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Artikel ; Online: Smart apps for self-reporting clinical information.

Houhamdi, Linda / Fournier, Pierre-Edouard

2022 Band 399, Heft 10335, Seite(n) 1575–1576

Mesh-Begriff(e)	Humans ; Mobile Applications ; Smartphone
Sprache	Englisch
Erscheinungsdatum	2022-04-07
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	3306-6
ISSN	1474-547X ; 0023-7507 ; 0140-6736
ISSN (online)	1474-547X
ISSN	0023-7507 ; 0140-6736
DOI	10.1016/S0140-6736(22)00453-6
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Coxiella burnetii

Azouzi, Farah / Olagne, Louis / Edouard, Sophie / Cammilleri, Serge / Magnan, Pierre-Edouard / Fournier, Pierre-Edouard / Million, Matthieu

Microorganisms

2023 Band 11, Heft 9

Abstract: Cardiovascular infections are the most severe and potentially lethal among the persistent ... ...

Abstract	Cardiovascular infections are the most severe and potentially lethal among the persistent focalized
Sprache	Englisch
Erscheinungsdatum	2023-08-24
Erscheinungsland	Switzerland
Dokumenttyp	Case Reports
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms11092146
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Draft Genomes of Two Fusobacterium simiae Strains.

Zoaiter, Malak / Fournier, Pierre-Edouard / Houhamdi, Linda

Microbiology resource announcements

2023 Band 12, Heft 4, Seite(n) e0125522

Abstract: Here, we reported two draft genomes of Fusobacterium simiae: strain DSM 19848, initially isolated from monkey dental plaque, and its close relative strain Marseille-Q7035, cultivated from a human intra-abdominal abscess puncture fluid. Their genome sizes ...

Abstract	Here, we reported two draft genomes of Fusobacterium simiae: strain DSM 19848, initially isolated from monkey dental plaque, and its close relative strain Marseille-Q7035, cultivated from a human intra-abdominal abscess puncture fluid. Their genome sizes are 2.4 Mb and 2.5Mb, respectively. Their G+C contents were 27.1% and 27.2%, respectively.
Sprache	Englisch
Erscheinungsdatum	2023-03-09
Erscheinungsland	United States
Dokumenttyp	Journal Article
ISSN	2576-098X
ISSN (online)	2576-098X
DOI	10.1128/mra.01255-22
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Coxiella burnetii Femoro-Popliteal Bypass Infection

Farah Azouzi / Louis Olagne / Sophie Edouard / Serge Cammilleri / Pierre-Edouard Magnan / Pierre-Edouard Fournier / Matthieu Million

Microorganisms, Vol 11, Iss 2146, p

A Case Report

2023 Band 2146

Abstract: Cardiovascular infections are the most severe and potentially lethal among the persistent focalized Coxiella burnetii infections. While aortic infections on aneurysms or prostheses are well-known, with specific complications (risk of fatal rupture), new ... ...

Abstract	Cardiovascular infections are the most severe and potentially lethal among the persistent focalized Coxiella burnetii infections. While aortic infections on aneurysms or prostheses are well-known, with specific complications (risk of fatal rupture), new non-aortic vascular infections are increasingly being described thanks to the emerging use of 18-fluorodeoxyglucose positron emission tomography ( 18 F-FDG PET-scan). Here, we describe an infection of a femoro-popliteal bypass that would not have been diagnosed without the use of PET-scan. It is well-known that vascular prosthetic material is a site favorable for bacterial persistence, but the description of unusual anatomical sites, outside the heart or aorta, should raise the clinicians’ awareness and generalize the indications for PET-scan, with careful inclusion of the upper and lower limbs (not included in PET-scan for cancer), particularly in the presence of vascular prostheses. Future studies will be needed to precisely determine their optimal management.
Schlagwörter	Q fever ; Coxiella burnetii ; PET-scan ; vascular graft infection ; Biology (General) ; QH301-705.5
Thema/Rubrik (Code)	333
Sprache	Englisch
Erscheinungsdatum	2023-08-01T00:00:00Z
Verlag	MDPI AG
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel ; Online: Incidental diagnosis of mpox virus infection in patients undergoing sexually transmitted infection screening-findings from a study in France.

