qinghai, Sichuan and Liaoning provinces. We then integrated relevant data from reported studies. Our final dataset comprised 1830 samples from 16 Han populations across 15 provinces in China, encompassing information on 89 Y-SNPs and 16 Y-STRs. Statistical analyses were conducted to assess Y-STR haplotype diversity (HD) and Y-SNP haplogroup frequencies. Additionally, we employed principal component analysis (PCA), phylogenetic tree and haplotype network to explore genetic differentiation within Han populations and the genetic relationships between Han populations and ethnic minorities surrounding them. Our results demonstrated that the O-M175 haplogroup represents the predominant paternal lineage in Han populations, with frequencies ranging from 60.53% (Qinghai Han) to 92.7% (Guangdong Han). Moreover, the subclades downstream of O-M175 showed distinct regional variations in their distribution patterns. The O2-M122 haplogroup was prevalent in all Han populations and demonstrated a gradual decline in frequency from north to south. Conversely, the distribution frequency of the O1b-M268 haplogroup decreased from south to north, particularly showed significant presence among Han populations in the Lingnan region. Haplogroup O1a-M119 distributed more frequently in the central Han populations. Our findings revealed that Chinese Han populations can be categorized into three subgroups: northern, central, and southern. Notably, there were significant differences among Han in Qinghai and other regions. Regarding the genetic relationships between Han populations and surrounding ethnic minorities, we observed a closer genetic affinity between different Han populations, but northern Han demonstrated a stronger relationship with the Hui ethnic group, while southern Han exhibited a closer connection with the Gelao and Li ethnic groups. In summary, this study presented a systematic analysis of haplogroup distribution, genetic substructure of Han populations and genetic relationships between Han populations and surrounding ethnic minorities based on 89 Y-SNPs and 16 Y-STRs systematically. Our research supplemented valuable insights into population genetics and forensic genetics, and provided data support for the forensic application of Y chromosome. The integration of Y-SNP haplogroups with Y-STR haplotypes offers enhanced understanding of the genetic substructure within Han populations, which holds significance for both population genetics research and forensic science applications.
    Mesh-Begriff(e) Humans ; Polymorphism, Single Nucleotide ; Phylogeny ; Microsatellite Repeats ; Genetics, Population ; Ethnicity/genetics ; Haplotypes ; Chromosomes, Human, Y/genetics ; China
    Sprache Englisch
    Erscheinungsdatum 2024-02-10
    Erscheinungsland China
    Dokumenttyp Journal Article
    ISSN 0253-9772
    ISSN 0253-9772
    DOI 10.16288/j.yczz.23-260
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Scutellaria Baicalensis Georgi Stem and Leaf Flavonoids Ameliorate the Learning and Memory Impairment in Rats Induced by Okadaic Acid.

    Ma, Shuai / Xu, Cong-Cong / Dong, Yong-Cai / Li, Cai-Xia / Shang, Ya-Zhen

    Combinatorial chemistry & high throughput screening

    2024  

    Abstract: Aim: The objective of this study is to explore the impact and underlying mechanism of Scutellaria baicalensis Georgi stem and leaf flavonoids (SSFs) on cognitive impairment caused by intracerebroventricular injection of okadaic acid (OA) in rats.: ... ...

