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Artikel: Exploring post-SEPSIS and post-COVID-19 syndromes: crossovers from pathophysiology to therapeutic approach.

Holmes, Darcy / Colaneri, Marta / Palomba, Emanuele / Gori, Andrea

2024 Band 10, Seite(n) 1280951

Abstract: Sepsis, driven by several infections, including COVID-19, can lead to post-sepsis syndrome (PSS) and post-acute sequelae of COVID-19 (PASC). Both these conditions share clinical and pathophysiological similarities, as survivors face persistent multi- ... ...

Abstract	Sepsis, driven by several infections, including COVID-19, can lead to post-sepsis syndrome (PSS) and post-acute sequelae of COVID-19 (PASC). Both these conditions share clinical and pathophysiological similarities, as survivors face persistent multi-organ dysfunctions, including respiratory, cardiovascular, renal, and neurological issues. Moreover, dysregulated immune responses, immunosuppression, and hyperinflammation contribute to these conditions. The lack of clear definitions and diagnostic criteria hampers comprehensive treatment strategies, and a unified therapeutic approach is significantly needed. One potential target might be the renin-angiotensin system (RAS), which plays a significant role in immune modulation. In fact, RAS imbalance can exacerbate these responses. Potential interventions involving RAS include ACE inhibitors, ACE receptor blockers, and recombinant human ACE2 (rhACE2). To address the complexities of PSS and PASC, a multifaceted approach is required, considering shared immunological mechanisms and the role of RAS. Standardization, research funding, and clinical trials are essential for advancing treatment strategies for these conditions.
Sprache	Englisch
Erscheinungsdatum	2024-01-05
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Review
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2023.1280951
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Post-exposure prophylaxis, STI testing and factors associated with follow-up attendance: a review of 4159 cases of acute post-sexual assault medical care.

Kane, Daniel / Holmes, Andrea / Eogan, Maeve

Sexually transmitted infections

2024 Band 100, Heft 1, Seite(n) 39–44

Abstract: Background: Sexual assault (SA) is a prevalent issue with enduring consequences. Post-SA medical care mainly focuses on injuries, sexually transmitted infection (STI) prevention and detection, as well as preventing unwanted pregnancies. Swift access to ... ...

Abstract	Background: Sexual assault (SA) is a prevalent issue with enduring consequences. Post-SA medical care mainly focuses on injuries, sexually transmitted infection (STI) prevention and detection, as well as preventing unwanted pregnancies. Swift access to post-SA medical care is vital with sexual assault treatment units (SATUs) streamlining this care. The primary aim of our study is to report on post-SA care provided at the national SATU network in Ireland with a secondary aim of analysing factors associated with follow-up attendance for STI testing. Methods: This is a retrospective cohort study of all acute attendances (<7 days from incident) at the national SATU network between 1 January 2017 to 31 December 2022. Results: A total of 4159 acute cases presented during the study period. Emergency contraception (EC) was administered to 53.8% (n=1899/3529) of cases, while postexposure prophylaxis (PEP) for chlamydia was given in 75.1% (n=3124/4159) and for HIV in 11.0% (n=304/3387). Hepatitis B vaccination was initiated in 53.7% (n=2233/4159) of cases. 1.4% (n=59/4159) of the attendees were referred to an emergency department for the treatment of injuries. Follow-up appointments were scheduled for 75.8% (3151/4159) of acute cases. 71.6% (n=2257/3151) attended follow-up.Certain factors were found to correlate with a higher likelihood of attending follow-up appointments: adolescents (p<0.0001), concern about drug-facilitated SA (DFSA) (p=0.01), no consumption of recreational drugs before the incident (p<0.0001), alcohol consumption prior to the incident (p=0.01), and not reporting the crime to the police (p<0.001). However, gender (p=0.06) and the presence of injury at time of primary attendance (p=0.97) were not predictive of likelihood of follow-up attendance. Conclusion: This study demonstrates that EC, chlamydia PEP, HIV PEP and hepatitis B vaccination were all administered at SATU. A small proportion of attenders required emergency injury care. Factors influencing attendance at follow-up include age, drug use, alcohol use and police involvement, highlighting the need for tailored patient-centred support.
Mesh-Begriff(e)	Pregnancy ; Female ; Adolescent ; Humans ; Retrospective Studies ; Follow-Up Studies ; Post-Exposure Prophylaxis ; Sexually Transmitted Diseases/diagnosis ; Sexually Transmitted Diseases/epidemiology ; Sexually Transmitted Diseases/prevention & control ; Sex Offenses ; HIV Infections/diagnosis ; HIV Infections/epidemiology ; HIV Infections/prevention & control ; Hepatitis B/diagnosis ; Hepatitis B/epidemiology ; Hepatitis B/prevention & control
Sprache	Englisch
Erscheinungsdatum	2024-01-17
Erscheinungsland	England
Dokumenttyp	Review ; Journal Article
ZDB-ID	1420303-0
ISSN	1472-3263 ; 1368-4973
ISSN (online)	1472-3263
ISSN	1368-4973
DOI	10.1136/sextrans-2023-055980
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Carbapenem or new β-lactam-β-lactamase inhibitors? An Italian survey supported by SITA, SIMIT and SIAARTI to identify the factors affecting empiric antimicrobial therapy choice in real-life clinical practice.

