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  1. Artikel: Complimentary address to Mr Koichi Tanaka, the winner of Nobel Prize in Chemistry 2002.

    Shimizu, Akira

    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

    2003  Band 792, Heft 1, Seite(n) 3–4

    Mesh-Begriff(e) Chemical Phenomena ; Chemistry ; Nobel Prize
    Sprache Englisch
    Erscheinungsdatum 2003-07-14
    Erscheinungsland Netherlands
    Dokumenttyp Address
    ISSN 1570-0232
    ISSN 1570-0232
    DOI 10.1016/s1570-0232(03)00313-1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Buch ; Konferenzbeitrag: Fluorescein angiography; proceedings... edited by Koichi Shimizu

    Shimizu, Kōichi

    1974  

    Titelvarianten Proceedings of the International Symposium on Fluorescein Angiography
    Veranstaltung/Kongress International Symposium on Fluorescein Angiography (1972, Tokyo)
    Mesh-Begriff(e) Eye/diagnostic imaging ; Fluorescein Angiography ; Radiography
    Sprache Englisch
    Umfang xix, 449 p., ill.
    Verlag Igaku Shoin
    Erscheinungsort Tokyo
    Dokumenttyp Buch ; Konferenzbeitrag
    Datenquelle Katalog der US National Library of Medicine (NLM)

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  3. Artikel: Near-Infrared Transillumination for Macroscopic Functional Imaging of Animal Bodies.

    Shimizu, Koichi

    Biology

    2023  Band 12, Heft 11

    Abstract: The classical transillumination technique has been revitalized through recent advancements in optical technology, enhancing its applicability in the realm of biomedical research. With a new perspective on near-axis scattered light, we have harnessed near- ...

    Abstract The classical transillumination technique has been revitalized through recent advancements in optical technology, enhancing its applicability in the realm of biomedical research. With a new perspective on near-axis scattered light, we have harnessed near-infrared (NIR) light to visualize intricate internal light-absorbing structures within animal bodies. By leveraging the principle of differentiation, we have extended the applicability of the Beer-Lambert law even in cases of scattering-dominant media, such as animal body tissues. This approach facilitates the visualization of dynamic physiological changes occurring within animal bodies, thereby enabling noninvasive, real-time imaging of macroscopic functionality in vivo. An important challenge inherent to transillumination imaging lies in the image blur caused by pronounced light scattering within body tissues. By extracting near-axis scattered components from the predominant diffusely scattered light, we have achieved cross-sectional imaging of animal bodies. Furthermore, we have introduced software-based techniques encompassing deconvolution using the point spread function and the application of deep learning principles to counteract the scattering effect. Finally, transillumination imaging has been elevated from two-dimensional to three-dimensional imaging. The effectiveness and applicability of these proposed techniques have been validated through comprehensive simulations and experiments involving human and animal subjects. As demonstrated through these studies, transillumination imaging coupled with emerging technologies offers a promising avenue for future biomedical applications.
    Sprache Englisch
    Erscheinungsdatum 2023-10-24
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology12111362
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Erratum: Optical parameters estimation in inhomogeneous turbid media using backscattered light: for transcutaneous scattering measurement of intravascular blood: erratum.

    Liang, Shiyang / Miyake, Takeo / Shimizu, Koichi

    Biomedical optics express

    2024  Band 15, Heft 2, Seite(n) 910

    Abstract: This corrects the article on p. 237 in vol. 15, PMID: 38223194.]. ...

    Abstract [This corrects the article on p. 237 in vol. 15, PMID: 38223194.].
    Sprache Englisch
    Erscheinungsdatum 2024-01-19
    Erscheinungsland United States
    Dokumenttyp Published Erratum
    ZDB-ID 2572216-5
    ISSN 2156-7085
    ISSN 2156-7085
    DOI 10.1364/BOE.517856
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Optical parameters estimation in inhomogeneous turbid media using backscattered light: for transcutaneous scattering measurement of intravascular blood.

    Liang, Shiyang / Miyake, Takeo / Shimizu, Koichi

    Biomedical optics express

    2023  Band 15, Heft 1, Seite(n) 237–255

    Abstract: In our earlier research, a technique was developed to estimate the effective attenuation coefficient of subcutaneous blood vessels from the skin surface using the spatial distribution of backscattered near-infrared (NIR) light. The scattering effect in ... ...

