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  1. Artikel ; Online: Characteristics of alpha smooth muscle actin-positive peritubular cells in prepubertal bovine testes.

    Kawabe, Yusuke / Numabe, Takashi / Tanemura, Kentaro / Hara, Kenshiro

    Biochemical and biophysical research communications

    2022  Band 609, Seite(n) 48–53

    Abstract: Characteristics of peritubular myoid cells (PMCs) in sexually immature cattle remain largely unknown. Here, we report the character and behavior of peritubular cells expressing alpha smooth muscle actin (αSMA), a marker of PMCs in adult testes, in ... ...

    Abstract Characteristics of peritubular myoid cells (PMCs) in sexually immature cattle remain largely unknown. Here, we report the character and behavior of peritubular cells expressing alpha smooth muscle actin (αSMA), a marker of PMCs in adult testes, in prepubertal testes procured from 5-months-old bulls. Elastin distribution around αSMA + PMCs was dim and discontinuous in prepubertal testes, but strong and continuous in adult testes. Fibroblast-specific protein 1 (FSP1) was rarely expressed in αSMA + PMCs of prepubertal testes, while in adult testes, majority of αSMA + PMCs were FSP1+. Moreover, αSMA + PMCs in prepubertal testes proliferated more actively than those in adult testes. In vitro culture of isolated seminiferous tubules from prepubertal testes revealed that αSMA + PMCs migrate from peritubular to interstitial area. Hence, in prepubertal bovine testes, (1) PMCs rarely portray fibroblast-like properties, (2) PMCs exhibit heterogeneity in FSP1 expression, (3) PMCs proliferate more actively than those in adult testes, and (4) PMCs have a potential to migrate to the interstitium. Our observations help to understand the maturation of PMCs and their involvement in bovine testicular function.
    Mesh-Begriff(e) Actins/metabolism ; Animals ; Cattle ; Fibroblasts/metabolism ; Male ; Muscle, Smooth/metabolism ; Seminiferous Tubules/metabolism ; Testis/metabolism
    Chemische Substanzen Actins
    Sprache Englisch
    Erscheinungsdatum 2022-04-07
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2022.03.149
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Characteristics of alpha smooth muscle actin-positive peritubular cells in prepubertal bovine testes

    Kawabe, Yusuke / Numabe, Takashi / Tanemura, Kentaro / Hara, Kenshiro

    Biochemical and biophysical research communications. 2022 June 18, v. 609

    2022  

    Abstract: Characteristics of peritubular myoid cells (PMCs) in sexually immature cattle remain largely unknown. Here, we report the character and behavior of peritubular cells expressing alpha smooth muscle actin (αSMA), a marker of PMCs in adult testes, in ... ...

    Abstract Characteristics of peritubular myoid cells (PMCs) in sexually immature cattle remain largely unknown. Here, we report the character and behavior of peritubular cells expressing alpha smooth muscle actin (αSMA), a marker of PMCs in adult testes, in prepubertal testes procured from 5-months-old bulls. Elastin distribution around αSMA + PMCs was dim and discontinuous in prepubertal testes, but strong and continuous in adult testes. Fibroblast-specific protein 1 (FSP1) was rarely expressed in αSMA + PMCs of prepubertal testes, while in adult testes, majority of αSMA + PMCs were FSP1+. Moreover, αSMA + PMCs in prepubertal testes proliferated more actively than those in adult testes. In vitro culture of isolated seminiferous tubules from prepubertal testes revealed that αSMA + PMCs migrate from peritubular to interstitial area. Hence, in prepubertal bovine testes, (1) PMCs rarely portray fibroblast-like properties, (2) PMCs exhibit heterogeneity in FSP1 expression, (3) PMCs proliferate more actively than those in adult testes, and (4) PMCs have a potential to migrate to the interstitium. Our observations help to understand the maturation of PMCs and their involvement in bovine testicular function.
    Schlagwörter actin ; adults ; elastin ; immatures ; puberty ; research ; smooth muscle
    Sprache Englisch
    Erscheinungsverlauf 2022-0618
    Umfang p. 48-53.
    Erscheinungsort Elsevier Inc.
    Dokumenttyp Artikel
    ZDB-ID 205723-2
    ISSN 0006-291X ; 0006-291X
    ISSN (online) 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2022.03.149
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  3. Artikel: School teachers' awareness of internet addiction in elementary school students: a regional survey in Japan.

