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  1. Artikel: A cost-benefit framework for prosocial motivation-Advantages and challenges.

    Contreras-Huerta, Luis Sebastian

    Frontiers in psychiatry

    2023  Band 14, Seite(n) 1170150

    Sprache Englisch
    Erscheinungsdatum 2023-03-24
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2023.1170150
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Risking further COVID-19 waves despite vaccination.

    Contreras, Sebastian / Priesemann, Viola

    The Lancet. Infectious diseases

    2021  Band 21, Heft 6, Seite(n) 745–746

    Mesh-Begriff(e) COVID-19 ; Humans ; SARS-CoV-2 ; Vaccination
    Sprache Englisch
    Erscheinungsdatum 2021-03-18
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(21)00167-5
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Describing a landscape we are yet discovering.

    Contreras, Sebastian / Dehning, Jonas / Priesemann, Viola

    Advances in statistical analysis : AStA : a journal of the German Statistical Society

    2022  Band 106, Heft 3, Seite(n) 399–402

    Sprache Englisch
    Erscheinungsdatum 2022-06-09
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2276384-3
    ISSN 1863-818X ; 1863-8171
    ISSN (online) 1863-818X
    ISSN 1863-8171
    DOI 10.1007/s10182-022-00449-5
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Overexpression of REST Represses the Epithelial-Mesenchymal Transition Process and Decreases the Aggressiveness of Prostate Cancer Cells.

    Indo, Sebastián / Orellana-Serradell, Octavio / Torres, María José / Castellón, Enrique A / Contreras, Héctor R

    International journal of molecular sciences

    2024  Band 25, Heft 6

    Abstract: The RE-1 silencing transcription factor (REST) is a repressor factor related to neuroendocrine prostate cancer (PCa) (NEPC), a poor prognostic stage mainly associated with castration-resistant PCa (CRPC). NEPC is associated with cell transdifferentiation ...

    Abstract The RE-1 silencing transcription factor (REST) is a repressor factor related to neuroendocrine prostate cancer (PCa) (NEPC), a poor prognostic stage mainly associated with castration-resistant PCa (CRPC). NEPC is associated with cell transdifferentiation and the epithelial-mesenchymal transition (EMT) in cells undergoing androgen deprivation therapy (ADT) and enzalutamide (ENZ). The effect of REST overexpression in the 22rv1 cell line (xenograft-derived prostate cancer) on EMT, migration, invasion, and the viability for ENZ was evaluated. EMT genes, Twist and Zeb1, and the androgen receptor (AR) were evaluated through an RT-qPCR and Western blot in nuclear and cytosolic fractions of REST-overexpressing 22rv1 cells (22rv1-REST). The migratory and invasive capacities of 22rv1-REST cells were evaluated via Transwell
    Mesh-Begriff(e) Male ; Humans ; Prostatic Neoplasms/metabolism ; Androgen Antagonists ; Transcription Factors ; Cell Line, Tumor ; Receptors, Androgen/metabolism ; Epithelial-Mesenchymal Transition/genetics ; Prostatic Neoplasms, Castration-Resistant/pathology ; Benzamides ; Nitriles ; Phenylthiohydantoin
    Chemische Substanzen enzalutamide (93T0T9GKNU) ; Androgen Antagonists ; Transcription Factors ; Receptors, Androgen ; Benzamides ; Nitriles ; Phenylthiohydantoin (2010-15-3)
    Sprache Englisch
    Erscheinungsdatum 2024-03-15
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25063332
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Cancer Stemness/Epithelial-Mesenchymal Transition Axis Influences Metastasis and Castration Resistance in Prostate Cancer: Potential Therapeutic Target.

    Castellón, Enrique A / Indo, Sebastián / Contreras, Héctor R

    International journal of molecular sciences

    2022  Band 23, Heft 23

    Abstract: Prostate cancer (PCa) is a leading cause of cancer death in men, worldwide. Mortality is highly related to metastasis and hormone resistance, but the molecular underlying mechanisms are poorly understood. We have studied the presence and role of cancer ... ...