    Abstract In our earlier research, a technique was developed to estimate the effective attenuation coefficient of subcutaneous blood vessels from the skin surface using the spatial distribution of backscattered near-infrared (NIR) light. The scattering effect in surrounding tissues was suppressed through the application of a differential principle, provided that the
    Sprache Englisch
    Erscheinungsdatum 2023-12-15
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2572216-5
    ISSN 2156-7085
    ISSN 2156-7085
    DOI 10.1364/BOE.510245
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Emerging Insights into the Role of BDNF on Health and Disease in Periphery.

    Ichimura-Shimizu, Mayuko / Kurrey, Khuleshwari / Miyata, Misaki / Dezawa, Takuya / Tsuneyama, Koichi / Kojima, Masami

    Biomolecules

    2024  Band 14, Heft 4

    Abstract: Brain-derived neurotrophic factor (BDNF) is a growth factor that promotes the survival and growth of developing neurons. It also enhances circuit formation to synaptic transmission for mature neurons in the brain. However, reduced BDNF expression and ... ...

    Abstract Brain-derived neurotrophic factor (BDNF) is a growth factor that promotes the survival and growth of developing neurons. It also enhances circuit formation to synaptic transmission for mature neurons in the brain. However, reduced BDNF expression and single nucleotide polymorphisms (SNP) are reported to be associated with functional deficit and disease development in the brain, suggesting that BDNF is a crucial molecule for brain health. Interestingly, BDNF is also expressed in the hypothalamus in appetite and energy metabolism. Previous reports demonstrated that BDNF knockout mice exhibited overeating and obesity phenotypes remarkably. Therefore, we could raise a hypothesis that the loss of function of BDNF may be associated with metabolic syndrome and peripheral diseases. In this review, we describe our recent finding that BDNF knockout mice develop metabolic dysfunction-associated steatohepatitis and recent reports demonstrating the role of one of the BDNF receptors, TrkB-T1, in some peripheral organ functions and diseases, and would provide an insight into the role of BDNF beyond the brain.
    Mesh-Begriff(e) Brain-Derived Neurotrophic Factor/metabolism ; Brain-Derived Neurotrophic Factor/genetics ; Animals ; Humans ; Receptor, trkB/metabolism ; Receptor, trkB/genetics ; Mice ; Mice, Knockout ; Energy Metabolism/genetics ; Obesity/metabolism ; Obesity/genetics ; Polymorphism, Single Nucleotide
    Chemische Substanzen Brain-Derived Neurotrophic Factor ; Receptor, trkB (EC 2.7.10.1) ; BDNF protein, human (7171WSG8A2)
    Sprache Englisch
    Erscheinungsdatum 2024-04-05
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom14040444
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Erratum to: Reoperation Rates of Microendoscopic Discectomy Compared With Conventional Open Lumbar Discectomy: A Large-database Study.

    Masuda, Soichiro / Fukasawa, Toshiki / Takeuchi, Masato / Fujibayashi, Shunsuke / Otsuki, Bungo / Murata, Koichi / Shimizu, Takayoshi / Matsuda, Shuichi / Kawakami, Koji

    Clinical orthopaedics and related research

    2024  Band 482, Heft 3, Seite(n) 569

    Sprache Englisch
    Erscheinungsdatum 2024-02-14
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Published Erratum
    ZDB-ID 80301-7
    ISSN 1528-1132 ; 0009-921X
    ISSN (online) 1528-1132
    ISSN 0009-921X
    DOI 10.1097/CORR.0000000000002982
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Pressure Dynamics on Intervertebral Disc Cages in Transforaminal Lumbar Interbody Fusion: A Cadaver Study.

    Takaki, Yoshiyama / Tanida, Shimei / Murata, Koichi / Shimizu, Takayoshi / Matsuda, Shuichi / Otsuki, Bungo

    World neurosurgery

    2024  

    Abstract: Objective: This study aimed to quantify the change in pressure on the cage during compression manipulation in lumbar interbody fusion. While the procedure involves applying compression between pedicle screws to press the cage against the endplate, the ... ...

