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  1. Artikel: Knowledge and behavior of Lebanese parents regarding melanoma prevention in public and private school children.

    Haddad, Léa El / Souaid, Tarek / Kadi, Diana / Hindy, Joya-Rita / Souaid, Karim / Kourie, Hampig Raphael / Tomb, Roland

    Melanoma management

    2022  Band 8, Heft 4, Seite(n) MMT59

    Abstract: Aim: Assess the knowledge and behavior of Lebanese parents when it comes to melanoma and its prevention in children.: Methods: A survey, to be completed by parents, was sent through children from three schools.: Results: During sun exposure only ... ...

    Abstract Aim: Assess the knowledge and behavior of Lebanese parents when it comes to melanoma and its prevention in children.
    Methods: A survey, to be completed by parents, was sent through children from three schools.
    Results: During sun exposure only 23.5% of 1012 respondents were always covering enough areas of their children's skin and 74.1% did not always apply sunscreen to their children. Parents of private school children were three times more likely to apply sunscreen to their children when exposed to sun, four times more likely to reapply sunscreen every 2-3 h and 21 times more likely to use a higher sun protection factor.
    Conclusion: Sun protection in children is insufficient and sunburns are frequent, illustrating the need for melanoma awareness campaigns.
    Sprache Englisch
    Erscheinungsdatum 2022-01-12
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 2045-0885
    ISSN 2045-0885
    DOI 10.2217/mmt-2021-0002
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Type I Interferon Signature in Chilblains Following SARS-CoV-2 mRNA Vaccine: A Case Report.

    Souaid, Karim / Oulès, Bénédicte / Sohier, Pierre / Deschamps, Lydia / Aractingi, Sélim / Dupin, Nicolas

    Acta dermato-venereologica

    2021  Band 101, Heft 11, Seite(n) adv00589

    Mesh-Begriff(e) COVID-19 ; COVID-19 Vaccines ; Chilblains ; Humans ; Interferon Type I ; RNA, Messenger/genetics ; SARS-CoV-2
    Chemische Substanzen COVID-19 Vaccines ; Interferon Type I ; RNA, Messenger
    Sprache Englisch
    Erscheinungsdatum 2021-11-10
    Erscheinungsland Sweden
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 80007-7
    ISSN 1651-2057 ; 0001-5555
    ISSN (online) 1651-2057
    ISSN 0001-5555
    DOI 10.2340/00015555-3888
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Contribution of fetal microchimeric cells to maternal wound healing in sickle cell ulcers.

    Alkobtawi, Mansour / Sbeih, Maria / Souaid, Karim / Ngô, Qui Trung / Nassar, Dany / Arbes, Hugo / Guillet, Henri / Habibi, Anoosha / Bartolucci, Pablo / Castela, Mathieu / Aractingi, Sélim / Oulès, Bénédicte

    Haematologica

    2023  Band 108, Heft 7, Seite(n) 1920–1933

    Abstract: Leg ulcers are a major complication of sickle cell disease (SCD). They are particularly challenging to treat and innovative therapies are needed. We previously showed that the healing of SCD ulcers is delayed because of decreased angiogenesis. During ... ...

    Abstract Leg ulcers are a major complication of sickle cell disease (SCD). They are particularly challenging to treat and innovative therapies are needed. We previously showed that the healing of SCD ulcers is delayed because of decreased angiogenesis. During pregnancy, fetal microchimeric cells (FMC) transferred to the mother are recruited to maternal wounds and improve angiogenesis. After delivery, FMC persist in maternal bone marrow for decades. Here, we investigated whether fetal cells could also improve SCD ulcers in the post-partum setting. We found that skin healing was similarly improved in post-partum mice and in pregnant mice, through increased proliferation and angiogenesis. In a SCD mouse model that recapitulates refractory SCD ulcers, we showed that the ulcers of post-partum SCD mice healed more quickly than those of virgin mice. This was associated with the recruitment of fetal cells in maternal wounds where they harbored markers of leukocytes and endothelial cells. In a retrospective cohort of SCD patients, using several parameters we found that SCD women who had ever had a baby had less of a burden related to leg ulcers compared to nulliparous women. Taken together, these results indicate that healing capacities of FMC are maintained long after delivery and may be exploited to promote wound healing in post-partum SCD patients.
    Mesh-Begriff(e) Pregnancy ; Female ; Mice ; Animals ; Ulcer/complications ; Endothelial Cells ; Retrospective Studies ; Wound Healing ; Leg Ulcer/complications ; Leg Ulcer/therapy ; Anemia, Sickle Cell/complications
    Sprache Englisch
    Erscheinungsdatum 2023-07-01
    Erscheinungsland Italy
    Dokumenttyp Journal Article
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2022.281140
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Triggers, clinical manifestations, and management of pediatric erythema multiforme: A systematic review.

