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  1. Buch ; Audio / Video ; Konferenzbeitrag: 2nd International Congress on Neurobiology, Psychopharmacology & Treatment Guidance

    Fountoulakis, Konstantinos N.

    Thessaloniki (Greece), November 24 - 27, 2011 ; selected papers

    2012  

    Veranstaltung/Kongress International Congress on Neurobiology, Psychopharmacology & Treatment Guidance (2, 2011, Thessaloniki)
    Verfasserangabe ed. Konstantinos N. Fountoulakis
    Thema/Rubrik (Code) a616 ; c21
    Sprache Englisch
    Umfang VII, 170 S. : Ill., graph. Darst. ; 1 CD-ROM, 12 cm
    Verlag Medimond
    Erscheinungsort Bologna
    Erscheinungsland Italien
    Dokumenttyp Buch ; Audio / Video ; Konferenzbeitrag
    HBZ-ID HT017335164
    ISBN 978-88-7587-641-8 ; 88-7587-641-X
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  2. Artikel ; Online: Neither serotonin disorder is at the core of depression nor dopamine at the core of schizophrenia; still these are biologically based mental disorders.

    Fountoulakis, Konstantinos N / Tsapakis, Eva Maria

    Molecular psychiatry

    2024  Band 29, Heft 1, Seite(n) 198–199

    Mesh-Begriff(e) Humans ; Schizophrenia/metabolism ; Dopamine/metabolism ; Serotonin/metabolism ; Depression ; Depressive Disorder/metabolism
    Chemische Substanzen Dopamine (VTD58H1Z2X) ; Serotonin (333DO1RDJY)
    Sprache Englisch
    Erscheinungsdatum 2024-02-19
    Erscheinungsland England
    Dokumenttyp Journal Article ; Letter
    ZDB-ID 1330655-8
    ISSN 1476-5578 ; 1359-4184
    ISSN (online) 1476-5578
    ISSN 1359-4184
    DOI 10.1038/s41380-024-02458-z
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Culturally sanctioned "scientific pluralism" opens the backdoor for the supernatural in Psychiatry.

    Fountoulakis, Konstantinos N

    Acta psychiatrica Scandinavica

    2021  Band 145, Heft 1, Seite(n) 109–110

    Mesh-Begriff(e) Cultural Diversity ; Humans ; Psychiatry
    Sprache Englisch
    Erscheinungsdatum 2021-11-10
    Erscheinungsland United States
    Dokumenttyp Letter ; Comment
    ZDB-ID 103-x
    ISSN 1600-0447 ; 0001-690X
    ISSN (online) 1600-0447
    ISSN 0001-690X
    DOI 10.1111/acps.13382
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Being strictly scientific is the only way forward for psychiatry.

    Fountoulakis, Konstantinos N

    Acta psychiatrica Scandinavica

    2021  Band 143, Heft 3, Seite(n) 187–188

    Mesh-Begriff(e) Humans ; Mental Disorders/therapy ; Psychiatry
    Sprache Englisch
    Erscheinungsdatum 2021-04-03
    Erscheinungsland United States
    Dokumenttyp Editorial
    ZDB-ID 103-x
    ISSN 1600-0447 ; 0001-690X
    ISSN (online) 1600-0447
    ISSN 0001-690X
    DOI 10.1111/acps.13284
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Should denialism of mental illness and its treatment be included among conspiracy theories?

    Fountoulakis, Konstantinos N

    European archives of psychiatry and clinical neuroscience

    2021  Band 271, Heft 4, Seite(n) 591–593

    Mesh-Begriff(e) Denial, Psychological ; Humans ; Mental Disorders/psychology ; Mental Disorders/therapy
    Sprache Englisch
    Erscheinungsdatum 2021-05-03
    Erscheinungsland Germany
    Dokumenttyp Editorial
    ZDB-ID 1045583-8
    ISSN 1433-8491 ; 0175-758X ; 0940-1334
    ISSN (online) 1433-8491
    ISSN 0175-758X ; 0940-1334
    DOI 10.1007/s00406-021-01272-w
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Climate rather than economic variables might have caused increase in US homicide but not suicide rates during the Great Depression.

