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Buch: Operative techniques in shoulder and elbow surgery

Ramsey, Matthew L. / Wiesel, Brent B. / Namdari, Surena / Williams, Gerald R.

Gerald R. Williams, Matthew L. Ramsey, Brent B. Wiesel, Surena Namdari

2022

Schlagwörter	Shoulder/Surgery ; Elbow/Surgery
Thema/Rubrik (Code)	617.572059
Sprache	Englisch
Umfang	xxi, 879, 8, I-22 Seiten, Illustrationen, 28 cm
Ausgabenhinweis	Third edition
Verlag	Wolters Kluwer
Erscheinungsort	Philadelphia
Erscheinungsland	Vereinigte Staaten
Dokumenttyp	Buch
Anmerkung	Zugang zur Online-Ausgabe über Code
HBZ-ID	HT021134545
ISBN	978-1-975172-10-7 ; 9781975174095 ; 1-975172-10-8 ; 1975174097
Datenquelle	Katalog ZB MED Medizin, Gesundheit

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Buch: Operative techniques in shoulder and elbow surgery

Williams, Gerald R. / Ramsey, Matthew L. / Wiesel, Brent B. / Wiesel, Sam W.

2016

Verfasserangabe	Gerald R. Williams, Jr., MD; Matthew L. Ramsey, MD; Brent B. Wiesel, MD ; Sam W. Wiesel, MD editor-in-chief
Schlagwörter	Shoulder / surgery ; Elbow / surgery ; Orthopedic Procedures / methods
Sprache	Englisch
Umfang	xx, 754, 8, I-17 Seiten, Illustrationen
Ausgabenhinweis	Second edition
Verlag	Wolters Kluwer
Erscheinungsort	Philadelphia
Erscheinungsland	Vereinigte Staaten
Dokumenttyp	Buch
Anmerkung	Zugang zur Internetausgabe über Code
HBZ-ID	HT018903597
ISBN	978-1-4511-9302-2 ; 1-4511-9302-5
Datenquelle	Katalog ZB MED Medizin, Gesundheit

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2016 A 581	ausleihbar (Lesesaal)	Lesesaal EG
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Artikel ; Online: The impact of correlated exposures and missing data on multiple informant models used to identify critical exposure windows.

Bather, Jemar R / Horton, Nicholas J / Coull, Brent A / Williams, Paige L

Statistics in medicine

2023 Band 42, Heft 8, Seite(n) 1171–1187

Abstract: There has been heightened interest in identifying critical windows of exposure for adverse health outcomes; that is, time points during which exposures have the greatest impact on a person's health. Multiple informant models implemented using generalized ...

Abstract	There has been heightened interest in identifying critical windows of exposure for adverse health outcomes; that is, time points during which exposures have the greatest impact on a person's health. Multiple informant models implemented using generalized estimating equations (MIM GEEs) have been applied to address this research question because they enable statistical comparisons of differences in associations across exposure windows. As interest rises in using MIMs, the feasibility and appropriateness of their application under settings of correlated exposures and partially missing exposure measurements requires further examination. We evaluated the impact of correlation between exposure measurements and missing exposure data on the power and differences in association estimated by the MIM GEE and an inverse probability weighted extension to account for informatively missing exposures. We assessed these operating characteristics under a variety of correlation structures, sample sizes, and missing data mechanisms considering various exposure-outcome scenarios. We showed that applying MIM GEEs maintains higher power when there is a single critical window of exposure and exposure measures are not highly correlated, but may result in low power and bias under other settings. We applied these methods to a study of pregnant women living with HIV to explore differences in association between trimester-specific viral load and infant neurodevelopment.
Mesh-Begriff(e)	Infant ; Humans ; Pregnancy ; Female ; Probability ; Bias ; Pregnancy Trimesters ; Sample Size ; Models, Statistical
Sprache	Englisch
Erscheinungsdatum	2023-01-16
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	843037-8
ISSN	1097-0258 ; 0277-6715
ISSN (online)	1097-0258
ISSN	0277-6715
DOI	10.1002/sim.9664
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Protein-Nanoparticle Complex Structure Determination by Cryo-Electron Microscopy.

Sen, Sagnik / Thaker, Amar / Sirajudeen, Luqmanal / Williams, Dewight / Nannenga, Brent L

ACS applied bio materials

2022

Abstract: Methods that allow the study of the structure of proteins in complex with nanomaterials promise to enhance our understanding of how biological molecules interface with inorganic materials. We used single-particle cryo-electron microscopy (cryo-EM) to ... ...