Colaneri, Marta / Genovese, Camilla / Lombardi, Andrea / Holmes, Darcy / Bandera, Alessandra / Gori, Andrea

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

2024

Abstract: While a tailored antibiotic treatment plan is often straightforward, what we often observe in daily clinical practice is a highly variable approach when defining empirical therapy. Specifically, a debate exists on preference to spare the new β-lactams ... ...

Abstract	While a tailored antibiotic treatment plan is often straightforward, what we often observe in daily clinical practice is a highly variable approach when defining empirical therapy. Specifically, a debate exists on preference to spare the new β-lactams and β-lactamase inhibitors (BL-BLIs) or to apply a carbapenem-sparing strategy first. To investigate, we designed a web survey aimed at investigating the variables considered relevant to empirically choosing one antibiotic over the other. Submitted to Italian infectious diseases and intensive care physicians through the support of Società Italiana di Malattie Infettive e Tropicali (SIMIT), Società Italiana di Terapia Antinfettiva (SITA) and Società Italiana Anestesia, Analgesia, Rianimazione e Terapia Intensiva (SIAARTI). We found that demographic characteristics were irrelevant when deciding for empirical therapy. Clinical and anamnestic data were most meaningful. Significantly considered were underlying comorbidities and previous exposure to antimicrobial treatments. History of third-generation cephalosporin-resistant, carbapenem-resistant and/or metallo-β-lactamase-producing Enterobacterales rectal colonisation and/or infection were considered the most relevant by most physicians. Unexpectedly, clinicians considered less the source of infection. These results prompt the need of straightforward methods to retrieve medical histories and the magnitude of rectal colonisation data, often not routinely obtained.
Sprache	Englisch
Erscheinungsdatum	2024-03-08
Erscheinungsland	Germany
Dokumenttyp	Journal Article
ZDB-ID	603155-9
ISSN	1435-4373 ; 0934-9723 ; 0722-2211
ISSN (online)	1435-4373
ISSN	0934-9723 ; 0722-2211
DOI	10.1007/s10096-024-04798-8
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Exploring post-SEPSIS and post-COVID-19 syndromes

Darcy Holmes / Marta Colaneri / Emanuele Palomba / Andrea Gori

Frontiers in Medicine, Vol

crossovers from pathophysiology to therapeutic approach

2024 Band 10

Abstract	Sepsis, driven by several infections, including COVID-19, can lead to post-sepsis syndrome (PSS) and post-acute sequelae of COVID-19 (PASC). Both these conditions share clinical and pathophysiological similarities, as survivors face persistent multi-organ dysfunctions, including respiratory, cardiovascular, renal, and neurological issues. Moreover, dysregulated immune responses, immunosuppression, and hyperinflammation contribute to these conditions. The lack of clear definitions and diagnostic criteria hampers comprehensive treatment strategies, and a unified therapeutic approach is significantly needed. One potential target might be the renin-angiotensin system (RAS), which plays a significant role in immune modulation. In fact, RAS imbalance can exacerbate these responses. Potential interventions involving RAS include ACE inhibitors, ACE receptor blockers, and recombinant human ACE2 (rhACE2). To address the complexities of PSS and PASC, a multifaceted approach is required, considering shared immunological mechanisms and the role of RAS. Standardization, research funding, and clinical trials are essential for advancing treatment strategies for these conditions.
Schlagwörter	post-sepsis syndrome (PSS) ; post-acute sequelae of COVID-19 (PASC) ; immune dysfunction ; renin-angiotensin system (RAS) ; angiotensin-converting enzyme 2 (ACE2) ; Medicine (General) ; R5-920
Thema/Rubrik (Code)	610
Sprache	Englisch
Erscheinungsdatum	2024-01-01T00:00:00Z
Verlag	Frontiers Media S.A.
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel ; Online: Soil salinization and chemically mediated plant-insect interactions in a changing climate.

Marroquin, Andrea / Holmes, Katherine / Salazar, Diego

Current opinion in insect science

2023 Band 60, Seite(n) 101130

Abstract: Increase in soil salinization due to climate change is a global phenomenon that can induce significant changes in plant growth, physiology, and chemistry, exacerbating growing threats to insect biodiversity. Insects that rely on plants are likely to be ... ...

