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  1. AU=Tung Ho Carmen Lok AU=Tung Ho Carmen Lok
  2. AU="Ahsan Waseem"
  3. AU="Pall, Emoke"
  4. AU=Schenkel Jason M.
  5. AU="Axel Kroeger"
  6. AU="Pelikan, Melisa"
  7. AU=Qi Yan Fei
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  11. AU="Hargett, Kirsten L"
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  13. AU="Bruijns, Sven"
  14. AU=Hollander S
  15. AU="Mishra, Bimal Kumar"
  16. AU="Kiersten Teitelbaum"
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  18. AU="Diego Rosselli"
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  21. AU="Elashoff, David A"
  22. AU="Di Salvo, Jessica"
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  25. AU=Sankar Krishana S
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  31. AU="Arrate, Clara"
  32. AU="Tarrach, Klaus"
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  36. AU=Chattopadhyay Sanchari
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  38. AU="Desmecht, Daniel"
  39. AU="Juškov, A. N"
  40. AU="Bach, Francis"
  41. AU="Afşin, Emine"
  42. AU="McLeod, Jonathan"
  43. AU=Srensen Morten Drby
  44. AU=de Noronha Lucia
  45. AU=Robinson Jennifer G
  46. AU=CHIACO JOHN MICHAEL S. CHUA
  47. AU="Simon, Benedikt"
  48. AU="Zhao, Andong"
  49. AU="Zhao, Tianshi"
  50. AU="Morris, Helen"

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  1. Artikel ; Online: Team-based learning: A medical student's perspective.

    Ho, Carmen Lok Tung

    Medical teacher

    2019  Band 41, Heft 9, Seite(n) 1087

    Mesh-Begriff(e) Education, Medical ; Humans ; Motivation ; Problem-Based Learning ; Students, Medical
    Sprache Englisch
    Erscheinungsdatum 2019-02-01
    Erscheinungsland England
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 424426-6
    ISSN 1466-187X ; 0142-159X
    ISSN (online) 1466-187X
    ISSN 0142-159X
    DOI 10.1080/0142159X.2018.1555370
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  2. Artikel: Peer tutoring scheme: a medical student's perspective.

    Ho, Carmen Lok Tung

    Advances in medical education and practice

    2018  Band 9, Seite(n) 605–606

    Sprache Englisch
    Erscheinungsdatum 2018-08-29
    Erscheinungsland New Zealand
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 2578539-4
    ISSN 1179-7258
    ISSN 1179-7258
    DOI 10.2147/AMEP.S178365
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  3. Artikel ; Online: The Effects of Testosterone Treatment on Cardiovascular Health.

    Jayasena, Channa N / Ho, Carmen Lok Tung / Bhasin, Shalender

    Endocrinology and metabolism clinics of North America

    2022  Band 51, Heft 1, Seite(n) 109–122

    Abstract: Current evidence suggests that testosterone therapy has numerous benefits and risks on cardiovascular health. Examples of this include published data that support improvements in insulin sensitivity and body composition which may reduce the risk of ... ...

    Abstract Current evidence suggests that testosterone therapy has numerous benefits and risks on cardiovascular health. Examples of this include published data that support improvements in insulin sensitivity and body composition which may reduce the risk of diabetes. On the other hand, testosterone therapy may offset such benefits by mild impairments in lipid parameters. Consequently, controversy on the effects of testosterone therapy on cardiovascular health remains. Studies are underway to clarify this important question for the benefit of men with hypogonadism.
    Mesh-Begriff(e) Cardiovascular Diseases/prevention & control ; Cardiovascular System ; Hormone Replacement Therapy ; Humans ; Hypogonadism/drug therapy ; Male ; Testosterone/pharmacology ; Testosterone/therapeutic use
    Chemische Substanzen Testosterone (3XMK78S47O)
    Sprache Englisch
    Erscheinungsdatum 2022-02-08
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 92116-6
    ISSN 1558-4410 ; 0889-8529
    ISSN (online) 1558-4410
    ISSN 0889-8529
    DOI 10.1016/j.ecl.2021.11.006
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Does norovirus induce acute hepatitis?

