LIVIVO - Suchergebnisse -

Suchergebnis

Treffer 1 - 10 von insgesamt 157

Suchoptionen

Artikel ; Online: Congenital Chylous Ascites: A Rare Cause of Infantile Ascites Treated With MCT-Based Diet and Octreotide.

Rashid, Rafia / Shafi Ahmed, Syed / Mahmud, Salahuddin

JPGN reports

2021 Band 3, Heft 1, Seite(n) e149

Abstract: Congenital chylous ascites (CCAs) are a rare disease that results from the accumulation of chylomicron-rich lymphatic fluid within the peritoneal cavity due to maldevelopment of the intra-abdominal lymphatic system. Medium-chain triglyceride (MCT)-based ... ...

Abstract	Congenital chylous ascites (CCAs) are a rare disease that results from the accumulation of chylomicron-rich lymphatic fluid within the peritoneal cavity due to maldevelopment of the intra-abdominal lymphatic system. Medium-chain triglyceride (MCT)-based diet, total parenteral nutrition (TPN), and repeated paracentesis are considered supportive management for CCA. Cases unresponsive to conservative treatment usually require surgical intervention. We report a case of CCA in a premature neonate treated successfully with intravenous infusion of octreotide (synthetic somatostatin analog), after failing to respond to supportive therapies. Due to the lack of standards in diagnosis and treatment, this disease constitutes a medical challenge, and individual therapy seems to be noteworthy.
Sprache	Englisch
Erscheinungsdatum	2021-12-10
Erscheinungsland	United States
Dokumenttyp	Case Reports
ISSN	2691-171X
ISSN (online)	2691-171X
DOI	10.1097/PG9.0000000000000149
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Zusatzmaterialien

Über subito bestellen

Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

Fernleihe an ZB MED

Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

Details ▾
- Kostenpflichtig bestellen

Artikel ; Online: Phenolic compounds as α-glucosidase inhibitors: a docking and molecular dynamics simulation study.

Swargiary, Ananta / Roy, Mritunjoy Kumar / Mahmud, Shafi

Journal of biomolecular structure & dynamics

2022 Band 41, Heft 9, Seite(n) 3862–3871

Abstract: Phenolic compounds possess significant biological activity. Several pieces of research emphasize the medicinal importance of phenolic compounds, including diabetes. The present study investigated the α-glucosidase inhibitory activity of phenolic ... ...

Abstract	Phenolic compounds possess significant biological activity. Several pieces of research emphasize the medicinal importance of phenolic compounds, including diabetes. The present study investigated the α-glucosidase inhibitory activity of phenolic compounds reported from several plants. The phenolic compounds reported in different literature were collected. Molecular docking was carried out using AutoDock Vina. Various physicochemical properties such as size, LogP, molecular complexity, hydrogen bonding properties of phenolic compounds were correlated with the binding affinities. Furthermore, MD simulation was carried out to study the structural stability of the docking complexes. A total of 155 phenolic compounds were reported from different plants. Amentoflavone showed the strongest binding affinity with α-glucosidase, much more potent than reference acarbose. The binding energy showed a good correlation with the molecular complexity, hydrogen bond donor and acceptor property and heavy atom counts of the compounds. The polarity of the surface area also showed a positive correlation with the binding affinity of the compounds. The best docking phenolic compound, amentoflavone, showed stable binding affinity and conformation during the simulation period compared to apoprotein and acarbose-docking complex. The top ten phenolic compounds, including amentoflavone, showed considerable drug-likeness properties with fewer toxicity effects. The study suggests that the amentoflavone could be a potential therapeutic drug as an α-glucosidase inhibitor and help control postprandial hyperglycemia.Communicated by Ramaswamy H. Sarma.
Mesh-Begriff(e)	Glycoside Hydrolase Inhibitors/pharmacology ; Glycoside Hydrolase Inhibitors/chemistry ; Acarbose/pharmacology ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; alpha-Glucosidases/chemistry ; Phenols/pharmacology
Chemische Substanzen	Glycoside Hydrolase Inhibitors ; Acarbose (T58MSI464G) ; alpha-Glucosidases (EC 3.2.1.20) ; Phenols
Sprache	Englisch
Erscheinungsdatum	2022-04-01
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2022.2058092
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Zusatzmaterialien

Verfügbar in ZB MED Köln/Königswinter

Zs.A 2093: Hefte anzeigen

Standort:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Über subito bestellen

Details ▾
- Im ZB MED-Bestand
- Kostenpflichtig bestellen

Artikel: Biochemical and

Paul, Gobindo Kumar / Mahmud, Shafi / Hasan, Md Mehedi / Zaman, Shahriar / Uddin, Md Salah / Saleh, Md Abu

Saudi journal of biological sciences

2021 Band 28, Heft 11, Seite(n) 6592–6605

Abstract: Aphanamixis ... ...

