Artikel ; Online: Adjusted comparison of outcomes between patients from CARTITUDE-1
2023 Band 108, Heft 8, Seite(n) 2192–2204
Abstract: Ciltacabtagene autoleucel (cilta-cel) is a chimeric antigen receptor T-cell therapy studied in patients with multiple myeloma exposed to three classes of treatment in the single-arm CARTITUDE-1 study. To assess the effectiveness of cilta-cel compared to ... ...
| Abstract | Ciltacabtagene autoleucel (cilta-cel) is a chimeric antigen receptor T-cell therapy studied in patients with multiple myeloma exposed to three classes of treatment in the single-arm CARTITUDE-1 study. To assess the effectiveness of cilta-cel compared to real-world clinical practice (RWCP), we performed adjusted comparisons using individual patients' data from CARTITUDE-1 and LocoMMotion, a prospective, multinational study of patients with multiple myeloma triple-class exposed of treatment. Comparisons were performed using inverse probability weighting. In CARTITUDE-1, 113 patients were enrolled, and 97 patients were infused with cilta-cel. In LocoMMotion, 248 patients were enrolled, and 170 patients were included in the comparisons versus infused patients. Ninety-two unique regimens were used in LocoMMotion, most frequently carfilzomib-dexamethasone (13.7%), pomalidomide-cyclophosphamide-dexamethasone (13.3%) and pomalidomidedexamethasone (11.3%). Adjusted comparisons showed that patients treated with cilta-cel were 3.12-fold more likely to respond to treatment than those managed by RWCP (response rate, 3.12, 95% confidence interval [95% CI]: 2.24-4.00), had their risk of progression or death reduced to by 85% (progression-free survival hazard ratio=0.15, 95% CI: 0.08-0.29), and a risk of death lowered by 80% (overall survival hazard ratio HR=0.20, 95% CI: 0.09-0.41). The incremental improvement in healthrelated quality of life from baseline for cilta-cel versus RWCP at week 52, as measured by EORTC QLQ-C30 Global Health Status, was 13.4 (95% CI: 3.5-23.6) and increased to 30.8 (95% CI: 21.8-39.8) when including death as additional information regarding patients' health status. Patients treated with cilta-cel experienced more adverse events than those managed with RWCP (any grade: 100% vs. 83.5%). The results from this study demonstrate improved efficacy outcomes of cilta-cel versus RWCP and highlight its potential as a novel and effective treatment option for patients with multiple myeloma triple-class exposed of antimyeloma treatment. CARTITUDE-1 is registered with clinicaltrials gov. Identifier: NCT03548207. LocoMMotion is registered with clinicaltrials gov. Identifier: NCT04035226. |
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| Mesh-Begriff(e) | Humans ; Multiple Myeloma/drug therapy ; Multiple Myeloma/etiology ; Proteasome Inhibitors/therapeutic use ; Immunomodulating Agents ; Prospective Studies ; Quality of Life ; Dexamethasone/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use |
| Chemische Substanzen | Proteasome Inhibitors ; Immunomodulating Agents ; Dexamethasone (7S5I7G3JQL) |
| Sprache | Englisch |
| Erscheinungsdatum | 2023-08-01 |
| Erscheinungsland | Italy |
| Dokumenttyp | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2333-4 |
| ISSN | 1592-8721 ; 0017-6567 ; 0390-6078 |
| ISSN (online) | 1592-8721 |
| ISSN | 0017-6567 ; 0390-6078 |
| DOI | 10.3324/haematol.2022.280482 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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