Artikel ; Online: The effect of Ding-kun-dan comparing with Marvelon on primary dysmenorrhea: A prospective, double-blind, multicenter, randomized controlled trial.
2023 Band 318, Heft Pt B, Seite(n) 116975
Abstract: Ethnopharmacological relevance: Ding-kun-dan (DKD), as one of well-known ... Aim of the study: To compare the effect of Ding-kun-dan (DKD) with Marvelon on relief of symptoms and ... 4: Conclusion: Ding-kun-dan is another available, effective and safe method for patients ...
| Abstract | Ethnopharmacological relevance: Ding-kun-dan (DKD), as one of well-known traditional Chinese medicine (TCM), is considered as an effective prescription to regulate menstruation, benefit Qi and nourish the blood. Previous studies had showed that DKD could improve sex hormone levels, insulin resistance, metabolism abnormalities and regulate immunity in animal models with polycystic ovary syndrome or endometriosis, however, little study conducted to reveal its clinical efficacy in Primary Dysmenorrhea (PD). Aim of the study: To compare the effect of Ding-kun-dan (DKD) with Marvelon on relief of symptoms and change of serum pain-related factors in patients with primary dysmenorrhea. Materials and method: 136 patients with primary dysmenorrhea were randomly assigned to the DKD group (n = 73, take one tablet per day from 5th day of the menstrual cycle for 10 days every 28 days) and the Marvelon group (n = 63, take one tablet per day from 5th day of the menstrual cycle for 21 days every 28 days), the therapeutic effects were analyzed through evaluating the change of VAS scores, CMSS scores and the level of PGF Results: Both DKD and Marvelon could effectively relief pain and other associated symptoms at each visit (Baseline, 4 Conclusion: Ding-kun-dan is another available, effective and safe method for patients with primary dysmenorrhea to choose, especially for those who are suffered from mild pain and/or contraindicated to hormonal agents. |
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| Mesh-Begriff(e) | Female ; Humans ; Desogestrel/therapeutic use ; Dinoprostone ; Double-Blind Method ; Dysmenorrhea/drug therapy ; Dysmenorrhea/diagnosis ; Endometriosis ; Medicine, Chinese Traditional ; Prospective Studies |
| Chemische Substanzen | Desogestrel (81K9V7M3A3) ; Dinoprostone (K7Q1JQR04M) |
| Sprache | Englisch |
| Erscheinungsdatum | 2023-07-29 |
| Erscheinungsland | Ireland |
| Dokumenttyp | Journal Article ; Multicenter Study ; Randomized Controlled Trial |
| ZDB-ID | 134511-4 |
| ISSN | 1872-7573 ; 0378-8741 |
| ISSN (online) | 1872-7573 |
| ISSN | 0378-8741 |
| DOI | 10.1016/j.jep.2023.116975 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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