Edouard, Sophie / Boschi, Céline / Colson, Philippe / Million, Matthieu / Fournier, Pierre-Edouard / La Scola, Bernard / Fenollar, Florence

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

2024 Band 143, Seite(n) 107009

Abstract: Objectives: This study aimed to investigate the prevalence of mpox virus (MPXV) infections in the general population consulting for routine sexually transmitted infections (STIs) in our Marseille public hospital. In fact, the recent worldwide MPXV ... ...

Abstract	Objectives: This study aimed to investigate the prevalence of mpox virus (MPXV) infections in the general population consulting for routine sexually transmitted infections (STIs) in our Marseille public hospital. In fact, the recent worldwide MPXV outbreak mainly impacted men who have sex with men and the prevalence of MPXV infections in the general population remains poorly defined. Methods: All samples addressed routinely to our microbiological laboratory for STIs between July 1 and October 15, 2022 were screened with MPXV-specific quantitative polymerase chain reaction. Results: A total of 2688 samples from 1896 patients suspected of having STIs were tested and eight (0.4%) patients were incidentally diagnosed with MPXV infection, including six men and two women. MPXV was detected in rectal swabs (n = 2), urine (n = 2), vaginal swabs (n = 2), a urethral swab (n = 1), and a skin swab (n = 1). Conclusions: This study suggests that some MPXV infections are likely to be underdiagnosed because of their non-specific clinical presentation and/or insufficient clinical knowledge of the disease. Our data showed that systematic screening was particularly useful for detecting MPXV in patients without classic lesions or cases of asymptomatic carriage in patients reporting recent high-risk exposure and in patients presenting no obvious risk factor.
Mesh-Begriff(e)	Humans ; Male ; Female ; Adult ; France/epidemiology ; Middle Aged ; Prevalence ; Incidental Findings ; Sexually Transmitted Diseases/diagnosis ; Sexually Transmitted Diseases/epidemiology ; Sexually Transmitted Diseases/virology ; Young Adult ; Mass Screening/methods
Sprache	Englisch
Erscheinungsdatum	2024-03-21
Erscheinungsland	Canada
Dokumenttyp	Journal Article
ZDB-ID	1331197-9
ISSN	1878-3511 ; 1201-9712
ISSN (online)	1878-3511
ISSN	1201-9712
DOI	10.1016/j.ijid.2024.107009
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Culture-negative endocarditis caused by <i>Stenotrophomonas maltophilia</i>: a report of two cases.

Balasubramanian, Rayvathy / Fournier, Pierre-Edouard / Menon, Thangam

Future microbiology

2022 Band 17, Seite(n) 819–822

Abstract: ... Stenotrophomonas maltophilia ... , an aerobic, non-fermenting, Gram-negative bacterium, is an emerging nosocomial pathogen. It is considered to be a low-grade pathogen, and infections due to ... S. maltophilia ... are uncommon. However, in the recent ... ...

