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  1. Buch ; Online: Coumarin and Its Derivatives

    Matos, Maria João / Matos, Maria João

    2021  

    Schlagwörter Research & information: general ; Biology, life sciences ; coumarin ; hydroxyl-modified coumarin ; photophysical ; thermal and structural characterization ; Glycyrrhiza uralensis ; glycyrol ; liquiritigenin ; cholinesterases ; human monoamine oxidases ; kinetics ; docking simulation ; chalcone ; neurodegenerative diseases ; adenosine receptors ; binding affinity ; docking ; 4-hydroxy-7-methoxycoumarin ; macrophage ; inflammation ; NF-κB ; MAPK ; calanolides ; pseudocalanolides ; calanolide A ; Calophyllum ; Calophyllaceae ; anti-HIV ; reverse transcriptase ; non-nucleoside reverse transcriptase inhibitors (NNRTIs) ; osthole ; umbelliferone ; esculin ; 4-hydroxycoumarin ; sorafenib ; apoptosis ; autophagy ; Yin Chen Hao ; constitutive androstane receptor ; scoparone ; coumarins ; quorum sensing ; QS inhibitors ; plant-derived molecules ; Chromobacterium violaceum ; immunoproteasome ; psoralen core ; non-peptidic ; electrophilic compounds ; warhead scan ; inflammatory bowel disease ; isocoumarin ; Crohn's disease ; ulcerative colitis ; glutathione ; oxidative stress ; complementary therapies ; intestinal inflammation ; benzopyrones ; five-membered aromatic heterocycles ; furan ; pyrrole ; thiophene ; selenophen ; dihydrocoumarin-fused dihydropyranones ; 3-aroylcoumarines ; benzyl 2,3-butadienoate ; 6'-(4-biphenyl)-β-iso-cinchonine ; biological applications ; drug discovery ; fluorescent probes ; warfarin ; acenocoumarol ; mechanical valve ; time in therapeutic range ; anticoagulation ; Ruta chalepensis ; Rutaceae ; chalepin ; chalepensin ; bioactivity ; biosynthesis ; coumarin3-carboxamides ; pyranocoumarins ; anticancer activity ; antibacterial activity ; free radical polymerization ; LED ; photocomposites ; direct laser write ; analytical methods ; model plant ; natural genetic variation ; natural products ; simple coumarins ; chalcocoumarin ; MAO-B ; molecular dynamics ; in silico studies ; dye-sensitized solar cells ; coumarin dyes ; thieno [3,2-b] thiophene ; charge transfer ; ethynylaryl ; esculetin ; antiplatelet activity ; impedance aggregometry ; COX ; polyphenols ; pyrazole ; imidazole ; thiazole ; oxazole ; triazole ; thiadiazole ; curcumin ; curcumin-coumarin hybrids ; neuroprotection ; monoamine oxidase inhibition ; cholinesterase inhibition ; scavenging activity ; Escherichia coli ; biotransformation ; ferulenol ; structural annotation ; in silico tools ; n/a
    Umfang 1 electronic resource (406 pages)
    Verlag MDPI - Multidisciplinary Digital Publishing Institute
    Erscheinungsort Basel, Switzerland
    Dokumenttyp Buch ; Online
    Anmerkung English ; Open Access
    HBZ-ID HT021291115
    ISBN 9783036527741 ; 3036527745
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  2. Artikel ; Online: Treating neurodegenerative diseases with multitarget drugs: an interview with Maria João Matos.

    Matos, Maria João

    Future medicinal chemistry

    2022  Band 14, Heft 12, Seite(n) 847–850

    Abstract: Neurodegenerative diseases are one of the leading causes of death, disability and dependency worldwide. Since the etiology of these complex pathologies is not completely known, the available therapeutic options can only cause temporary relief of the ... ...