Abstract	Aphanamixis polystachya
Sprache	Englisch
Erscheinungsdatum	2021-07-16
Erscheinungsland	Saudi Arabia
Dokumenttyp	Journal Article
ZDB-ID	2515206-3
ISSN	2213-7106 ; 1319-562X
ISSN (online)	2213-7106
ISSN	1319-562X
DOI	10.1016/j.sjbs.2021.07.032
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Zusatzmaterialien

Über subito bestellen

Details ▾
- Kostenpflichtig bestellen

Artikel ; Online: Screening of phytochemicals as potent inhibitor of 3-chymotrypsin and papain-like proteases of SARS-CoV2: an in silico approach to combat COVID-19.

Swargiary, Ananta / Mahmud, Shafi / Saleh, Md Abu

Journal of biomolecular structure & dynamics

2020 Band 40, Heft 5, Seite(n) 2067–2081

Abstract: COVID-19 and its causative organism SARS-CoV2 that emerged from Wuhan city, China have paralyzed the world. With no clinically approved drugs, the global health system is struggling to find an effective treatment measure. At this crucial juncture, ... ...

Abstract	COVID-19 and its causative organism SARS-CoV2 that emerged from Wuhan city, China have paralyzed the world. With no clinically approved drugs, the global health system is struggling to find an effective treatment measure. At this crucial juncture, screening of plant-derived compounds may be an effective strategy to combat COVID-19. The present study investigated the binding affinity of phytocompounds with 3-Chymotrypsin-like (3CLpro) and Papain-like proteases (PLpro) of SARS-CoV2 using
Mesh-Begriff(e)	COVID-19 ; Chymotrypsin ; Humans ; Molecular Docking Simulation ; Papain ; Peptide Hydrolases ; Phytochemicals/pharmacology ; RNA, Viral ; SARS-CoV-2
Chemische Substanzen	Phytochemicals ; RNA, Viral ; Peptide Hydrolases (EC 3.4.-) ; Chymotrypsin (EC 3.4.21.1) ; Papain (EC 3.4.22.2)
Schlagwörter	covid19
Sprache	Englisch
Erscheinungsdatum	2020-10-22
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2020.1835729
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Zusatzmaterialien

Verfügbar in ZB MED Köln/Königswinter

Zs.A 2093: Hefte anzeigen

Standort:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Über subito bestellen

Details ▾
- Im ZB MED-Bestand
- Kostenpflichtig bestellen

Artikel ; Online: In silico design of an epitope-based vaccine against choline binding protein A of Streptococcus pneumoniae

Meherunnesa Munia / Shafi Mahmud / Mohammed Mohasin / K.M. Kaderi Kibria

Informatics in Medicine Unlocked, Vol 23, Iss , Pp 100546- (2021)

2021

Abstract: Streptococcus pneumoniae (Pneumococcus) accounts for a major global health burden that causes bacterial pneumonia, sepsis, otitis media, and meningitis. It is responsible for great morbidity and mortality globally. Available pneumonia vaccines are either ...

