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  1. Artikel ; Online: Combining chemotherapy and immunotherapy for advanced anal cancer: are we ready?

    Martinelli, Erika / Ciardiello, Davide

    The Lancet. Oncology

    2024  Band 25, Heft 4, Seite(n) 416–417

    Mesh-Begriff(e) Humans ; Anus Neoplasms/drug therapy ; Combined Modality Therapy ; Immunotherapy/adverse effects
    Sprache Englisch
    Erscheinungsdatum 2024-03-28
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(24)00131-1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Angiogenesis inhibition in metastatic colorectal cancer continuum of care.

    Martinelli, Erika / Ciardiello, Fortunato

    Lancet (London, England)

    2023  Band 402, Heft 10395, Seite(n) 4–5

    Mesh-Begriff(e) Humans ; Bevacizumab/therapeutic use ; Angiogenesis Inhibitors/therapeutic use ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/pathology ; Continuity of Patient Care ; Neovascularization, Pathologic/drug therapy ; Neovascularization, Pathologic/pathology
    Chemische Substanzen Bevacizumab (2S9ZZM9Q9V) ; Angiogenesis Inhibitors
    Sprache Englisch
    Erscheinungsdatum 2023-06-15
    Erscheinungsland England
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(23)00867-X
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Endoscopic calcium electroporation for unfit-for-surgery bleeding colorectal cancer: the dawn of a new treatment?

    Pellegrino, Raffaele / Nacca, Valeria / Paragliola, Fernando / Martinelli, Erika / Federico, Alessandro / Gravina, Antonietta G

    Minerva medica

    2024  

    Sprache Englisch
    Erscheinungsdatum 2024-04-10
    Erscheinungsland Italy
    Dokumenttyp Journal Article
    ZDB-ID 123586-2
    ISSN 1827-1669 ; 0026-4806
    ISSN (online) 1827-1669
    ISSN 0026-4806
    DOI 10.23736/S0026-4806.24.09270-X
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Targeting the EGFR signalling pathway in metastatic colorectal cancer.

    Napolitano, Stefania / Martini, Giulia / Ciardiello, Davide / Del Tufo, Sara / Martinelli, Erika / Troiani, Teresa / Ciardiello, Fortunato

    The lancet. Gastroenterology & hepatology

    2024  

    Abstract: Epidermal growth factor receptor (EGFR) and its activated downstream signalling pathways play a crucial role in colorectal cancer development and progression. After four decades of preclinical, translational, and clinical research, it has been shown that ...

    Abstract Epidermal growth factor receptor (EGFR) and its activated downstream signalling pathways play a crucial role in colorectal cancer development and progression. After four decades of preclinical, translational, and clinical research, it has been shown that blocking the EGFR signalling pathway at different molecular levels represents a fundamental therapeutic strategy for patients with metastatic colorectal cancer. Nevertheless, the efficacy of molecularly targeted therapies is inescapably limited by the insurgence of mechanisms of acquired cancer cell resistance. Thus, in the era of precision medicine, a deeper understanding of the complex molecular landscape of metastatic colorectal cancer is required to deliver the best treatment choices to all patients. Major efforts are currently ongoing to improve patient selection, improve the efficacy of available treatments targeting the EGFR pathway, and develop novel combination strategies to overcome therapy resistance within the continuum of care of metastatic colorectal cancer.
    Sprache Englisch
    Erscheinungsdatum 2024-04-29
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Review
    ISSN 2468-1253
    ISSN (online) 2468-1253
    DOI 10.1016/S2468-1253(23)00479-X
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Towards the era of precision medicine in metastatic colorectal cancer.