Abstract	Methods that allow the study of the structure of proteins in complex with nanomaterials promise to enhance our understanding of how biological molecules interface with inorganic materials. We used single-particle cryo-electron microscopy (cryo-EM) to demonstrate the potential for cryo-EM analysis to reveal structural details of protein-nanoparticle complexes. Two protein-nanomaterial complexes, namely, GroEL bound to platinum nanoparticles (GroEL-PtNP) and ferritin bound to an iron oxide nanoparticle, were used as model samples. For the GroEL-PtNP complex, a final reconstruction was obtained to 3.93 Å, which allowed us to fit the atomic model of GroEL into the resulting map. This sets the stage for future work and improvements on the use of cryo-EM for the study of protein-nanomaterial complexes.
Sprache	Englisch
Erscheinungsdatum	2022-05-19
Erscheinungsland	United States
Dokumenttyp	Journal Article
ISSN	2576-6422
ISSN (online)	2576-6422
DOI	10.1021/acsabm.2c00130
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: In Science Journals.

Ash, Caroline / Vignieri, Sacha / Osborne, Ian S / Williams, Ifor / Fogg, Christiana N / Alderton, Gemma / Ray, L Bryan / Scanlon, Seth Thomas / Grocholski, Brent / Hines, Pamela J / Wong, Wei

Science (New York, N.Y.)

2023 Band 379, Heft 6632, Seite(n) 549–550

Abstract: Highlights from ... ...

Abstract	Highlights from the
Sprache	Englisch
Erscheinungsdatum	2023-02-09
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	128410-1
ISSN	1095-9203 ; 0036-8075
ISSN (online)	1095-9203
ISSN	0036-8075
DOI	10.1126/science.adh0386
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 27: Hefte anzeigen			Standort: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Artikel ; Online: Seasonal variations of menstrual cycle length in a large, US-based, digital cohort.

Li, Huichu / Curry, Christine L / Fischer-Colbrie, Tyler / Onnela, Jukka-Pekka / Williams, Michelle A / Hauser, Russ / Coull, Brent A / Jukic, Anne Marie Z / Mahalingaiah, Shruthi

International journal of hygiene and environmental health

2023 Band 256, Seite(n) 114308

Mesh-Begriff(e)	Female ; Humans ; Seasons ; Menstrual Cycle
Sprache	Englisch
Erscheinungsdatum	2023-12-15
Erscheinungsland	Germany
Dokumenttyp	Journal Article
ZDB-ID	2009176-X
ISSN	1618-131X ; 1438-4639
ISSN (online)	1618-131X
ISSN	1438-4639
DOI	10.1016/j.ijheh.2023.114308
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Association between diseases of despair and atherosclerotic cardiovascular disease among insured adults in the USA: a retrospective cohort study from 2017 to 2021.

Nudy, Matthew / Galper, Kathleen / George, Daniel R / Williams, Brent A / Kraschnewski, Jennifer L / Sinoway, Lawrence / Brignone, Emily

BMJ open

2023 Band 13, Heft 9, Seite(n) e074102

Abstract: Objectives: To assess associations between diseases of despair (DoD) and incident atherosclerotic cardiovascular disease (ASCVD) among insured adults in the USA.: Design: Retrospective cohort study.: Setting: Highmark insurance claims data in the ... ...

