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Artikel ; Online: Pathogenesis-Related Proteins (PRs) countering environmental stress in Plants: A Review

Islam, Monirul / El-Sappah, Ahmed H. / Ali, Hayssam M. / Zandi, Peiman / Huang, Qiulan / Soaud, Salma A. / Alazizi, Esmail M.Y. / Wafa, Hany A.M. / Hossain / Liang, Yan

South African Journal of Botany.

2023

Abstract: Plants are sessile; they cannot move to avoid adverse environmental conditions. Pathogenesis-related (PR) proteins are induced in the plant by imposing different biotic stresses such as pathogens and abiotic stresses like drought, cold, salinity, heavy ... ...

Abstract	Plants are sessile; they cannot move to avoid adverse environmental conditions. Pathogenesis-related (PR) proteins are induced in the plant by imposing different biotic stresses such as pathogens and abiotic stresses like drought, cold, salinity, heavy metal etc. There are currently nineteen families of PR proteins (PR-1 to PR-19), with 17 confirmed and two putative PR families identified and classified based on their biochemical nature. PR proteins promote innate resistance in plants by disintegrating fungal cell walls, permeabilizing membranes, suppressing transcription, and inactivating ribosomes. Previous research has shown that they play an important role in determining resistance to phytopathogens, making them a promising candidate for developing disease-resistant crop varieties. Plant genetic engineering could be used to create disease-resistant transgenic crops by utilizing several PR genes (thaumatin, osmotin-like proteins, chitinases, glucanases, defensins, thionins, oxalate oxidase, oxalate oxidase-like proteins/germin-like proteins, and LTPs). In this review, we attempt to demonstrate the types and biochemical nature of various PR proteins, as well as their insight mechanism for pathogen resistance and the use of PR proteins for disease-tolerant plants developed at a low cost.
Schlagwörter	botany ; chitinase ; cold ; disease resistance ; drought ; fungi ; genetically modified organisms ; heavy metals ; oxalate oxidase ; oxalates ; plant pathogens ; ribosomes ; salinity ; allergens ; jasmonic acid ; pr protein ; salicylic acid ; resistance
Sprache	Englisch
Erscheinungsort	Elsevier B.V.
Dokumenttyp	Artikel ; Online
Anmerkung	Pre-press version
ZDB-ID	2126918-X
ISSN	0254-6299
ISSN	0254-6299
DOI	10.1016/j.sajb.2023.07.003
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel ; Online: A heterocyclic compound inhibits viral release by inducing cell surface BST2/Tetherin/CD317/HM1.24

bioRxiv

Abstract: The introduction of combined antiretroviral therapy (cART) has greatly improved the quality of life of human immunodeficiency virus type 1 (HIV-1)-infected individuals. Nonetheless, the ever-present desire to seek out a full remedy for HIV-1 infections ... ...

Abstract	The introduction of combined antiretroviral therapy (cART) has greatly improved the quality of life of human immunodeficiency virus type 1 (HIV-1)-infected individuals. Nonetheless, the ever-present desire to seek out a full remedy for HIV-1 infections makes the discovery of novel antiviral medication compelling. Owing to this, a new late-stage inhibitor, Lenacapavir/Sunlenca, an HIV multi-phase suppressor, was clinically authorized in 2022. Besides unveiling cutting-edge antivirals inhibiting late-stage proteins or processes, newer therapeutics targeting host restriction factors hold promise for the curative care of HIV-1 infections. Notwithstanding, bone marrow stromal antigen 2 (BST2)/Tetherin/CD317/HM1.24, which entraps progeny virions is an appealing HIV-1 therapeutic candidate. In this study, a novel drug screening system was established, using the Jurkat/Vpr-HiBiT T cells, to identify drugs that could obstruct HIV-1 release; the candidate compounds were selected from the Ono Pharmaceutical compound library. Jurkat T cells expressing Vpr-HiBiT were infected with NL4-3, and the amount of virus release was quantified indirectly by the amount of Vpr-HiBiT incorporated into the progeny virions. Subsequently, the candidate compounds that suppressed viral release were used to synthesize the heterocyclic compound, HT-7, which reduces HIV-1 release with less cellular toxicity. Notably, HT-7 increased cell surface BST2 coupled with HIV-1 release reduction in Jurkat cells but not Jurkat/KO-BST2 cells. Seemingly, HT-7 impeded simian immunodeficiency virus (SIV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) release. Concisely, these results suggest that the reduction in viral release, following HT-7 treatment, resulted from the modulation of cell surface expression of BST2 by HT-7.
Schlagwörter	covid19
Sprache	Englisch
Erscheinungsdatum	2024-05-05
Verlag	Cold Spring Harbor Laboratory
Dokumenttyp	Artikel ; Online
DOI	10.1101/2024.05.03.592399
Datenquelle	COVID19