    Napolitano, Stefania / Troiani, Teresa / Martinelli, Erika / Ciardiello, Fortunato

    ESMO open

    2020  Band 5, Heft 2

    Mesh-Begriff(e) Colorectal Neoplasms/epidemiology ; Humans ; Neoplasm Metastasis ; Precision Medicine/methods
    Sprache Englisch
    Erscheinungsdatum 2020-03-27
    Erscheinungsland England
    Dokumenttyp Editorial
    ISSN 2059-7029
    ISSN (online) 2059-7029
    DOI 10.1136/esmoopen-2020-000685
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: European expert panel consensus on the clinical management of BRAF

    Martinelli, Erika / Arnold, Dirk / Cervantes, Andres / Stintzing, Sebastian / Van Cutsem, Eric / Tabernero, Josep / Taieb, Julien / Wasan, Harpreet / Ciardiello, Fortunato

    Cancer treatment reviews

    2023  Band 115, Seite(n) 102541

    Abstract: Metastatic colorectal cancer (mCRC) is a heterogenous disease caused by various genetic alterations. The ... ...

    Abstract Metastatic colorectal cancer (mCRC) is a heterogenous disease caused by various genetic alterations. The BRAF
    Mesh-Begriff(e) Humans ; Proto-Oncogene Proteins B-raf/genetics ; Colorectal Neoplasms/therapy ; Colorectal Neoplasms/drug therapy ; Colonic Neoplasms ; Rectal Neoplasms ; Mutation
    Chemische Substanzen Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; BRAF protein, human (EC 2.7.11.1)
    Sprache Englisch
    Erscheinungsdatum 2023-03-11
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Review
    ZDB-ID 125102-8
    ISSN 1532-1967 ; 0305-7372
    ISSN (online) 1532-1967
    ISSN 0305-7372
    DOI 10.1016/j.ctrv.2023.102541
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: The Role of Dual-Energy CT for the Assessment of Liver Metastasis Response to Treatment: Above the RECIST 1.1 Criteria.

    Reginelli, Alfonso / Del Canto, Mariateresa / Clemente, Alfredo / Gragnano, Eduardo / Cioce, Fabrizio / Urraro, Fabrizio / Martinelli, Erika / Cappabianca, Salvatore

    Journal of clinical medicine

    2023  Band 12, Heft 3

    Abstract: Imaging assessment of liver lesions is fundamental to predict therapeutic response and improve patient survival rates. Dual-Energy Computed Tomography (DECT) is an increasingly used technique in the oncologic field with many emerging applications. The ... ...

    Abstract Imaging assessment of liver lesions is fundamental to predict therapeutic response and improve patient survival rates. Dual-Energy Computed Tomography (DECT) is an increasingly used technique in the oncologic field with many emerging applications. The assessment of iodine concentration within a liver lesion reflects the biological properties of the tumor and provides additional information to radiologists that is normally invisible to the human eye. The possibility to predict tumor aggressiveness and therapeutic response based on quantitative and reproducible parameters obtainable from DECT images could improve clinical decisions and drive oncologists to choose the best therapy according to metastasis biological features. Moreover, in comparison with standard dimensional criteria, DECT provides further data on the cancer microenvironment, especially for patients treated with antiangiogenic-based drugs, in which tumor shrinkage is a late parameter of response. We investigated the predictive role of DECT in the early assessment of liver metastasis response to treatment in comparison with standard dimensional criteria during antiangiogenetic-based therapy.
    Sprache Englisch
    Erscheinungsdatum 2023-01-22
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12030879
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Different fractions from wheat flour provide distinctive phenolic profiles and different bioaccessibility of polyphenols following in vitro digestion.

    Zhang, Leilei / García-Pérez, Pascual / Martinelli, Erika / Giuberti, Gianluca / Trevisan, Marco / Lucini, Luigi

    Food chemistry

    2022  Band 404, Heft Pt A, Seite(n) 134540

    Abstract: Wheat is a prevalent food worldwide, although its production arises several tonnes of industrial by-products that merit valorisation, owing to sustainable demands. In this work, an untargeted metabolomics approach was applied to shed light on the profile ...