    Abstract Neurodegenerative diseases are one of the leading causes of death, disability and dependency worldwide. Since the etiology of these complex pathologies is not completely known, the available therapeutic options can only cause temporary relief of the symptoms, but cannot cure them. Life-changing therapeutic solutions are urgently needed, as the number of people suffering from these pathologies has been increasing quickly over the last few decades. Recent studies regarding the paradigm of using multitarget compounds to treat both Alzheimer's and Parkinson's diseases have been analyzed and included in the review entitled
    Mesh-Begriff(e) Alzheimer Disease/drug therapy ; Humans ; Neurodegenerative Diseases/drug therapy ; Parkinson Disease/drug therapy
    Sprache Englisch
    Erscheinungsdatum 2022-05-06
    Erscheinungsland England
    Dokumenttyp Interview
    ISSN 1756-8927
    ISSN (online) 1756-8927
    DOI 10.4155/fmc-2022-0077
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Buch ; Online: COVID-19. Normas de Orientação Clínica - Medicina Dentária

    Guerra, Fernando / Mata, António Duarte / Vinagre, Alexandra / Costa, Ana Luísa / Vieira, Andreia Luís / Falcão, Carlos / Chaves, Catarina / Herrera, David / Baptista, Isabel Poiares / Toro, Ivan / Braga, João / Ramos, João Carlos / Santos, João Miguel / Silveira, João Miguel / Tondela, João Paulo / Palma, Paulo / Nicolau, Pedro / Gomes, Pedro Sousa / Dias, Ricardo /
    Rocha, Salomão / Matos, Sérgio

    2020  

    Umfang 1 electronic resource (180 pages)
    Verlag Coimbra University Press
    Dokumenttyp Buch ; Online
    Anmerkung Dental Medicine, Dentistry Guidelines, Evidence based Medicine, SARS CoV 2 , Covid 19 ; Open Access
    HBZ-ID HT020589140
    ISBN 9789892619859 ; 9892619854
    DOI 10.14195/978-989-26-1986-6
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  4. Artikel ; Online: Coumarin and Its Derivatives-Editorial.

    Matos, Maria João

    Molecules (Basel, Switzerland)

    2021  Band 26, Heft 20

    Abstract: Coumarins are widely distributed in nature and can be found in a large number of naturally occurring and synthetic bioactive molecules [ ... ]. ...

    Abstract Coumarins are widely distributed in nature and can be found in a large number of naturally occurring and synthetic bioactive molecules [...].
    Mesh-Begriff(e) Coumarins/chemistry ; Humans
    Chemische Substanzen Coumarins ; coumarin (A4VZ22K1WT)
    Sprache Englisch
    Erscheinungsdatum 2021-10-19
    Erscheinungsland Switzerland
    Dokumenttyp Editorial
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26206320
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.MO 81: Hefte anzeigen

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  5. Artikel ; Online: Multitarget therapeutic approaches for Alzheimer's and Parkinson's diseases: an opportunity or an illusion?

    Matos, Maria João

    Future medicinal chemistry

    2021  Band 13, Heft 15, Seite(n) 1301–1309

    Abstract: Alzheimer's and Parkinson's disease are the most prevalent neurodegenerative diseases and the leading causes of dementia worldwide. The etiology of these multifactorial pathologies is not completely known. The available therapeutic approaches can cause ... ...