Abstract	Objectives: To assess associations between diseases of despair (DoD) and incident atherosclerotic cardiovascular disease (ASCVD) among insured adults in the USA. Design: Retrospective cohort study. Setting: Highmark insurance claims data in the USA from 2017 to 2021. Participants: Adults with at least 10 months of continuous insurance enrolment, no record of ASCVD in the 2016 baseline year and no missing data on study variables. Primary and secondary outcome measures: Cox proportional hazard regression was used to calculate crude and adjusted hazard ratios (HR) and 95% confidence intervals (CI) to assess risk of ASCVD (composite of ischaemic cardiomyopathy, non-fatal ischaemic stroke, peripheral arterial disease or non-fatal acute myocardial infarction) by baseline DoD overall, and by the component conditions comprising DoD (alcohol-related disorders, substance-related disorders, suicidality) individually and in combination. Results: The DoD-exposed group had an age-adjusted rate of 20.5 ASCVD events per 1000 person-years, compared with 11.7 among the unexposed. In adjusted models, overall DoD was associated with increased risk of incident ASCVD (HR 1.42, 95% CI 1.36 to 1.47). Individually and in combination, component conditions of DoD were associated with higher risk for ASCVD relative to no DoD. Substance-related disorders were associated with 50% higher risk of incident ASCVD (HR 1.5, 95% CI 1.41 to 1.59), alcohol-related disorders and suicidality/intentional self-harm were associated with 33% and 30% higher risk, respectively (HR 1.33, 95% CI 1.26 to 1.41; HR 1.30, 95% CI 1.11 to 1.52). Co-occurring DoD components conferred higher risk still. The highest risk combination was substance-related disorders+suicidality (HR 2.01, 95% CI 1.44 to 2.82). Conclusions: Among this cohort of insured adults, documented DoD was associated with increased ASCVD risk. Further research to understand and address cardiovascular disease prevention in those with DoD could reduce costs, morbidity and mortality. Further examination of overlapping structural factors that may be contributing to concurrent rises in ASCVD and DoD in the USA is needed.
Mesh-Begriff(e)	Adult ; Humans ; United States/epidemiology ; Brain Ischemia ; Cardiovascular Diseases/epidemiology ; Retrospective Studies ; Stroke ; Atherosclerosis/epidemiology ; Peripheral Arterial Disease ; Alcohol-Related Disorders
Sprache	Englisch
Erscheinungsdatum	2023-09-06
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2023-074102
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Sporadic Creutzfeldt-Jakob disease infected human cerebral organoids retain the original human brain subtype features following transmission to humanized transgenic mice.

Groveman, Bradley R / Race, Brent / Foliaki, Simote T / Williams, Katie / Hughson, Andrew G / Baune, Chase / Zanusso, Gianluigi / Haigh, Cathryn L

Acta neuropathologica communications

2023 Band 11, Heft 1, Seite(n) 28

Abstract: Human cerebral organoids (COs) are three-dimensional self-organizing cultures of cerebral brain tissue differentiated from induced pluripotent stem cells. We have recently shown that COs are susceptible to infection with different subtypes of Creutzfeldt- ...

Abstract	Human cerebral organoids (COs) are three-dimensional self-organizing cultures of cerebral brain tissue differentiated from induced pluripotent stem cells. We have recently shown that COs are susceptible to infection with different subtypes of Creutzfeldt-Jakob disease (CJD) prions, which in humans cause different manifestations of the disease. The ability to study live human brain tissue infected with different CJD subtypes opens a wide array of possibilities from differentiating mechanisms of cell death and identifying neuronal selective vulnerabilities to testing therapeutics. However, the question remained as to whether the prions generated in the CO model truly represent those in the infecting inoculum. Mouse models expressing human prion protein are commonly used to characterize human prion disease as they reproduce many of the molecular and clinical phenotypes associated with CJD subtypes. We therefore inoculated these mice with COs that had been infected with two CJD subtypes (MV1 and MV2) to see if the original subtype characteristics (referred to as strains once transmitted into a model organism) of the infecting prions were maintained in the COs when compared with the original human brain inocula. We found that disease characteristics caused by the molecular subtype of the disease associated prion protein were similar in mice inoculated with either CO derived material or human brain material, demonstrating that the disease associated prions generated in COs shared strain characteristics with those in humans. As the first and only in vitro model of human neurodegenerative disease that can faithfully reproduce different subtypes of prion disease, these findings support the use of the CO model for investigating human prion diseases and their subtypes.
Mesh-Begriff(e)	Humans ; Mice ; Animals ; Creutzfeldt-Jakob Syndrome/metabolism ; Mice, Transgenic ; Prion Proteins/genetics ; Prion Proteins/metabolism ; Neurodegenerative Diseases/metabolism ; Brain/metabolism ; Prions/metabolism ; Prion Diseases/metabolism ; Organoids/metabolism
Chemische Substanzen	Prion Proteins ; Prions
Sprache	Englisch
Erscheinungsdatum	2023-02-14
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2715589-4
ISSN	2051-5960 ; 2051-5960
ISSN (online)	2051-5960
ISSN	2051-5960
DOI	10.1186/s40478-023-01512-1
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Neural cell engraftment therapy for sporadic Creutzfeldt-Jakob disease restores neuroelectrophysiological parameters in a cerebral organoid model.

