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  1. Artikel ; Online: Immunoglobulins or convalescent plasma to tackle COVID-19: buying time to save lives - current situation and perspectives.

    Tamburello, Adriana / Marando, Marco

    Swiss medical weekly

    2020  Band 150, Seite(n) w20264

    Mesh-Begriff(e) Betacoronavirus ; Coronavirus Infections/immunology ; Coronavirus Infections/therapy ; Humans ; Immunization, Passive ; Immunoglobulins/immunology ; Immunoglobulins/therapeutic use ; Pandemics ; Pneumonia, Viral/immunology ; Pneumonia, Viral/therapy
    Chemische Substanzen Immunoglobulins
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-04-28
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2036179-8
    ISSN 1424-3997 ; 1424-7860
    ISSN (online) 1424-3997
    ISSN 1424-7860
    DOI 10.4414/smw.2020.20264
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Immunoglobulins or convalescent plasma to tackle COVID-19: buying time to save lives - current situation and perspectives

    Tamburello, Adriana / Marando, Marco

    Swiss Med Wkly

    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #133420
    Datenquelle COVID19

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  3. Artikel ; Online: Immunoglobulins or convalescent plasma to tackle COVID-19

    Marando, Marco / Tamburello, Adriana

    Swiss Medical Weekly ; ISSN 1424-3997

    buying time to save lives – current situation and perspectives

    2020  

    Schlagwörter General Medicine ; covid19
    Sprache Englisch
    Verlag EMH Swiss Medical Publishers, Ltd.
    Erscheinungsland ch
    Dokumenttyp Artikel ; Online
    DOI 10.4414/smw.2020.20264
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: False-Negative Nasopharyngeal Swab RT-PCR Assays in Typical COVID-19: Role of Ultra-low-dose Chest CT and Bronchoscopy in Diagnosis.

    Marando, Marco / Tamburello, Adriana / Gianella, Pietro

    European journal of case reports in internal medicine

    2020  Band 7, Heft 7, Seite(n) 1680

    Abstract: On 11 March 2020, the WHO declared COVID-19 a pandemic and global health emergency. We describe the clinical features and role of ultra-low-dose chest computed tomography (CT) and bronchoscopy in the diagnosis of coronavirus disease (COVID-19). In our ... ...

    Abstract On 11 March 2020, the WHO declared COVID-19 a pandemic and global health emergency. We describe the clinical features and role of ultra-low-dose chest computed tomography (CT) and bronchoscopy in the diagnosis of coronavirus disease (COVID-19). In our patient, who was highly suggestive clinically and radiologically for COVID-19, we had two false-negative results for nasopharyngeal and oral swab reverse-transcriptase polymerase chain reaction (RT-PCR) assays for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Eventually, we confirmed the diagnosis using bronchoscopy and bronchoalveolar lavage (BAL).
    Learning points: Clinical and laboratory findings in COVID-19 are unspecific.Chest CT has a diagnostic sensitivity comparable to nasopharyngeal swab RT-PCR assay but lacks specificity.RT-PCR assays on biological specimens, particularly nasopharyngeal swabs, are considered the diagnostic gold standard.Bronchoscopy and bronchoalveolar lavage can help confirm the diagnosis and should be performed in patients in whom diagnostic-driven treatment for COVID-19, such as tocilizumab or remdesivir, is being considered.
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-04-24
    Erscheinungsland Italy
    Dokumenttyp Journal Article
    ISSN 2284-2594
    ISSN (online) 2284-2594
    DOI 10.12890/2020_001680
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: COVID-19 and Pulmonary Embolism: Not a Coincidence.

    Tamburello, Adriana / Bruno, Giovanni / Marando, Marco

    European journal of case reports in internal medicine

    2020  Band 7, Heft 6, Seite(n) 1692

    Abstract: In December 2019, a novel coronavirus called SARS-CoV-2 was reported to be responsible for a cluster of acute atypical respiratory pneumonia cases in Wuhan, in Hubei province, China. The disease caused by this virus is called COVID-19 (coronavirus ... ...