Abstract	Increase in soil salinization due to climate change is a global phenomenon that can induce significant changes in plant growth, physiology, and chemistry, exacerbating growing threats to insect biodiversity. Insects that rely on plants are likely to be indirectly impacted by changes in soil salt content through changes in plant chemistry, yet few studies link changes in plant metabolism to impacts on higher trophic levels. Some salinity-mediated changes in specialized metabolites may be predictable due to highly conserved metabolic pathways shared between herbivore defense and stress resistance, but recent studies also suggest substantial variation across plant species and habitats. To date, most of the research on salinity and chemically mediated plant-insect interactions has focused on herbivores, particularly in agricultural systems. Published effects of salinity on pollinators and parasitoids are scarce. Future research will need to focus more on the role of plant chemistry to bridge the divide between studies of plant and insect responses to salinization.
Mesh-Begriff(e)	Animals ; Soil ; Insecta/physiology ; Ecosystem ; Herbivory/physiology ; Plants/chemistry ; Climate Change
Chemische Substanzen	Soil
Sprache	Englisch
Erscheinungsdatum	2023-10-13
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article ; Review
ZDB-ID	2772833-X
ISSN	2214-5753 ; 2214-5745
ISSN (online)	2214-5753
ISSN	2214-5745
DOI	10.1016/j.cois.2023.101130
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: An integrative conceptual review of multiperspective frameworks in personality research and a roadmap for extended applications in organizational psychology.

Smith, Mickey B / Wu, I-Heng Ray / Holmes, R Michael / Hodge, Andréa M

The Journal of applied psychology

2024

Abstract: Multiperspective frameworks, such as the social relations model, socioanalytic theory, the realistic accuracy model, the self-other knowledge asymmetry model, and the trait-reputation-identity model, have advanced understanding of personality over the ... ...

Abstract	Multiperspective frameworks, such as the social relations model, socioanalytic theory, the realistic accuracy model, the self-other knowledge asymmetry model, and the trait-reputation-identity model, have advanced understanding of personality over the last 40 years. Due to a resurgence of interest in multiperspective research on personality and other constructs in organizational psychology, we conducted an integrative conceptual review of these specific multirater frameworks and their application in work settings. Our review identifies similarities and differences in these frameworks and suggests that they collectively represent an invaluable resource for personality researchers and the broader field of organizational psychology. Through our review, we distinguish multiperspective frameworks from similar approaches (e.g., multirater designs), track the evolution of these frameworks, and leverage current applications of these frameworks to craft a future research agenda. Our review serves as a roadmap to help scholars apply multiperspective logic more thoroughly and systematically in personality research and beyond. We close with a discussion of practical implications. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
Sprache	Englisch
Erscheinungsdatum	2024-04-15
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	219157-x
ISSN	1939-1854 ; 0021-9010
ISSN (online)	1939-1854
ISSN	0021-9010
DOI	10.1037/apl0001195
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Geospatial Management and Analysis of Microstructural Data from San Andreas Fault Observatory at Depth (SAFOD) Core Samples

Holmes, Elliott M / Gaughan, Andrea E / Biddle, Donald J / Stevens, Forrest R / Hadizadeh, Jafar

ISPRS international journal of geo-information. 2021 May 14, v. 10, no. 5

2021

Abstract: ... remote sensing techniques to the data. Using 26 core billet samples from the San Andreas Fault Observatory ...

Abstract	Core samples obtained from scientific drilling could provide large volumes of direct microstructural and compositional data, but generating results via the traditional treatment of such data is often time-consuming and inefficient. Unifying microstructural data within a spatially referenced Geographic Information System (GIS) environment provides an opportunity to readily locate, visualize, correlate, and apply remote sensing techniques to the data. Using 26 core billet samples from the San Andreas Fault Observatory at Depth (SAFOD), this study developed GIS-based procedures for: 1. Spatially referenced visualization and storage of various microstructural data from core billets; 2. 3D modeling of billets and thin section positions within each billet, which serve as a digital record after irreversible fragmentation of the physical billets; and 3. Vector feature creation and unsupervised classification of a multi-generation calcite vein network from cathodluminescence (CL) imagery. Building on existing work which is predominantly limited to the 2D space of single thin sections, our results indicate that a GIS can facilitate spatial treatment of data even at centimeter to nanometer scales, but also revealed challenges involving intensive 3D representations and complex matrix transformations required to create geographically translated forms of the within-billet coordinate systems, which are suggested for consideration in future studies.
Schlagwörter	calcite ; geographic information systems ; spatial data
Sprache	Englisch
Erscheinungsverlauf	2021-0514
Erscheinungsort	Multidisciplinary Digital Publishing Institute
Dokumenttyp	Artikel
Anmerkung	NAL-AP-2-clean
ZDB-ID	2655790-3
ISSN	2220-9964
ISSN	2220-9964
DOI	10.3390/ijgi10050332
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel: Resistance Training Recommendations for Children and Adolescents With Cystic Fibrosis-Related Diabetes.