Williams, Katie / Foliaki, Simote T / Race, Brent / Smith, Anna / Thomas, Tina / Groveman, Bradley R / Haigh, Cathryn L

Stem cell research & therapy

2023 Band 14, Heft 1, Seite(n) 348

Abstract: Background: Sporadic Creutzfeldt-Jakob disease (sCJD), the most common human prion disease, is a fatal neurodegenerative disease with currently no treatment options. Stem cell therapy for neurodegenerative diseases is emerging as a possible treatment ... ...

Abstract	Background: Sporadic Creutzfeldt-Jakob disease (sCJD), the most common human prion disease, is a fatal neurodegenerative disease with currently no treatment options. Stem cell therapy for neurodegenerative diseases is emerging as a possible treatment option. However, while there are a few clinical trials for other neurodegenerative disorders such as Parkinson's disease, prion disease cell therapy research has so far been confined to animal models. Methods: Here, we use a novel approach to study cell therapies in sCJD using a human cerebral organoid model. Cerebral organoids can be infected with sCJD prions allowing us to assess how neural precursor cell (NPC) therapy impacts the progression of sCJD. After 90 days of sCJD or mock infection, organoids were either seeded with NPCs or left unseeded and monitored for cellular composition changes, prion infection parameters and neuroelectrophysiological function at 180 days post-infection. Results: Our results showed NPCs integrated into organoids leading to an increase in neuronal markers and changes in cell signaling irrespective of sCJD infection. Although a small, but significant, decrease in protease-resistant PrP deposition was observed in the CJD-infected organoids that received the NPCs, other disease-associated parameters showed minimal changes. However, the NPCs had a beneficial impact on organoid function following infection. sCJD infection caused reduction in neuronal spike rate and mean burst spike rate, indicative of reduced action potentials. NPC seeding restored these electrophysiological parameters to the uninfected control level. Conclusions: Together with the previous animal studies, our results support that cell therapy may have some functional benefit for the treatment of human prion diseases.
Mesh-Begriff(e)	Animals ; Humans ; Creutzfeldt-Jakob Syndrome/therapy ; Neurodegenerative Diseases ; Prions ; Prion Diseases ; Organoids
Chemische Substanzen	Prions
Sprache	Englisch
Erscheinungsdatum	2023-12-05
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	2548671-8
ISSN	1757-6512 ; 1757-6512
ISSN (online)	1757-6512
ISSN	1757-6512
DOI	10.1186/s13287-023-03591-2
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Early intranasal medication administration in out-of-hospital cardiac arrest: Two randomized simulation trials.

Dowker, Stephen R / Downey, Madison L / Majhail, Noor K / Scott, Isabella G / Mathisson, Jonah / Rizk, Daniel / Trumpower, Brad / Yake, Debra / Williams, Michelle / Coulter-Thompson, Emilee I / Brent, Christine M / Smith, Graham C / Swor, Robert / Berger, David A / Rooney, Deborah M / Neumar, Robert W / Friedman, Charles P / Cooke, James M / Missel, Amanda L

Journal of the American College of Emergency Physicians open

2024 Band 5, Heft 1, Seite(n) e13100

Abstract: Objective: Intranasal medications have been proposed as adjuncts to out-of-hospital cardiac arrest (OHCA) care. We sought to quantify the effects of intranasal medication administration (INMA) in OHCA workflows.: Methods: We conducted separate ... ...

Abstract	Objective: Intranasal medications have been proposed as adjuncts to out-of-hospital cardiac arrest (OHCA) care. We sought to quantify the effects of intranasal medication administration (INMA) in OHCA workflows. Methods: We conducted separate randomized OHCA simulation trials with lay rescuers (LRs) and first responders (FRs). Participants were randomized to groups performing hands-only cardiopulmonary resuscitation (CPR)/automated external defibrillator with or without INMA during the second analysis phase. Time to compression following the second shock (CPR2) was the primary outcome and compression quality (chest compression rate (CCR) and fraction (CCF)) was the secondary outcome. We fit linear regression models adjusted for CPR training in the LR group and service years in the FR group. Results: Among LRs, INMA was associated with a significant increase in CPR2 (mean diff. 44.1 s, 95% CI: 14.9, 73.3), which persisted after adjustment ( Conclusions: INMA in LR resuscitation was associated with diminished resuscitation performance. INMA by FR did not impede key times or quality.
Sprache	Englisch
Erscheinungsdatum	2024-01-21
Erscheinungsland	United States
Dokumenttyp	Journal Article
ISSN	2688-1152
ISSN (online)	2688-1152
DOI	10.1002/emp2.13100
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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