    Abstract Aim: The objective of this study is to explore the impact and underlying mechanism of Scutellaria baicalensis Georgi stem and leaf flavonoids (SSFs) on cognitive impairment caused by intracerebroventricular injection of okadaic acid (OA) in rats.
    Methods: An experimental model of Alzheimer's disease (AD) was induced in rats by intracerebroventricular injection of OA, resulting in memory impairment. The Morris water maze test was employed to confirm the successful establishment of the memory impairment model. The rats that exhibited significant memory impairment were randomly divided into different groups, including a model group, three SSFs dose groups (25, 50, and 100 mg/kg), and a positive control group treated with Ginkgo biloba tablets (GLT) at a dose of 200 mg/kg. To evaluate the learning and memory abilities of the rats, the Morris water maze test was conducted. Hematoxylin-eosin (HE) staining was used to observe any morphological changes in neurons. Immunohistochemistry (IHC) was performed to measure the expression of choline acetyltransferase (ChAT) protein. Western blotting (WB) was utilized to assess the phosphorylation levels of tau protein at Ser262 and Ser396. The activities of inducible nitric oxide synthase (iNOS) and constitutive nitric oxide synthase (cNOS) were quantified using ultraviolet spectrophotometry. The levels of inflammatory factors, including interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6), were measured using ELISA.
    Results: In rats, the administration of OA via intracerebroventricular injection resulted in cognitive impairment, neuropathological changes, and alterations in protein expression and activity levels. Specifically, the protein expression of ChAT was significantly reduced (P<0.01), while the phosphorylation levels of tau protein at Ser262 and Ser396 were significantly increased (P<0.01). Moreover, iNOS activity in the hippocampus and cerebral cortex exhibited a significant increase (P<0.01), whereas cNOS activity showed a decrease (P<0.05). Furthermore, the levels of IL-1β and TNF-α in the cerebral cortex were elevated (P<0.01), while the level of IL-6 was decreased (P<0.05). The administration of three doses of SSFs and GLT to rats exhibited varying degrees of improvement in the aforementioned pathological alterations induced by OA.
    Conclusion: SSFs demonstrated the ability to enhance cognitive function and mitigate memory deficits in rats following intracerebroventricular injection of OA. This beneficial effect may be attributed to the modulation of ChAT protein expression, tau hyperphosphorylation, NOS activity, and inflammatory cytokine levels by SSFs.
    Sprache Englisch
    Erscheinungsdatum 2024-01-09
    Erscheinungsland United Arab Emirates
    Dokumenttyp Journal Article
    ZDB-ID 2064785-2
    ISSN 1875-5402 ; 1386-2073
    ISSN (online) 1875-5402
    ISSN 1386-2073
    DOI 10.2174/0113862073265060231127054325
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5577: Hefte anzeigen Standort:
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  7. Artikel ; Online: Remote Radical Azidation of Unactivated C(sp

    Li, Jiawei / Zhong, Sishi / Zhou, Pan / Li, Xu / Xie, Danyang / Cai, Yunfei / Xia, Yong

    Organic letters

    2024  Band 26, Heft 17, Seite(n) 3519–3523

    Abstract: An efficient method for remote radical C( ... ...

    Abstract An efficient method for remote radical C(sp
    Sprache Englisch
    Erscheinungsdatum 2024-04-23
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.4c00862
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Association between dietary intake of saturated fatty acid subgroups and breast cancer risk.

    Jiang, Ying / Li, Lan-Ting / Hou, Si-Han / Chen, Le-Ning / Zhang, Cai-Xia

    Food & function

    2024  Band 15, Heft 4, Seite(n) 2282–2294

    Abstract: The impact of dietary saturated fatty acids (SFAs) on breast cancer risk may vary depending on their carbon chain lengths, attributable to the discrepancy in their dietary sources and biological activities. The associations between SFA subgroups ... ...

