LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Erweiterte Suche

Suchergebnis

Treffer 1 - 8 von insgesamt 8

Suchoptionen

  1. Artikel ; Online: Attenuated dopamine receptor signaling in nucleus accumbens core in a rat model of chemically-induced neuropathy.

    Selley, Dana E / Lazenka, Matthew F / Sim-Selley, Laura J / Secor McVoy, Julie R / Potter, David N / Chartoff, Elena H / Carlezon, William A / Negus, S Stevens

    Neuropharmacology

    2020  Band 166, Seite(n) 107935

    Abstract: Neuropathy is major source of chronic pain that can be caused by mechanically or chemically induced nerve injury. Intraplantar formalin injection produces local necrosis over a two-week period and has been used to model neuropathy in rats. To determine ... ...

    Abstract Neuropathy is major source of chronic pain that can be caused by mechanically or chemically induced nerve injury. Intraplantar formalin injection produces local necrosis over a two-week period and has been used to model neuropathy in rats. To determine whether neuropathy alters dopamine (DA) receptor responsiveness in mesolimbic brain regions, we examined dopamine D
    Mesh-Begriff(e) Animals ; Conditioning, Operant/drug effects ; Conditioning, Operant/physiology ; Disease Models, Animal ; Dopamine Agonists/pharmacology ; Dopamine Antagonists/pharmacology ; Dose-Response Relationship, Drug ; Formaldehyde/toxicity ; Male ; Neuralgia/chemically induced ; Neuralgia/metabolism ; Nucleus Accumbens/drug effects ; Nucleus Accumbens/metabolism ; Rats ; Rats, Sprague-Dawley ; Receptors, Dopamine D1/agonists ; Receptors, Dopamine D1/antagonists & inhibitors ; Receptors, Dopamine D1/metabolism ; Receptors, Dopamine D2/agonists ; Receptors, Dopamine D2/metabolism ; Signal Transduction/drug effects ; Signal Transduction/physiology
    Chemische Substanzen DRD2 protein, rat ; Dopamine Agonists ; Dopamine Antagonists ; Drd1 protein, rat ; Receptors, Dopamine D1 ; Receptors, Dopamine D2 ; Formaldehyde (1HG84L3525)
    Sprache Englisch
    Erscheinungsdatum 2020-01-07
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 218272-5
    ISSN 1873-7064 ; 0028-3908
    ISSN (online) 1873-7064
    ISSN 0028-3908
    DOI 10.1016/j.neuropharm.2020.107935
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Ui I Zs.242: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  2. Artikel: Effects of the anticonvulsant lacosamide compared to valproate and lamotrigine on cocaine-enhanced reward in rats

    Béguin, Cécile / Potter, David N / Carlezon, William A., Jr / Stöhr, Thomas / Cohen, Bruce M

    Brain research. 2012 Oct. 15, v. 1479

    2012  

    Abstract: Some drugs developed as anticonvulsants (notably, valproate and lamotrigine) have therapeutic effects in bipolar and related disorders. Lacosamide, a recently approved anticonvulsant, has unique effects on sodium channels that may play a role in ... ...

    Abstract Some drugs developed as anticonvulsants (notably, valproate and lamotrigine) have therapeutic effects in bipolar and related disorders. Lacosamide, a recently approved anticonvulsant, has unique effects on sodium channels that may play a role in producing the mood-stabilizing effects of anticonvulsant drugs. We tested whether lacosamide would have effects similar to or different from valproate and lamotrigine in a model of reward and elevated mood. The intracranial self-stimulation (ICSS) test is sensitive to the function of brain reward systems. Changes in ICSS may model aspects of disorders characterized by abnormalities of reward and motivation. Cocaine elevates mood, and reduction of cocaine-induced facilitation of ICSS has been used to predict antimanic-like or mood stabilizing effects of drugs. We tested lacosamide, lamotrigine, and valproate in the rat ICSS test alone or in the presence of cocaine. A high dose of lacosamide (30mg/kg) significantly elevated ICSS thresholds, indicating that it reduced the rewarding impact of medial forebrain bundle stimulation. Lower doses (3–10mg/kg) did not alter ICSS, but blocked the cocaine-induced lowering of ICSS thresholds. The highest doses of valproate (300mg/kg) and lamotrigine (30mg/kg) also elevated ICSS thresholds, and only these high doses significantly lowered cocaine-induced effects. Of the drugs tested, only lacosamide significantly attenuated the reward-facilitating effects of cocaine at doses that had no effects on ICSS response in the absence of cocaine. Abnormalities of mood and reward are common in psychiatric disorders, and these results suggest that lacosamide deserves further study in models of these disorders.
    Schlagwörter anticonvulsants ; brain ; cocaine ; emotions ; models ; motivation ; rats ; sodium channels ; therapeutics
    Sprache Englisch
    Erscheinungsverlauf 2012-1015
    Umfang p. 44-51.
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ZDB-ID 1200-2
    ISSN 1872-6240 ; 0006-8993
    ISSN (online) 1872-6240
    ISSN 0006-8993
    DOI 10.1016/j.brainres.2012.08.030
    Datenquelle NAL Katalog (AGRICOLA)

