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  1. Buch ; Online ; E-Book: Small fiber neuropathy and related syndromes: pain and neurodegeneration

    Hsieh, Sung-Tsang / Praveen, Anand / Gibbons, Christopher H. / Sommer, Claudia

    2019  

    Verfasserangabe Sung-Tsang Hsieh, Anand Praveen, Christopher H. Gibbons, Claudia Sommer editors
    Sprache Englisch
    Umfang 1 Online-Ressource (xxi, 184 Seiten), Illustrationen
    Ausgabenhinweis First edition
    Verlag Springer Nature Singapore
    Erscheinungsort Singapore
    Erscheinungsland Deutschland
    Dokumenttyp Buch ; Online ; E-Book
    Bemerkung Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020045125
    ISBN 978-981-13-3546-4 ; 9789811335457 ; 981-13-3546-X ; 9811335451
    DOI 10.1007/978-981-13-3546-4
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  2. Artikel ; Online: Terpenes in

    Anand, Uma / Anand, Praveen / Sodergren, Mikael Hans

    International journal of molecular sciences

    2023  Band 24, Heft 22

    Abstract: ... Terpenes ... ...

    Abstract Terpenes in
    Mesh-Begriff(e) Rats ; Animals ; Capsaicin/pharmacology ; Cannabis/metabolism ; Adenosine Triphosphatases ; Terpenes/pharmacology ; Calcium/metabolism ; Neurons/metabolism ; TRPV Cation Channels ; Ganglia, Spinal/metabolism ; Cells, Cultured
    Chemische Substanzen Capsaicin (S07O44R1ZM) ; Adenosine Triphosphatases (EC 3.6.1.-) ; Terpenes ; Calcium (SY7Q814VUP) ; TRPV Cation Channels
    Sprache Englisch
    Erscheinungsdatum 2023-11-15
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242216340
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Phytochemical Molecules Binding with the Proteins of Mycolic Acid Synthesis Pathway of Mycobacterium tuberculosis

    Rishabh Gaur / Praveen Kumar Anand

    Journal of Molecular Docking, Vol 2, Iss

    2022  Band 2

    Abstract: Resistance against anti-tubercular drugs is a significant problem. This elucidates the need for novel drug targets. Altering and targeting the enzymes involved in cell wall synthesis led to fatal damage to the bacterial cell. Mycolic acids are critically ...

    Abstract Resistance against anti-tubercular drugs is a significant problem. This elucidates the need for novel drug targets. Altering and targeting the enzymes involved in cell wall synthesis led to fatal damage to the bacterial cell. Mycolic acids are critically responsible for the virulence of Mycobacterium Tuberculosis. This pathway represents an essential reservoir of novel targets for developing new TB drugs. The study aims to identify phytochemicals with the capacity to bind with enzymes of mycolic acid synthesis pathways. This study shows the interaction between phytochemicals and proteins responsible for mycolic acid synthesis is shown through bioinformatics & molecular docking tools. Docking showed binding affinity between protein molecules of the mycolic acid synthesis pathway and ligand molecules in the study. PKS13 (polyketide synthase) interacts with the ligand beta-amyrin acetate with a vina score of -7.1 Kcal/mol. At the same time, its binding energy with Piperine is -6.8 Kcal/mol. DprE1 (Decaprenylphosphoryl-bet-D-ribose-2-epimerase), the other protein docked with beta-amyrin acetate, showed a vina score of -9.7 Kcal/mol binding energy. Piperine with DprE1 exhibits interaction with a score of -8.3 Kcal/mol. Beta-amyrin acetate is docked with a score of -6.9 Kcal/mol against KasA (Beta-ketoacyl-acyl carrier protein synthase). On the other hand, Piperine with KasA gave a result of -7.0 Kcal/mol. Piperine and Beta-amyrin acetate binds to PKS13, DprE1 & KasA protein/enzymes responsible for mycolic acid biosynthesis.
    Schlagwörter Piperine ; Mycolic acid ; Tuberculosis ; Docking ; β-amyrin acetate ; Pharmacy and materia medica ; RS1-441 ; Chemistry ; QD1-999
    Sprache Englisch
    Erscheinungsdatum 2022-12-01T00:00:00Z
    Verlag Institute for Researches and Community Services Universitas Muhammadiyah Palangkaraya
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Epigenetic Perspective of Immunotherapy for Cancers

