LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Erweiterte Suche

Suchergebnis

Treffer 1 - 10 von insgesamt 524

Suchoptionen

  1. Buch: Epigenetics and cancer

    Sarkar, Fazlul H.

    2013  

    Verfasserangabe Fazlul H. Sarkar ed
    Sprache Englisch
    Umfang X, 287 S. : Ill., graph. Darst.
    Verlag Springer
    Erscheinungsort Dordrecht u.a.
    Erscheinungsland Niederlande
    Dokumenttyp Buch
    HBZ-ID HT017681507
    ISBN 978-94-007-6611-2 ; 94-007-6611-4 ; 9789400766129 ; 9400766122
    Datenquelle Katalog ZB MED Medizin, Gesundheit

    Zusatzmaterialien

    Kategorien

  2. Buch: MicroRNA targeted cancer therapy

    Sarkar, Fazlul H.

    2014  

    Verfasserangabe Fazlul H. Sarkar ed
    Schlagwörter Cancer/Gene therapy ; Non-coding RNA/Therapeutic use
    Thema/Rubrik (Code) 616.9940695
    Sprache Englisch
    Umfang X, 351 S., illustrations (black and white, and colour), 24 cm
    Verlag Springer
    Erscheinungsort Cham u.a.
    Erscheinungsland Schweiz
    Dokumenttyp Buch
    Anmerkung Includes bibliographical references
    HBZ-ID HT018285187
    ISBN 978-3-319-05133-8 ; 9783319051345 ; 3-319-05133-4 ; 3319051342
    Datenquelle Katalog ZB MED Medizin, Gesundheit

    Kategorien

  3. Buch: Nutraceuticals and cancer

    Sarkar, Fazlul H.

    2012  

    Verfasserangabe Fazlul H. Sarkar ed
    Sprache Englisch
    Umfang XII, 379 S. : Ill., graph. Darst., 24 cm
    Verlag Springer
    Erscheinungsort Dordrecht u.a.
    Erscheinungsland Niederlande
    Dokumenttyp Buch
    HBZ-ID HT017079240
    ISBN 978-94-007-2629-1 ; 978-94-0072629-1 ; 94-0072629-5 ; 94-007-2629-5 ; 9789400726307 ; 9400726309
    Datenquelle Katalog ZB MED Medizin, Gesundheit

    Zusatzmaterialien

    Kategorien

  4. Artikel ; Online: Novel Holistic Approaches for Overcoming Therapy Resistance in Pancreatic and Colon Cancers.

    Sarkar, Fazlul H

    Medical principles and practice : international journal of the Kuwait University, Health Science Centre

    2016  Band 25 Suppl 2, Seite(n) 3–10

    Abstract: Gastrointestinal (GI) cancers, such as of the colon and pancreas, are highly resistant to both standard and targeted therapeutics. Therapy-resistant and heterogeneous GI cancers harbor highly complex signaling networks (the resistome) that resist ... ...

    Abstract Gastrointestinal (GI) cancers, such as of the colon and pancreas, are highly resistant to both standard and targeted therapeutics. Therapy-resistant and heterogeneous GI cancers harbor highly complex signaling networks (the resistome) that resist apoptotic programming. Commonly used gemcitabine or platinum-based regimens fail to induce meaningful (i.e. disease-reversing) perturbations in the resistome, resulting in high rates of treatment failure. The GI cancer resistance networks are, in part, due to interactions between parallel signaling and aberrantly expressed microRNAs (miRNAs) that collectively promote the development and survival of drug-resistant cancer stem cells with epithelial-to-mesenchymal transition (EMT) characteristics. The lack of understanding of the resistance networks associated with this subpopulation of cells as well as reductionist, single protein-/pathway-targeted approaches have made 'effective drug design' a difficult task. We propose that the successful design of novel therapeutic regimens to target drug-resistant GI tumors is only possible if network-based drug avenues and agents, in particular 'natural agents' with no known toxicity, are correctly identified. Natural agents (dietary agents or their synthetic derivatives) can individually alter miRNA profiles, suppress EMT pathways and eliminate cancer stem-like cells that derive from pancreatic cancer and colon cancer, by partially targeting multiple yet meaningful networks within the GI cancer resistome. However, the efficacy of these agents as combinations (e.g. consumed in the diet) against this resistome has never been studied. This short review article provides an overview of the different challenges involved in the understanding of the GI resistome, and how novel computational biology can help in the design of effective therapies to overcome resistance.
    Mesh-Begriff(e) Antineoplastic Agents/therapeutic use ; Biological Products/therapeutic use ; Colonic Neoplasms/drug therapy ; Dietary Supplements ; Drug Discovery/methods ; Drug Discovery/trends ; Drug Resistance, Neoplasm ; Gastrointestinal Neoplasms/drug therapy ; Humans ; MicroRNAs ; Pancreatic Neoplasms/drug therapy
    Chemische Substanzen Antineoplastic Agents ; Biological Products ; MicroRNAs
    Sprache Englisch
    Erscheinungsdatum 2016
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 645108-1
    ISSN 1423-0151 ; 1011-7571
    ISSN (online) 1423-0151
    ISSN 1011-7571
    DOI 10.1159/000435814
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  5. Buch: MicroRNA targeted cancer therapy