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Bonn

    Z 88/503: Hefte anzeigen

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  3. Artikel: Differential signaling properties at the kappa opioid receptor of 12-epi-salvinorin A and its analogues

    Béguin, Cécile / Potuzak, Justin / Xu, Wei / Liu-Chen, Lee-Yuan / Streicher, John M / Groer, Chad E / Bohn, Laura M / Carlezon, William A., Jr / Cohen, Bruce M

    Bioorganic & medicinal chemistry letters. 2012 Jan. 15, v. 22, no. 2

    2012  

    Abstract: The kappa opioid receptor (KOPR) has been identified as a potential drug target to prevent or alter the course of mood, anxiety and addictive disorders or reduce response to stress. In a search for highly potent and selective KOPR partial agonists as ... ...

    Abstract The kappa opioid receptor (KOPR) has been identified as a potential drug target to prevent or alter the course of mood, anxiety and addictive disorders or reduce response to stress. In a search for highly potent and selective KOPR partial agonists as pharmacological tools, we have modified 12-epi-salvinorin A, a compound which we have previously observed to be a KOPR partial agonist. Five analogues of 12-epi-salvinorin A were synthesized and their effects on G protein activation as well as β-arrestin2 recruitment were evaluated. Only 12-epi-salvinorin A (1) partially activated signaling through G proteins, yet acted as a full agonist in the β-arrestin 2 DiscoveRx assay. Other salvinorin analogues tested in these functional assays were full agonists in both assays of KOPR activation. By comparison, the non-selective opioid ligand nalbuphine, known to be a partial agonist for G-protein activation, was also a partial agonist for the β-arrestin mediated signaling pathway activated through KOPR.
    Schlagwörter proteins ; drugs ; stress response ; signal transduction ; agonists ; anxiety
    Sprache Englisch
    Erscheinungsverlauf 2012-0115
    Umfang p. 1023-1026.
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    Anmerkung 2019-12-06
    ZDB-ID 1063195-1
    ISSN 1464-3405 ; 0960-894X
    ISSN (online) 1464-3405
    ISSN 0960-894X
    DOI 10.1016/j.bmcl.2011.11.128
    Datenquelle NAL Katalog (AGRICOLA)

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 3203: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  4. Artikel ; Online: 8-epi-Salvinorin B

    Thomas A. Munro / Katharine K. Duncan / Richard J. Staples / Wei Xu / Lee-Yuan Liu-Chen / Cécile Béguin / William A. Carlezon Jr. / Bruce M. Cohen

    Beilstein Journal of Organic Chemistry, Vol 3, Iss 1, p

    crystal structure and affinity at the κ opioid receptor

    2007  Band 1

    Abstract: There have been many reports of epimerization of salvinorins at C-8 under basic conditions, but little evidence has been presented to establish the structure of these compounds. We report here the first crystal structure of an 8-epi-salvinorin or ... ...

    Abstract There have been many reports of epimerization of salvinorins at C-8 under basic conditions, but little evidence has been presented to establish the structure of these compounds. We report here the first crystal structure of an 8-epi-salvinorin or derivative: the title compound, 2b. The lactone adopts a boat conformation with the furan equatorial. Several lines of evidence suggest that epimerization proceeds via enolization of the lactone rather than a previously proposed indirect mechanism. Consistent with the general trend in related compounds, the title compound showed lower affinity at the kappa opioid receptor than the natural epimer salvinorin B (2a). The related 8-epi-acid 4b showed no affinity.
    Schlagwörter Science ; Q ; Organic chemistry ; QD241-441
    Sprache Englisch
    Erscheinungsdatum 2007-01-01T00:00:00Z
    Verlag Beilstein-Institut
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  5. Artikel: Mania-like behavior induced by disruption of CLOCK

    Roybal, Kole / Theobold, David / Graham, Ami / DiNieri, Jennifer A / Russo, Scott J / Krishnan, Vaishnav / Chakravarty, Sumana / Peevey, Joseph / Oehrlein, Nathan / Birnbaum, Shari / Vitaterna, Martha H / Orsulak, Paul / Takahashi, Joseph S / Nestler, Eric J / Carlezon, William A. Jr / McClung, Colleen A

    Proceedings of the National Academy of Sciences of the United States of America. 2007 Apr. 10, v. 104, no. 15

    2007  

    Abstract: Circadian rhythms and the genes that make up the molecular clock have long been implicated in bipolar disorder. Genetic evidence in bipolar patients suggests that the central transcriptional activator of molecular rhythms, CLOCK, may be particularly ... ...