    Abstract Objective: This study aimed to quantify the change in pressure on the cage during compression manipulation in lumbar interbody fusion. While the procedure involves applying compression between pedicle screws to press the cage against the endplate, the exact compression force remains elusive. We hypothesize that an intact facet joint might serve as a fulcrum, potentially reducing cage pressure.
    Methods: Pressure on the intervertebral disc cage was measured during compression manipulation in 4 donor cadavers undergoing lumbar interbody fusion. Unilateral facetectomy models with both normal and parallel compression and bilateral facetectomy models were included. A transforaminal lumbar interbody fusion cage with a built-in load cell measured the compression force.
    Results: Pressure data from 14 discs indicated a consistent precompression pressure average of 68.16 N. Following compression, pressures increased to 125.99 N and 140.84 N for normal and parallel compression postunilateral facetectomy, respectively, and to 154.58 N and 150.46 N for bilateral models. A strong linear correlation (correlation coefficient: 0.967, P < 0.0001) between precompression and postcompression pressures emphasized the necessity of sufficient precompression pressure for achieving desired postcompression outcomes. None of the data showed a decrease in compression force to the cage with the compression maneuver.
    Conclusions: Both normal and parallel compression maneuvers effectively increased the pressure on the cage, irrespective of the facet joint resection status. Compression manipulation consistently enhanced compressive force on the cage. However, when baseline pressure is low, the manipulation might not yield significant increases in compression force. This underlines the essential role of meticulous precompression preparation in enhancing surgical outcomes.
    Sprache Englisch
    Erscheinungsdatum 2024-03-21
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2024.03.080
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: Sagittal Section Hounsfield Units of the Upper Instrumented Vertebrae as a Predictor of Proximal Junctional Vertebral Fractures Following Adult Spinal Deformity Surgery.

    Murata, Koichi / Otsuki, Bungo / Shimizu, Takayoshi / Sono, Takashi / Fujibayashi, Shunsuke / Matsuda, Shuichi

    Asian spine journal

    2024  

    Abstract: Study design: A retrospective observational study.: Purpose: This study aimed to determine an accurate and convenient screening method for predicting proximal junctional fractures (PJFr) following surgery for adult spinal deformity (ASD) using ... ...

    Abstract Study design: A retrospective observational study.
    Purpose: This study aimed to determine an accurate and convenient screening method for predicting proximal junctional fractures (PJFr) following surgery for adult spinal deformity (ASD) using computed tomography (CT)-based measurement of Hounsfield units (HUs).
    Overview of literature: CT-based measurement of HUs is an alternative tool for assessing bone mineral density. However, the optimal method for predicting adjacent vertebral fractures following spinal fusion using HUs remains unclear.
    Methods: This retrospective observational study included 42 patients who underwent reconstructive surgery for ASD. Elliptical regions of interest (ROIs) on the axial section and rectangular ROIs on the sagittal section were placed at the upper instrumented vertebrae (UIV), UIV+1, and UIV+2. In addition, the HU value of the L2 vertebra was used as the representative.
    Results: PJFr occurred in 28.6% of patients within 2 years following surgery. The HU values obtained from the axial sections of L2, UIV, UIV+1, and UIV+2 were not significantly associated with the incidence of PJFr within 2 years, except for the ROI set in the lower region of the L2 vertebra. However, the HU value of the anterior third of the UIV in the sagittal section was significantly lower in the PJFr group than in the nonPJFr group (87.0 vs. 160.3, p =0.001). A UIV HU value of <100 was associated with a higher incidence of PJFr than an HU vaue of >100 (p <0.05).
    Conclusions: Measurements of HU in the anterior one-third of the UIV in the sagittal section demonstrated predictive ability for PJFr following ASD surgery. A UIV HU value of <100 emerged as a risk factor for PJFr.
    Sprache Englisch
    Erscheinungsdatum 2024-04-23
    Erscheinungsland Korea (South)
    Dokumenttyp Journal Article
    ZDB-ID 2559763-2
    ISSN 1976-7846 ; 1976-1902
    ISSN (online) 1976-7846
    ISSN 1976-1902
    DOI 10.31616/asj.2023.0339
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Differences in joint angles during pole vaulting between male pole vaulters with and without chronic low back pain

    Enoki Shota / Kuramochi Rieko / Nakayama Koichi / Takigawa Hiroko / Shimizu Takuya

    Biomedical Human Kinetics, Vol 15, Iss 1, Pp 131-

    2023  Band 138

    Abstract: Study aim: To determine the difference in joint angles of the shoulder, hip, and trunk (angle of the upper torso and lower torso) during vaulting between male pole vaulters with and without chronic low back pain (LBP) and to examine the relationship ... ...

    Abstract Study aim: To determine the difference in joint angles of the shoulder, hip, and trunk (angle of the upper torso and lower torso) during vaulting between male pole vaulters with and without chronic low back pain (LBP) and to examine the relationship between the range of motion (ROM) and maximum angle of the same joint during vaulting in all participants.
    Schlagwörter back pain ; lumbago ; track and field ; 3d-dlt ; Sports medicine ; RC1200-1245 ; Physiology ; QP1-981
    Sprache Englisch
    Erscheinungsdatum 2023-01-01T00:00:00Z
    Verlag Sciendo
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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