Holmes, Clifton J / Granados, Andrea

Strength and conditioning journal

2021 Band 44, Heft 1, Seite(n) 111–118

Abstract: Cystic fibrosis (CF) is the most prevalent hereditary life-threatening disease in the Caucasian population. With the improvement in clinical care, individuals with CF are living longer, and CF-related diabetes (CFRD) has emerged as a major complication. ... ...

Abstract	Cystic fibrosis (CF) is the most prevalent hereditary life-threatening disease in the Caucasian population. With the improvement in clinical care, individuals with CF are living longer, and CF-related diabetes (CFRD) has emerged as a major complication. The diagnosis of CFRD is associated with shortening survival, increasing morbidity, worsening physical capacity, and body composition. Engagement in exercise training has become a prominent nonpharmacologic intervention that aims to improve fitness and clinical outcomes in individuals with CF and CFRD. This column will specifically focus on the potential benefits of resistance training and provide recommendations for children and adolescents with CF and CFRD.
Sprache	Englisch
Erscheinungsdatum	2021-04-27
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	2095938-2
ISSN	1533-4295 ; 1524-1602
ISSN (online)	1533-4295
ISSN	1524-1602
DOI	10.1519/ssc.0000000000000641
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: The influence of jaw-muscle fibre-type phenotypes on estimating maximum muscle and bite forces in primates.

Holmes, Megan / Taylor, Andrea B

Interface focus

2021 Band 11, Heft 5, Seite(n) 20210009

Abstract: Numerous anthropological studies have been aimed at estimating jaw-adductor muscle forces, which, in turn, are used to estimate bite force. While primate jaw adductors show considerable intra- and intermuscular heterogeneity in fibre types, studies ... ...

Abstract	Numerous anthropological studies have been aimed at estimating jaw-adductor muscle forces, which, in turn, are used to estimate bite force. While primate jaw adductors show considerable intra- and intermuscular heterogeneity in fibre types, studies generally model jaw-muscle forces by treating the jaw adductors as either homogeneously slow or homogeneously fast muscles. Here, we provide a novel extension of such studies by integrating fibre architecture, fibre types and fibre-specific tensions to estimate maximum muscle forces in the masseter and temporalis of five anthropoid primates:
Sprache	Englisch
Erscheinungsdatum	2021-08-13
Erscheinungsland	England
Dokumenttyp	Journal Article
ISSN	2042-8898
ISSN	2042-8898
DOI	10.1098/rsfs.2021.0009
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Geospatial Management and Analysis of Microstructural Data from San Andreas Fault Observatory at Depth (SAFOD) Core Samples

Elliott M. Holmes / Andrea E. Gaughan / Donald J. Biddle / Forrest R. Stevens / Jafar Hadizadeh

ISPRS International Journal of Geo-Information, Vol 10, Iss 332, p

2021 Band 332

Abstract: ... remote sensing techniques to the data. Using 26 core billet samples from the San Andreas Fault Observatory ...

Abstract	Core samples obtained from scientific drilling could provide large volumes of direct microstructural and compositional data, but generating results via the traditional treatment of such data is often time-consuming and inefficient. Unifying microstructural data within a spatially referenced Geographic Information System (GIS) environment provides an opportunity to readily locate, visualize, correlate, and apply remote sensing techniques to the data. Using 26 core billet samples from the San Andreas Fault Observatory at Depth (SAFOD), this study developed GIS-based procedures for: 1. Spatially referenced visualization and storage of various microstructural data from core billets; 2. 3D modeling of billets and thin section positions within each billet, which serve as a digital record after irreversible fragmentation of the physical billets; and 3. Vector feature creation and unsupervised classification of a multi-generation calcite vein network from cathodluminescence (CL) imagery. Building on existing work which is predominantly limited to the 2D space of single thin sections, our results indicate that a GIS can facilitate spatial treatment of data even at centimeter to nanometer scales, but also revealed challenges involving intensive 3D representations and complex matrix transformations required to create geographically translated forms of the within-billet coordinate systems, which are suggested for consideration in future studies.
Schlagwörter	Geographic Information Systems (GIS) ; remote sensing ; structural geology ; 3D visualization ; spatial analyses ; Geography (General) ; G1-922
Thema/Rubrik (Code)	910
Sprache	Englisch
Erscheinungsdatum	2021-05-01T00:00:00Z
Verlag	MDPI AG
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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