    Sunita Keshari / Praveen Barrodia / Anand Kamal Singh

    Cells, Vol 12, Iss 365, p

    2023  Band 365

    Abstract: Immunotherapy has brought new hope for cancer patients in recent times. However, despite the promising success of immunotherapy, there is still a need to address major challenges including heterogeneity in response among patients, the reoccurrence of the ...

    Abstract Immunotherapy has brought new hope for cancer patients in recent times. However, despite the promising success of immunotherapy, there is still a need to address major challenges including heterogeneity in response among patients, the reoccurrence of the disease, and iRAEs (immune-related adverse effects). The first critical step towards solving these issues is understanding the epigenomic events that play a significant role in the regulation of specific biomolecules in the context of the immune population present in the tumor immune microenvironment (TIME) during various treatments and responses. A prominent advantage of this step is that it would enable researchers to harness the reversibility of epigenetic modifications for their druggability. Therefore, we reviewed the crucial studies in which varying epigenomic events were captured with immuno-oncology set-ups. Finally, we discuss the therapeutic possibilities of their utilization for the betterment of immunotherapy in terms of diagnosis, progression, and cure for cancer patients.
    Schlagwörter cancer ; immunotherapy ; epigenetics ; immune checkpoint drugs ; epigenetic drugs ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2023-01-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Recent advancements in the role of histone acetylation dynamics to improve stress responses in plants.

    Bajpai, Sanjay Kumar / Nisha / Pandita, Shivali / Bahadur, Anand / Verma, Praveen C

    Molecular biology reports

    2024  Band 51, Heft 1, Seite(n) 413

    Abstract: In eukaryotes, transcriptional regulation is determined by the DNA sequence and is facilitated through sophisticated and complex chromatin alterations and histone remodelling. Recent research has shown that the histone acetylation dynamic, an ... ...

    Abstract In eukaryotes, transcriptional regulation is determined by the DNA sequence and is facilitated through sophisticated and complex chromatin alterations and histone remodelling. Recent research has shown that the histone acetylation dynamic, an intermittent and reversible substitution, constitutes a prerequisite for chromatin modification. These changes in chromatin structure modulate genome-wide and specific changes in response to external and internal cues like cell differentiation, development, growth, light temperature, and biotic stresses. Histone acetylation dynamics also control the cell cycle. HATs and HDACs play a critical role in gene expression modulation during plant growth and response to environmental circumstances. It has been well established that HATs and HDACs interact with various distinct transcription factors and chromatin-remodelling proteins (CRPs) involved in the transcriptional regulation of several developmental processes. This review explores recent research on histone acyltransferases and histone deacetylases, mainly focusing on their involvement in plant biotic stress responses. Moreover, we also emphasized the research gaps that must be filled to fully understand the complete function of histone acetylation dynamics during biotic stress responses in plants. A thorough understanding of histone acetylation will make it possible to enhance tolerance against various kinds of stress and decrease yield losses in many crops.
    Mesh-Begriff(e) Histones/genetics ; Acetylation ; Plants/genetics ; Protein Processing, Post-Translational ; Chromatin/metabolism ; Histone Acetyltransferases/metabolism
    Chemische Substanzen Histones ; Chromatin ; Histone Acetyltransferases (EC 2.3.1.48)
    Sprache Englisch
    Erscheinungsdatum 2024-03-12
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Review
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-024-09300-3
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Controlling the Morphological Features, Aspect Ratio and Emission Patterns of Supramolecular Copolymers by Restricted Dimensional Growth.