Abstract	Streptococcus pneumoniae (Pneumococcus) accounts for a major global health burden that causes bacterial pneumonia, sepsis, otitis media, and meningitis. It is responsible for great morbidity and mortality globally. Available pneumonia vaccines are either carbohydrate-based vaccines or not protective against specific serotypes. Besides, antibiotic resistance to pneumococci justifies further attention to explore new vaccine candidates. The invariant peptide-based vaccines are not only immunogenic for all age groups but also protective against all serotypes of pneumococci. Initially, we searched for potential vaccine candidates of pneumococcus through literature mining. We found Choline binding protein A (CbpA) as a potential immunogenic extracellular protein. Next we applied the immunoinformatic approach to design a multi-epitope based vaccine (MEV) candidate of CbpA against pneumococcus. Furthermore, the protein sequence revealed the immunogenic T-cell epitopes of CbpA. The affinity between the T-cell epitope and MHC molecule was evaluated by Molecular docking (MD) analyses. We found a single 15-mer T-cell epitope (AMATGWLQYNGSWYY), which has not only affinity for both MHC class I and class II but also has the highest population coverage. Besides, the B-cell and IFNγ-inducing epitopes were also selected. All the peptides were assessed for conservancy, allergenicity, immunogenicity, and hydrophobicity. Finally, we assembled the best T-cell, B-cell, and IFNγ-inducing epitopes to make an MEV. The docking and MD simulation study revealed a strong affinity between the MEV and Toll-like receptors. Therefore, we propose that MEV of CbpA could be a novel vaccine candidate, which may induce both humoral and cellular immune responses to non-serotype-specific pneumococcus.
Schlagwörter	Streptococcus pneumoniae ; MHC ; Choline binding protein A (CbpA) ; Epitope based vaccine ; Computer applications to medicine. Medical informatics ; R858-859.7
Thema/Rubrik (Code)	570
Sprache	Englisch
Erscheinungsdatum	2021-01-01T00:00:00Z
Verlag	Elsevier
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

Volltext online

Volltext online

Zusatzmaterialien

Fernleihe an ZB MED

Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

Artikel: Identification of Zinc-Binding Inhibitors of Matrix Metalloproteinase-9 to Prevent Cancer Through Deep Learning and Molecular Dynamics Simulation Approach.

Mathpal, Shalini / Sharma, Priyanka / Joshi, Tushar / Pande, Veena / Mahmud, Shafi / Jeong, Mi-Kyung / Obaidullah, Ahmad J / Chandra, Subhash / Kim, Bonglee

Frontiers in molecular biosciences

2022 Band 9, Seite(n) 857430

Abstract: The overexpression of matrix metalloproteinase-9 (MMP-9) is associated with tumor development and angiogenesis, and hence, it has been considered an attractive drug target for anticancer therapy. To assist in drug design endeavors for MMP-9 targets, ... ...

Abstract	The overexpression of matrix metalloproteinase-9 (MMP-9) is associated with tumor development and angiogenesis, and hence, it has been considered an attractive drug target for anticancer therapy. To assist in drug design endeavors for MMP-9 targets, an
Sprache	Englisch
Erscheinungsdatum	2022-03-31
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2814330-9
ISSN	2296-889X
ISSN	2296-889X
DOI	10.3389/fmolb.2022.857430
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Zusatzmaterialien

Über subito bestellen

Details ▾
- Kostenpflichtig bestellen

Artikel ; Online: Screening of phytochemicals as potent inhibitor of 3-chymotrypsin and papain-like proteases of SARS-CoV2

Swargiary, Ananta / Mahmud, Shafi / Saleh, Md. Abu

Journal of Biomolecular Structure and Dynamics

an in silico approach to combat COVID-19

2020 , Seite(n) 1–15

Schlagwörter	Molecular Biology ; Structural Biology ; General Medicine ; covid19
Sprache	Englisch
Verlag	Informa UK Limited
Erscheinungsland	uk
Dokumenttyp	Artikel ; Online
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2020.1835729
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

Volltext online

Volltext online

Zusatzmaterialien

Verfügbar in ZB MED Köln/Königswinter

Zs.A 2093: Hefte anzeigen

Standort:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Über subito bestellen

Details ▾

Artikel: Inhibition of

Benrahou, Kaoutar / Naceiri Mrabti, Hanae / Bouyahya, Abdelhakim / Daoudi, Nour Elhouda / Bnouham, Mohamed / Mezzour, Hicham / Mahmud, Shafi / Alshahrani, Mohammed Merae / Obaidullah, Ahmad J / Cherrah, Yahia / Faouzi, My El Abbes

Evidence-based complementary and alternative medicine : eCAM

2022 Band 2022, Seite(n) 5868682

Abstract: ... Erodium ... ...

Abstract	Erodium guttatum
Sprache	Englisch
Erscheinungsdatum	2022-08-17
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2022/5868682
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Zusatzmaterialien

Verfügbar in ZB MED Köln/Königswinter

Zs.A 5995: Hefte anzeigen

Standort:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Über subito bestellen

Details ▾
- Im ZB MED-Bestand
- Kostenpflichtig bestellen

Artikel: Determination of Volatile Compounds of

Hamad Al-Mijalli, Samiah / ELsharkawy, Eman R / Abdallah, Emad M / Hamed, Munerah / El Omari, Nasreddine / Mahmud, Shafi / Alshahrani, Mohammed Merae / Mrabti, Hanae Naceiri / Bouyahya, Abdelhakim

Evidence-based complementary and alternative medicine : eCAM

2022 Band 2022, Seite(n) 9306251

Abstract: ... Mentha ... ...

