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  1. Artikel ; Online: Efficient association mapping from k-mers-An application in finding sex-specific sequences.

    Mehrab, Zakaria / Mobin, Jaiaid / Tahmid, Ibrahim Asadullah / Rahman, Atif

    PloS one

    2021  Band 16, Heft 1, Seite(n) e0245058

    Abstract: ... free association mapping methods based on k-mers from sequencing reads. Here we present an improved implementation ...

    Abstract Genome wide association studies (GWAS) attempt to map genotypes to phenotypes in organisms. This is typically performed by genotyping individuals using microarray or by aligning whole genome sequencing reads to a reference genome. Both approaches require knowledge of a reference genome which hinders their application to organisms with no or incomplete reference genomes. This caveat can be removed by using alignment-free association mapping methods based on k-mers from sequencing reads. Here we present an improved implementation of an alignment free association mapping method. The new implementation is faster and includes additional features to make it more flexible than the original implementation. We have tested our implementation on an E. Coli ampicillin resistance dataset and observe improvement in execution time over the original implementation while maintaining accuracy in results. We also demonstrate that the method can be applied to find sex specific sequences.
    Mesh-Begriff(e) Algorithms ; Ampicillin Resistance/genetics ; Escherichia coli/genetics ; Female ; Genome, Bacterial ; Genome-Wide Association Study ; Humans ; Male ; Phenotype ; Sequence Analysis, DNA ; Whole Genome Sequencing
    Sprache Englisch
    Erscheinungsdatum 2021-01-07
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0245058
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: "Durch den Einsatz des gesamten Therapiespektrums bei Psoriasis gemeinsam mehr lernen". Interview mit K. Asadullah, Potsdam

    Asadullah, K.

    Ästhetische Dermatologie

    2019  Band -, Heft 1, Seite(n) 26

    Sprache Deutsch
    Dokumenttyp Artikel
    ZDB-ID 2095469-4
    ISSN 1868-0496 ; 1615-5327
    Datenquelle Current Contents Medizin

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  3. Artikel ; Online: Reference-free Association Mapping from Sequencing Reads Using k-mers.

    Mehrab, Zakaria / Mobin, Jaiaid / Tahmid, Ibrahim Asadullah / Pachter, Lior / Rahman, Atif

    Bio-protocol

    2020  Band 10, Heft 21, Seite(n) e3815

    Abstract: ... studies which is based on counting k-mers in sequenced reads, testing for associations between k-mers and ... the phenotype of interest, and local assembly of the k-mers of statistical significance. The method can map ...

    Abstract Association mapping is the process of linking phenotypes with genotypes. In genome wide association studies (GWAS), individuals are first genotyped using microarrays or by aligning sequenced reads to reference genomes. However, both these approaches rely on reference genomes which limits their application to organisms with no or incomplete reference genomes. To address this, reference free association mapping methods have been developed. Here we present the protocol of an alignment free method for association studies which is based on counting k-mers in sequenced reads, testing for associations between k-mers and the phenotype of interest, and local assembly of the k-mers of statistical significance. The method can map associations of categorical phenotypes to sequence and structural variations without requiring prior sequencing of reference genomes.
    Sprache Englisch
    Erscheinungsdatum 2020-11-05
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2833269-6
    ISSN 2331-8325 ; 2331-8325
    ISSN (online) 2331-8325
    ISSN 2331-8325
    DOI 10.21769/BioProtoc.3815
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Efficient association mapping from k-mers-An application in finding sex-specific sequences.

    Zakaria Mehrab / Jaiaid Mobin / Ibrahim Asadullah Tahmid / Atif Rahman

    PLoS ONE, Vol 16, Iss 1, p e

    2021  Band 0245058

    Abstract: ... free association mapping methods based on k-mers from sequencing reads. Here we present an improved implementation ...