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Artikel ; Online: A heterocyclic compound inhibits viral release by inducing cell surface BST2/Tetherin/CD317/HM1.24

bioRxiv

Abstract	The introduction of combined antiretroviral therapy (cART) has greatly improved the quality of life of human immunodeficiency virus type 1 (HIV-1)-infected individuals. Nonetheless, the ever-present desire to seek out a full remedy for HIV-1 infections makes the discovery of novel antiviral medication compelling. Owing to this, a new late-stage inhibitor, Lenacapavir/Sunlenca, an HIV multi-phase suppressor, was clinically authorized in 2022. Besides unveiling cutting-edge antivirals inhibiting late-stage proteins or processes, newer therapeutics targeting host restriction factors hold promise for the curative care of HIV-1 infections. Notwithstanding, bone marrow stromal antigen 2 (BST2)/Tetherin/CD317/HM1.24, which entraps progeny virions is an appealing HIV-1 therapeutic candidate. In this study, a novel drug screening system was established, using the Jurkat/Vpr-HiBiT T cells, to identify drugs that could obstruct HIV-1 release; the candidate compounds were selected from the Ono Pharmaceutical compound library. Jurkat T cells expressing Vpr-HiBiT were infected with NL4-3, and the amount of virus release was quantified indirectly by the amount of Vpr-HiBiT incorporated into the progeny virions. Subsequently, the candidate compounds that suppressed viral release were used to synthesize the heterocyclic compound, HT-7, which reduces HIV-1 release with less cellular toxicity. Notably, HT-7 increased cell surface BST2 coupled with HIV-1 release reduction in Jurkat cells but not Jurkat/KO-BST2 cells. Seemingly, HT-7 impeded simian immunodeficiency virus (SIV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) release. Concisely, these results suggest that the reduction in viral release, following HT-7 treatment, resulted from the modulation of cell surface expression of BST2 by HT-7.
Schlagwörter	covid19
Sprache	Englisch
Erscheinungsdatum	2024-05-05
Verlag	Cold Spring Harbor Laboratory
Dokumenttyp	Artikel ; Online
DOI	10.1101/2024.05.03.592399
Datenquelle	COVID19

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Artikel ; Online: Design of a BIST implemented AES crypto-processor ASIC.

Ali, Md Liakot / Rahman, Md Shazzatur / Hossain, Fakir Sharif

PloS one

2021 Band 16, Heft 11, Seite(n) e0259956

Abstract: This paper presents the design of a Built-in-self-Test (BIST) implemented Advanced Encryption Standard (AES) cryptoprocessor Application Specific Integrated Circuit (ASIC). AES has been proved as the strongest symmetric encryption algorithm declared by ... ...