Abstract	Stenotrophomonas maltophilia, an aerobic, non-fermenting, Gram-negative bacterium, is an emerging nosocomial pathogen. It is considered to be a low-grade pathogen, and infections due to S. maltophilia are uncommon. However, in the recent past, S. maltophilia infections have been on the rise, particularly in patients who are either immunocompromised, aged or on long-term antibiotic therapy. Endocarditis due to S. maltophilia is extremely rare. This is a report of two patients with S. maltophilia endocarditis who were diagnosed by 16S rRNA gene sequencing.
Mesh-Begriff(e)	Aged ; Anti-Bacterial Agents/therapeutic use ; Endocarditis/complications ; Endocarditis/diagnosis ; Endocarditis/drug therapy ; Gram-Negative Bacterial Infections/diagnosis ; Gram-Negative Bacterial Infections/drug therapy ; Humans ; RNA, Ribosomal, 16S/genetics ; Stenotrophomonas maltophilia/genetics
Chemische Substanzen	Anti-Bacterial Agents ; RNA, Ribosomal, 16S
Sprache	Englisch
Erscheinungsdatum	2022-06-01
Erscheinungsland	England
Dokumenttyp	Case Reports ; Journal Article
ZDB-ID	2254620-0
ISSN	1746-0921 ; 1746-0913
ISSN (online)	1746-0921
ISSN	1746-0913
DOI	10.2217/fmb-2021-0313
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Carbonyl Cyanide 3-Chloro Phenyl Hydrazone (CCCP) Restores the Colistin Sensitivity in Brucella intermedia

Malak Zoaiter / Zaher Zeaiter / Oleg Mediannikov / Cheikh Sokhna / Pierre-Edouard Fournier

International Journal of Molecular Sciences, Vol 24, Iss 2106, p

2023 Band 2106

Abstract: Brucella intermedia (formerly Ochrobactrum intermedium ), a non-fermentative bacterium, has been isolated from animals and human clinical specimens. It is naturally resistant to polymyxins, including colistin (CO), and may cause opportunistic infections ... ...

Abstract	Brucella intermedia (formerly Ochrobactrum intermedium ), a non-fermentative bacterium, has been isolated from animals and human clinical specimens. It is naturally resistant to polymyxins, including colistin (CO), and may cause opportunistic infections in humans. We isolated six Brucella intermedia strains from Senegalese monkey stool. In order to determine whether an efflux pump mechanism was involved in CO resistance in B. intermedia, we evaluated the effects of verapamil (VRP), reserpine (RSP), phe-arg β-naphthylamide dihydrochloride (PAβN) and carbonyl cyanide 3-chloro phenyl hydrazone (CCCP), four efflux pump inhibitors, on these colistin-resistant strains. Using the broth microdilution method, a CO and CCCP combination of 2 µg/mL and 10 µg/mL, respectively, significantly reduced the CO minimal inhibitory concentration (MIC) of B. intermedia , supporting an efflux pump mechanism. In contrast, VRP, PAβN and RSP did not restore CO susceptibility. A time kill assay showed a bactericidal effect of the CO–CCCP combination. Genomic analysis revealed a potential implication in the CO resistance mechanism of some conserved efflux pumps, such as YejABEF, NorM and EmrAB, as previously reported in other bacteria. An inhibitory effect of the CO–CCCP combination was observed on biofilm formation using the crystal violet method. These results suggest that the intrinsic CO resistance in Brucella intermedia is linked to an efflux pump mechanism and that the synergistic effect of CO–CCCP may open a new field to identify new treatments to restore antibiotic efficacy in humans.
Schlagwörter	intrinsic colistin resistance ; efflux pump inhibitors ; carbonyl cyanide 3-chloro phenyl hydrazone ; CO-MIC ; synergy ; efflux pump ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Thema/Rubrik (Code)	540
Sprache	Englisch
Erscheinungsdatum	2023-01-01T00:00:00Z
Verlag	MDPI AG
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel ; Online: Carbonyl Cyanide 3-Chloro Phenyl Hydrazone (CCCP) Restores the Colistin Sensitivity in

Zoaiter, Malak / Zeaiter, Zaher / Mediannikov, Oleg / Sokhna, Cheikh / Fournier, Pierre-Edouard

International journal of molecular sciences

2023 Band 24, Heft 3

Abstract: ... Brucella ... ...

