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  1. Artikel ; Online: Bidirectional Evolution of SARS-CoV-2 Virus in Immunocompromised Hosts.

    Chew, Charmaine W Y / Young, Barnaby E / Tambyah, Paul A / Vasoo, Shawn / Chan, Conrad E Z

    Influenza and other respiratory viruses

    2024  Band 18, Heft 3, Seite(n) e13266

    Mesh-Begriff(e) Humans ; SARS-CoV-2/genetics ; COVID-19 ; Immunocompromised Host
    Sprache Englisch
    Erscheinungsdatum 2024-03-11
    Erscheinungsland England
    Dokumenttyp Letter
    ZDB-ID 2274538-5
    ISSN 1750-2659 ; 1750-2640
    ISSN (online) 1750-2659
    ISSN 1750-2640
    DOI 10.1111/irv.13266
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Efficacy and Safety of Ensovibep for Adults Hospitalized With COVID-19.

    Mylonakis, Eleftherios / Barkauskas, Christina / Poulakou, Garyfallia / Young, Barnaby E

    Annals of internal medicine

    2023  Band 176, Heft 2, Seite(n) eL220456

    Mesh-Begriff(e) Adult ; Humans ; COVID-19 ; Recombinant Fusion Proteins ; SARS-CoV-2 ; Hospitalization
    Chemische Substanzen ensovibep (PV6AA88RDU) ; Recombinant Fusion Proteins
    Sprache Englisch
    Erscheinungsdatum 2023-02-20
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/L22-0456
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Clinical Predictors for Abnormal ALT in Patients Infected with COVID-19—A Retrospective Single Centre Study

    Wei Da Chew / Jonathan Kuang / Huiyu Lin / Li Wei Ang / Wei Lyn Yang / David C. Lye / Barnaby E. Young

    Pathogens, Vol 12, Iss 473, p

    2023  Band 473

    Abstract: Objective: Abnormal liver tests have been associated with worse clinical outcomes in patients infected with COVID-19. This retrospective observational study from Singapore aims to elucidate simple clinical predictors of abnormal alanine aminotransferase ( ...

    Abstract Objective: Abnormal liver tests have been associated with worse clinical outcomes in patients infected with COVID-19. This retrospective observational study from Singapore aims to elucidate simple clinical predictors of abnormal alanine aminotransferase (ALT) in COVID-19 infections. Design: 717 patients hospitalised with COVID-19 at the National Centre for Infectious Diseases (NCID), Singapore, from 23 January–15 April 2020 were screened, of which 163 patients with baseline normal alanine transferase (ALT) and at least two subsequent ALTs performed were included in the final analysis. Information on baseline demographics, clinical characteristics and biochemical laboratory tests were collected. Results: 30.7% of patients developed abnormal ALT. They were more likely to be older (60 vs. 55, p = 0.022) and have comorbidities of hyperlipidaemia and hypertension. The multivariate logistic regression showed that R-factor ≥1 on admission (adjusted odds ratio (aOR) 3.13, 95% Confidence Interval (CI) 1.41–6.95) and hypoxia (aOR 3.54, 95% CI 1.29–9.69) were independent risk factors for developing abnormal ALT. The patients who developed abnormal ALT also ran a more severe course of illness with a greater proportion needing supplementary oxygen (58% vs. 18.6%, p < 0.0005), admission to the Intensive Care Unit (ICU)/High Dependency Unit (HDU) (32% vs. 11.5%, p = 0.003) and intubation (20% vs. 2.7%, p < 0.0005). There was no difference in death rate between the two groups. Conclusions: Liver injury is associated with poor clinical outcomes in patients with COVID-19. R-factor ≥1 on admission and hypoxia are independent simple clinical predictors for developing abnormal ALT in COVID-19.
    Schlagwörter COVID-19 ; ALT ; R-factor ; hypoxia ; liver test ; Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2023-03-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel: Clinical Predictors for Abnormal ALT in Patients Infected with COVID-19-A Retrospective Single Centre Study.

    Chew, Wei Da / Kuang, Jonathan / Lin, Huiyu / Ang, Li Wei / Yang, Wei Lyn / Lye, David C / Young, Barnaby E

    Pathogens (Basel, Switzerland)

    2023  Band 12, Heft 3

    Abstract: Objective: Abnormal liver tests have been associated with worse clinical outcomes in patients infected with COVID-19. This retrospective observational study from Singapore aims to elucidate simple clinical predictors of abnormal alanine aminotransferase ...

    Abstract Objective: Abnormal liver tests have been associated with worse clinical outcomes in patients infected with COVID-19. This retrospective observational study from Singapore aims to elucidate simple clinical predictors of abnormal alanine aminotransferase (ALT) in COVID-19 infections.
    Design: 717 patients hospitalised with COVID-19 at the National Centre for Infectious Diseases (NCID), Singapore, from 23 January-15 April 2020 were screened, of which 163 patients with baseline normal alanine transferase (ALT) and at least two subsequent ALTs performed were included in the final analysis. Information on baseline demographics, clinical characteristics and biochemical laboratory tests were collected.
    Results: 30.7% of patients developed abnormal ALT. They were more likely to be older (60 vs. 55,
    Conclusions: Liver injury is associated with poor clinical outcomes in patients with COVID-19. R-factor ≥1 on admission and hypoxia are independent simple clinical predictors for developing abnormal ALT in COVID-19.
    Sprache Englisch
    Erscheinungsdatum 2023-03-16
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12030473
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Neutralization escape of emerging subvariants XBB.1.5/1.9.1 and XBB.2.3 from current therapeutic monoclonal antibodies.