    Carmen Lok Tung Ho / Olivia Oligbu / Fatma Asaid / Godwin Oligbu

    AIMS Public Health, Vol 7, Iss 1, Pp 148-

    2020  Band 157

    Abstract: Background: Norovirus is the commonest cause of acute viral gastroenteritis with significant morbidity. Extra intestinal manifestation following norovirus infection is rare and the mechanism is unknown. Methods: We undertook a review of the English ... ...

    Abstract Background: Norovirus is the commonest cause of acute viral gastroenteritis with significant morbidity. Extra intestinal manifestation following norovirus infection is rare and the mechanism is unknown. Methods: We undertook a review of the English literature published from January 1967 to April 2019 to evaluate the risk of acute viral hepatitis due to norovirus gastroenteritis. Data sources included MEDLINE, EMBASE, Cochrane library, and references within identified articles. Results: We identified 126 potential studies and included 5 publications involving 17 cases of norovirus induced hepatitis, and all had elevated ALT (31.7–458IU/l) and AST levels (45.6–1150IU/l). Majority of the cases were below the age of 18 (88%, n = 15) and almost two-third (64.7%, n = 11) had supportive treatment, mainly intravenous fluid administration. In cases reporting sex, there were more females than males (62.5%, 5/8 vs. 37.5%, 3/8). The duration of illness was longer, on average 10 days, compared to 3 days in those without elevated transaminitis and it took an average of 22.5 days for liver enzymes to settle. All patients recovered fully with no progression to chronic liver disease. Conclusion: Norovirus gastroenteritis is a self-limiting illness with majority not requiring hospitalisation and invasive investigations. We recommend that clinicians should be aware of norovirus induced transaminitis, and to suspect this especially in children who are likely to have protracted illness and require hospitalisation due to norovirus acute hepatitis.
    Schlagwörter norovirus ; acute hepatitis ; transaminitis ; gastroenteritis ; liver ; Public aspects of medicine ; RA1-1270
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2020-03-01T00:00:00Z
    Verlag AIMS Press
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Does norovirus induce acute hepatitis?

    Ho, Carmen Lok Tung / Oligbu, Olivia / Asaid, Fatma / Oligbu, Godwin

    AIMS public health

    2020  Band 7, Heft 1, Seite(n) 148–157

    Abstract: Background: Norovirus is the commonest cause of acute viral gastroenteritis with significant morbidity. Extra intestinal manifestation following norovirus infection is rare and the mechanism is unknown.: Methods: We undertook a review of the English ... ...

    Abstract Background: Norovirus is the commonest cause of acute viral gastroenteritis with significant morbidity. Extra intestinal manifestation following norovirus infection is rare and the mechanism is unknown.
    Methods: We undertook a review of the English literature published from January 1967 to April 2019 to evaluate the risk of acute viral hepatitis due to norovirus gastroenteritis. Data sources included MEDLINE, EMBASE, Cochrane library, and references within identified articles.
    Results: We identified 126 potential studies and included 5 publications involving 17 cases of norovirus induced hepatitis, and all had elevated ALT (31.7-458IU/l) and AST levels (45.6-1150IU/l). Majority of the cases were below the age of 18 (88%, n = 15) and almost two-third (64.7%, n = 11) had supportive treatment, mainly intravenous fluid administration. In cases reporting sex, there were more females than males (62.5%, 5/8 vs. 37.5%, 3/8). The duration of illness was longer, on average 10 days, compared to 3 days in those without elevated transaminitis and it took an average of 22.5 days for liver enzymes to settle. All patients recovered fully with no progression to chronic liver disease.
    Conclusion: Norovirus gastroenteritis is a self-limiting illness with majority not requiring hospitalisation and invasive investigations. We recommend that clinicians should be aware of norovirus induced transaminitis, and to suspect this especially in children who are likely to have protracted illness and require hospitalisation due to norovirus acute hepatitis.
    Sprache Englisch
    Erscheinungsdatum 2020-03-09
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2777115-5
    ISSN 2327-8994 ; 2327-8994
    ISSN (online) 2327-8994
    ISSN 2327-8994
    DOI 10.3934/publichealth.2020013
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Periorbital squamous cell carcinoma with simultaneous adenocarcinoma in the right orbit.