    Kawabe, Kentaro / Horiuchi, Fumie / Hosokawa, Rie / Nakachi, Kiwamu / Soga, Junya / Ueno, Shu-Ichi

    Frontiers in psychiatry

    2023  Band 14, Seite(n) 1187387

    Abstract: In recent years, concerns about internet addiction (IA) among children have been increasing. This study focused on the awareness of IA in elementary school teachers. A web-based anonymous survey was conducted in November 2021. The participants completed ... ...

    Abstract In recent years, concerns about internet addiction (IA) among children have been increasing. This study focused on the awareness of IA in elementary school teachers. A web-based anonymous survey was conducted in November 2021. The participants completed an original questionnaire about their awareness of IA. The participants were divided into three groups based on their positions in the classroom: class teachers, support teachers, and administrative teachers. Out of 283 participants, over 70% had not approached students with IA and had little practical knowledge about the disorder. Support and administrative teachers had more opportunities to interact with students with IA than class teachers (
    Sprache Englisch
    Erscheinungsdatum 2023-07-13
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2023.1187387
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Effects of social media on body dissatisfaction in junior high school girls in Japan.

    Hosokawa, Rie / Kawabe, Kentaro / Nakachi, Kiwamu / Soga, Junya / Horiuchi, Fumie / Ueno, Shu-Ichi

    Eating behaviors

    2022  Band 48, Seite(n) 101685

    Abstract: Aims: Body dissatisfaction (BD) is a serious problem related to the incidence of eating disorders. Social media (SM) use is known to be associated with BD. With a view to preventing the incidence of eating disorders, this study aimed to investigate the ... ...

    Abstract Aims: Body dissatisfaction (BD) is a serious problem related to the incidence of eating disorders. Social media (SM) use is known to be associated with BD. With a view to preventing the incidence of eating disorders, this study aimed to investigate the association between SM and BD, particularly, the role of SM in the encouragement of thinness and its relationship with adolescent girls' BD.
    Methods: Junior high school girls aged 12-15 in Japan completed the Body Shape Questionnaire (BSQ), Eating Attitudes Test-26, Bulimic Investigatory Test Edinburgh, Depression Self-Rating Scale for Children, and SM usage. Participants were classified into two groups based on their BSQ cut-off score.
    Results: Overall, 161 students were recruited (44 participants with BD; 117 without BD). The BD group used SM more than the non-BD group (χ
    Conclusions: The risks of SM use increasing BD in adolescent girls should be considered to prevent mental disorders, including eating disorders.
    Mesh-Begriff(e) Female ; Adolescent ; Child ; Humans ; Body Dissatisfaction ; Thinness ; Body Image ; Social Media ; Japan ; Feeding and Eating Disorders
    Sprache Englisch
    Erscheinungsdatum 2022-11-23
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2073366-5
    ISSN 1873-7358 ; 1471-0153
    ISSN (online) 1873-7358
    ISSN 1471-0153
    DOI 10.1016/j.eatbeh.2022.101685
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Influence of an Esports Program on Problematic Gaming in Children with Autistic Spectrum Disorder: A Pilot Study.

    Kawabe, Kentaro / Horiuchi, Fumie / Hosokawa, Rie / Nakachi, Kiwamu / Soga, Junya / Ueno, Shu-Ichi

    Behavioral sciences (Basel, Switzerland)

    2022  Band 12, Heft 6

    Abstract: Esports (electronic sports) programs are a variant of competitive gaming and have expanded worldwide in recent years. The prevalence of problematic gaming and gaming disorders (GD) is predicted to increase in adolescents. Children with autism spectrum ... ...