Abstract	Mentha piperita
Sprache	Englisch
Erscheinungsdatum	2022-06-14
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2022/9306251
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Zusatzmaterialien

Verfügbar in ZB MED Köln/Königswinter

Zs.A 5995: Hefte anzeigen

Standort:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Über subito bestellen

Details ▾
- Im ZB MED-Bestand
- Kostenpflichtig bestellen

Artikel ; Online: Identification and in silico molecular modelling study of newly isolated Bacillus subtilis SI-18 strain against S9 protein of Rhizoctonia solani

Md. Samiul Islam / Shafi Mahmud / Razia Sultana / Wubei Dong

Arabian Journal of Chemistry, Vol 13, Iss 12, Pp 8600-

2020 Band 8612

Abstract: The numerous bioactive components from Bacillus subtilis are commonly used as antimicrobial agents for reducing plant diseases caused by fungal pathovars. In this study, we isolated and identified B. subtilis SI-18 strain from twenty isolates of ... ...

Abstract	The numerous bioactive components from Bacillus subtilis are commonly used as antimicrobial agents for reducing plant diseases caused by fungal pathovars. In this study, we isolated and identified B. subtilis SI-18 strain from twenty isolates of rhizosphere soil through morphological and molecular approaches, and explored its inhibitory activities against Rhizoctonia solani. According to morphological features and 16S rRNA and gyrB gene sequence analysis, B. subtilis SI-18 strain was identified. Additionally, the culture filtrate of B. subtilis SI-18 resulted in the suppression of R. solani mycelium growth and material leakage from the cells. Then, we have performed homology modelling and molecular docking study of S9 protein from R. solani where three potential compounds (D1, D2, and D3) were identified among 134 antimicrobial compounds derived from B. subtilis group based on higher binding energy and interaction at the active grove of the target protein. The D1 compound creates alkyl bond at Val48 whereas D2 also binds with Val48 by creating hydrogen bond. On the other hand, two hydrogen bonds were observed at Val48 and Ile52 by D3, which might be responsible for possible blocking of the target S9 protein of R. solani. To validate the docking study and understand the change in drug-ligand conformation, molecular dynamics simulation was assessed where rigid conformation was found for D1, D2 and D3 complexes. Moreover, ADMET study confirms that no toxicity and carcinogenicity were found for screened compounds. Based on our studies, we demonstrated that compounds D1, D2, and D3 derived from B. subtilis can be a potential inhibitor of S9 protein of R. solani that might be a possible strategy for fungal disease prevention.
Schlagwörter	Bacillus subtilis ; Antimicrobial potential ; Rhizoctonia solani ; S9 protein ; Molecular docking ; Chemistry ; QD1-999
Thema/Rubrik (Code)	500
Sprache	Englisch
Erscheinungsdatum	2020-12-01T00:00:00Z
Verlag	Elsevier
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

Volltext online

Volltext online

Zusatzmaterialien

Fernleihe an ZB MED

Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

Zum Seitenanfang

Zusatzmaterialien

Kategorien

Über subito bestellen

Fernleihe an ZB MED

Zusatzmaterialien

Kategorien

Verfügbar in ZB MED Köln/Königswinter

Über subito bestellen

Zusatzmaterialien

Kategorien

Über subito bestellen

Zusatzmaterialien

Kategorien

Verfügbar in ZB MED Köln/Königswinter

Über subito bestellen

Volltext online

Zusatzmaterialien

Kategorien

Fernleihe an ZB MED

Zusatzmaterialien

Kategorien

Über subito bestellen

Volltext online

Zusatzmaterialien

Kategorien

Verfügbar in ZB MED Köln/Königswinter

Über subito bestellen

Zusatzmaterialien

Kategorien

Verfügbar in ZB MED Köln/Königswinter

Über subito bestellen

Zusatzmaterialien

Kategorien

Verfügbar in ZB MED Köln/Königswinter

Über subito bestellen

Volltext online

Zusatzmaterialien

Kategorien

Fernleihe an ZB MED