    Ho, Carmen Lok Tung / Visavadia, Bhavin / Shah, Keval / Deshmukh, Manjiri

    International journal of surgery case reports

    2020  Band 67, Seite(n) 187–190

    Abstract: Introduction: Cutaneous squamous cell carcinoma (cSCC) is an invasive and malignant tumour that is common in the orbital region. However, adenocarcinoma of the lacrimal gland has an incidence of less than one case per million per year. We present a ... ...

    Abstract Introduction: Cutaneous squamous cell carcinoma (cSCC) is an invasive and malignant tumour that is common in the orbital region. However, adenocarcinoma of the lacrimal gland has an incidence of less than one case per million per year. We present a patient who experienced a cSCC and adenocarcinoma of the lacrimal gland, which is unusual for both these cancers to present in the same patient in such close proximity.
    Presentation of case: A 47-year old male patient was referred for management of a cSCC of the right upper eyelid. This was treated surgically by means of wide local excision and orbital exenteration. Histological analysis of the resection specimen found an incidental synchronous lacrimal gland adenocarcinoma. To our knowledge this is the first case report to describe this phenomenon.
    Discussion: Although SCC is the most common secondary epithelial neoplasms of the orbit region, adenocarcinomas are rare in this same region. Currently, when performing a literature search, there has been no cases found that documents a poorly differentiated cSCC with a synchronous adenocarcinoma of the lacrimal gland. This is mainly because there are improved facilities and accessible healthcare. This report will mainly focus on the presentation and management of this patient case.
    Conclusion: To our knowledge this is the first case report documenting a poorly differentiated cSCC and a synchronous adenocarcinoma of the lacrimal gland. Our case report raises the awareness of the possibility of patients with synchronous tumours and is a valuable addition to the literature.
    Sprache Englisch
    Erscheinungsdatum 2020-02-06
    Erscheinungsland Netherlands
    Dokumenttyp Case Reports
    ISSN 2210-2612
    ISSN 2210-2612
    DOI 10.1016/j.ijscr.2020.02.006
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  7. Artikel ; Online: Clinical Characteristics of Children with COVID-19.

    Tung Ho, Carmen Lok / Oligbu, Peter / Ojubolamo, Olakunle / Pervaiz, Muhammad / Oligbu, Godwin

    AIMS public health

    2020  Band 7, Heft 2, Seite(n) 258–273

    Abstract: Background: In December 2019, the infection caused by 2019 novel coronavirus (COVID-19) led to an outbreak in Wuhan, situated in the Hubei Province of China. Following this, there has been a rapid increase in the number of cases. On 12th March 2020, ... ...

    Abstract Background: In December 2019, the infection caused by 2019 novel coronavirus (COVID-19) led to an outbreak in Wuhan, situated in the Hubei Province of China. Following this, there has been a rapid increase in the number of cases. On 12th March 2020, there were over 100,000 confirmed cases and almost 4,300 deaths worldwide. The clinical profile of children with COVID-19 is unknown due to the few number of cases reported. Currently, available data suggest they may have a milder form of illness.
    Methods: A review of the literature published from June 2019 to March 2020 was undertaken to evaluate the clinical presentation, management and outcomes of COVID-19 in in children. Data sources included EMBASE, MEDLINE, Cochrane library, ISI Web of Knowledge and references within identified articles.
    Results: We identified 303 potential studies, and 295 were excluded for reasons including duplicates, experimental studies and case reports. Eight studies were eligible for inclusion, including a total of 820 paediatric cases of COVID-19. Asymptomatic cases represented 14.3% (n = 117) of the total number of cases identified, and thus the remaining 85.7% (n = 703) experienced symptoms. Fever was the commonest symptom in 53.9% (n = 48) of cases, followed by cough in 39.3% (n = 35) of cases, and rhinorrhoea or pharyngeal congestion in 13.5% (n = 12) of cases. Diarrhoea and sore throats were less common symptoms, 7.9% (n = 7) and 9.0% (n = 8) respectively. Other symptoms, including fatigue, headache and dizziness were rare.
    Conclusion: Children are disproportionately affected by COVID-19 and are more likely to run a milder cause of illness following this infection compared to adults. This outbreak only started 3 months ago, therefore, further population wide studies are needed to validate these findings.
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-05-06
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2777115-5
    ISSN 2327-8994 ; 2327-8994
    ISSN (online) 2327-8994
    ISSN 2327-8994
    DOI 10.3934/publichealth.2020022
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Clinical Characteristics of Children with COVID-19