    Abstract Alzheimer's and Parkinson's disease are the most prevalent neurodegenerative diseases and the leading causes of dementia worldwide. The etiology of these multifactorial pathologies is not completely known. The available therapeutic approaches can cause temporary relief of symptoms but cannot slow down their progression or cure them. Life-changing therapeutic solutions are urgently needed, as the number of people suffering from these pathologies has been increasing quickly over the last few decades. Several targets are being studied, and innovative approaches are being pursued to find new therapeutic options. This overview is focused on the most recent information regarding the paradigm of using multitarget compounds to treat both Alzheimer's and Parkinson's disease.
    Mesh-Begriff(e) Alzheimer Disease/drug therapy ; Alzheimer Disease/pathology ; Donepezil/chemistry ; Donepezil/pharmacology ; Donepezil/therapeutic use ; Drug Synergism ; Humans ; Indans/chemistry ; Indans/pharmacology ; Indans/therapeutic use ; Neuroprotective Agents/chemistry ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/therapeutic use ; Parkinson Disease/drug therapy ; Parkinson Disease/pathology ; Protein Aggregates/drug effects ; Small Molecule Libraries/chemistry ; Small Molecule Libraries/pharmacology ; Small Molecule Libraries/therapeutic use
    Chemische Substanzen Indans ; Neuroprotective Agents ; Protein Aggregates ; Small Molecule Libraries ; rasagiline (003N66TS6T) ; Donepezil (8SSC91326P)
    Sprache Englisch
    Erscheinungsdatum 2021-06-17
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 1756-8927
    ISSN (online) 1756-8927
    DOI 10.4155/fmc-2021-0119
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Forensic psychological procedures in cases of technology-facilitated sexual abuse among adolescents: A scoping review.

    Vale, Maria / Gomes, João P / Matos, Marlene

    Behavioral sciences & the law

    2024  

    Abstract: Technology-facilitated sexual abuse refers to the use of information and communication technologies to facilitate both virtual and in-person sexual crimes. Research on this topic has focused on rates, risk factors, and consequences. This scoping review ... ...

    Abstract Technology-facilitated sexual abuse refers to the use of information and communication technologies to facilitate both virtual and in-person sexual crimes. Research on this topic has focused on rates, risk factors, and consequences. This scoping review aims to understand whether and how forensic psychological procedures are adapted to assess adolescent victims and how Internet-based information might be useful as complementary data. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extensions for Scoping Reviews guidelines, searches were conducted in April 2023 in five electronic databases to include Portuguese, Spanish, or English quantitative, qualitative, or mixed-method peer-reviewed studies. Of the 2523 studies, six were considered eligible. Identified procedures include forensic interviews following the National Institute for Child Health and Human Development Protocol, and risk and trauma assessments. While discussing technology's role in abuse during interviews was informative, confronting adolescents with evidence of their abuse had adverse effects on their testimony and recovery. The assessment tools often had a narrow focus or overlooked the abuse unless explicitly disclosed, implied a referral, or when safeguarding concerns were raised. Clinical, forensic, and criminal implications are elaborated.
    Sprache Englisch
    Erscheinungsdatum 2024-04-18
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 232671-1
    ISSN 1099-0798 ; 0735-3936
    ISSN (online) 1099-0798
    ISSN 0735-3936
    DOI 10.1002/bsl.2658
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 4672: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Artikel ; Online: Coumarin and Its Derivatives—Editorial

    Maria João Matos

    Molecules, Vol 26, Iss 6320, p

    2021  Band 6320

    Abstract: Coumarins are widely distributed in nature and can be found in a large number of naturally occurring and synthetic bioactive molecules [.] ...

    Abstract Coumarins are widely distributed in nature and can be found in a large number of naturally occurring and synthetic bioactive molecules [.]
    Schlagwörter n/a ; Organic chemistry ; QD241-441
    Sprache Englisch
    Erscheinungsdatum 2021-10-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

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  8. Artikel: Medicinal Chemistry in Portugal and Spain: A Strong Iberian Alliance.

    Matos, Maria João / Blanco, Maria-Jesus

    ACS medicinal chemistry letters

    2022  Band 13, Heft 6, Seite(n) 871–872

    Sprache Englisch
    Erscheinungsdatum 2022-06-09
    Erscheinungsland United States
    Dokumenttyp Editorial
    ISSN 1948-5875
    ISSN 1948-5875
    DOI 10.1021/acsmedchemlett.2c00194
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Modelling patient trajectories using multimodal information.

