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  1. Artikel: Recurrent Metastatic Pulmonary Synovial Sarcoma during Pregnancy: A Case Report and Literature Review.

    De Rocco, Silvia / Di Biasi, Jasmine / Fantasia, Ilaria / Tabacco, Sara / Ricevuto, Enrico / Palumbo, Pierpaolo / Imbergamo, Ilenia / Ludovisi, Manuela / Guido, Maurizio

    Diagnostics (Basel, Switzerland)

    2024  Band 14, Heft 4

    Abstract: Primary pulmonary synovial sarcoma is a rare type of soft tissue tumor. Exceptionally it can occur during pregnancy, representing a challenge in management and treatment given its notable aggressiveness and the not infrequent incidence of maternal death. ...

    Abstract Primary pulmonary synovial sarcoma is a rare type of soft tissue tumor. Exceptionally it can occur during pregnancy, representing a challenge in management and treatment given its notable aggressiveness and the not infrequent incidence of maternal death. We report our case of metastatic recurrence of pulmonary synovial sarcoma during pregnancy, with the aim to emphasize the decision-making, diagnostic, and therapeutic multidisciplinary processes and the evolution of the pathology. Besides, we focused on the analysis of the limited literature data available on the topic.
    Sprache Englisch
    Erscheinungsdatum 2024-02-14
    Erscheinungsland Switzerland
    Dokumenttyp Case Reports
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics14040424
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Misclassification bias in estimating clinical severity of SARS-CoV-2 variants - Authors' reply.

    Nyberg, Tommy / Ferguson, Neil M / Blake, Joshua / Hinsley, Wes / Bhatt, Samir / De Angelis, Daniela / Thelwall, Simon / Presanis, Anne M

    Lancet (London, England)

    2022  Band 400, Heft 10355, Seite(n) 809–810

    Mesh-Begriff(e) COVID-19 ; Humans ; SARS-CoV-2/genetics
    Sprache Englisch
    Erscheinungsdatum 2022-09-07
    Erscheinungsland England
    Dokumenttyp Letter ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(22)01432-5
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  3. Artikel ; Online: Waning of 2-Dose BNT162b2 and mRNA-1273 Vaccine Effectiveness Against Symptomatic SARS-CoV-2 Infection Accounting for Depletion-of-Susceptibles Bias.

    Andrejko, Kristin L / Pry, Jake M / Myers, Jennifer F / Mehrotra, Megha / Lamba, Katherine / Lim, Esther / Fukui, Nozomi / DeGuzman, Jennifer L / Openshaw, John / Watt, James / Jain, Seema / Lewnard, Joseph A / Covid-Case-Control Study Team, On Behalf Of The California

    American journal of epidemiology

    2022  Band 192, Heft 6, Seite(n) 895–907

    Abstract: ... have arisen in postlicensure evaluations. "Depletion of susceptibles," a bias driven by differential ... estimates, hindering interpretation. We enrolled California residents who received molecular SARS-CoV-2 ... serological study to adjust for "depletion-of-susceptibles" bias and estimated VE for 3 doses, by time ...

    Abstract Concerns about the duration of protection conferred by coronavirus disease 2019 (COVID-19) vaccines have arisen in postlicensure evaluations. "Depletion of susceptibles," a bias driven by differential accrual of infection among vaccinated and unvaccinated individuals, may obscure vaccine effectiveness (VE) estimates, hindering interpretation. We enrolled California residents who received molecular SARS-CoV-2 tests in a matched, test-negative design, case-control study to estimate VE of mRNA-based COVID-19 vaccines between February 23 and December 5, 2021. We analyzed waning protection following 2 vaccine doses using conditional logistic regression models. Additionally, we used data from a population-based serological study to adjust for "depletion-of-susceptibles" bias and estimated VE for 3 doses, by time since second dose receipt. Pooled VE of BNT162b2 and mRNA-1273 against symptomatic SARS-CoV-2 infection was 91.3% (95% confidence interval (CI): 83.8, 95.4) at 14 days after second-dose receipt and declined to 50.8% (95% CI: 19.7, 69.8) at 7 months. Adjusting for depletion-of-susceptibles bias, we estimated VE of 53.2% (95% CI: 23.6, 71.2) at 7 months after primary mRNA vaccination series. A booster dose of BN162b2 or mRNA-1273 increased VE to 95.0% (95% CI: 82.8, 98.6). These findings confirm that observed waning of protection is not attributable to epidemiologic bias and support ongoing efforts to administer additional vaccine doses to mitigate burden of COVID-19.
    Mesh-Begriff(e) Humans ; 2019-nCoV Vaccine mRNA-1273 ; BNT162 Vaccine ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Vaccines ; Case-Control Studies ; Vaccine Efficacy ; SARS-CoV-2/genetics ; RNA, Messenger
    Chemische Substanzen 2019-nCoV Vaccine mRNA-1273 (EPK39PL4R4) ; BNT162 Vaccine ; COVID-19 Vaccines ; RNA, Messenger
    Sprache Englisch
    Erscheinungsdatum 2022-04-29
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 2937-3
    ISSN 1476-6256 ; 0002-9262
    ISSN (online) 1476-6256
    ISSN 0002-9262
    DOI 10.1093/aje/kwad017
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Recruitment location influences bias and uncertainty in SARS-CoV-2 seroprevalence estimates.