    Abstract Wheat is a prevalent food worldwide, although its production arises several tonnes of industrial by-products that merit valorisation, owing to sustainable demands. In this work, an untargeted metabolomics approach was applied to shed light on the profile of free and bound phenolic compounds in white and wholegrain flours, as well as the major wheat by-products, namely wheat bran, wheat shorts and wheat middlings. By-products and wholegrain flours were found to be rich sources of ferulic acid derivatives, lignans, and alkylresorcinols, mostly bound to wheat fibre components, whereas different flavonoids were found in their free forms. Afterwards, the in vitro gastrointestinal digestion of these matrices showed that flour phenolics, in particular lignans, were more bioaccessible than those from wheat by-products. These results support the carrier effect attributed to dietary fibre and open a wide perspective on the use of underexploited wheat by-products to formulate novel functional foods.
    Mesh-Begriff(e) Flour/analysis ; Polyphenols/analysis ; Triticum/metabolism ; Phenols/analysis ; Dietary Fiber/analysis ; Digestion ; Lignans
    Chemische Substanzen Polyphenols ; Phenols ; Dietary Fiber ; Lignans
    Sprache Englisch
    Erscheinungsdatum 2022-10-07
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 243123-3
    ISSN 1873-7072 ; 0308-8146
    ISSN (online) 1873-7072
    ISSN 0308-8146
    DOI 10.1016/j.foodchem.2022.134540
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Different fractions from wheat flour provide distinctive phenolic profiles and different bioaccessibility of polyphenols following in vitro digestion

    Zhang, Leilei / García-Pérez, Pascual / Martinelli, Erika / Giuberti, Gianluca / Trevisan, Marco / Lucini, Luigi

    Food Chemistry. 2023 Mar., v. 404 p.134540-

    2023  

    Abstract: Wheat is a prevalent food worldwide, although its production arises several tonnes of industrial by-products that merit valorisation, owing to sustainable demands. In this work, an untargeted metabolomics approach was applied to shed light on the profile ...

    Abstract Wheat is a prevalent food worldwide, although its production arises several tonnes of industrial by-products that merit valorisation, owing to sustainable demands. In this work, an untargeted metabolomics approach was applied to shed light on the profile of free and bound phenolic compounds in white and wholegrain flours, as well as the major wheat by-products, namely wheat bran, wheat shorts and wheat middlings. By-products and wholegrain flours were found to be rich sources of ferulic acid derivatives, lignans, and alkylresorcinols, mostly bound to wheat fibre components, whereas different flavonoids were found in their free forms. Afterwards, the in vitro gastrointestinal digestion of these matrices showed that flour phenolics, in particular lignans, were more bioaccessible than those from wheat by-products. These results support the carrier effect attributed to dietary fibre and open a wide perspective on the use of underexploited wheat by-products to formulate novel functional foods.
    Schlagwörter alkylresorcinols ; bioavailability ; dietary fiber ; digestion ; ferulic acid ; flavonoids ; food chemistry ; gastrointestinal system ; lignans ; metabolomics ; polyphenols ; wheat ; wheat bran ; wheat flour ; Triticum aestivum ; Wheat fibre ; Bran ; Wholegrain flour ; Phenolic compounds ; Functional foods ; ADF ; ADL ; DM ; FWGF ; NDF ; RWGF ; WS ; WB ; WF ; WM
    Sprache Englisch
    Erscheinungsverlauf 2023-03
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel ; Online
    ZDB-ID 243123-3
    ISSN 1873-7072 ; 0308-8146
    ISSN (online) 1873-7072
    ISSN 0308-8146
    DOI 10.1016/j.foodchem.2022.134540
    Datenquelle NAL Katalog (AGRICOLA)

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  10. Artikel ; Online: Retraction notice to "Antitumor activity of bortezomib in human cancer cells with acquired resistance to anti-epidermal growth factor receptor tyrosine kinase inhibitors" [Lung Cancer 71 (2011) 283-290].

    Morgillo, Floriana / D'Aiuto, Elena / Troiani, Teresa / Martinelli, Erika / Cascone, Tina / De Palma, Raffaele / Orditura, Michele / De Vita, Ferdinando / Ciardiello, Fortunato

    Lung cancer (Amsterdam, Netherlands)

    2023  Band 181, Seite(n) 107226

    Sprache Englisch
    Erscheinungsdatum 2023-05-09
    Erscheinungsland Ireland
    Dokumenttyp Journal Article ; Retraction of Publication
    ZDB-ID 632771-0
    ISSN 1872-8332 ; 0169-5002
    ISSN (online) 1872-8332
    ISSN 0169-5002
    DOI 10.1016/j.lungcan.2023.107226
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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