    Fountoulakis, Konstantinos N / Fountoulakis, Nikolaos K

    Psychiatry research

    2022  Band 309, Seite(n) 114378

    Abstract: Background: It is widely believed that during the Great Depression (1929-1933) there was a rise in suicidal rates which was causally related to the increase in unemployment. There are no studies on the effect the Great Depression had on homicidal rates ... ...

    Abstract Background: It is widely believed that during the Great Depression (1929-1933) there was a rise in suicidal rates which was causally related to the increase in unemployment. There are no studies on the effect the Great Depression had on homicidal rates METHODS: The data concerning suicide, homicide, economic and climatic variables for the years 1900-1940 for the whole of the US were gathered from the US Center for Disease Control, the Maddison Project, the National Bureau of Economic Research and the National Climatic Data Center. Time Series Analysis was performed.
    Results: The results are inconclusive on the role of economic factors but preclude any role of climate on suicidal rates during the years 1900-1940 in the US. Suicidal rates might have a 24-years periodicity, however much longer time series are needed to confirm this. On the contrary they strongly suggest an effect of higher temperatures on homicidal rates after 1922.
    Conclusions: The results of the current study suggest a direct and clear effect of climate (higher temperatures) on the increasing homicidal rates in the US after 1922 but failed to establish a causal relationship between suicide rates and economic or climate variables. These should be considered together with increasing concerns on the possible effect of climate change on mental health.
    Mesh-Begriff(e) Depression ; Homicide/psychology ; Humans ; Suicidal Ideation ; Suicide/psychology ; Unemployment/psychology
    Sprache Englisch
    Erscheinungsdatum 2022-01-15
    Erscheinungsland Ireland
    Dokumenttyp Journal Article
    ZDB-ID 445361-x
    ISSN 1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
    ISSN (online) 1872-7123 ; 1872-7506
    ISSN 0925-4927 ; 0165-1781
    DOI 10.1016/j.psychres.2021.114378
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Brain Volume Changes Under Treatment With Antipsychotics.

    Fountoulakis, Konstantinos N

    JAMA psychiatry

    2020  Band 77, Heft 8, Seite(n) 876–877

    Mesh-Begriff(e) Antipsychotic Agents/adverse effects ; Brain/diagnostic imaging ; Depressive Disorder, Major/drug therapy ; Humans ; Neuroimaging
    Chemische Substanzen Antipsychotic Agents
    Sprache Englisch
    Erscheinungsdatum 2020-03-20
    Erscheinungsland United States
    Dokumenttyp Letter ; Comment
    ZDB-ID 2701203-7
    ISSN 2168-6238 ; 2168-622X
    ISSN (online) 2168-6238
    ISSN 2168-622X
    DOI 10.1001/jamapsychiatry.2020.1358
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Pharmacodynamic properties of lumateperone and its efficacy in acute bipolar depression: a mechanistic hypothesis based on data.

    Fountoulakis, Konstantinos N / Tohen, Mauricio / Zarate, Carlos A

    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology

    2024  Band 81, Seite(n) 1–9

    Abstract: The treatment of bipolar depression is one of the most challenging needs in contemporary psychiatry. Currently, only quetiapine, olanzapine-fluoxetine combination, lurasidone, cariprazine, and recently lumateperone have been FDA-approved to treat this ... ...