Abstract	This paper presents the design of a Built-in-self-Test (BIST) implemented Advanced Encryption Standard (AES) cryptoprocessor Application Specific Integrated Circuit (ASIC). AES has been proved as the strongest symmetric encryption algorithm declared by USA Govt. and it outperforms all other existing cryptographic algorithms. Its hardware implementation offers much higher speed and physical security than that of its software implementation. Due to this reason, a number of AES cryptoprocessor ASIC have been presented in the literature, but the problem of testability in the complex AES chip is not addressed yet. This research introduces a solution to the problem for the AES cryptoprocessor ASIC implementing mixed-mode BIST technique, a hybrid of pseudo-random and deterministic techniques. The BIST implemented ASIC is designed using IEEE industry standard Hardware Description Language(HDL). It has been simulated using Electronic Design Automation (EDA)tools for verification and validation using the input-output data from the National Institute of Standard and Technology (NIST) of the USA Govt. The simulation results show that the design is working as per desired functionalities in different modes of operation of the ASIC. The current research is compared with those of other researchers, and it shows that it is unique in terms of BIST implementation into the ASIC chip.
Mesh-Begriff(e)	Algorithms ; Computer Security/instrumentation ; Computer Simulation ; Industry ; Pattern Recognition, Automated ; United States
Sprache	Englisch
Erscheinungsdatum	2021-11-16
Erscheinungsland	United States
Dokumenttyp	Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0259956
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Design of a BIST implemented AES crypto-processor ASIC.

Md Liakot Ali / Md Shazzatur Rahman / Fakir Sharif Hossain

PLoS ONE, Vol 16, Iss 11, p e

2021 Band 0259956

Abstract	This paper presents the design of a Built-in-self-Test (BIST) implemented Advanced Encryption Standard (AES) cryptoprocessor Application Specific Integrated Circuit (ASIC). AES has been proved as the strongest symmetric encryption algorithm declared by USA Govt. and it outperforms all other existing cryptographic algorithms. Its hardware implementation offers much higher speed and physical security than that of its software implementation. Due to this reason, a number of AES cryptoprocessor ASIC have been presented in the literature, but the problem of testability in the complex AES chip is not addressed yet. This research introduces a solution to the problem for the AES cryptoprocessor ASIC implementing mixed-mode BIST technique, a hybrid of pseudo-random and deterministic techniques. The BIST implemented ASIC is designed using IEEE industry standard Hardware Description Language(HDL). It has been simulated using Electronic Design Automation (EDA)tools for verification and validation using the input-output data from the National Institute of Standard and Technology (NIST) of the USA Govt. The simulation results show that the design is working as per desired functionalities in different modes of operation of the ASIC. The current research is compared with those of other researchers, and it shows that it is unique in terms of BIST implementation into the ASIC chip.
Schlagwörter	Medicine ; R ; Science ; Q
Thema/Rubrik (Code)	005
Sprache	Englisch
Erscheinungsdatum	2021-01-01T00:00:00Z
Verlag	Public Library of Science (PLoS)
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel ; Online: Design of a BIST implemented AES crypto-processor ASIC

Md. Liakot Ali / Md. Shazzatur Rahman / Fakir Sharif Hossain

PLoS ONE, Vol 16, Iss

2021 Band 11

Abstract	This paper presents the design of a Built-in-self-Test (BIST) implemented Advanced Encryption Standard (AES) cryptoprocessor Application Specific Integrated Circuit (ASIC). AES has been proved as the strongest symmetric encryption algorithm declared by USA Govt. and it outperforms all other existing cryptographic algorithms. Its hardware implementation offers much higher speed and physical security than that of its software implementation. Due to this reason, a number of AES cryptoprocessor ASIC have been presented in the literature, but the problem of testability in the complex AES chip is not addressed yet. This research introduces a solution to the problem for the AES cryptoprocessor ASIC implementing mixed-mode BIST technique, a hybrid of pseudo-random and deterministic techniques. The BIST implemented ASIC is designed using IEEE industry standard Hardware Description Language(HDL). It has been simulated using Electronic Design Automation (EDA)tools for verification and validation using the input-output data from the National Institute of Standard and Technology (NIST) of the USA Govt. The simulation results show that the design is working as per desired functionalities in different modes of operation of the ASIC. The current research is compared with those of other researchers, and it shows that it is unique in terms of BIST implementation into the ASIC chip.
Schlagwörter	Medicine ; R ; Science ; Q
Thema/Rubrik (Code)	005
Sprache	Englisch
Erscheinungsdatum	2021-01-01T00:00:00Z
Verlag	Public Library of Science (PLoS)
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel ; Online: La pandemia de la COVID-19. Una oportunidad para aprender a conciliar trabajo y familia en las Fuerzas Armadas españolas