    Das, Gourab / Anand, Anjali / Vedhanarayanan, Balaraman / Padmakumar, Akhil / Praveen, Vakayil K / Ajayaghosh, Ayyappanpillai

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2023  Band 29, Heft 58, Seite(n) e202301819

    Abstract: One of the bottlenecks associated with supramolecular polymerization of functional π-systems is the spontaneous assembly of monomers leading to one- or two-dimensional (1D or 2D) polymers without control over chain length and optical properties. In the ... ...

    Abstract One of the bottlenecks associated with supramolecular polymerization of functional π-systems is the spontaneous assembly of monomers leading to one- or two-dimensional (1D or 2D) polymers without control over chain length and optical properties. In the case of supramolecular copolymerization of monomers that are structurally too diverse, preferential self-sorting occurs unless they are closely interacting donor-acceptor pairs. Herein, it is established that the spontaneous 1D polymerization of a phenyleneethynylene (PE) derivative and the 2D polymerization of a Bodipy derivative (BODIPY) can be controlled by copolymerizing them in different ratios, leading to unusual spindle-shaped structures with controlled aspect ratio, as evident by scanning electron microscopy (SEM), transmission electron microscopy (TEM) and confocal laser scanning microscopy (CLSM) studies. For example, when the content of BODIPY is 50 % in the BODIPY-PE mixture, the 1D polymerization of PE is significantly restricted to form elongated spindle-like structures having an aspect ratio of 4-6. The addition of 75 % of BODIPY to PE resulted in circular spindles having an aspect ratio of 1-2.5, thereby completely restricting the 1D polymerization of PE monomers. Moreover, the resultant supramolecular copolymers exhibited morphology and aspect ratio dependent emission features as observed by the time-resolved emission studies.
    Sprache Englisch
    Erscheinungsdatum 2023-09-14
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202301819
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  7. Artikel ; Online: Capsaicin 8% patch Qutenza and other current treatments for neuropathic pain in chemotherapy-induced peripheral neuropathy (CIPN).

    Privitera, Rosario / Anand, Praveen

    Current opinion in supportive and palliative care

    2021  Band 15, Heft 2, Seite(n) 125–131

    Abstract: Purpose of review: Current oral treatments for neuropathic pain associated with chemotherapy-induced peripheral neuropathy (CIPN) have limited clinical efficacy, and undesirable side-effects. Topically delivered treatments have the advantage of avoiding ...

    Abstract Purpose of review: Current oral treatments for neuropathic pain associated with chemotherapy-induced peripheral neuropathy (CIPN) have limited clinical efficacy, and undesirable side-effects. Topically delivered treatments have the advantage of avoiding CNS side-effects, while relieving pain. We have reviewed treatments of neuropathic pain associated with CIPN, focusing on the Capsaicin 8% patch, which can provide pain relief for up to 3 months or longer after a single 30-60-min application.
    Recent findings: Capsaicin 8% patch is a licensed treatment in the EU/UK for neuropathic pain and shown to be safe and effective in providing pain relief for patients with CIPN. Repeated daily oral or topical administrations are not required, as with other current treatments. The side-effects are transient and restricted to the time around patch application. New evidence suggests the Capsaicin 8% patch can promote the regeneration and restoration of skin nerve fibres in CIPN, in addition to the pain relief.
    Summary: The Capsaicin 8% patch is now often a preferred a treatment option for localised neuropathic pain conditions, including the feet and hands in patients with CIPN. Capsaicin 8% patch can be repeated three-monthly, if needed, for a year. In addition to pain relief, it may have a disease-modifying effect.
    Mesh-Begriff(e) Administration, Topical ; Antineoplastic Agents/adverse effects ; Capsaicin/therapeutic use ; Humans ; Neuralgia/chemically induced ; Neuralgia/drug therapy ; Pain Management
    Chemische Substanzen Antineoplastic Agents ; Capsaicin (S07O44R1ZM)
    Sprache Englisch
    Erscheinungsdatum 2021-04-26
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2633726-5
    ISSN 1751-4266 ; 1751-4258
    ISSN (online) 1751-4266
    ISSN 1751-4258
    DOI 10.1097/SPC.0000000000000545
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 6946: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Artikel ; Online: Epigenetic Perspective of Immunotherapy for Cancers.