    Zoghaib, Samer / Kechichian, Elio / Souaid, Karim / Soutou, Boutros / Helou, Josiane / Tomb, Roland

    Journal of the American Academy of Dermatology

    2019  Band 81, Heft 3, Seite(n) 813–822

    Abstract: Background: Erythema multiforme (EM) is an acute inflammatory mucocutaneous condition. EM is rarely described in children and infants.: Objective: To investigate the triggers, clinical manifestations, and treatment of pediatric EM.: Methods: ... ...

    Abstract Background: Erythema multiforme (EM) is an acute inflammatory mucocutaneous condition. EM is rarely described in children and infants.
    Objective: To investigate the triggers, clinical manifestations, and treatment of pediatric EM.
    Methods: Systematic literature review of pediatric EM.
    Results: After full-text article review, we included 113 articles, representing 580 patients. The mean age was 5.6 years, ranging 0.1-17 years. Infectious agents were the main triggers: herpes simplex virus (HSV) in 104 patients (17.9%) and Mycoplasma pneumoniae in 91 patients (15.7%). In total, 140 cases (24.1%) were drug-related and 89 cases (15.3%) had other triggers, such as vaccines (19 patients, 3.2%). In total, 229 patients had EM major (39.5%). Treatment was supportive care only (180 patients, 31.1%), systemic corticosteroids (115 patients, 19.8%), antivirals (85 patients, 14.6%), and antibiotics (66 patients, 11.3%), mostly macrolides (45 patients, 7.7%). Long-term sequelae were rare (1.3%). Pediatric EM was reported in 19 infants (3.2%). The main trigger was vaccination (9 patients). Infantile EM was EM major in 2 cases and EM minor in 17. Infants were less prone to develop EM major than older children (P < .01). Pediatric EM was recurrent in 83 cases (14.3%), which was triggered by HSV in 36 patients (61%). Recurrence affected older children.
    Limitations: Potential confusion between Steven Johnson syndrome and EM major in addition to publication bias.
    Conclusion: Pediatric EM is a rare disease, mainly triggered by infections. This condition can affect all mucosal surfaces, most commonly the oral mucosae. The diagnosis is clinical, and management relies on supportive care. Vaccines are a particular trigger in infants. Recurrent cases are most commonly linked to HSV. Dermatologists and pediatricians should be aware of this potentially recurrent and severe condition.
    Mesh-Begriff(e) Adolescent ; Age Factors ; Anti-Bacterial Agents/therapeutic use ; Antiviral Agents/therapeutic use ; Child ; Child, Preschool ; Diagnosis, Differential ; Drug Eruptions/diagnosis ; Drug Eruptions/etiology ; Drug Eruptions/therapy ; Erythema Multiforme/diagnosis ; Erythema Multiforme/etiology ; Erythema Multiforme/therapy ; Glucocorticoids/therapeutic use ; Herpes Simplex/complications ; Herpes Simplex/drug therapy ; Humans ; Infant ; Mouth Mucosa/microbiology ; Mouth Mucosa/pathology ; Palliative Care/methods ; Pneumonia, Mycoplasma/complications ; Pneumonia, Mycoplasma/drug therapy ; Rare Diseases/diagnosis ; Rare Diseases/etiology ; Rare Diseases/therapy ; Recurrence ; Severity of Illness Index ; Vaccination/adverse effects
    Chemische Substanzen Anti-Bacterial Agents ; Antiviral Agents ; Glucocorticoids
    Sprache Englisch
    Erscheinungsdatum 2019-07-19
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Systematic Review
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2019.02.057
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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