    Abstract Circadian rhythms and the genes that make up the molecular clock have long been implicated in bipolar disorder. Genetic evidence in bipolar patients suggests that the central transcriptional activator of molecular rhythms, CLOCK, may be particularly important. However, the exact role of this gene in the development of this disorder remains unclear. Here we show that mice carrying a mutation in the Clock gene display an overall behavioral profile that is strikingly similar to human mania, including hyperactivity, decreased sleep, lowered depression-like behavior, lower anxiety, and an increase in the reward value for cocaine, sucrose, and medial forebrain bundle stimulation. Chronic administration of the mood stabilizer lithium returns many of these behavioral responses to wild-type levels. In addition, the Clock mutant mice have an increase in dopaminergic activity in the ventral tegmental area, and their behavioral abnormalities are rescued by expressing a functional CLOCK protein via viral-mediated gene transfer specifically in the ventral tegmental area. These findings establish the Clock mutant mice as a previously unrecognized model of human mania and reveal an important role for CLOCK in the dopaminergic system in regulating behavior and mood.
    Sprache Englisch
    Erscheinungsverlauf 2007-0410
    Umfang p. 6406-6411.
    Erscheinungsort National Academy of Sciences
    Dokumenttyp Artikel
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    Datenquelle NAL Katalog (AGRICOLA)

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Bonn

    Z 4' 63/44: Hefte anzeigen
    87/25270: Hefte anzeigen
    Qa 4' 169/3: Hefte anzeigen
    Z 8.7: Hefte anzeigen

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  6. Artikel ; Online: It is time to take a stand for medical research and against terrorism targeting medical scientists.

    Krystal, John H / Carter, Cameron S / Geschwind, Daniel / Manji, Husseini K / March, John S / Nestler, Eric J / Zubieta, Jon-Kar / Charney, Dennis S / Goldman, David / Gur, Raquel E / Lieberman, Jeffrey A / Roy-Byrne, Peter / Rubinow, David R / Anderson, Stewart A / Barondes, Samuel / Berman, Karen F / Blair, James / Braff, David L / Brown, E Sherwood /
    Calabrese, Joseph R / Carlezon, William A / Cook, Edwin H / Davidson, Richard J / Davis, Michael / Desimone, Robert / Drevets, Wayne C / Duman, Ronald S / Essock, Susan M / Faraone, Stephen V / Freedman, Robert / Friston, Karl J / Gelernter, Joel / Geller, Barbara / Gill, Michael / Gould, Elizabeth / Grace, Anthony A / Grillon, Christian / Gueorguieva, Ralitza / Hariri, Ahmad R / Innis, Robert B / Jones, Edward G / Kleinman, Joel E / Koob, George F / Krystal, Andrew D / Leibenluft, Ellen / Levinson, Douglas F / Levitt, Pat R / Lewis, David A / Liberzon, Israel / Lipska, Barbara K / Marder, Stephen R / Markou, Athina / Mason, Graeme F / McDougle, Christopher J / McEwen, Bruce S / McMahon, Francis J / Meaney, Michael J / Meltzer, Herbert Y / Merikangas, Kathleen R / Meyer-Lindenberg, Andreas / Mirnics, Károly / Monteggia, Lisa M / Neumeister, Alexander / O'Brien, Charles P / Owen, Michael J / Pine, Daniel S / Rapoport, Judith L / Rauch, Scott L / Robbins, Trevor W / Rosenbaum, Jerrold F / Rosenberg, David R / Ross, Christopher A / Rush, A John / Sackeim, Harold A / Sanacora, Gerard / Schatzberg, Alan F / Shaham, Yavin / Siever, Larry J / Sunderland, Trey / Tecott, Laurence H / Thase, Michael E / Todd, Richard D / Weissman, Myrna M / Yehuda, Rachel / Yoshikawa, Takeo / Young, Elizabeth A / McCandless, R

    Biological psychiatry

    2007  Band 63, Heft 8, Seite(n) 725–727

    Mesh-Begriff(e) Animal Experimentation ; Animal Rights ; Animals ; Attitude of Health Personnel ; Biomedical Research ; Crime/prevention & control ; Ethics, Research ; Humans ; Primates ; Research Personnel ; Terrorism/prevention & control ; United States
    Sprache Englisch
    Erscheinungsdatum 2007-11-20
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 209434-4
    ISSN 1873-2402 ; 0006-3223
    ISSN (online) 1873-2402
    ISSN 0006-3223
    DOI 10.1016/j.biopsych.2008.03.005
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 720: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  7. Artikel: Effects of the anticonvulsant lacosamide compared to valproate and lamotrigine on cocaine-enhanced reward in rats

    Béguin, Cécile / Potter, David N. / Carlezon, William A., Jr / Stöhr, Thomas / Cohen, Bruce M.