    Silva, João Figueira / Matos, Sérgio

    Journal of biomedical informatics

    2022  Band 134, Seite(n) 104195

    Abstract: Background: Electronic Health Records (EHRs) aggregate diverse information at the patient level, holding a trajectory representative of the evolution of the patient health status throughout time. Although this information provides context and can be ... ...

    Abstract Background: Electronic Health Records (EHRs) aggregate diverse information at the patient level, holding a trajectory representative of the evolution of the patient health status throughout time. Although this information provides context and can be leveraged by physicians to monitor patient health and make more accurate prognoses/diagnoses, patient records can contain information from very long time spans, which combined with the rapid generation rate of medical data makes clinical decision making more complex. Patient trajectory modelling can assist by exploring existing information in a scalable manner, and can contribute in augmenting health care quality by fostering preventive medicine practices (e.g. earlier disease diagnosis).
    Methods: We propose a solution to model patient trajectories that combines different types of information (e.g. clinical text, standard codes) and considers the temporal aspect of clinical data. This solution leverages two different architectures: one supporting flexible sets of input features, to convert patient admissions into dense representations; and a second exploring extracted admission representations in a recurrent-based architecture, where patient trajectories are processed in sub-sequences using a sliding window mechanism.
    Results: The developed solution was evaluated on two different clinical outcomes, unexpected patient readmission and disease progression, using the publicly available Medical Information Mart for Intensive Care (MIMIC)-III clinical database. The results obtained demonstrate the potential of the first architecture to model readmission and diagnoses prediction using single patient admissions. While information from clinical text did not show the discriminative power observed in other existing works, this may be explained by the need to fine-tune the clinicalBERT model. Finally, we demonstrate the potential of the sequence-based architecture using a sliding window mechanism to represent the input data, attaining comparable performances to other existing solutions.
    Conclusion: Herein, we explored DL-based techniques to model patient trajectories and propose two flexible architectures that explore patient admissions on an individual and sequence basis. The combination of clinical text with other types of information led to positive results, which can be further improved by including a fine-tuned version of clinicalBERT in the architectures. The proposed solution can be publicly accessed at https://github.com/bioinformatics-ua/PatientTM.
    Mesh-Begriff(e) Disease Progression ; Electronic Health Records ; Humans ; Patient Readmission ; Physicians ; Prognosis
    Sprache Englisch
    Erscheinungsdatum 2022-09-21
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2057141-0
    ISSN 1532-0480 ; 1532-0464
    ISSN (online) 1532-0480
    ISSN 1532-0464
    DOI 10.1016/j.jbi.2022.104195
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Image Significance in the Diagnosis of Another Case of Herpetic Encephalitis.

    Manata, José Pedro / Silva, Bernardo / Sousa, Mafalda / Matos Costa, João

    Cureus

    2024  Band 16, Heft 2, Seite(n) e53883

    Abstract: Herpes simplex virus 1 (HSV-1) causes necrotizing encephalitis, usually located in the temporal lobes and with a high mortality rate if not diagnosed and treated early. Cranial computed tomography (CT) scan, although not very sensitive, can help by ... ...

    Abstract Herpes simplex virus 1 (HSV-1) causes necrotizing encephalitis, usually located in the temporal lobes and with a high mortality rate if not diagnosed and treated early. Cranial computed tomography (CT) scan, although not very sensitive, can help by highlighting hemorrhagic foci and edema in the frontotemporal lobes, given the tropism of the virus for these areas. We present the case of a 70-year-old male who came to the emergency department (ED) with fever and confusion. Despite an unclear cerebrospinal fluid (CSF) result, the CT scan showed a spot of hypodensity in the mesial aspect of the left temporal lobe. He was given 21 days of intravenous acyclovir, and his neurological condition normalized. These cranial CT alterations, although not pathognomonic, indicate a strong suspicion of herpetic encephalitis.
    Sprache Englisch
    Erscheinungsdatum 2024-02-08
    Erscheinungsland United States
    Dokumenttyp Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.53883
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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