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  1. Artikel: Case Report: Metagenomic Next-Generation Sequencing in Diagnosis of Talaromycosis of an Immunocompetent Patient.

    Shi, Jiejun / Yang, Naibin / Qian, Guoqing

    Frontiers in medicine

    2021  Band 8, Seite(n) 656194

    Abstract: Background: ...

    Abstract Background:
    Sprache Englisch
    Erscheinungsdatum 2021-03-29
    Erscheinungsland Switzerland
    Dokumenttyp Case Reports
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2021.656194
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  2. Artikel ; Online: Relationship between skeletal muscle mass loss and metabolic dysfunction-associated fatty liver disease among Chinese patients with metabolic dysregulation.

    Xu, Miao / Lin, Yi / Yang, Naibin / Li, Jialin / Li, Li / Ding, Huiqing / Xu, Chengfu

    Revista da Associacao Medica Brasileira (1992)

    2024  Band 70, Heft 3, Seite(n) e20230963

    Abstract: Objective: The aim of this study was to explore the correlation between skeletal muscle content and the presence and severity of metabolic dysfunction-associated fatty liver disease in patients with metabolic dysregulation in China.: Methods: A cross- ...

    Abstract Objective: The aim of this study was to explore the correlation between skeletal muscle content and the presence and severity of metabolic dysfunction-associated fatty liver disease in patients with metabolic dysregulation in China.
    Methods: A cross-sectional study was conducted among patients from the endocrinology outpatient department at Ningbo First Hospital, in Ningbo, China, in April 2021. Adult patients with metabolic dysregulation who accepted FibroScan ultrasound were included in the study. However, those without clinical data on skeletal muscle mass were excluded. FibroScan ultrasound was used to noninvasively evaluate metabolic dysfunction-associated fatty liver disease. The controlled attenuation parameter was used as an evaluation index for the severity of liver steatosis. Bioelectrical impedance analysis was used to measure the skeletal muscle index.
    Results: A total of 153 eligible patients with complete data were included in the final analysis. As the grading of liver steatosis intensifies, skeletal muscle index decreases (men: Ptrend<0.001, women: Ptrend=0.001), while body mass index, blood pressure, blood lipid, uric acid, aminotransferase, and homeostatic model assessment of insulin resistance increase (Ptrend<0.01). After adjusting for confounding factors, a negative association between skeletal muscle index and the presence of metabolic dysfunction-associated fatty liver disease was observed in men (OR=0.691, p=0.027) and women (OR=0.614, p=0.022). According to the receiver operating characteristic curve, the best cutoff values of skeletal muscle index for predicting the metabolic dysfunction-associated fatty liver disease presence were 40.37% for men (sensitivity, 87.5%; specificity, 61.5%) and 33.95% for women (sensitivity, 78.6%; specificity, 63.8%).
    Conclusion: Skeletal muscle mass loss among patients with metabolic dysregulation was positively associated with metabolic dysfunction-associated fatty liver disease severity in both sexes. The skeletal muscle index cutoff value could be used to predict metabolic dysfunction-associated fatty liver disease.
    Mesh-Begriff(e) Adult ; Male ; Humans ; Female ; Cross-Sectional Studies ; Non-alcoholic Fatty Liver Disease/complications ; Non-alcoholic Fatty Liver Disease/diagnostic imaging ; Outpatients ; Blood Pressure ; China
    Sprache Englisch
    Erscheinungsdatum 2024-03-04
    Erscheinungsland Brazil
    Dokumenttyp Journal Article
    ZDB-ID 731969-1
    ISSN 1806-9282 ; 0104-4230 ; 0004-5241 ; 0102-843X
    ISSN (online) 1806-9282
    ISSN 0104-4230 ; 0004-5241 ; 0102-843X
    DOI 10.1590/1806-9282.20230963
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  3. Artikel ; Online: The association between atherogenic index of plasma and metabolic dysfunction-associated fatty liver disease as detected by FibroScan.

    Wang, Aili / Li, Jialin / Li, Li / Ding, Huiqing / Yang, Naibin / Xu, Miao

    Nutricion hospitalaria

    2024  Band 41, Heft 2, Seite(n) 384–392

    Abstract: Introduction: Objectives: this study aimed to explore the potential of the atherogenic index of plasma (AIP) as a predictor of metabolic dysfunction-associated fatty liver disease (MAFLD). Methods: a cross-sectional study, including data from 4473 ... ...