    Abstract The treatment of bipolar depression is one of the most challenging needs in contemporary psychiatry. Currently, only quetiapine, olanzapine-fluoxetine combination, lurasidone, cariprazine, and recently lumateperone have been FDA-approved to treat this condition. The neurobiology of bipolar depression and the possible mechanistic targets of bipolar antidepressant therapy remain elusive. The current study investigated whether the pharmacodynamic properties of lumateperone fit into a previously developed model which was the first to be derived based on the strict combination of clinical and preclinical data. The authors performed a systematic review of the literature to identify the pharmacodynamic properties of lumateperone. The original model suggests that a constellation of effects on different receptors is necessary, but refinements, including the present study, suggest that the inhibition of the serotonin reuptake at the first level, the 5HT-2A blockade at the second level, and the norepinephrine alpha-1 receptors blockade at a third level in combination with D1 blockade contribute to the antidepressant effect in acute bipolar depression. The D2 blockade acts as a protective mechanism and reduces the risk of switching to mania/hypomania.
    Mesh-Begriff(e) Humans ; Bipolar Disorder/drug therapy ; Antipsychotic Agents/pharmacology ; Antipsychotic Agents/therapeutic use ; Lurasidone Hydrochloride/pharmacology ; Lurasidone Hydrochloride/therapeutic use ; Antidepressive Agents/pharmacology ; Antidepressive Agents/therapeutic use ; Heterocyclic Compounds, 4 or More Rings
    Chemische Substanzen lumateperone (70BSQ12069) ; Antipsychotic Agents ; Lurasidone Hydrochloride (O0P4I5851I) ; Antidepressive Agents ; Heterocyclic Compounds, 4 or More Rings
    Sprache Englisch
    Erscheinungsdatum 2024-02-03
    Erscheinungsland Netherlands
    Dokumenttyp Review ; Journal Article
    ZDB-ID 1082947-7
    ISSN 1873-7862 ; 0924-977X
    ISSN (online) 1873-7862
    ISSN 0924-977X
    DOI 10.1016/j.euroneuro.2024.01.002
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Correlation of temperament and character to adherence with mandatory facemask use in the general population during the COVID-19 lockdown: A hypothesis based on data.

    Fountoulakis, Konstantinos N / Fountoulakis, Nikolaos K / Theodorakis, Pavlos N

    Journal of affective disorders

    2022  Band 316, Seite(n) 118–119

    Mesh-Begriff(e) COVID-19/prevention & control ; Character ; Communicable Disease Control ; Humans ; Masks ; Temperament
    Sprache Englisch
    Erscheinungsdatum 2022-08-03
    Erscheinungsland Netherlands
    Dokumenttyp Letter
    ZDB-ID 135449-8
    ISSN 1573-2517 ; 0165-0327
    ISSN (online) 1573-2517
    ISSN 0165-0327
    DOI 10.1016/j.jad.2022.07.074
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Neurocognitive impairment and evidence-based treatment options in Bipolar disorder.

    Fountoulakis, Konstantinos N

    Annals of general psychiatry

    2020  Band 19, Seite(n) 54

    Abstract: Background: The current paper briefly summarizes the literature on the neurocognitive deficit and its treatment in BD patients.: Methods: The material was chosen on the basis of previous systematic reviews the author has taken part in.: Results: ... ...

    Abstract Background: The current paper briefly summarizes the literature on the neurocognitive deficit and its treatment in BD patients.
    Methods: The material was chosen on the basis of previous systematic reviews the author has taken part in.
    Results: The data so far suggest that the deficit is qualitatively similar but quantitatively milder in comparison to schizophrenia, it is present already since the first episode, is weakly related to mood symptoms and somewhat stronger to psychotic symptoms, it probably determines much of the disability and treatment is problematic. This deficit is also present during periods of euthymia. The possible adverse effect of psychotropic medication is rather small if any at all and is confounded by the specific clinical symptoms, for which medication is used for their treatment. This is especially true concerning antipsychotics and psychotic symptoms. The origin and the etiopathogenesis of the core neurocognitive impairment remain elusive. The presence of a neurodegenerative and of a neurodevelopmental component has both data in favor and against and they are both the focus of debate.
    Conclusions: Treatment of the neurocognitive deficit and restoration of functioning is problematic. The data are limited and treatment options are few and with a weak overall effect. Pharmacological treatments, ECT and rTMS present some hard data, while the literature is inconclusive concerning psychotherapeutic interventions.
    Sprache Englisch
    Erscheinungsdatum 2020-09-23
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2090401-0
    ISSN 1744-859X ; 1475-2832
    ISSN 1744-859X ; 1475-2832
    DOI 10.1186/s12991-020-00304-4
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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