Artikel ; Online: Monocyte-crosstalk drives interferon-mediated signaling following SARS-CoV-2 exposure.
2022 Band 18, Heft 9, Seite(n) e11256
Abstract: Cells of the innate immune system represent the first line of defense against SARS-CoV-2 and play an essential role in activating adaptive immunity, which mediates long-term protection. In addition, the same cells are key drivers of tissue damage by ... ...
Abstract | Cells of the innate immune system represent the first line of defense against SARS-CoV-2 and play an essential role in activating adaptive immunity, which mediates long-term protection. In addition, the same cells are key drivers of tissue damage by causing the hyperinflammatory state and cytokine storm that makes COVID-19 a deadly disease. Thus, careful dissection of the host-pathogen interaction on a cellular level is essential to understanding SARS-CoV-2 pathogenesis and developing new treatment modalities against COVID-19. In their recent work, Goffinet and colleagues (Kazmierski et al, 2022) investigate the cell-intrinsic responses of human primary peripheral blood mononuclear cells (PBMCs) exposed to SARS coronaviruses. |
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Mesh-Begriff(e) | COVID-19/drug therapy ; Humans ; Immunity, Innate ; Interferons ; Leukocytes, Mononuclear ; Monocytes ; SARS-CoV-2 |
Chemische Substanzen | Interferons (9008-11-1) |
Sprache | Englisch |
Erscheinungsdatum | 2022-09-12 |
Erscheinungsland | England |
Dokumenttyp | Journal Article ; Comment |
ZDB-ID | 2193510-5 |
ISSN | 1744-4292 ; 1744-4292 |
ISSN (online) | 1744-4292 |
ISSN | 1744-4292 |
DOI | 10.15252/msb.202211256 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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