    Keshari, Sunita / Barrodia, Praveen / Singh, Anand Kamal

    Cells

    2023  Band 12, Heft 3

    Abstract: Immunotherapy has brought new hope for cancer patients in recent times. However, despite the promising success of immunotherapy, there is still a need to address major challenges including heterogeneity in response among patients, the reoccurrence of the ...

    Abstract Immunotherapy has brought new hope for cancer patients in recent times. However, despite the promising success of immunotherapy, there is still a need to address major challenges including heterogeneity in response among patients, the reoccurrence of the disease, and iRAEs (immune-related adverse effects). The first critical step towards solving these issues is understanding the epigenomic events that play a significant role in the regulation of specific biomolecules in the context of the immune population present in the tumor immune microenvironment (TIME) during various treatments and responses. A prominent advantage of this step is that it would enable researchers to harness the reversibility of epigenetic modifications for their druggability. Therefore, we reviewed the crucial studies in which varying epigenomic events were captured with immuno-oncology set-ups. Finally, we discuss the therapeutic possibilities of their utilization for the betterment of immunotherapy in terms of diagnosis, progression, and cure for cancer patients.
    Mesh-Begriff(e) Humans ; Epigenomics ; Neoplasms/therapy ; Neoplasms/drug therapy ; Immunotherapy/adverse effects ; Medical Oncology ; Epigenesis, Genetic ; Tumor Microenvironment
    Sprache Englisch
    Erscheinungsdatum 2023-01-19
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12030365
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Sonocatalytic degradation of nitrobenzene with metal oxide clay nanocomposites

    Saini, Pooja / Chakinala, Nandana / Surolia, Praveen K. / Chakinala, Anand Gupta

    Journal of Chemical Technology & Biotechnology. 2024 Feb., v. 99, no. 2 p.385-395

    2024  

    Abstract: BACKGROUND: The presence of a wide range of persistent toxic organic pollutants in industrial effluents poses a serious threat to human and environmental health, emphasising the necessity for developing cost‐effective methods for treating toxic effluents. ...

    Abstract BACKGROUND: The presence of a wide range of persistent toxic organic pollutants in industrial effluents poses a serious threat to human and environmental health, emphasising the necessity for developing cost‐effective methods for treating toxic effluents. This study focuses on the synthesis, characterization and evaluation of metal oxide [iron (Fe), copper (Cu) and zinc (Zn)]‐doped clay composite for the sonocatalytic degradation of nitrobenzene (NB) in the presence of ultrasound. RESULTS AND CONCLUSIONS: Among the metal oxides studied, Cu and Fe oxide‐modified clay performed better in the degradation of NB (~99% in the presence of air) compared to a ZnO/clay composite. Process optimization studies were carried with CuO/clay composite at different pHs (2.5–11.5), feed concentrations (50–200 mg L⁻¹) and catalyst loadings (0.25–1.0 g L⁻¹). Neutral pH conditions and higher catalyst loadings of 1 g L⁻¹ were found to be optimal for the efficient degradation of 50 ppm NB. Among the scavengers tested, ethylenediamine tetra acetic acid exhibited strong scavenging effects, resulting in reduced NB degradation compared to isopropyl alcohol and tin tetrachloride, regardless of the scavenger concentration (0.5 and 40 mmol L⁻¹). The catalyst was found to be sufficiently stable for up to four cycles under identical conditions. Additionally, these materials were found to be effective in the degradation of other pollutants [Terephthalic acid, Rhodamine‐B, Ciprofloxacin]. These findings contribute to the development of cost‐effective strategies for the treatment of industrial effluents, reducing the risks posed to both the environment and human health. © 2023 Society of Chemical Industry (SCI).
    Schlagwörter acetic acid ; air ; biotechnology ; catalysts ; ciprofloxacin ; clay ; copper ; cost effectiveness ; environmental health ; ethylenediamines ; human health ; humans ; isopropyl alcohol ; nanocomposites ; nitrobenzenes ; pH ; sonocatalysis ; tin ; toxicity ; ultrasonics ; zinc
    Sprache Englisch
    Erscheinungsverlauf 2024-02
    Umfang p. 385-395.
    Erscheinungsort John Wiley & Sons, Ltd.
    Dokumenttyp Artikel ; Online
    Anmerkung JOURNAL ARTICLE
    ZDB-ID 1479465-2
    ISSN 1097-4660 ; 0268-2575
    ISSN (online) 1097-4660
    ISSN 0268-2575
    DOI 10.1002/jctb.7540
    Datenquelle NAL Katalog (AGRICOLA)