    Abstract Genome wide association studies (GWAS) attempt to map genotypes to phenotypes in organisms. This is typically performed by genotyping individuals using microarray or by aligning whole genome sequencing reads to a reference genome. Both approaches require knowledge of a reference genome which hinders their application to organisms with no or incomplete reference genomes. This caveat can be removed by using alignment-free association mapping methods based on k-mers from sequencing reads. Here we present an improved implementation of an alignment free association mapping method. The new implementation is faster and includes additional features to make it more flexible than the original implementation. We have tested our implementation on an E. Coli ampicillin resistance dataset and observe improvement in execution time over the original implementation while maintaining accuracy in results. We also demonstrate that the method can be applied to find sex specific sequences.
    Schlagwörter Medicine ; R ; Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2021-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Solid-liquid phase equilibria of H2O-Mn(H2PO2)2-MnCl2-NaCl, H2O-Mn(H2PO2)2-MnCl2 and (H2O-NaCl- MnCl2 systems at 323.15 K

    Adiguzel Vedat / Liu Wei / Memon Asadullah / Zhou Hongtao / Akbar Imran / Zafar Atif / Ansari Ubedullah

    Journal of the Serbian Chemical Society, Vol 86, Iss 1, Pp 91-

    2021  Band 102

    Abstract: ... system and H2O–NaCl–MnCl2 and H2O– –MnCl2–Mn(H2PO2)2 ternary systems were investigated at 323.15 K ...

    Abstract The solid–liquid phase equilibria (SLE) and densities of H2O–NaCl– –MnCl2–Mn(H2PO2)2 quaternary system and H2O–NaCl–MnCl2 and H2O– –MnCl2–Mn(H2PO2)2 ternary systems were investigated at 323.15 K by the isothermal solution saturation method. The analyses of the liquid and solid phases were used to determine the composition of the solid phase using the Schreinemakers graphic method. The ternary systems contain one invariant point, two invariant curves and two crystallization regions. In the quaternary system, there is one invariant point, three invariant curves and three crystallization areas corresponding to NaCl, MnCl2⋅4H2O and Mn(H2PO2)⋅2H2O. The crystallization area of Mn(H2PO2)2⋅H2O, being the largest in comparison with those of other salts, occupied 80.75 % of the total crystallization area.
    Schlagwörter manganese hypophosphite ; manganese chloride ; ternary system ; schreinmakers method ; density ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 660
    Sprache Englisch
    Erscheinungsdatum 2021-01-01T00:00:00Z
    Verlag Serbian Chemical Society
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Buch: Cytokine and anti-cytokine therapy in dermatology 2006

    Asadullah, K.

    2006  

    Verfasserangabe eds. K. Asadullah
    Sprache Englisch
    Umfang 339 S. : Ill., graph. Darst.
    Verlag Transworld Research Network
    Erscheinungsort Trivandrum
    Erscheinungsland Indien
    Dokumenttyp Buch
    HBZ-ID HT014981482
    ISBN 81-7895-220-3 ; 978-81-7895-220-8
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  7. Buch ; Dissertation / Habilitation: Zytokine bei "kutanen T-Zell-Lymphomen" und "Psoriasis", zwei T-Zell-vermittelten Dermatosen mit Modellcharakter

    Asadullah, Khusru

    pathophysiologische Bedeutung und Implikation für die therapeutische Intervention

    1999  

    Verfasserangabe von Khusru Asadullah
    Sprache Deutsch
    Umfang 194 S. in getr. Zählung, Ill., graph. Darst., 30 cm
    Ausgabenhinweis [Mikrofiche-Ausg.]
    Erscheinungsland Deutschland
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Berlin, Humboldt-Univ., Habil.-Schr., 1999
    HBZ-ID HT013143951
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  8. Buch ; Dissertation / Habilitation: Die Behandlung der Problematik 'Betreuung Sterbender' in der Hochschulausbildung Medizin in der DDR und der BRD

    Asadullah, Khusru

    1991  

    Verfasserangabe vorgelegt von Khusru Asadullah
    Umfang IV, 114 Bl.
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Berlin, Humboldt Univ., Diss., 1991
    HBZ-ID HT003894879
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  9. Artikel: Effectiveness of local drug delivery system using 1% metronidazole gel and mouthwash in treating periodontal diseases.

    Hasan, Faiza / Ikram, Rahila / Abbas, Afshan / Asadullah, Kamran

    Pakistan journal of pharmaceutical sciences

    2021  Band 33, Heft 5, Seite(n) 2053–2058

    Abstract: The gold standard therapy for treating the periodontal infections is the removal of bacterial plaque and deposits of calculus from tooth surfaces by scaling and root planning. In order to eliminate these bacterial reservoirs, beside conventional ... ...