    Abstract The impact of dietary saturated fatty acids (SFAs) on breast cancer risk may vary depending on their carbon chain lengths, attributable to the discrepancy in their dietary sources and biological activities. The associations between SFA subgroups classified by chain length and breast cancer risk remain controversial. In this case-control study, we aimed to investigate the association between the dietary intake of SFA subgroups, classified by chain lengths, and odds of breast cancer in China. This study included 1661 cases of breast cancer (confirmed as primary and histologically) and 1674 frequency-matched controls. Face-to-face interviews were used to collect basic information, while dietary intake information was obtained by a food frequency questionnaire. The unconditional logistic regression model was used to calculate the odds ratios (ORs) and 95% confidence intervals (95% CIs). All SFA subgroups were inversely associated with odds of breast cancer. The adjusted ORs (95% CIs) were 0.78 (0.61-0.99) for medium-chain SFAs, 0.50 (0.31-0.83) for long even-chain SFAs, 0.69 (0.54-0.88) for long odd-chain, and 0.67 (0.48-0.95) for very long-chain SFAs, respectively. In the restricted cubic spline (RCS) models, a non-linear M-shaped association was observed between long odd-chain SFAs and odds of breast cancer (
    Mesh-Begriff(e) Humans ; Female ; Fatty Acids ; Prospective Studies ; Risk Factors ; Breast Neoplasms/epidemiology ; Breast Neoplasms/etiology ; Case-Control Studies ; Eating ; Dietary Fats
    Chemische Substanzen Fatty Acids ; Dietary Fats
    Sprache Englisch
    Erscheinungsdatum 2024-02-19
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/d3fo04279k
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Bonn

    Z 7872: Hefte anzeigen

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  9. Artikel ; Online: FluPMT: Prediction of Predominant Strains of Influenza A Viruses Via Multi-task Learning.

    Cai, Changfeng / Li, Jianghui / Xia, Yuanling / Li, Weihua

    IEEE/ACM transactions on computational biology and bioinformatics

    2024  Band PP

    Abstract: Seasonal influenza vaccines play a crucial role in saving numerous lives annually. However, the constant evolution of the influenza A virus necessitates frequent vaccine updates to ensure its ongoing effectiveness. The decision to develop a new vaccine ... ...

    Abstract Seasonal influenza vaccines play a crucial role in saving numerous lives annually. However, the constant evolution of the influenza A virus necessitates frequent vaccine updates to ensure its ongoing effectiveness. The decision to develop a new vaccine strain is generally based on the assessment of the current predominant strains. Nevertheless, the process of vaccine production and distribution is very time-consuming, leaving a window for the emergence of new variants that could decrease vaccine effectiveness, so predictions of influenza A virus evolution can inform vaccine evaluation and selection. Hence, we present FluPMT, a novel sequence prediction model that applies an encoder-decoder architecture to predict the hemagglutinin (HA) protein sequence of the upcoming season's predominant strain by capturing the patterns of evolution of influenza A viruses. Specifically, we employ time series to model the evolution of influenza A viruses, and utilize attention mechanisms to explore dependencies among residues of sequences. Additionally, antigenic distance prediction based on graph network representation learning is incorporated into the sequence prediction as an auxiliary task through a multi-task learning framework. Experimental results on two influenza datasets highlight the exceptional predictive performance of FluPMT, offering valuable insights into virus evolutionary dynamics, as well as vaccine evaluation and production.
    Sprache Englisch
    Erscheinungsdatum 2024-03-18
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 1557-9964
    ISSN (online) 1557-9964
    DOI 10.1109/TCBB.2024.3378468
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Alteromonas Aquimaris sp. nov., Isolated from Surface Seawater.

    Wang, Qin / Hu, Xin-Yuan / Sun, Li-Ping / Niu, Hui-Jing / Pei, Cai-Xia / Li, Yi / Xia, Cheng-Qiang

    Current microbiology

    2023  Band 80, Heft 11, Seite(n) 343

    Abstract: A Gram-negative, aerobic, motile by flagellum, and rod-shaped bacterium, designated ASW11- ... ...

    Abstract A Gram-negative, aerobic, motile by flagellum, and rod-shaped bacterium, designated ASW11-7
    Mesh-Begriff(e) Alteromonas/genetics ; Phylogeny ; RNA, Ribosomal, 16S/genetics ; China ; DNA
    Chemische Substanzen RNA, Ribosomal, 16S ; DNA (9007-49-2)
    Sprache Englisch
    Erscheinungsdatum 2023-09-19
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 134238-1
    ISSN 1432-0991 ; 0343-8651
    ISSN (online) 1432-0991
    ISSN 0343-8651
    DOI 10.1007/s00284-023-03472-0
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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