    Brown, Tyler S / de Salazar Munoz, Pablo Martinez / Bhatia, Abhishek / Bunda, Bridget / Williams, Ellen K / Bor, David / Miller, James S / Mohareb, Amir M / Thierauf, Julia / Yang, Wenxin / Villalba, Julian / Naranbai, Vivek / Beltran, Wilfredo Garcia / Miller, Tyler E / Kress, Doug / Stelljes, Kristen / Johnson, Keith / Larremore, Daniel B / Lennerz, Jochen /
    Iafrate, A John / Balsari, Satchit / Buckee, Caroline O / Grad, Yonatan H

    medRxiv : the preprint server for health sciences

    2021  

    Abstract: ... to rapidly estimate a community's seroprevalence. However, biases and uncertainty due to site selection and ... use of convenience samples are poorly understood. Using data from a SARS-CoV-2 serosurveillance study ... of bias. Our results demonstrated that study-site selection informed by mobility patterns can markedly ...

    Abstract The initial phase of the COVID-19 pandemic in the US was marked by limited diagnostic testing, resulting in the need for seroprevalence studies to estimate cumulative incidence and define epidemic dynamics. In lieu of systematic representational surveillance, venue-based sampling was often used to rapidly estimate a community's seroprevalence. However, biases and uncertainty due to site selection and use of convenience samples are poorly understood. Using data from a SARS-CoV-2 serosurveillance study we performed in Somerville, Massachusetts, we found that the uncertainty in seroprevalence estimates depends on how well sampling intensity matches the known or expected geographic distribution of seropositive individuals in the study area. We use GPS-estimated foot traffic to measure and account for these sources of bias. Our results demonstrated that study-site selection informed by mobility patterns can markedly improve seroprevalence estimates. Such data should be used in the design and interpretation of venue-based serosurveillance studies.
    Sprache Englisch
    Erscheinungsdatum 2021-10-05
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2021.02.03.21251011
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Circulating and Tumor-Associated Neutrophils in the Era of Immune Checkpoint Inhibitors: Dynamics, Phenotypes, Metabolism, and Functions.

    Gibellini, Lara / Borella, Rebecca / Santacroce, Elena / Serattini, Eugenia / Boraldi, Federica / Quaglino, Daniela / Aramini, Beatrice / De Biasi, Sara / Cossarizza, Andrea

    Cancers

    2023  Band 15, Heft 13

    Abstract: Neutrophils are the most abundant myeloid cells in the blood and are a considerable immunological component of the tumor microenvironment. However, their functional importance has often been ignored, as they have always been considered a mono-dimensional ...

    Abstract Neutrophils are the most abundant myeloid cells in the blood and are a considerable immunological component of the tumor microenvironment. However, their functional importance has often been ignored, as they have always been considered a mono-dimensional population of terminally differentiated, short-living cells. During the last decade, the use of cutting-edge, single-cell technologies has revolutionized the classical view of these cells, unmasking their phenotypic and functional heterogeneity. In this review, we summarize the emerging concepts in the field of neutrophils in cancer, by reviewing the recent literature on the heterogeneity of both circulating neutrophils and tumor-associated neutrophils, as well as their possible significance in tumor prognosis and resistance to immune checkpoint inhibitors.
    Sprache Englisch
    Erscheinungsdatum 2023-06-24
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15133327
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  6. Artikel: Cell metabolism: Functional and phenotypic single cell approaches.

    De Biasi, Sara / Gigan, Julien Paul / Borella, Rebecca / Santacroce, Elena / Lo Tartaro, Domenico / Neroni, Anita / Paschalidis, Nikolaos / Piwocka, Katarzyna / Argüello, Rafael José / Gibellini, Lara / Cossarizza, Andrea

    Methods in cell biology

    2024  Band 186, Seite(n) 151–187

    Abstract: Several metabolic pathways are essential for the physiological regulation of immune cells, but their dysregulation can cause immune dysfunction. Hypermetabolic and hypometabolic states represent deviations in the magnitude and flexibility of effector ... ...