    Titelübersetzung Asociación entre el índice aterogénico del plasma y la enfermedad hepática grasa asociada a disfunción metabólica detectada por FibroScan.
    Abstract Introduction: Objectives: this study aimed to explore the potential of the atherogenic index of plasma (AIP) as a predictor of metabolic dysfunction-associated fatty liver disease (MAFLD). Methods: a cross-sectional study, including data from 4473 participants in the National Health and Nutrition Examination Survey (NHANES) 2017-2018, was performed. A control attenuation parameter (CAP) ≥ 285 dB/m was used to confirm hepatic steatosis. Degrees of liver stiffness were confirmed according to liver stiffness measurement (LSM). Weighted multivariate logistic regression models were used to assess the association between AIP and the risk for MAFLD and liver fibrosis. Finally, receiver operating characteristic (ROC) curve analysis was used to test the accuracy of AIP in predicting MAFLD. Results: the association between AIP and the prevalence of MAFLD was positive in all three multivariate logistic regression models (model 1, odds ratio (OR), 18.2 (95 % confidence interval (CI), 14.4-23.1); model 2, OR, 17.0 (95 % CI, 13.3-21.8); model 3, OR, 5.2 (95 % CI, 3.9-7.0)). Moreover, this positive relationship was found to be significant in patients of different sexes and whether they had diabetes. However, no significant differences were observed between AIP and significant fibrosis or cirrhosis as assessed by different liver fibrosis indices. Finally, ROC curve analysis demonstrated that the AIP index also demonstrated positive diagnostic utility (area under the ROC curve, 0.733 (95 % CI, 0.718-0.747); p < 0.001). Conclusion: This study revealed a positive association between AIP and MAFLD among American adults. Furthermore, this association persisted in different sexes and whether they had diabetes.
    Mesh-Begriff(e) Humans ; Male ; Female ; Cross-Sectional Studies ; Middle Aged ; Adult ; Elasticity Imaging Techniques ; Nutrition Surveys ; Atherosclerosis/blood ; Atherosclerosis/diagnostic imaging ; Fatty Liver/diagnostic imaging ; Fatty Liver/blood ; Fatty Liver/epidemiology ; Fatty Liver/complications ; Liver Cirrhosis/diagnostic imaging ; Liver Cirrhosis/blood ; Aged ; Metabolic Diseases/blood ; Metabolic Diseases/epidemiology ; Metabolic Diseases/complications
    Sprache Englisch
    Erscheinungsdatum 2024-04-15
    Erscheinungsland Spain
    Dokumenttyp Journal Article
    ZDB-ID 1481223-x
    ISSN 1699-5198 ; 0212-1611
    ISSN (online) 1699-5198
    ISSN 0212-1611
    DOI 10.20960/nh.04891
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  4. Artikel ; Online: Association between body roundness index and non-alcoholic fatty liver disease detected by Fibroscan in America.

    Jiang, Ningning / Zhang, Shengguo / Chu, Jinguo / Yang, Naibin / Lu, Mingqin

    Journal of clinical laboratory analysis

    2023  Band 37, Heft 19-20, Seite(n) e24973

    Abstract: Background: The prevalence of non-alcoholic fatty liver disease (NAFLD) and obesity is worldwide on the rise. Body roundness index (BRI), as a newly developed anthropometric indicator, has been recently reported to identify obesity. However, it is still ...