    Abstract The gold standard therapy for treating the periodontal infections is the removal of bacterial plaque and deposits of calculus from tooth surfaces by scaling and root planning. In order to eliminate these bacterial reservoirs, beside conventional treatment, chemo therapeutic agents are commonly prescribed by periodontologists. To avoid the systemic side effects and development of antibiotics resistance, local drug delivery methods has gained the attention of dentists to treat periodontal infections, along with scaling and root planning. The aim of this study was to evaluate the effectiveness of local drug delivery system in combination with scaling and root planning, by using 1% metronidazole gel and mouthwash. The patients were divided into 3 groups. Group I: conventional treatment group. Group II: patients received treatment with gel. Group III: patients received treatment with mouthwash. All groups received treatment for 30 days. Clinical parameters and salivary concentration of TNF-α, PGE2 and nitric oxide were measured before and after treatment in both groups. All clinical parameters and inflammatory biomarkers significantly reduced in gel and mouthwash group patients (p≤0.001) as compared to patients received conventional treatment. The gel is found to be more efficacious than mouthwash especially in reducing clinical attachment loss (p< 0.05) and in reducing inflammatory biomarkers (p≤0.001). We strongly suggest the use of metronidazole via local drug delivery system combined with scaling and root planning to treat periodontal diseases.
    Mesh-Begriff(e) Administration, Oral ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/chemistry ; Combined Modality Therapy ; Dental Scaling ; Dinoprostone/metabolism ; Drug Compounding ; Drug Delivery Systems ; Female ; Gels ; Humans ; Inflammation Mediators/metabolism ; Male ; Metronidazole/administration & dosage ; Metronidazole/chemistry ; Mouthwashes/administration & dosage ; Mouthwashes/chemistry ; Nitric Oxide/metabolism ; Pakistan ; Periodontal Diseases/diagnosis ; Periodontal Diseases/metabolism ; Periodontal Diseases/microbiology ; Periodontal Diseases/therapy ; Root Planing ; Saliva/metabolism ; Time Factors ; Treatment Outcome ; Tumor Necrosis Factor-alpha/metabolism
    Chemische Substanzen Anti-Bacterial Agents ; Gels ; Inflammation Mediators ; Mouthwashes ; TNF protein, human ; Tumor Necrosis Factor-alpha ; Metronidazole (140QMO216E) ; Nitric Oxide (31C4KY9ESH) ; Dinoprostone (K7Q1JQR04M)
    Sprache Englisch
    Erscheinungsdatum 2021-04-06
    Erscheinungsland Pakistan
    Dokumenttyp Comparative Study ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 885131-1
    ISSN 1011-601X
    ISSN 1011-601X
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Adsorption of hexavalent chromium onto alkali-modified biochar derived from Lepironia articulata: A kinetic, equilibrium, and thermodynamic study.

    Asadullah / Kaewsichan, Lupong / Tohdee, Kanogwan

    Water environment research : a research publication of the Water Environment Federation

    2019  Band 91, Heft 11, Seite(n) 1433–1446

    Abstract: Hydrochar obtained after hydrothermal carbonization (HTC) of Lepironia articulata (LA) was modified into biochar by reacting with a specific amount of KOH in a tubular reactor under slow pyrolysis. The physical and chemical properties of the hydrochar ... ...

    Abstract Hydrochar obtained after hydrothermal carbonization (HTC) of Lepironia articulata (LA) was modified into biochar by reacting with a specific amount of KOH in a tubular reactor under slow pyrolysis. The physical and chemical properties of the hydrochar and modified biochar were characterized. The performance of modified biochar (LABC) was investigated through batch sorption experiments. Removal (%) and the maximum adsorption capacity (q
    Mesh-Begriff(e) Adsorption ; Alkalies ; Charcoal ; Chromium ; Hydrogen-Ion Concentration ; Kinetics ; Thermodynamics ; Water Pollutants, Chemical
    Chemische Substanzen Alkalies ; Water Pollutants, Chemical ; biochar ; Chromium (0R0008Q3JB) ; Charcoal (16291-96-6) ; chromium hexavalent ion (18540-29-9)
    Sprache Englisch
    Erscheinungsdatum 2019-06-02
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1098976-6
    ISSN 1554-7531 ; 1047-7624 ; 1061-4303
    ISSN (online) 1554-7531
    ISSN 1047-7624 ; 1061-4303
    DOI 10.1002/wer.1138
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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