    Abstract Prostate cancer (PCa) is a leading cause of cancer death in men, worldwide. Mortality is highly related to metastasis and hormone resistance, but the molecular underlying mechanisms are poorly understood. We have studied the presence and role of cancer stem cells (CSCs) and the Epithelial-Mesenchymal transition (EMT) in PCa, using both in vitro and in vivo models, thereby providing evidence that the stemness-mesenchymal axis seems to be a critical process related to relapse, metastasis and resistance. These are complex and related processes that involve a cooperative action of different cancer cell subpopulations, in which CSCs and mesenchymal cancer cells (MCCs) would be responsible for invading, colonizing pre-metastatic niches, initiating metastasis and an evading treatments response. Manipulating the stemness-EMT axis genes on the androgen receptor (AR) may shed some light on the effect of this axis on metastasis and castration resistance in PCa. It is suggested that the EMT gene SNAI2/Slug up regulates the stemness gene Sox2, and vice versa, inducing AR expression, promoting metastasis and castration resistance. This approach will provide new sight about the role of the stemness-mesenchymal axis in the metastasis and resistance mechanisms in PCa and their potential control, contributing to develop new therapeutic strategies for patients with metastatic and castration-resistant PCa.
    Sprache Englisch
    Erscheinungsdatum 2022-11-29
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232314917
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Cancer Stemness/Epithelial–Mesenchymal Transition Axis Influences Metastasis and Castration Resistance in Prostate Cancer

    Enrique A. Castellón / Sebastián Indo / Héctor R. Contreras

    International Journal of Molecular Sciences, Vol 23, Iss 14917, p

    Potential Therapeutic Target

    2022  Band 14917

    Abstract: Prostate cancer (PCa) is a leading cause of cancer death in men, worldwide. Mortality is highly related to metastasis and hormone resistance, but the molecular underlying mechanisms are poorly understood. We have studied the presence and role of cancer ... ...

    Abstract Prostate cancer (PCa) is a leading cause of cancer death in men, worldwide. Mortality is highly related to metastasis and hormone resistance, but the molecular underlying mechanisms are poorly understood. We have studied the presence and role of cancer stem cells (CSCs) and the Epithelial–Mesenchymal transition (EMT) in PCa, using both in vitro and in vivo models, thereby providing evidence that the stemness–mesenchymal axis seems to be a critical process related to relapse, metastasis and resistance. These are complex and related processes that involve a cooperative action of different cancer cell subpopulations, in which CSCs and mesenchymal cancer cells (MCCs) would be responsible for invading, colonizing pre-metastatic niches, initiating metastasis and an evading treatments response. Manipulating the stemness–EMT axis genes on the androgen receptor (AR) may shed some light on the effect of this axis on metastasis and castration resistance in PCa. It is suggested that the EMT gene SNAI2/Slug up regulates the stemness gene Sox2, and vice versa, inducing AR expression, promoting metastasis and castration resistance. This approach will provide new sight about the role of the stemness–mesenchymal axis in the metastasis and resistance mechanisms in PCa and their potential control, contributing to develop new therapeutic strategies for patients with metastatic and castration-resistant PCa.
    Schlagwörter prostate cancer ; Epithelial–Mesenchymal transition ; cancer stem cell ; castration resistance ; metastasis ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-11-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Konferenzbeitrag: 3D-Analyse einer Glenoiddysplasie-Korrektur mit einer augmentierten Basisplatte

    Navas Contreras, Luis Alfredo / Schmidt, Sebastian / Gühring, Thorsten

    2023  , Seite(n) AB67–3135

    Veranstaltung/Kongress Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2023); Berlin; ; Berufsverband für Orthopädie und Unfallchirurgie; 2023
    Schlagwörter Medizin, Gesundheit ; Glenoidbasisplatte ; Schultergelenkpfanne ; Schultergelenkpfannenneigung ; Skapularkerbe ; präoperative Planung ; umgekehrte Schulterarthroplastik
    Erscheinungsdatum 2023-10-23
    Verlag German Medical Science GMS Publishing House; Düsseldorf
    Dokumenttyp Konferenzbeitrag
    DOI 10.3205/23dkou340
    Datenquelle German Medical Science

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  8. Artikel ; Online: Rethinking COVID-19 vaccine allocation: it is time to care about our neighbours.