    Abstract Background: The prevalence of non-alcoholic fatty liver disease (NAFLD) and obesity is worldwide on the rise. Body roundness index (BRI), as a newly developed anthropometric indicator, has been recently reported to identify obesity. However, it is still unclear whether BRI is associated with the prevalence of NAFLD.
    Methods: Data were from the National Health and Nutrition Examination Survey (NHANES) 2017-2018. NAFLD was diagnosed based on hepatic steatosis defined by CAP values ≥274 dB/m. Multivariable logistic regression analysis was performed to detect the association between BRI and the odds of NAFLD. Subgroup analysis stratified by age, gender, BMI, and race was further conducted. To explore the potential ability of BRI in predicting NAFLD, the area under the curve (AUC) of BRI was calculated by receiver operating characteristic (ROC) analysis.
    Results: Among the 4467 study participants, 1718 (38.5%) were diagnosed with NAFLD. Compared to the non-NAFLD group, participants with NAFLD had a higher level of BRI. The positive associations between BRI and NAFLD were detected in all three models (mode 1: OR = 1.71, 95% CI: 1.65-1.78, p < 0.0001; mode 2: OR = 1.78, 95% CI: 1.71-1.86, p < 0.0001; mode3: OR = 1.23, 95% CI: 1.11-1.35, p < 0.0001). The positive association steadily existed in different subgroups after stratified by age, gender, and BMI. Moreover, the non-linear association between BRI and NAFLD was detected, presenting inverted U-shaped curves. Furthermore, BRI had a high predictive value (AUC = 0.807) in identifying NAFLD.
    Conclusions: BRI was positively associated with the prevalence of NAFLD among individuals in America, regardless of age, gender, and BMI. Besides, BRI presented a high ability for identifying NAFLD.
    Mesh-Begriff(e) Humans ; Non-alcoholic Fatty Liver Disease/diagnostic imaging ; Non-alcoholic Fatty Liver Disease/epidemiology ; Nutrition Surveys ; Body Mass Index ; Obesity/epidemiology ; Anthropometry
    Sprache Englisch
    Erscheinungsdatum 2023-10-18
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 645095-7
    ISSN 1098-2825 ; 0887-8013
    ISSN (online) 1098-2825
    ISSN 0887-8013
    DOI 10.1002/jcla.24973
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  5. Artikel ; Online: Mesencephalic Astrocyte-derived Neurotrophic Factor Supports Hepatitis B Virus-Induced Immunotolerance.

    Xie, Huiyuan / Deng, Haiyan / Yang, Xiaoping / Gao, Xianxian / Yang, Shanru / Chen, Weiyi / Wang, Yixuan / Yang, Naibin / Yong, Liang / Hou, Xin

    Cellular and molecular gastroenterology and hepatology

    2024  

    Abstract: Background & aims: The immune tolerance induced by Hepatitis B virus (HBV) is a major challenge for achieving effective viral clearance, and the mechanisms involved are not well understood. One potential factor involved in modulating immune responses is ...

    Abstract Background & aims: The immune tolerance induced by Hepatitis B virus (HBV) is a major challenge for achieving effective viral clearance, and the mechanisms involved are not well understood. One potential factor involved in modulating immune responses is mesencephalic astrocyte-derived neurotrophic factor (MANF), which has been reported to be increased in patients with chronic hepatitis B. In this study, our objective is to examine the role of MANF in regulating immune responses to HBV.
    Methods: We utilized a commonly used HBV-harboring mouse model, where mice were hydrodynamically injected with the pAAV/HBV1.2 plasmid. We assessed the HBV load by measuring the levels of various markers including HBsAg, HBeAg, HBcAg, HBV DNA, and HBV RNA.
    Results: Our study revealed that following HBV infection, both myeloid cells and hepatocytes exhibited increased expression of MANF. Moreover, we observed that mice with myeloid-specific MANF knockout (Manf
    Conclusion: The current study reveals that MANF plays a previously unrecognized regulatory role in liver tolerance by expanding MDSCs in the liver through IL-6/ STAT3 signaling, leading to MDSC-mediated CD8
    Sprache Englisch
    Erscheinungsdatum 2024-05-15
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2819778-1
    ISSN 2352-345X ; 2352-345X
    ISSN (online) 2352-345X
    ISSN 2352-345X
    DOI 10.1016/j.jcmgh.2024.05.008
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  6. Artikel ; Online: The association between non-alcoholic fatty liver disease and serum ferritin levels in American adults.

    Yang, Naibin / Lu, Yi / Cao, Liwen / Lu, Mingqin

    Journal of clinical laboratory analysis

    2022  Band 36, Heft 2, Seite(n) e24225

    Abstract: Background: Elevated serum ferritin levels (SFLs) was previously reported to be related with hepatic histologic severity and advanced liver fibrosis among non-alcoholic fatty liver disease (NAFLD) patients. However, whether NAFLD influences SFLs remains ...