    Abstract Esports (electronic sports) programs are a variant of competitive gaming and have expanded worldwide in recent years. The prevalence of problematic gaming and gaming disorders (GD) is predicted to increase in adolescents. Children with autism spectrum disorder (ASD) have a high rate of digital gaming use, and their characteristics, such as social communication deficits and restricted interests, might contribute to problematic gaming. In this study, we aimed to examine whether participation in an Esports program would lead to problematic gaming or GD in children with ASD. The Internet Gaming Disorder Test (IGD-20) scores, Kid-KINDL scores, and gaming time at home were assessed in eight children with ASD before beginning the Esports program and at the three-month follow-up timepoint. The program was held once a week at the welfare service center, where the participants played a set game for 60 min. The results indicated there was no significant worsening in any of the scores after the program. Our program provided the participation time and frequency of Esports, type of game, and motivation of the participants are adequately considered. Even though this pilot study is limited by the small sample size, we concluded that the risk of these activities leading to problematic gaming might be low.
    Sprache Englisch
    Erscheinungsdatum 2022-05-31
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2651997-5
    ISSN 2076-328X
    ISSN 2076-328X
    DOI 10.3390/bs12060172
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  6. Artikel ; Online: Practical clinical guidelines and pharmacological treatment for attention-deficit hyperactivity disorder in Asia.

    Kawabe, Kentaro / Horiuchi, Fumie / Matsumoto, Yu / Inoue, Saori / Okazawa, Maya / Hosokawa, Rie / Nakachi, Kiwamu / Soga, Junya / Ueno, Shu-Ichi

    Neuropsychopharmacology reports

    2023  Band 44, Heft 1, Seite(n) 29–33

    Abstract: Attention-deficit hyperactivity disorder (ADHD) is characterized by persistent symptoms of inattention, hyperactivity, and impulsivity. Both, stimulant and nonstimulant medications have been approved for the treatment of this disorder. Several Western ... ...

    Abstract Attention-deficit hyperactivity disorder (ADHD) is characterized by persistent symptoms of inattention, hyperactivity, and impulsivity. Both, stimulant and nonstimulant medications have been approved for the treatment of this disorder. Several Western guidelines recommend the use of prescribed Food and Drug Administration (FDA)-approved medications for ADHD along with parental training in behavior management and behavioral classroom intervention. In 2022, new Japanese guidelines for ADHD were issued, which recommended school environment management and psychosocial treatment as the first-line treatment, with pharmacological treatment added as the second-line treatment. Although Japanese guidelines, including pharmacological treatments, have been established, the guidelines and utilization of ADHD medications across Asian regions are unclear. Therefore, to appropriately evaluate the strategy of pharmacological treatments for ADHD, we investigated Asian regional guidelines for ADHD medication in children. We also reviewed the guidelines in Malaysia, Singapore, India, and the Republic of Korea and found that these guidelines differ from Western guidelines.
    Mesh-Begriff(e) United States ; Child ; Humans ; Attention Deficit Disorder with Hyperactivity/drug therapy ; Central Nervous System Stimulants/therapeutic use ; Asia
    Chemische Substanzen Central Nervous System Stimulants
    Sprache Englisch
    Erscheinungsdatum 2023-12-07
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ISSN 2574-173X
    ISSN (online) 2574-173X
    DOI 10.1002/npr2.12381
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Combination treatment with guanfacine extended release and blonanserin for Tourette's syndrome comorbid with attention deficit hyperactivity disorder.

    Kawabe, Kentaro / Horiuchi, Fumie / Ueno, Shu-Ichi

    Psychiatry and clinical neurosciences

    2019  Band 73, Heft 12, Seite(n) 762–763

    Mesh-Begriff(e) Adrenergic alpha-2 Receptor Agonists/therapeutic use ; Attention Deficit Disorder with Hyperactivity/drug therapy ; Attention Deficit Disorder with Hyperactivity/epidemiology ; Child ; Comorbidity ; Delayed-Action Preparations/therapeutic use ; Drug Therapy, Combination/methods ; Guanfacine/therapeutic use ; Humans ; Male ; Piperazines/therapeutic use ; Piperidines/therapeutic use ; Tourette Syndrome/drug therapy ; Tourette Syndrome/epidemiology
    Chemische Substanzen Adrenergic alpha-2 Receptor Agonists ; Delayed-Action Preparations ; Piperazines ; Piperidines ; Guanfacine (30OMY4G3MK) ; blonanserin (AQ316B4F8C)
    Sprache Englisch
    Erscheinungsdatum 2019-10-23
    Erscheinungsland Australia
    Dokumenttyp Case Reports ; Letter
    ZDB-ID 1292906-2
    ISSN 1440-1819 ; 1323-1316
    ISSN (online) 1440-1819
    ISSN 1323-1316
    DOI 10.1111/pcn.12935
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Sleep Habits and Electronic Media Usage in Japanese Children: A Prospective Comparative Analysis of Preschoolers.