    Contreras, Sebastian / Olivera-Nappa, Álvaro / Priesemann, Viola

    The Lancet regional health. Europe

    2021  Band 12, Seite(n) 100277

    Sprache Englisch
    Erscheinungsdatum 2021-12-01
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 2666-7762
    ISSN (online) 2666-7762
    DOI 10.1016/j.lanepe.2021.100277
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Rethinking COVID-19 vaccine allocation

    Sebastian Contreras / Álvaro Olivera-Nappa / Viola Priesemann

    The Lancet Regional Health. Europe, Vol 12, Iss , Pp 100277- (2022)

    it is time to care about our neighbours

    2022  

    Schlagwörter Public aspects of medicine ; RA1-1270
    Sprache Englisch
    Erscheinungsdatum 2022-01-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: 2‐D Vp and Vs Models of the Indian Oceanic Crust Adjacent to the NinetyEast Ridge

    Contreras‐Reyes, Eduardo / Obando‐Orrego, Sebastián / Grevemeyer, Ingo

    Journal of Geophysical Research: Solid Earth. 2023 Mar., v. 128, no. 3 p.e2022JB025701-

    2023  

    Abstract: Until now, few offshore seismic studies have acquired simultaneously P‐ and S‐ wave data to derive in detail the seismic structure of the oceanic crust. We present 2‐D Vₚ and Vₛ models using wide‐angle seismic data at the Indian basin adjacent to the ... ...

    Abstract Until now, few offshore seismic studies have acquired simultaneously P‐ and S‐ wave data to derive in detail the seismic structure of the oceanic crust. We present 2‐D Vₚ and Vₛ models using wide‐angle seismic data at the Indian basin adjacent to the NinetyEast Ridge. Here, an outcrop basement located at the middle of the seismic line presents uppermost crustal Poisson's ratios (ν) of 0.28–0.29 (Vₚ ∼ 4.2 km/s and Vₛ ∼ 2.3 km/s). At the flanks of the outcrop basement, the sediment cover is 200–300 m thick and ν values are similar (0.28–0.3), but Vₚ and Vₛ values are higher (4.5–4.8 and 2.4–2.6 km/s, respectively). We interpret the relatively lower Vₚ and Vₛ around the basement outcrop in terms of hydrothermal alteration, while at the flanks of the basement outcrop, hydrothermal alteration has most likely ceased by sedimentation and compaction processes. Across the seismic layer 2, the Vₚ–Vₛ trend is linear and follows a ν value of 0.28–0.29, however, at the seismic layer 2/3 transition, the Vₚ–Vₛ trend abruptly changes following a ν value of 0.25–0.26. These reduced observed ν values at the layer 2/3 transition are lower than those reported by laboratory measurements for gabbro (ν ∼ 0.293) and are interpreted in terms of epidotization at the dike‐gabbro contact and/or crack‐change properties around the lower part of the intrusive sheeted dike section.
    Schlagwörter basins ; geophysics ; research ; sediments
    Sprache Englisch
    Erscheinungsverlauf 2023-03
    Erscheinungsort John Wiley & Sons, Ltd
    Dokumenttyp Artikel ; Online
    Anmerkung JOURNAL ARTICLE
    ISSN 2169-9313
    DOI 10.1029/2022JB025701
    Datenquelle NAL Katalog (AGRICOLA)

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