    Carmen Lok Tung Ho / Peter Oligbu / Olakunle Ojubolamo / Muhammad Pervaiz / Godwin Oligbu

    AIMS Public Health, Vol 7, Iss 2, Pp 258-

    2020  Band 273

    Abstract: Background: In December 2019, the infection caused by 2019 novel coronavirus (COVID-19) led to an outbreak in Wuhan, situated in the Hubei Province of China. Following this, there has been a rapid increase in the number of cases. On 12th March 2020, ... ...

    Abstract Background: In December 2019, the infection caused by 2019 novel coronavirus (COVID-19) led to an outbreak in Wuhan, situated in the Hubei Province of China. Following this, there has been a rapid increase in the number of cases. On 12th March 2020, there were over 100,000 confirmed cases and almost 4,300 deaths worldwide. The clinical profile of children with COVID-19 is unknown due to the few number of cases reported. Currently, available data suggest they may have a milder form of illness. Methods: A review of the literature published from June 2019 to March 2020 was undertaken to evaluate the clinical presentation, management and outcomes of COVID-19 in in children. Data sources included EMBASE, MEDLINE, Cochrane library, ISI Web of Knowledge and references within identified articles. Results: We identified 303 potential studies, and 295 were excluded for reasons including duplicates, experimental studies and case reports. Eight studies were eligible for inclusion, including a total of 820 paediatric cases of COVID-19. Asymptomatic cases represented 14.3% (n = 117) of the total number of cases identified, and thus the remaining 85.7% (n = 703) experienced symptoms. Fever was the commonest symptom in 53.9% (n = 48) of cases, followed by cough in 39.3% (n = 35) of cases, and rhinorrhoea or pharyngeal congestion in 13.5% (n = 12) of cases. Diarrhoea and sore throats were less common symptoms, 7.9% (n = 7) and 9.0% (n = 8) respectively. Other symptoms, including fatigue, headache and dizziness were rare. Conclusion: Children are disproportionately affected by COVID-19 and are more likely to run a milder cause of illness following this infection compared to adults. This outbreak only started 3 months ago, therefore, further population wide studies are needed to validate these findings.
    Schlagwörter covid-19 ; coronavirus ; infectious disease ; pandemic ; 2019-ncov ; severe acute respiratory syndrome coronavirus 2 ; paediatric ; children ; sars-cov-2 ; virus ; Public aspects of medicine ; RA1-1270 ; covid19
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2020-06-01T00:00:00Z
    Verlag AIMS Press
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel: Clinical Characteristics of Children with COVID-19

    Tung Ho, Carmen Lok / Oligbu, Peter / Ojubolamo, Olakunle / Pervaiz, Muhammad / Oligbu, Godwin

    AIMS public health

    Abstract: Background: In December 2019, the infection caused by 2019 novel coronavirus (COVID-19) led to an outbreak in Wuhan, situated in the Hubei Province of China Following this, there has been a rapid increase in the number of cases On 12th March 2020, there ... ...

    Abstract Background: In December 2019, the infection caused by 2019 novel coronavirus (COVID-19) led to an outbreak in Wuhan, situated in the Hubei Province of China Following this, there has been a rapid increase in the number of cases On 12th March 2020, there were over 100,000 confirmed cases and almost 4,300 deaths worldwide The clinical profile of children with COVID-19 is unknown due to the few number of cases reported Currently, available data suggest they may have a milder form of illness Methods: A review of the literature published from June 2019 to March 2020 was undertaken to evaluate the clinical presentation, management and outcomes of COVID-19 in in children Data sources included EMBASE, MEDLINE, Cochrane library, ISI Web of Knowledge and references within identified articles Results: We identified 303 potential studies, and 295 were excluded for reasons including duplicates, experimental studies and case reports Eight studies were eligible for inclusion, including a total of 820 paediatric cases of COVID-19 Asymptomatic cases represented 14 3% (n = 117) of the total number of cases identified, and thus the remaining 85 7% (n = 703) experienced symptoms Fever was the commonest symptom in 53 9% (n = 48) of cases, followed by cough in 39 3% (n = 35) of cases, and rhinorrhoea or pharyngeal congestion in 13 5% (n = 12) of cases Diarrhoea and sore throats were less common symptoms, 7 9% (n = 7) and 9 0% (n = 8) respectively Other symptoms, including fatigue, headache and dizziness were rare Conclusion: Children are disproportionately affected by COVID-19 and are more likely to run a milder cause of illness following this infection compared to adults This outbreak only started 3 months ago, therefore, further population wide studies are needed to validate these findings
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #629530
    Datenquelle COVID19