    Brain research

    Band v. 1479

    Abstract: Some drugs developed as anticonvulsants (notably, valproate and lamotrigine) have therapeutic effects in bipolar and related disorders. Lacosamide, a recently approved anticonvulsant, has unique effects on sodium channels that may play a role in ... ...

    Abstract Some drugs developed as anticonvulsants (notably, valproate and lamotrigine) have therapeutic effects in bipolar and related disorders. Lacosamide, a recently approved anticonvulsant, has unique effects on sodium channels that may play a role in producing the mood-stabilizing effects of anticonvulsant drugs. We tested whether lacosamide would have effects similar to or different from valproate and lamotrigine in a model of reward and elevated mood. The intracranial self-stimulation (ICSS) test is sensitive to the function of brain reward systems. Changes in ICSS may model aspects of disorders characterized by abnormalities of reward and motivation. Cocaine elevates mood, and reduction of cocaine-induced facilitation of ICSS has been used to predict antimanic-like or mood stabilizing effects of drugs. We tested lacosamide, lamotrigine, and valproate in the rat ICSS test alone or in the presence of cocaine. A high dose of lacosamide (30mg/kg) significantly elevated ICSS thresholds, indicating that it reduced the rewarding impact of medial forebrain bundle stimulation. Lower doses (3–10mg/kg) did not alter ICSS, but blocked the cocaine-induced lowering of ICSS thresholds. The highest doses of valproate (300mg/kg) and lamotrigine (30mg/kg) also elevated ICSS thresholds, and only these high doses significantly lowered cocaine-induced effects. Of the drugs tested, only lacosamide significantly attenuated the reward-facilitating effects of cocaine at doses that had no effects on ICSS response in the absence of cocaine. Abnormalities of mood and reward are common in psychiatric disorders, and these results suggest that lacosamide deserves further study in models of these disorders.
    Schlagwörter sodium channels ; models ; therapeutics ; anticonvulsants ; cocaine ; emotions ; motivation ; rats ; brain
    Sprache Englisch
    Dokumenttyp Artikel
    ISSN 0006-8993
    Datenquelle AGRIS - International Information System for the Agricultural Sciences and Technology

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  8. Artikel: Differential signaling properties at the kappa opioid receptor of 12-epi-salvinorin A and its analogues

    Béguin, Cécile / Potuzak, Justin / Xu, Wei / Liu-Chen, Lee-Yuan / Streicher, John M. / Groer, Chad E. / Bohn, Laura M. / Carlezon, William A., Jr. / Cohen, Bruce M.

    Bioorganic & medicinal chemistry letters

    Band v. 22,, Heft no. 2

    Abstract: The kappa opioid receptor (KOPR) has been identified as a potential drug target to prevent or alter the course of mood, anxiety and addictive disorders or reduce response to stress. In a search for highly potent and selective KOPR partial agonists as ... ...

    Abstract The kappa opioid receptor (KOPR) has been identified as a potential drug target to prevent or alter the course of mood, anxiety and addictive disorders or reduce response to stress. In a search for highly potent and selective KOPR partial agonists as pharmacological tools, we have modified 12-epi-salvinorin A, a compound which we have previously observed to be a KOPR partial agonist. Five analogues of 12-epi-salvinorin A were synthesized and their effects on G protein activation as well as β-arrestin2 recruitment were evaluated. Only 12-epi-salvinorin A (1) partially activated signaling through G proteins, yet acted as a full agonist in the β-arrestin 2 DiscoveRx assay. Other salvinorin analogues tested in these functional assays were full agonists in both assays of KOPR activation. By comparison, the non-selective opioid ligand nalbuphine, known to be a partial agonist for G-protein activation, was also a partial agonist for the β-arrestin mediated signaling pathway activated through KOPR.
    Schlagwörter drugs ; agonists ; anxiety ; recruitment ; signal transduction ; proteins ; stress response
    Sprache Englisch
    Dokumenttyp Artikel
    ISSN 0960-894X
    Datenquelle AGRIS - International Information System for the Agricultural Sciences and Technology

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

Zum Seitenanfang