    Horiuchi, Fumie / Oka, Yasunori / Kawabe, Kentaro / Ueno, Shu-Ichi

    International journal of environmental research and public health

    2020  Band 17, Heft 14

    Abstract: Children are increasingly exposed to electronic media, which can potentially influence their sleep habits. However, few studies have investigated the effects of children's life patterns on sleep habits and electronic media usage. This study investigated ... ...

    Abstract Children are increasingly exposed to electronic media, which can potentially influence their sleep habits. However, few studies have investigated the effects of children's life patterns on sleep habits and electronic media usage. This study investigated the differences in sleep habits and electronic media usage between 18- and 42-month-old children attending nursery schools, kindergartens, or staying at home, and respectively enrolled 183 (boys,
    Mesh-Begriff(e) Child, Preschool ; Female ; Habits ; Humans ; Infant ; Japan ; Life Style ; Male ; Microcomputers ; Prospective Studies ; Sleep ; Surveys and Questionnaires ; Television
    Sprache Englisch
    Erscheinungsdatum 2020-07-17
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1660-4601
    ISSN (online) 1660-4601
    DOI 10.3390/ijerph17145189
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Behavioral Affect in Children with Autism Spectrum Disorder during School Closures Due to the COVID-19 Pandemic in Japan: A Case-Controlled Study.

    Hosokawa, Rie / Kawabe, Kentaro / Nakachi, Kiwamu / Yoshino, Ayumi / Horiuchi, Fumie / Ueno, Shu-Ichi

    Developmental neuropsychology

    2021  Band 46, Heft 4, Seite(n) 288–297

    Abstract: Children with autism spectrum disorder (ASD) could experience more stress due to the changes consequent to school closures because of the coronavirus disease 2019 (COVID-19) pandemic. This study investigated differences in behavioral affect between ... ...

    Abstract Children with autism spectrum disorder (ASD) could experience more stress due to the changes consequent to school closures because of the coronavirus disease 2019 (COVID-19) pandemic. This study investigated differences in behavioral affect between children with ASD and typically developing children (TD). We conducted an online survey with mothers. The data of 84 children with ASD and 361 TD children aged 6 to 18 years were analyzed. Children with ASD were more frustrated due to the changes in their schedule and engaged more in restricted and repetitive behavior. Children with ASD had different types of behavioral affect compared to TD.
    Mesh-Begriff(e) Autism Spectrum Disorder/epidemiology ; COVID-19 ; Child ; Female ; Humans ; Japan/epidemiology ; Pandemics ; Schools
    Sprache Englisch
    Erscheinungsdatum 2021-06-23
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 632665-1
    ISSN 1532-6942 ; 8756-5641
    ISSN (online) 1532-6942
    ISSN 8756-5641
    DOI 10.1080/87565641.2021.1939350
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  10. Artikel ; Online: Editorial: comorbidities, concomitant medications, and potential drug-drug interactions with interferon-free direct-acting anti-viral agents in chronic hepatitis C.

    Kawabe, Naoto / Hashimoto, Senju / Yoshioka, Kentaro

    Alimentary pharmacology & therapeutics

    2018  Band 49, Heft 1, Seite(n) 116–117

    Mesh-Begriff(e) Antiviral Agents ; Drug Interactions ; Hepacivirus ; Hepatitis C ; Hepatitis C, Chronic ; Humans ; Interferons ; Taiwan
    Chemische Substanzen Antiviral Agents ; Interferons (9008-11-1)
    Sprache Englisch
    Erscheinungsdatum 2018-12-13
    Erscheinungsland England
    Dokumenttyp Editorial ; Comment
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.15051
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