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  10. Artikel ; Online: Focal therapy versus radical prostatectomy and external beam radiotherapy as primary treatment options for non-metastatic prostate cancer: results of a cost-effectiveness analysis.

    Reddy, Deepika / van Son, Marieke / Peters, Max / Bertoncelli Tanaka, Mariana / Dudderidge, Tim / Cullen, Emma / Ho, Carmen Lok Tung / Hindley, Richard G / Emara, Amr / McCracken, Stuart / Orczyk, Clement / Shergill, Iqbal / Mangar, Stephen / Nigam, Raj / Virdi, Jaspal / Moore, Caroline M / Arya, Manit / Shah, Taimur T / Winkler, Mathias /
    Emberton, Mark / Falconer, Alison / Belsey, Jonathan / Ahmed, Hashim U

    Journal of medical economics

    2023  Band 26, Heft 1, Seite(n) 1099–1107

    Abstract: Aims: Focal therapy treats individual areas of tumour in non-metastatic prostate cancer in patients unsuitable for active surveillance. The aim of this work was to evaluate the cost-effectiveness of focal therapy versus prostatectomy and external beam ... ...

    Abstract Aims: Focal therapy treats individual areas of tumour in non-metastatic prostate cancer in patients unsuitable for active surveillance. The aim of this work was to evaluate the cost-effectiveness of focal therapy versus prostatectomy and external beam radiotherapy (EBRT).
    Materials and methods: A Markov cohort health state transition model with four health states (stable disease, local recurrence, metastatic disease and death) was created, evaluating costs and utilities over a 10-year time horizon for patients diagnosed with non-metastatic prostate cancer. National Health Service (NHS) for England perspective was used, based on direct healthcare costs. Clinical transition probabilities were derived from prostate cancer registries in patients undergoing radical prostatectomy, EBRT and focal therapy using cryotherapy (Boston Scientific) or high-intensity focused ultrasound (HIFU) (Sonablate). Propensity score matching was used to ensure that at-risk populations were comparable. Variables included age, prostate-specific antigen (PSA), International Society of Urological Pathology (ISUP) grade group, maximum cancer core length (mm), T-stage and year of treatment.
    Results: Focal therapy was associated with a lower overall cost and higher quality-adjusted life year (QALY) gains than either prostatectomy or EBRT, dominating both treatment strategies. Positive incremental net monetary benefit (NMB) values confirm focal therapy as cost-effective versus the alternatives at a willingness to pay (WTP) threshold of £30,000/QALY. One-way deterministic sensitivity analyses revealed consistent results.
    Limitations: Data used to calculate the transition probabilities were derived from a limited number of hospitals meaning that other potential treatment options were excluded. Limited data were available on later outcomes and none on quality of life data, therefore, literature-based estimates were used.
    Conclusions: Cost-effectiveness modelling demonstrates use of focal therapy (cryotherapy or HIFU) is associated with greater QALY gains at a lower overall cost than either radical prostatectomy or EBRT, representing good value for money in the NHS.
    Mesh-Begriff(e) Male ; Humans ; Cost-Effectiveness Analysis ; State Medicine ; Quality of Life ; Cost-Benefit Analysis ; Prostatic Neoplasms/radiotherapy ; Prostatic Neoplasms/surgery ; Prostatectomy
    Sprache Englisch
    Erscheinungsdatum 2023-09-01
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2270945-9
    ISSN 1941-837X ; 1369-6998
    ISSN (online) 1941-837X
    ISSN 1369-6998
    DOI 10.1080/13696998.2023.2251849
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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