    Abstract Several metabolic pathways are essential for the physiological regulation of immune cells, but their dysregulation can cause immune dysfunction. Hypermetabolic and hypometabolic states represent deviations in the magnitude and flexibility of effector cells in different contexts, for example in autoimmunity, infections or cancer. To study immunometabolism, most methods focus on bulk populations and rely on in vitro activation assays. Nowadays, thanks to the development of single-cell technologies, including multiparameter flow cytometry, mass cytometry, RNA cytometry, among others, the metabolic state of individual immune cells can be measured in a variety of samples obtained in basic, translational and clinical studies. Here, we provide an overview of different single-cell approaches that are employed to investigate both mitochondrial functions and cell dependence from mitochondria metabolism. Moreover, besides the description of the appropriate experimental settings, we discuss the strengths and weaknesses of different approaches with the aim to suggest how to study cell metabolism in the settings of interest.
    Mesh-Begriff(e) Single-Cell Analysis/methods ; Humans ; Mitochondria/metabolism ; Animals ; Flow Cytometry/methods ; Phenotype
    Sprache Englisch
    Erscheinungsdatum 2024-03-25
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ISSN 0091-679X
    ISSN 0091-679X
    DOI 10.1016/bs.mcb.2024.02.024
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Sampling bias and incorrect rooting make phylogenetic network tracing of SARS-COV-2 infections unreliable.

    Mavian, Carla / Pond, Sergei Kosakovsky / Marini, Simone / Magalis, Brittany Rife / Vandamme, Anne-Mieke / Dellicour, Simon / Scarpino, Samuel V / Houldcroft, Charlotte / Villabona-Arenas, Julian / Paisie, Taylor K / Trovão, Nídia S / Boucher, Christina / Zhang, Yun / Scheuermann, Richard H / Gascuel, Olivier / Lam, Tommy Tsan-Yuk / Suchard, Marc A / Abecasis, Ana / Wilkinson, Eduan /
    de Oliveira, Tulio / Bento, Ana I / Schmidt, Heiko A / Martin, Darren / Hadfield, James / Faria, Nuno / Grubaugh, Nathan D / Neher, Richard A / Baele, Guy / Lemey, Philippe / Stadler, Tanja / Albert, Jan / Crandall, Keith A / Leitner, Thomas / Stamatakis, Alexandros / Prosperi, Mattia / Salemi, Marco

    Proceedings of the National Academy of Sciences of the United States of America

    2020  Band 117, Heft 23, Seite(n) 12522–12523

    Mesh-Begriff(e) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Phylogeny ; Pneumonia, Viral ; Severe acute respiratory syndrome-related coronavirus ; SARS-CoV-2 ; Selection Bias
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-05-07
    Erscheinungsland United States
    Dokumenttyp Letter ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2007295117
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Immunosenescence and vaccine efficacy revealed by immunometabolic analysis of SARS-CoV-2-specific cells in multiple sclerosis patients.

    De Biasi, Sara / Lo Tartaro, Domenico / Neroni, Anita / Rau, Moritz / Paschalidis, Nikolaos / Borella, Rebecca / Santacroce, Elena / Paolini, Annamaria / Gibellini, Lara / Ciobanu, Alin Liviu / Cuccorese, Michela / Trenti, Tommaso / Rubio, Ignacio / Vitetta, Francesca / Cardi, Martina / Argüello, Rafael José / Ferraro, Diana / Cossarizza, Andrea

    Nature communications

    2024  Band 15, Heft 1, Seite(n) 2752

    Abstract: ... can influence immune responses to SARS-CoV-2 and vaccine efficacy. However, data on the detailed phenotypic ... the phenotype, function and the single-cell metabolic profile of SARS-CoV-2-specific T and B cells up to 8 ... ocrelizumab. Almost all patients display functional immune response to SARS-CoV-2. Different ...

    Abstract Disease-modifying therapies (DMT) administered to patients with multiple sclerosis (MS) can influence immune responses to SARS-CoV-2 and vaccine efficacy. However, data on the detailed phenotypic, functional and metabolic characteristics of antigen (Ag)-specific cells following the third dose of mRNA vaccine remain scarce. Here, using flow cytometry and 45-parameter mass cytometry, we broadly investigate the phenotype, function and the single-cell metabolic profile of SARS-CoV-2-specific T and B cells up to 8 months after the third dose of mRNA vaccine in a cohort of 94 patients with MS treated with different DMT, including cladribine, dimethyl fumarate, fingolimod, interferon, natalizumab, teriflunomide, rituximab or ocrelizumab. Almost all patients display functional immune response to SARS-CoV-2. Different metabolic profiles characterize antigen-specific-T and -B cell response in fingolimod- and natalizumab-treated patients, whose immune response differs from all the other MS treatments.
    Mesh-Begriff(e) Humans ; Multiple Sclerosis ; Immunosuppressive Agents/therapeutic use ; Fingolimod Hydrochloride/therapeutic use ; SARS-CoV-2 ; Natalizumab/therapeutic use ; Vaccine Efficacy ; mRNA Vaccines ; COVID-19/prevention & control ; Immunosenescence
    Chemische Substanzen Immunosuppressive Agents ; Fingolimod Hydrochloride (G926EC510T) ; Natalizumab ; mRNA Vaccines
    Sprache Englisch
    Erscheinungsdatum 2024-03-29
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-47013-0
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Gene Expression Analysis of T-Cells by Single-Cell RNA-Seq.