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  10. Artikel ; Online: Photocatalytic performance of Bi/Zn co‐doped sol–gel synthesized TiO2 nanoparticles

    Mishra, Saurav / Chakinala, Nandana / Chakinala, Anand G. / Surolia, Praveen K.

    Journal of Chemical Technology & Biotechnology. 2024 Feb., v. 99, no. 2 p.531-539

    2024  

    Abstract: BACKGROUND: Semiconductor photocatalysts based on TiO₂ nanoparticles were synthesized via the sol–gel method and subsequently modified using monometallic (Bi‐TiO₂, Zn‐TiO₂) and bimetallic (Bi/Zn‐TiO₂) doping through the wet‐impregnation technique. The ... ...

    Abstract BACKGROUND: Semiconductor photocatalysts based on TiO₂ nanoparticles were synthesized via the sol–gel method and subsequently modified using monometallic (Bi‐TiO₂, Zn‐TiO₂) and bimetallic (Bi/Zn‐TiO₂) doping through the wet‐impregnation technique. The prepared photocatalysts underwent comprehensive characterization using X‐ray diffraction analysis, Fourier transform infrared spectroscopy, ultraviolet–visible diffuse‐reflectance spectroscopy, field emission scanning electron microscopy, photoluminescence, and thermal gravimetric analysis. The photocatalytic performance of these well‐characterized photocatalysts was assessed for the degradation of the model organic pollutant, nitrobenzene. RESULTS: Among the various doped TiO₂ catalysts, Bi/Zn co‐doping at a ratio of 0.25:0.75 (w/w) exhibited the most remarkable synergistic effect, achieving approximately 82% degradation of a 50 ppm nitrobenzene solution within just 90 min of reaction time under ultraviolet light irradiation. The rate constant for this process was determined to be 1.79 × 10⁻² min⁻¹, suggesting a pseudo‐first‐order kinetics model. CONCLUSION: The successful co‐doping of Bi and Zn metals to TiO₂ resulted in improved photocatalytic performance. The enhanced performance could be attributed to the improved charge transfer facilitated by the synergistic effect among doped metals and TiO₂. This finding highlights the significance of bimetallic doping and its potential applications in improving the photocatalytic efficiency of TiO₂ nanoparticles for environmental remediation. © 2023 Society of Chemical Industry (SCI).
    Schlagwörter Fourier transform infrared spectroscopy ; X-ray diffraction ; biotechnology ; electron microscopy ; irradiation ; models ; nanoparticles ; nitrobenzenes ; photocatalysis ; photocatalysts ; photoluminescence ; pollutants ; reflectance spectroscopy ; remediation ; semiconductors ; sol-gel processing ; synergism ; thermogravimetry ; titanium dioxide ; ultraviolet radiation
    Sprache Englisch
    Erscheinungsverlauf 2024-02
    Umfang p. 531-539.
    Erscheinungsort John Wiley & Sons, Ltd.
    Dokumenttyp Artikel ; Online
    Anmerkung JOURNAL ARTICLE
    ZDB-ID 1479465-2
    ISSN 1097-4660 ; 0268-2575
    ISSN (online) 1097-4660
    ISSN 0268-2575
    DOI 10.1002/jctb.7555
    Datenquelle NAL Katalog (AGRICOLA)

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