    Sarkar, Fazlul H

    2014  

    Verfasserangabe Fazlul H. Sarkar, editor
    Mesh-Begriff(e) MicroRNAs/therapeutic use ; Neoplasms/therapy ; Genetic Therapy/methods
    Sprache Englisch
    Umfang x, 351 pages :, illustrations
    Dokumenttyp Buch
    ISBN 9783319051338 ; 3319051334 ; 9783319051345 ; 3319051342
    Datenquelle Katalog der US National Library of Medicine (NLM)

    Zusatzmaterialien

    Kategorien

  6. Buch: Epigenetics and cancer

    Sarkar, Fazlul H

    2013  

    Verfasserangabe Fazlul H. Sarkar, editor
    Mesh-Begriff(e) Neoplasms/genetics ; Epigenesis, Genetic ; MicroRNAs
    Sprache Englisch
    Umfang x, 287 pages :, illustrations
    Dokumenttyp Buch
    ISBN 9789400766112 ; 9789400766129 ; 9400766114 ; 9400766122
    Datenquelle Katalog der US National Library of Medicine (NLM)

    Zusatzmaterialien

    Kategorien

  7. Artikel ; Online: Correction to: The versatile role of exosomes in cancer progression: diagnostic and therapeutic implications.

    Sundararajan, Vignesh / Sarkar, Fazlul H / Ramasamy, Thamil Selvee

    Cellular oncology (Dordrecht)

    2018  Band 41, Heft 4, Seite(n) 463

    Abstract: In the title of above mentioned article the word 'versatile' had been replaced by 'multifaceted'. ...

    Abstract In the title of above mentioned article the word 'versatile' had been replaced by 'multifaceted'.
    Sprache Englisch
    Erscheinungsdatum 2018-07-25
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Published Erratum
    ZDB-ID 2595109-9
    ISSN 2211-3436 ; 1875-8606 ; 2211-3428
    ISSN (online) 2211-3436
    ISSN 1875-8606 ; 2211-3428
    DOI 10.1007/s13402-018-0396-2
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  8. Artikel ; Online: Nutraceuticals and cancer. Preface.

    Sarkar, Fazlul H

    Cancer metastasis reviews

    2010  Band 29, Heft 3, Seite(n) 381–382

    Mesh-Begriff(e) Animals ; Dietary Supplements ; Humans ; Neoplasms/diet therapy
    Sprache Englisch
    Erscheinungsdatum 2010-09
    Erscheinungsland Netherlands
    Dokumenttyp Introductory Journal Article
    ZDB-ID 604857-2
    ISSN 1573-7233 ; 0167-7659
    ISSN (online) 1573-7233
    ISSN 0167-7659
    DOI 10.1007/s10555-010-9243-2
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  9. Buch: Nutraceuticals and cancer

    Sarkar, Fazlul H

    2012  

    Verfasserangabe Fazlul H. Sarkar, editor
    Mesh-Begriff(e) Neoplasms/diet therapy ; Functional Food
    Sprache Englisch
    Umfang xii, 379 p. :, ill.
    Verlag Springer
    Erscheinungsort Dordrecht
    Dokumenttyp Buch
    ISBN 9789400726291 ; 9400726295 ; 9789400726307 ; 9400726309
    Datenquelle Katalog der US National Library of Medicine (NLM)

    Zusatzmaterialien

    Kategorien

  10. Artikel ; Online: Current trends in the chemoprevention of cancer.

    Sarkar, Fazlul H

    Pharmaceutical research

    2010  Band 27, Heft 6, Seite(n) 945–949

    Mesh-Begriff(e) Anticarcinogenic Agents/therapeutic use ; Chemoprevention/trends ; Humans ; Neoplasms/drug therapy ; Neoplasms/prevention & control
    Chemische Substanzen Anticarcinogenic Agents
    Sprache Englisch
    Erscheinungsdatum 2010-04-17
    Erscheinungsland United States
    Dokumenttyp Editorial ; Interview ; Introductory Journal Article
    ZDB-ID 843063-9
    ISSN 1573-904X ; 0724-8741 ; 0739-0742
    ISSN (online) 1573-904X
    ISSN 0724-8741 ; 0739-0742
    DOI 10.1007/s11095-010-0146-2
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

Zum Seitenanfang