    Abstract Background: Elevated serum ferritin levels (SFLs) was previously reported to be related with hepatic histologic severity and advanced liver fibrosis among non-alcoholic fatty liver disease (NAFLD) patients. However, whether NAFLD influences SFLs remains uncertain and needs more clinical evidences. This study explored the differences of SFLs in US adults with or without NAFLD.
    Methods: We conducted a cross-sectional study of 3689 participants aged 18-80 years using the National Health and Nutrition Examination Survey (NHANES) 2017-2018 cycle. NAFLD status was confirmed based on controlled attenuation parameter (CAP) values ≥274 dB/m through vibration controlled and transient elastography (VCTE). We performed weighted multivariable logistic regression models to evaluate the associations between NAFLD and SFLs in different age and gender.
    Results: There was a positive association between NAFLD and SFLs in all three models (model 1:β = 23.07, 95% CI: 10.32, 35.81; model 2:β = 23.68, 95% CI: 10.86, 36.50; model 3:β = 13.86, 95% CI: 0.29, 27.43). After adjusting for the covariates, this positive association persisted in females (β = 16.22, 95% CI: 2.81, 29.62). Further, relationships between NAFLD and SFLs were significantly different in various age groups. In the subgroup stratified by gender, their associations further differed. In males, the positive association was more prominent in 50-64 age group (β = 70.89, 95% CI: 25.14, 116.64). In females, this positive association was more prominent in 18-34 age group (β = 20.72, 95% CI: 7.45, 33.99). However, no correlations between severe steatosis, significant fibrosis, advanced fibrosis, cirrhosis, and SFLs in adults with NAFLD were found.
    Conclusion: This study indicated that US adults suffered with NAFLD had significantly higher SFLs compared with their counterparts in non-NAFLD group. Moreover, the associations between NAFLD and SFLs further differed by age and gender.
    Mesh-Begriff(e) Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Cross-Sectional Studies ; Female ; Ferritins/blood ; Humans ; Liver Cirrhosis/blood ; Liver Cirrhosis/complications ; Male ; Middle Aged ; Non-alcoholic Fatty Liver Disease/blood ; Non-alcoholic Fatty Liver Disease/complications ; Nutrition Surveys ; Sex Factors ; United States
    Chemische Substanzen Ferritins (9007-73-2)
    Sprache Englisch
    Erscheinungsdatum 2022-01-07
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 645095-7
    ISSN 1098-2825 ; 0887-8013
    ISSN (online) 1098-2825
    ISSN 0887-8013
    DOI 10.1002/jcla.24225
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  7. Artikel ; Online: Case Report

    Jiejun Shi / Naibin Yang / Guoqing Qian

    Frontiers in Medicine, Vol

    Metagenomic Next-Generation Sequencing in Diagnosis of Talaromycosis of an Immunocompetent Patient

    2021  Band 8

    Abstract: Background: Talaromycosis is a serious fungal infection which is rare in immunocompetent people. Since its clinical manifestations lack specificity, it is easy to escape diagnosis or be misdiagnosed leading to high mortality and poor prognosis. It is ... ...

    Abstract Background: Talaromycosis is a serious fungal infection which is rare in immunocompetent people. Since its clinical manifestations lack specificity, it is easy to escape diagnosis or be misdiagnosed leading to high mortality and poor prognosis. It is necessary to be alert to the disease when broad-spectrum antibiotics do not work well in immunocompetent patients.Case Presentation: A 79-year-old man was admitted to our Infectious Diseases Department for recurrent fever and cough. Before admission he has been treated with piperacillin-tazobactam, moxifloxacin followed by antituberculous agents in other hospitals while his symptoms were not thoroughly eased. During the first hospitalization in another hospital, he has been ordered a series of examination including radionuclide whole body bone imaging, transbronchial needle aspiration for subcarinal nodes. However, the results were negative showing no neoplasm. After being admitted to our hospital, he underwent various routine examinations. The initial diagnosis was bacterial pneumonia, and he was given meropenem injection and tigecycline injection successively, but there were no improvement of symptoms and inflammatory indicators. In the end, the main pathogen Talaromyces marneffei was confirmed using Metagenomic Next-Generation Sequencing (mNGS), and his clinical symptoms gradually relieved after targeted antifungal treatment using voriconazole.Conclusion: When empirical anti-infective treatment is ineffective, it is necessary to consider the possibility of opportunistic fungal infections on immunocompetent patients. mNGS, as a new generation of pathogenic testing methods, can often detect pathogenic bacteria faster than traditional methods, providing important help for clinical decision-making.
    Schlagwörter talaromyces marneffei ; immunocompetent ; next-generation sequencing ; anti-fungal treatment ; case report ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2021-03-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
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  8. Artikel: Case Report: Metagenomic Next-Generation Sequencing in Diagnosis of Disseminated Tuberculosis of an Immunocompetent Patient.