    Abstract In December 2019, a novel coronavirus called SARS-CoV-2 was reported to be responsible for a cluster of acute atypical respiratory pneumonia cases in Wuhan, in Hubei province, China. The disease caused by this virus is called COVID-19 (coronavirus disease 2019). The virus is transmitted between humans and the outbreak was declared a pandemic by the World Health Organization (WHO) on 11 March 2020. Coagulopathy is a common abnormality in patients with COVID-19 due to inflammation, hypoxia, immobilisation, endothelial damage and diffuse intravascular coagulation. However, the data on this topic are still limited. Here we report the case of a man presenting with pneumonia complicated by bilateral pulmonary embolism.
    Learning points: SARS-CoV-2 is a novel infectious agent that causes COVID-19, which can manifest in several ways, affecting endothelial cells and most organs.There is growing evidence that SARS-CoV-2-mediated endothelial damage is due to direct viral injury and the systemic inflammatory response, possibly together with a cytokine storm.As endothelial damage can manifest as thromboembolic disease, such as pulmonary thromboembolism, appropriate anti-thrombotic preventive strategies should be followed, and proper screening and treatment for thromboembolic complications should be implemented.
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-05-04
    Erscheinungsland Italy
    Dokumenttyp Journal Article
    ISSN 2284-2594
    ISSN (online) 2284-2594
    DOI 10.12890/2020_001692
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Diagnostic sensitivity of RT-PCR assays on nasopharyngeal specimens for detection of SARS-CoV-2 infection: A Systematic Review and Meta-Analysis.

    Marando, Marco / Tamburello, Adriana / Gianella, Pietro / Taylor, Rebecca / Bernasconi, Enos / Fusi-Schmidhauser, Tanja

    Caspian journal of internal medicine

    2022  Band 13, Heft Suppl 3, Seite(n) 139–147

    Abstract: Background: Reverse transcription polymerase chain reaction (RT-PCR) is the current standard of reference in the diagnosis of SARS-CoV-2 infection. In outpatient clinical practice, nasopharyngeal swab RT-PCR testing is still the most common procedure. ... ...

    Abstract Background: Reverse transcription polymerase chain reaction (RT-PCR) is the current standard of reference in the diagnosis of SARS-CoV-2 infection. In outpatient clinical practice, nasopharyngeal swab RT-PCR testing is still the most common procedure. The purpose of this systematic review and meta-analysis was to evaluate the sensitivity of RT-PCR nasopharyngeal assays.
    Methods: We searched three databases, including PubMed/MEDLINE, EMBASE, and Cochrane Library, using a comprehensive strategy. Studies investigating the sensitivity of SARS-CoV-2 RT-PCR nasopharyngeal assays in adults were included. Two reviewers extracted data and assessed trial quality independently. Pooled sensitivity and its confidence interval were computed using the meta package in R.
    Results: Thirteen studies were found eligible for the inclusion in the systematic review. Out of these, 25 different sub-studies were identified and included in the meta-analysis, which reported the sensitivities of 25 different nasopharyngeal RT-PCR assays. Finally, the overall pooled sensitivity resulted 89% (95% CI, 85.4 to 91.8%).
    Conclusion: Our study suggests that RT-PCR assays on nasopharyngeal specimens have a substantial sensitivity for diagnosing SARS-CoV-2 infection.
    Sprache Englisch
    Erscheinungsdatum 2022-07-14
    Erscheinungsland Iran
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2971933-1
    ISSN 2008-6172 ; 2008-6164
    ISSN (online) 2008-6172
    ISSN 2008-6164
    DOI 10.22088/cjim.13.0.139
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: COVID-19 and Pulmonary Embolism

    Adriana Tamburello / Giovanni Bruno / Marco Marando

    European Journal of Case Reports in Internal Medicine (2020)

    Not a Coincidence

    2020  

    Abstract: In December 2019, a novel coronavirus called SARS-CoV-2 was reported to be responsible for a cluster of acute atypical respiratory pneumonia cases in Wuhan, in Hubei province, China. The disease caused by this virus is called COVID-19 (coronavirus ... ...

    Abstract In December 2019, a novel coronavirus called SARS-CoV-2 was reported to be responsible for a cluster of acute atypical respiratory pneumonia cases in Wuhan, in Hubei province, China. The disease caused by this virus is called COVID-19 (coronavirus disease 2019). The virus is transmitted between humans and the outbreak was declared a pandemic by the World Health Organization (WHO) on 11 March 2020. Coagulopathy is a common abnormality in patients with COVID?19 due to inflammation, hypoxia, immobilisation, endothelial damage and diffuse intravascular coagulation. However, the data on this topic are still limited. Here we report the case of a man presenting with pneumonia complicated by bilateral pulmonary embolism.
    Schlagwörter coronavirus ; covid-19 ; sars-cov-2 ; pulmonary embolism ; coagulation abnormalities ; tocilizumab ; Medicine ; R ; covid19
    Sprache Englisch
    Erscheinungsdatum 2020-05-01T00:00:00Z
    Verlag SMC MEDIA SRL
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: False-Negative Nasopharyngeal Swab RT-PCR Assays in Typical COVID-19

    Marco Marando / Adriana Tamburello / Pietro Gianella

    European Journal of Case Reports in Internal Medicine (2020)

    Role of Ultra-low-dose Chest CT and Bronchoscopy in Diagnosis

    2020  

    Abstract: On 11 March 2020, the WHO declared COVID-19 a pandemic and global health emergency. We describe the clinical features and role of ultra-low-dose chest computed tomography (CT) and bronchoscopy in the diagnosis of coronavirus disease (COVID-19). In our ... ...

