Artikel ; Online: Histomorphological patterns of regional lymph nodes in COVID-19 lungs.
2021 Band 42, Heft Suppl 1, Seite(n) 89–97
Abstract: Background: A dysregulated immune response is considered one of the major factors leading to severe COVID-19. Previously described mechanisms include the development of a cytokine storm, missing immunoglobulin class switch, antibody-mediated enhancement, ...
Titelübersetzung | Reaktionsmuster der lokoregionären Lymphknoten im Abflussgebiet von COVID-19-Lungen. |
---|---|
Abstract | Background: A dysregulated immune response is considered one of the major factors leading to severe COVID-19. Previously described mechanisms include the development of a cytokine storm, missing immunoglobulin class switch, antibody-mediated enhancement, and aberrant antigen presentation. Objectives: To understand the heterogeneity of immune response in COVID-19, a thorough investigation of histomorphological patterns in regional lymph nodes was performed. Materials and methods: Lymph nodes from the cervical, mediastinal, and hilar regions were extracted from autopsies of patients with lethal COVID-19 (n = 20). Histomorphological characteristics, SARS-CoV‑2 qRT-PCR, and gene expression profiling on common genes involved in immunologic response were analyzed. Results: Lymph nodes displayed moderate to severe capillary stasis and edema, an increased presence of extrafollicular plasmablasts, mild to moderate plasmacytosis, a dominant population of CD8 Conclusions: Taken together, our findings imply a dysregulated immune response in lethal COVID-19. The absence/hypoplasia of germinal centers and increased presence of plasmablasts implies a transient B‑cell response, implying an impaired development of long-term immunity against SARS-CoV‑2 in such occasions. |
Mesh-Begriff(e) | CD8-Positive T-Lymphocytes ; COVID-19 ; Humans ; Lung ; Lymph Nodes ; SARS-CoV-2 |
Sprache | Englisch |
Erscheinungsdatum | 2021-05-05 |
Erscheinungsland | Germany |
Dokumenttyp | Journal Article |
ZDB-ID | 135954-x |
ISSN | 1432-1963 ; 0172-8113 |
ISSN (online) | 1432-1963 |
ISSN | 0172-8113 |
DOI | 10.1007/s00292-021-00945-6 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
Volltext online
Zusatzmaterialien
Kategorien
Verfügbar in ZB MED Köln/Königswinter
Zs.A 1543: Hefte anzeigen | Standort: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
Über subito bestellen
Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.