    Ye, Yuanting / Yang, Naibin / Zhou, Jingying / Qian, Guoqing / Chu, Jinguo

    Frontiers in medicine

    2021  Band 8, Seite(n) 687984

    Abstract: Disseminated tuberculosis (TB) is a rare disease and mainly occurs in immunodeficient patients. It is marked by hematogenous or lymphatic dissemination ... ...

    Abstract Disseminated tuberculosis (TB) is a rare disease and mainly occurs in immunodeficient patients. It is marked by hematogenous or lymphatic dissemination of
    Sprache Englisch
    Erscheinungsdatum 2021-07-12
    Erscheinungsland Switzerland
    Dokumenttyp Case Reports
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2021.687984
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Relative bradycardia presented as a clinical feature of Brucella melitensis infection

    Kai Huang / Xuxia Yu / Yushan Yu / Yin Cen / Jie Shu / Naibin Yang / Jinguo Chu

    Frontiers in Medicine, Vol

    A case report

    2022  Band 9

    Abstract: Brucellosis, caused by Brucella species, is an infectious disease transmitted through contact with infected animals or their secretions. The clinical disease is characterized by fever and headache. Relative bradycardia is an inappropriate response of ... ...

    Abstract Brucellosis, caused by Brucella species, is an infectious disease transmitted through contact with infected animals or their secretions. The clinical disease is characterized by fever and headache. Relative bradycardia is an inappropriate response of heart rate to body temperature, in which the heart rate does not increase proportionally despite a high fever. In this report, we document one case of Brucella melitensis infection demonstrating relative bradycardia. To our knowledge, this is the first report of relative bradycardia in a patient with brucellosis.
    Schlagwörter brucellosis ; Brucella melitensis ; relative bradycardia ; clinical feature ; heart rate and body temperature relationship ; Medicine (General) ; R5-920
    Sprache Englisch
    Erscheinungsdatum 2022-12-01T00:00:00Z
    Verlag Frontiers Media S.A.
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  10. Artikel: Autophagy genes CCL2 and MYC are considered as potential biomarkers for pulmonary embolism.

    Zhang, Xuehui / Yang, Naibin / Shao, Lijiang / Chen, Xuxia / Chen, Xueqin

    American journal of translational research

    2022  Band 14, Heft 8, Seite(n) 5896–5904

    Abstract: Objective: The pathogenesis of pulmonary embolism (PE) remains unclear. This study was designed to determine the differential genes associated with PE autophagy via the gene expression omnibus (GEO).: Methods: Microarray data sets GSE11851 and ... ...

    Abstract Objective: The pathogenesis of pulmonary embolism (PE) remains unclear. This study was designed to determine the differential genes associated with PE autophagy via the gene expression omnibus (GEO).
    Methods: Microarray data sets GSE11851 and GSE13535 were downloaded from the GEO to determine the differentially expressed genes (DEGs) of PE, and the protein-protein interaction (PPI) and hub gene networks were constructed by string and Cytoscape software. Additionally, the two data sets were screened to find the autophagy-related genes with common differential expression. Then, autophagy-related hub genes (ARHGs) overlapping with autophagy-related genes and hub genes were identified. Next, the mRNA-miRNA network was constructed, and finally the expressions of hub genes were determined with GSE11851 and GSE13535.
    Results: A total of 235 common DEGs were identified, and C-C motif chemokine ligand 2 (CCL2) and MYC proto-oncogene (MYC) were identified to be the ARHGs of PE. Additionally, a co-expression network of mRNAs and miRNAs, consisting of 94 nodes and 103 edges, was constructed by Cytoscape. PE samples showed significantly higher expressions of CCL2 and MYC than the control samples (P < 0.05). According to gene set enrichment analysis (GSEA), CCL2 was closely correlated with oxidative stress and inflammatory reaction, while MYC was closely correlated with inflammatory reaction.
    Conclusion: According to analysis, CCL2 and MYC, with high expression in PE samples, are promising potential markers of PE.
    Sprache Englisch
    Erscheinungsdatum 2022-08-15
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2471058-1
    ISSN 1943-8141
    ISSN 1943-8141
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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