    Lo Tartaro, Domenico / De Biasi, Sara / Forcato, Mattia / Gibellini, Lara / Cossarizza, Andrea

    Methods in molecular biology (Clifton, N.J.)

    2021  Band 2285, Seite(n) 277–296

    Abstract: During the last decade, the rapid progress in the development of next-generation sequencing (NGS) technologies has provided relevant insights into complex biological systems, ranging from cancer genomics to microbiology. Among NGS technologies, single- ... ...

    Abstract During the last decade, the rapid progress in the development of next-generation sequencing (NGS) technologies has provided relevant insights into complex biological systems, ranging from cancer genomics to microbiology. Among NGS technologies, single-cell RNA sequencing is currently used to decipher the complex heterogeneity of several biological samples, including T cells. Even if this technique requires specialized equipment and expertise, nowadays it is broadly applied in research. In this chapter, we will provide an optimized protocol for the isolation of T cells and the preparation of RNA sequencing libraries by using droplet digital technology (ddSEQ, Bio-Rad Laboratories). We will also illustrate a guide to the main steps of data processing and options for data interpretation. This protocol will support users in building a single-cell experimental framework, from sample preparation to data interpretation.
    Mesh-Begriff(e) CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; Cell Separation ; Gene Expression Regulation ; Gene Library ; Humans ; Lab-On-A-Chip Devices ; Microfluidic Analytical Techniques/instrumentation ; RNA-Seq ; Research Design ; Single-Cell Analysis ; Workflow
    Sprache Englisch
    Erscheinungsdatum 2021-04-30
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1311-5_22
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  10. Artikel ; Online: Waning of two-dose BNT162b2 and mRNA-1273 vaccine effectiveness against symptomatic SARS-CoV-2 infection is robust to depletion-of-susceptibles bias

    Andrejko, Kristin L / Pry, Jake M / Myers, Jennifer F / Mehrotra, Megha / Lamba, Katherine / Lim, Esther / Fukui, Nozomi / DeGuzman, Jennifer L. / Openshaw, John / Watt, James / Jain, Seema / Lewnard, Joseph A.

    medRxiv

    Abstract: ... in postlicensure evaluations. However, "depletion of susceptibles" bias driven by differential accrual of infection ... molecular SARS-CoV-2 tests in a matched, test-negative design case-control study to estimate VE of mRNA ... study to quantify the potential contribution of the "depletion-of-susceptibles" bias to time-varying VE ...

    Abstract Concerns about the duration of protection conferred by COVID-19 vaccines have arisen in postlicensure evaluations. However, "depletion of susceptibles" bias driven by differential accrual of infection among vaccinated and unvaccinated individuals may contribute to the appearance of waning vaccine effectiveness (VE) in epidemiologic studies, potentially hindering interpretation of estimates. We enrolled California residents who received molecular SARS-CoV-2 tests in a matched, test-negative design case-control study to estimate VE of mRNA-based COVID-19 vaccines between 23 February and 5 December 2021. We analyzed waning protection following 2 vaccine doses using conditional logistic regression models. Additionally, we used data from case-based surveillance along with estimated case-to-infection ratios from a population-based serological study to quantify the potential contribution of the "depletion-of-susceptibles" bias to time-varying VE estimates for 2 doses. We also estimated VE for 3 doses relative to 0 doses and 2 doses, by time since second dose receipt. Pooled VE of BNT162b2 and mRNA-1273 against symptomatic SARS-CoV-2 infection was 91.3% (95% confidence interval: 83.8-95.4%) at 14 days after second-dose receipt and declined to 50.8% (31.2-75.6%) at 7 months. Accounting for differential depletion-of-susceptibles among vaccinated and unvaccinated individuals, we estimated VE was 53.2% (23.6-71.2%) at 7 months among individuals who had completed the primary series (2 doses). With receipt of a third dose of BN162b2 or mRNA-1273, VE increased to 95.0% (82.8-98.6%), compared with zero doses. These findings confirm that observed waning of protection is not attributable to epidemiologic bias and support ongoing efforts to administer additional vaccine doses to mitigate burden of COVID-19.
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2022-06-03
    Verlag Cold Spring Harbor Laboratory Press
    Dokumenttyp Artikel ; Online
    DOI 10.1101/2022.06.03.22275958
    Datenquelle COVID19

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