Sheima Hossain-López / Dolores Ruiz-Berdún

Musas, Vol 7, Iss 1, Pp 3-

2022 Band 24

Abstract: ... ocasionó el cierre de centros educativos complicando la situación para las familias con menores a cargo ... Armadas españolas (F.A.S.). Dada la distribución asimétrica de las tareas de cuidado en España y ... transversal y retrospectivo a través de un cuestionario electrónico, anónimo y autoadministrado a una muestra ...

Abstract	El confinamiento, impuesto durante la primera ola de la pandemia causada por el virus SARS-CoV-2, ocasionó el cierre de centros educativos complicando la situación para las familias con menores a cargo. El desafío fue aún mayor entre los trabajadores denominados «esenciales», como el personal de las Fuerzas Armadas españolas (F.A.S.). Dada la distribución asimétrica de las tareas de cuidado en España y la posición minoritaria de las féminas en la institución armada, la situación de las mujeres mil-itares era potencialmente crítica. Objetivo. Analizar el uso de las medidas extraordinarias de conciliación, implementadas por el Ministerio de Defensa durante el estado de alarma. Material y método. Se realizó un estudio cuantitativo, transversal y retrospectivo a través de un cuestionario electrónico, anónimo y autoadministrado a una muestra de 473 mujeres militares. Resultados. Durante el periodo analizado, aumentó ligeramente el porcentaje de mujeres militares que hacían uso de medidas de conciliación familiar. Sin embargo, en casos de parejas/exparejas donde ambos progenitores son militares, se duplicó el número de padres que disfrutaron de ellas. Por su parte, las familias monomarentales optaron por la permanencia de la madre en el domicilio. Conclusiones. El confinamiento cambió el perfil de uso de la conciliación familiar en las F.A.S., con mayor presencia de las madres en hogares monomarentales, pero también mayor corresponsabilidad en hogares con ambos progenitores militares. Nuevos análisis sobre los factores que han propiciado esta mayor corresponsabilidad podrían aportar valiosa información para lograr reducir las consecuencias profesionales de la maternidad en las mujeres de las F.A.S.
Schlagwörter	Public aspects of medicine ; RA1-1270 ; Women. Feminism ; HQ1101-2030.7
Sprache	Spanisch
Erscheinungsdatum	2022-01-01T00:00:00Z
Verlag	Universitat de Barcelona
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel ; Online: DEVELOPING A LINEAR PROGRAMMING MODEL TO MAXIMIZE PROFIT WITH MINIMIZED LEAD TIME OF A COMPOSITE TEXTILE MILL

Sourav Kumar Ghosh / Sumon Hossain / Hafijur Rahman / Naurin Zoha / Mohammad Arif-Ul Islam

ITEGAM-JETIA, Vol 6, Iss

2020 Band 22

Abstract: In the competitive market of apparel manufacturing, lead time for production plays a significant role in the delivery of the produces impacting the entire supply chain. Nowadays, composite manufacturers are leaning towards delivering within the shortest ... ...