    Chye, De Hoe / Chew, Charmaine W Y / Yeo, He Ping / Tambyah, Paul A / Young, Barnaby E / Tan, Gladys G Y / Tan, Boon Huan / Vasoo, Shawn / Chan, Conrad E Z

    Journal of medical virology

    2023  Band 95, Heft 9, Seite(n) e29074

    Sprache Englisch
    Erscheinungsdatum 2023-09-04
    Erscheinungsland United States
    Dokumenttyp Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.29074
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: What's new in critical illness and injury science? Preventing surgical infections requires the right antibiotic for the right duration.

    Young, Barnaby E

    International journal of critical illness and injury science

    2012  Band 2, Heft 2, Seite(n) 55–56

    Sprache Englisch
    Erscheinungsdatum 2012-07-10
    Erscheinungsland India
    Dokumenttyp Journal Article
    ZDB-ID 2638865-0
    ISSN 2231-5004 ; 2229-5151
    ISSN (online) 2231-5004
    ISSN 2229-5151
    DOI 10.4103/2229-5151.97267
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Influenza on cruise ships.

    Young, Barnaby E / Wilder-Smith, Annelies

    Journal of travel medicine

    2018  Band 25, Heft 1

    Mesh-Begriff(e) Alaska ; Disease Outbreaks ; Humans ; Influenza, Human/epidemiology ; Pilot Projects ; Ships ; Travel
    Sprache Englisch
    Erscheinungsdatum 2018-12-11
    Erscheinungsland England
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 1212504-0
    ISSN 1708-8305 ; 1195-1982
    ISSN (online) 1708-8305
    ISSN 1195-1982
    DOI 10.1093/jtm/tay146
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Comparative neutralisation profile of SARS-CoV-2 omicron subvariants BA.2.75 and BA.5.

    Tan, Chee-Wah / Lim, Beng-Lee / Young, Barnaby E / Yeoh, Aileen Ying-Yan / Yung, Chee-Fu / Yap, Wee-Chee / Althaus, Thomas / Chia, Wan-Ni / Zhu, Feng / Lye, David Chien / Wang, Lin-Fa

    The Lancet. Microbe

    2022  Band 3, Heft 12, Seite(n) e898

    Mesh-Begriff(e) Humans ; SARS-CoV-2 ; COVID-19
    Sprache Englisch
    Erscheinungsdatum 2022-08-10
    Erscheinungsland England
    Dokumenttyp Letter
    ISSN 2666-5247
    ISSN (online) 2666-5247
    DOI 10.1016/S2666-5247(22)00220-8
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Reply.

    Jun Seah, Ivan Yu / Anderson, Danielle E / Wang, Linfa / Young, Barnaby Edward / Lye, David Chien / Agrawal, Rupesh

    Ophthalmology

    2020  Band 127, Heft 11, Seite(n) e104–e105

    Mesh-Begriff(e) Betacoronavirus ; COVID-19 ; Coronavirus ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Virus Shedding
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-05-25
    Erscheinungsland United States
    Dokumenttyp Letter ; Comment
    ZDB-ID 392083-5
    ISSN 1549-4713 ; 0161-6420
    ISSN (online) 1549-4713
    ISSN 0161-6420
    DOI 10.1016/j.ophtha.2020.05.041
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Inflammatory risk contributes to post-COVID endothelial dysfunction through anti-ACKR1 autoantibody.

    Lee, Ee-Soo / Nguyen, Nhi / Young, Barnaby E / Wee, Hannah / Wazny, Vanessa / Lee, Khang Leng / Tay, Kai Yi / Goh, Liuh Ling / Chioh, Florence Wj / Law, Michelle Cy / Lee, I Russel / Ang, Lay Teng / Loh, Kyle M / Chan, Mark Y / Fan, Bingwen E / Dalan, Rinkoo / Lye, David C / Renia, Laurent / Cheung, Christine

    Life science alliance

    2024  Band 7, Heft 7

    Abstract: Subclinical vascular impairment can be exacerbated in individuals who experience sustained inflammation after COVID-19 infection. Our study explores the prevalence and impact of autoantibodies on vascular dysfunction in healthy COVID-19 survivors, an ... ...

    Abstract Subclinical vascular impairment can be exacerbated in individuals who experience sustained inflammation after COVID-19 infection. Our study explores the prevalence and impact of autoantibodies on vascular dysfunction in healthy COVID-19 survivors, an area that remains inadequately investigated. Focusing on autoantibodies against the atypical chemokine receptor 1 (ACKR1), COVID-19 survivors demonstrated significantly elevated anti-ACKR1 autoantibodies, correlating with systemic cytokines, circulating damaged endothelial cells, and endothelial dysfunction. An independent cohort linked these autoantibodies to increased vascular disease outcomes during a median 6.7-yr follow-up. We analyzed a single-cell transcriptome atlas of endothelial cells from diverse mouse tissues, identifying enriched
    Mesh-Begriff(e) Humans ; Autoantibodies/immunology ; COVID-19/immunology ; Animals ; Mice ; Female ; Male ; SARS-CoV-2/immunology ; Inflammation/immunology ; Middle Aged ; Endothelium, Vascular/metabolism ; Endothelium, Vascular/immunology ; Immunoglobulin G/immunology ; Immunoglobulin G/blood ; Endothelial Cells/metabolism ; Endothelial Cells/immunology ; Adult ; Aged
    Chemische Substanzen Autoantibodies ; Immunoglobulin G
    Sprache Englisch
    Erscheinungsdatum 2024-05-13
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2575-1077
    ISSN (online) 2575-1077
    DOI 10.26508/lsa.202402598
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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