    Abstract On 11 March 2020, the WHO declared COVID-19 a pandemic and global health emergency. We describe the clinical features and role of ultra-low-dose chest computed tomography (CT) and bronchoscopy in the diagnosis of coronavirus disease (COVID-19). In our patient, who was highly suggestive clinically and radiologically for COVID-19, we had two false-negative results for nasopharyngeal and oral swab reverse-transcriptase polymerase chain reaction (RT-PCR) assays for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Eventually, we confirmed the diagnosis using bronchoscopy and bronchoalveolar lavage (BAL).
    Schlagwörter coronavirus ; covid-19 ; rt-pcr ; ultra-low-dose chest ct ; bronchoscopy ; Medicine ; R ; covid19
    Sprache Englisch
    Erscheinungsdatum 2020-04-01T00:00:00Z
    Verlag SMC MEDIA SRL
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Diagnostic sensitivity of RT-PCR assays on nasopharyngeal specimens for detection of SARS-CoV-2 infection

    Marco Marando / Adriana Tamburello / Pietro Gianella / Rebecca Taylor / Enos Bernasconi / Tanja Fusi-Schmidhauser

    Caspian Journal of Internal Medicine, Vol 13, Iss Covid 19 Supplement 2, Pp 139-

    A Systematic Review and Meta-Analysis

    2022  Band 147

    Abstract: Background: Reverse transcription polymerase chain reaction (RT-PCR) is the current standard of reference in the diagnosis of SARS-CoV-2 infection. In outpatient clinical practice, nasopharyngeal swab RT-PCR testing is still the most common procedure. ... ...

    Abstract Background: Reverse transcription polymerase chain reaction (RT-PCR) is the current standard of reference in the diagnosis of SARS-CoV-2 infection. In outpatient clinical practice, nasopharyngeal swab RT-PCR testing is still the most common procedure. The purpose of this systematic review and meta-analysis was to evaluate the sensitivity of RT-PCR nasopharyngeal assays. Methods: We searched three databases, including PubMed/MEDLINE, EMBASE, and Cochrane Library, using a comprehensive strategy. Studies investigating the sensitivity of SARS-CoV-2 RT-PCR nasopharyngeal assays in adults were included. Two reviewers extracted data and assessed trial quality independently. Pooled sensitivity and its confidence interval were computed using the meta package in R. Results: Thirteen studies were found eligible for the inclusion in the systematic review. Out of these, 25 different sub-studies were identified and included in the meta-analysis, which reported the sensitivities of 25 different nasopharyngeal RT-PCR assays. Finally, the overall pooled sensitivity resulted 89% (95% CI, 85.4 to 91.8%). Conclusion: Our study suggests that RT-PCR assays on nasopharyngeal specimens have a substantial sensitivity for diagnosing SARS-CoV-2 infection.
    Schlagwörter nasopharyngeal swabs ; sars-cov-2 ; rt-pcr assay ; diagnostic yield ; Internal medicine ; RC31-1245
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-01-01T00:00:00Z
    Verlag Babol University of Medical Sciences
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel: Viewpoint: "Alcohol Consumption in Late Adolescence is Associated with an Increased Risk of Severe Liver Disease Later in Life".

    Tamburello, Adriana / Marando, Marco / Bellentani, Stefano

    Annals of hepatology

    2018  Band 17, Heft 3, Seite(n) 343–344

    Abstract: Drinking alcohol during adolescence predispose to severe liver disease in the adult phase. This is the main message of this prospective study. Each daily gram of alcohol men consumed in their youth was linked with a two percent increase in the risk of ... ...

    Abstract Drinking alcohol during adolescence predispose to severe liver disease in the adult phase. This is the main message of this prospective study. Each daily gram of alcohol men consumed in their youth was linked with a two percent increase in the risk of severe liver disease. No threshold level emerged for liver damage and this is a warning for all the sociologists and politics. New legiferation and educational campaigns addressed to young people, with particular attention to the access to alcohol, prices and advertising are necessary.
    Mesh-Begriff(e) Adolescent ; Adult ; Alcohol Drinking ; Humans ; Liver Diseases ; Male ; Prospective Studies
    Sprache Englisch
    Erscheinungsdatum 2018-04-09
    Erscheinungsland Mexico
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 2188733-0
    ISSN 1665-2681
    ISSN 1665-2681
    DOI 10.5604/01.3001.0011.7379
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

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