Abstract	Brucella intermedia
Mesh-Begriff(e)	Humans ; Colistin/pharmacology ; Carbonyl Cyanide m-Chlorophenyl Hydrazone/pharmacology ; Hydrazones ; Anti-Bacterial Agents/pharmacology ; Brucella ; Microbial Sensitivity Tests
Chemische Substanzen	Colistin (Z67X93HJG1) ; mesoxalonitrile (1115-12-4) ; Carbonyl Cyanide m-Chlorophenyl Hydrazone (555-60-2) ; Hydrazones ; Anti-Bacterial Agents
Sprache	Englisch
Erscheinungsdatum	2023-01-20
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24032106
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Genomic evolution and adaptation of arthropod-associated Rickettsia

Khalid El Karkouri / Eric Ghigo / Didier Raoult / Pierre-Edouard Fournier

Scientific Reports, Vol 12, Iss 1, Pp 1-

2022 Band 15

Abstract: Abstract Rickettsia species are endosymbionts hosted by arthropods and are known to cause mild to fatal diseases in humans. Here, we analyse the evolution and diversity of 34 Rickettsia species using a pangenomic meta-analysis (80 genomes/41 plasmids). ... ...

Abstract	Abstract Rickettsia species are endosymbionts hosted by arthropods and are known to cause mild to fatal diseases in humans. Here, we analyse the evolution and diversity of 34 Rickettsia species using a pangenomic meta-analysis (80 genomes/41 plasmids). Phylogenomic trees showed that Rickettsia spp. diverged into two Spotted Fever groups, a Typhus group, a Canadensis group and a Bellii group, and may have inherited their plasmids from an ancestral plasmid that persisted in some strains or may have been lost by others. The results suggested that the ancestors of Rickettsia spp. might have infected Acari and/or Insecta and probably diverged by persisting inside and/or switching hosts. Pangenomic analysis revealed that the Rickettsia genus evolved through a strong interplay between genome degradation/reduction and/or expansion leading to possible distinct adaptive trajectories. The genus mainly shared evolutionary relationships with α-proteobacteria, and also with γ/β/δ-proteobacteria, cytophagia, actinobacteria, cyanobacteria, chlamydiia and viruses, suggesting lateral exchanges of several critical genes. These evolutionary processes have probably been orchestrated by an abundance of mobile genetic elements, especially in the Spotted Fever and Bellii groups. In this study, we provided a global evolutionary genomic view of the intracellular Rickettsia that may help our understanding of their diversity, adaptation and fitness.
Schlagwörter	Medicine ; R ; Science ; Q
Thema/Rubrik (Code)	590
Sprache	Englisch
Erscheinungsdatum	2022-03-01T00:00:00Z
Verlag	Nature Portfolio
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel ; Online: Past Bartonelloses.

Fournier, Pierre-Edouard

Microbiology spectrum

2016 Band 4, Heft 3

Abstract: The origins of human infectious diseases have long fascinated scientists worldwide. Paleomicrobiology offers a unique access to the history of these infections and sheds light on ancient and historical epidemics. In this chapter, we review the ... ...

Abstract	The origins of human infectious diseases have long fascinated scientists worldwide. Paleomicrobiology offers a unique access to the history of these infections and sheds light on ancient and historical epidemics. In this chapter, we review the paleomicrobiological evidence for Bartonella infections.
Mesh-Begriff(e)	Animals ; Bacteriological Techniques/methods ; Bartonella/isolation & purification ; Bartonella Infections/epidemiology ; Bartonella Infections/history ; Fossils/microbiology ; History, 15th Century ; History, 16th Century ; History, 17th Century ; History, 18th Century ; History, 19th Century ; History, Ancient ; History, Medieval ; Humans ; Paleopathology/methods
Sprache	Englisch
Erscheinungsdatum	2016-06-20
Erscheinungsland	United States
Dokumenttyp	Historical Article ; Journal Article ; Review
ISSN	2165-0497
ISSN (online)	2165-0497
DOI	10.1128/microbiolspec.PoH-0007-2015
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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