Abstract	In the competitive market of apparel manufacturing, lead time for production plays a significant role in the delivery of the produces impacting the entire supply chain. Nowadays, composite manufacturers are leaning towards delivering within the shortest possible time to retain customers in this competitive market. To meet this challenge, proper production planning either using the correct method or the appropriate tools is a prerequisite condition; otherwise, mills will inevitably suffer losses or fail to drain out the maximum possible profit from the produces and may also suffer from promoting more expenses rather than yielding revenues. This study deals with the development of a linear programming model in order to reduce the complexity of the scheduling problem of a Composite Textile Industry in pursuit of maximizing profit or minimizing production costs. The model is developed considering process segmentation, utilization of machines and other resources, with respect to lead time. Four different components of the lead time are derived and an excel solver is used in solving the model.
Schlagwörter	Technology ; T ; Technology (General) ; T1-995 ; Science (General) ; Q1-390
Thema/Rubrik (Code)	670
Sprache	Englisch
Erscheinungsdatum	2020-04-01T00:00:00Z
Verlag	Institute of Technology and Education Galileo da Amazônia
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel ; Online: Pulmonary tuberculosis induces a systemic hypercoagulable state.

The Journal of infection

2015 Band 70, Heft 4, Seite(n) 324–334

Abstract: Objectives: Human tuberculosis (TB) remains an important cause of death globally. Bangladesh is one of the most affected countries. We aimed to investigate the impact of pulmonary TB on pro- and anticoagulant mechanisms.: Methods: This prospective ... ...

Abstract	Objectives: Human tuberculosis (TB) remains an important cause of death globally. Bangladesh is one of the most affected countries. We aimed to investigate the impact of pulmonary TB on pro- and anticoagulant mechanisms. Methods: This prospective study was conducted in Chittagong, Bangladesh. We performed an in-depth analysis of coagulation activation and inhibition in plasma obtained from 64 patients with primary lung TB and 11 patients with recurrent lung TB and compared these with 37 healthy controls. Additionally, in nine patients coagulation activation was studied in bronchoalveolar lavage fluid (BALF) harvested from the site of infection and compared with BALF from a contralateral unaffected lung subsegment. Results: Relative to uninfected controls, primary and recurrent TB were associated with a systemic net procoagulant state, as indicated by enhanced activation of coagulation (elevated plasma levels of thrombin-antithrombin complexes, D-dimer and fibrinogen) together with impaired anticoagulant mechanisms (reduced plasma levels of antithrombin, protein C activity, free protein S, and protein C inhibitor). Activation of coagulation did not correlate with plasma concentrations of established TB biomarkers. Coagulation activation could not be detected at the primary site of infection in a subset of TB patients. Conclusions: Pulmonary TB is associated with a systemic hypercoagulable state.
Mesh-Begriff(e)	Antithrombin III ; Bangladesh ; Biomarkers/blood ; Blood Coagulation/physiology ; Bronchoalveolar Lavage Fluid ; Bronchoscopy ; Female ; Fibrinogen/analysis ; Humans ; Inflammation ; Male ; Middle Aged ; Peptide Hydrolases/blood ; Prospective Studies ; Thrombophilia/etiology ; Tuberculosis, Pulmonary/blood ; Tuberculosis, Pulmonary/complications
Chemische Substanzen	Biomarkers ; antithrombin III-protease complex ; Antithrombin III (9000-94-6) ; Fibrinogen (9001-32-5) ; Peptide Hydrolases (EC 3.4.-)
Sprache	Englisch
Erscheinungsdatum	2015-04
Erscheinungsland	England
Dokumenttyp	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	424417-5
ISSN	1532-2742 ; 0163-4453
ISSN (online)	1532-2742
ISSN	0163-4453
DOI	10.1016/j.jinf.2014.10.006
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: A current perspective on Sjögren's syndrome.

Nazmul-Hossain, Abu N M / Morarasu, George M / Schmidt, Samuel K / Walker, Amber J / Myers, Sandra L / Rhodus, Nelson L

The Journal of the Michigan Dental Association

2012 Band 94, Heft 3, Seite(n) 64–70

Sprache	Englisch
Erscheinungsdatum	2012-03
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	603716-1
ISSN	0026-2102
ISSN	0026-2102
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